Primary pancreatic lymphoma(PPL)is an extremely rare form of extranodal malignant lymphoma.The most common histological subtype of PPL is diffuse large B cell lymphoma(DLBCL).In rare cases,PPL can also present as foll...Primary pancreatic lymphoma(PPL)is an extremely rare form of extranodal malignant lymphoma.The most common histological subtype of PPL is diffuse large B cell lymphoma(DLBCL).In rare cases,PPL can also present as follicular lymphoma,small lymphocytic lymphoma,and T cell lymphoma either of non-Hodgkin’s lymphoma or of Hodgkin’s lymphoma.T-cell/histiocyterich large B-cell lymphoma(T/HRBCL)is an uncommon morphologic variant of DLBCL with aggressive clinical course,it is predominantly a nodal disease,but extranodal sites such as bone marrow,liver,and spleen can be involved.Pancreatic involvement of T/HRBCL was not presented before.Herein,we report a 48-year-old male who was hospitalized with complaints of jaundice,dark brown urine,pale stools,and nausea.The radiological evaluation revealed a pancreatic head mass and,following operative biopsy,the tumor was diagnosed as T/HRBCL.The patient achieved remission after six cycles of CHOP chemotherapy.Therefore,T/HRBCL can be treated similarly to the stage-matched DLBCL and both of them get equivalent outcomes after chemotherapy.展开更多
For decades,memory research has centered on the role of neurons,which do not function in isolation.However,astrocytes play important roles in regulating neuronal recruitment and function at the local and network level...For decades,memory research has centered on the role of neurons,which do not function in isolation.However,astrocytes play important roles in regulating neuronal recruitment and function at the local and network levels,forming the basis for information processing as well as memory formation and storage.In this review,we discuss the role of astrocytes in memory functions and their cellular underpinnings at multiple time points.We summarize important breakthroughs and controversies in the field as well as potential avenues to further illuminate the role of astrocytes in memory processes.展开更多
Compared to data on adolescents and adults,limited research has been conducted on biological correlates among young children with possible psychological difficulties,especially in Asian countries.By focusing on variou...Compared to data on adolescents and adults,limited research has been conducted on biological correlates among young children with possible psychological difficulties,especially in Asian countries.By focusing on various peripheral biochemical indicators,we investigated potential biological correlates of psychological states in a community sample of Taiwan Residents school children aged6–10 years.In total,307 students(159 obese children and148 normal-weight children) were selected from first- and fourth-grade school children in eight elementary schools in the Taipei metropolitan area in 2009.These children underwent a comprehensive health examination,including a physical examination,blood sample analysis,andquestionnaire administration in a hospital.Differences in anthropometric and serum biochemical readings were compared between children with average and worse levels on each of the five psychological domains.We found that interleukin(IL)-1β [b = 1.29,95 % confidence interval(CI) 0.50–2.09],IL-10(b = 1.61,95 % CI \0.01–3.24),fasting blood glucose(b = 0.08,95 % CI 0.01–0.15),homocysteine(b = 0.63,95 % CI 0.09–1.18),and aspartate transaminase(AST)(b = 0.15,95 % CI \0.01–0.31)were significantly positively associated with anxiety.In addition,IL-1β,insulin,AST,and alanine aminotransaminase(ALT) were significantly positively associated with depression.Anger and disruptive behaviors were also related to specific biological correlates.Specific biological correlates,including AST/ALT,cardiovascular diseaserelated variables,and specific cytokines,were linked to particular psychological states among young children in this Asian population.These might provide a route for better understanding the biological aspects of children's mental health and might contribute to research on diagnostic or predictive biomarkers for psychiatric diseases in young children.展开更多
Astrocytes,which are at least as abundant as neurons in the central nervous system,are crucial for sustaining nearly all aspects of brain functions,including ion and neurotransmitter homeostasis,neural circuit formati...Astrocytes,which are at least as abundant as neurons in the central nervous system,are crucial for sustaining nearly all aspects of brain functions,including ion and neurotransmitter homeostasis,neural circuit formation,synaptic plasticity,and function as well as neurovascular coupling[1].Astrocytes are also involved in diseases,including Huntington’s disease(HD)[2].展开更多
文摘Primary pancreatic lymphoma(PPL)is an extremely rare form of extranodal malignant lymphoma.The most common histological subtype of PPL is diffuse large B cell lymphoma(DLBCL).In rare cases,PPL can also present as follicular lymphoma,small lymphocytic lymphoma,and T cell lymphoma either of non-Hodgkin’s lymphoma or of Hodgkin’s lymphoma.T-cell/histiocyterich large B-cell lymphoma(T/HRBCL)is an uncommon morphologic variant of DLBCL with aggressive clinical course,it is predominantly a nodal disease,but extranodal sites such as bone marrow,liver,and spleen can be involved.Pancreatic involvement of T/HRBCL was not presented before.Herein,we report a 48-year-old male who was hospitalized with complaints of jaundice,dark brown urine,pale stools,and nausea.The radiological evaluation revealed a pancreatic head mass and,following operative biopsy,the tumor was diagnosed as T/HRBCL.The patient achieved remission after six cycles of CHOP chemotherapy.Therefore,T/HRBCL can be treated similarly to the stage-matched DLBCL and both of them get equivalent outcomes after chemotherapy.
