BACKGROUND Forearm crisscross injury is rare in children;there is no relevant literature so far.Surgeons lack experience and knowledge in treating this type of crisscross injury.We report a case of forearm crisscross ...BACKGROUND Forearm crisscross injury is rare in children;there is no relevant literature so far.Surgeons lack experience and knowledge in treating this type of crisscross injury.We report a case of forearm crisscross injury in a child for the first time and analyze its mechanism.CASE SUMMARY An 8-year-old boy experienced pain in his left forearm when he accidentally fell while skateboarding.Physical examination revealed swelling and deformity of the left forearm.We performed imaging and the results revealed left radial head dislocation,left distal radial epiphyseal separation from the shaft,and interruption of the continuity of the dorsal cortex of the left distal ulna.Anteroposterior and lateral X-ray films showed that the radius and ulna were crisscrossed.A diagnosis of superior radioulnar joint dislocation,left distal radial epiphyseal injury,and left distal ulnar fracture was made.After unsuccessful manual reduction,we adopted a minimally invasive procedure and succeeded.After a 14-wk period of follow-up,the patient had good left upper limb function,no complaints of pain or limited range of motion,and good follow-up results.CONCLUSION This is the first report of a child with a forearm crisscross injury in which the mechanism and the differences from adult crisscross injury are analyzed.Minimally invasive surgery with intramedullary fixation can achieve a good therapeutic effect.This case provides a reference for the treatment of similar patients in the future.展开更多
Near-infrared light(NIR)triggered transdermal drug delivery systems are of great interest due to their on-demand drug release,which enable to enhance drug treatment efficiency as well as reduce side effect.Herein,a NI...Near-infrared light(NIR)triggered transdermal drug delivery systems are of great interest due to their on-demand drug release,which enable to enhance drug treatment efficiency as well as reduce side effect.Herein,a NIR-triggered microneedle(MN)patch array has been fabricated through depositing the photothermal conversion agent and anti-diabetic drug-loaded polymer vesicles with upper critical solution temperature(UCST)into dissolvable polymer matrix.The UCST-type polymer has a clearing point temperature of 41℃ and the drug-loaded polymer vesicles present excellent NIR-triggered and temperature responsive drug release behavior in vitro due to the disassociation of polymer vesicles upon NIR irradiation.After applying MNs to diabetic rats,significant hypoglycemic effect is achieved upon interval NIR irradiation and the blood glucose concentration can decrease to normal state for several hours,which enables to achieve the goal of on-demand drug release.This work suggests that the NIR-triggered MN drug release device has a potential application in the treatment of diabetes,especially for those requiring an active drug release manner.展开更多
文摘BACKGROUND Forearm crisscross injury is rare in children;there is no relevant literature so far.Surgeons lack experience and knowledge in treating this type of crisscross injury.We report a case of forearm crisscross injury in a child for the first time and analyze its mechanism.CASE SUMMARY An 8-year-old boy experienced pain in his left forearm when he accidentally fell while skateboarding.Physical examination revealed swelling and deformity of the left forearm.We performed imaging and the results revealed left radial head dislocation,left distal radial epiphyseal separation from the shaft,and interruption of the continuity of the dorsal cortex of the left distal ulna.Anteroposterior and lateral X-ray films showed that the radius and ulna were crisscrossed.A diagnosis of superior radioulnar joint dislocation,left distal radial epiphyseal injury,and left distal ulnar fracture was made.After unsuccessful manual reduction,we adopted a minimally invasive procedure and succeeded.After a 14-wk period of follow-up,the patient had good left upper limb function,no complaints of pain or limited range of motion,and good follow-up results.CONCLUSION This is the first report of a child with a forearm crisscross injury in which the mechanism and the differences from adult crisscross injury are analyzed.Minimally invasive surgery with intramedullary fixation can achieve a good therapeutic effect.This case provides a reference for the treatment of similar patients in the future.
基金financially supported by the Natural Science Foundation of Zhejiang Province(No.LY20E030005)the Opening Project of Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices(No.PMND201905)。
文摘Near-infrared light(NIR)triggered transdermal drug delivery systems are of great interest due to their on-demand drug release,which enable to enhance drug treatment efficiency as well as reduce side effect.Herein,a NIR-triggered microneedle(MN)patch array has been fabricated through depositing the photothermal conversion agent and anti-diabetic drug-loaded polymer vesicles with upper critical solution temperature(UCST)into dissolvable polymer matrix.The UCST-type polymer has a clearing point temperature of 41℃ and the drug-loaded polymer vesicles present excellent NIR-triggered and temperature responsive drug release behavior in vitro due to the disassociation of polymer vesicles upon NIR irradiation.After applying MNs to diabetic rats,significant hypoglycemic effect is achieved upon interval NIR irradiation and the blood glucose concentration can decrease to normal state for several hours,which enables to achieve the goal of on-demand drug release.This work suggests that the NIR-triggered MN drug release device has a potential application in the treatment of diabetes,especially for those requiring an active drug release manner.