基金supported by grants from the STI2030-Major Projects(2022ZD02047022022ZD0214300)+2 种基金the National Natural Science Foundation of China(82090032,31830033,and 32271014)the Key Area Research and Development Program of Guangdong Province(2018B030334001 and 2018B030340001)the Science and Technology Program of Guangzhou(202007030013).
文摘For decades,memory research has centered on the role of neurons,which do not function in isolation.However,astrocytes play important roles in regulating neuronal recruitment and function at the local and network levels,forming the basis for information processing as well as memory formation and storage.In this review,we discuss the role of astrocytes in memory functions and their cellular underpinnings at multiple time points.We summarize important breakthroughs and controversies in the field as well as potential avenues to further illuminate the role of astrocytes in memory processes.
基金supported by Taipei Medical University Hospital(98TMU-TMUH-01-5,99TMU-TMUH-02-4)
文摘Compared to data on adolescents and adults,limited research has been conducted on biological correlates among young children with possible psychological difficulties,especially in Asian countries.By focusing on various peripheral biochemical indicators,we investigated potential biological correlates of psychological states in a community sample of Taiwan Residents school children aged6–10 years.In total,307 students(159 obese children and148 normal-weight children) were selected from first- and fourth-grade school children in eight elementary schools in the Taipei metropolitan area in 2009.These children underwent a comprehensive health examination,including a physical examination,blood sample analysis,andquestionnaire administration in a hospital.Differences in anthropometric and serum biochemical readings were compared between children with average and worse levels on each of the five psychological domains.We found that interleukin(IL)-1β [b = 1.29,95 % confidence interval(CI) 0.50–2.09],IL-10(b = 1.61,95 % CI \0.01–3.24),fasting blood glucose(b = 0.08,95 % CI 0.01–0.15),homocysteine(b = 0.63,95 % CI 0.09–1.18),and aspartate transaminase(AST)(b = 0.15,95 % CI \0.01–0.31)were significantly positively associated with anxiety.In addition,IL-1β,insulin,AST,and alanine aminotransaminase(ALT) were significantly positively associated with depression.Anger and disruptive behaviors were also related to specific biological correlates.Specific biological correlates,including AST/ALT,cardiovascular diseaserelated variables,and specific cytokines,were linked to particular psychological states among young children in this Asian population.These might provide a route for better understanding the biological aspects of children's mental health and might contribute to research on diagnostic or predictive biomarkers for psychiatric diseases in young children.
基金the National Natural Science Foundation of China(31430032,81329003,81671356,31801007 and 81881240049)the Program for Changjiang Scholars and Innovative Research Team in University(IRT_16R37)+3 种基金the Science and Technology Program of Guangdong Province,China(2018B030334001)Basic and Applied Basic Research Foundation of Guangdong Province,China(2020A1515011310)Science and Technology Program of Guangzhou Municipality(201707020027)Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence Fund(2019019).
文摘Astrocytes,which are at least as abundant as neurons in the central nervous system,are crucial for sustaining nearly all aspects of brain functions,including ion and neurotransmitter homeostasis,neural circuit formation,synaptic plasticity,and function as well as neurovascular coupling[1].Astrocytes are also involved in diseases,including Huntington’s disease(HD)[2].