EBV-positive diffuse large B-cell lymphoma(DLBCL),which has a clonal EBV carrying proliferation of B-cells,defines a new DLBCL subtype and predicts a poor prognosis.Further studies are needed to explore the underlying...EBV-positive diffuse large B-cell lymphoma(DLBCL),which has a clonal EBV carrying proliferation of B-cells,defines a new DLBCL subtype and predicts a poor prognosis.Further studies are needed to explore the underlying mechanisms in EBV lymphomagenesis.EBV encoded microRNAs(miRNAs)have been proven to contribute to the pathogenesis and oncogenesis of EBV-associated malignancies.^(1)In this study,research has focused on the pathological roles of miRNAs in EBV-positive DLBCL progression and survival,which might provide ideas for therapeutic decision to improve the prognosis.展开更多
基金the National Natural Science Foundation of China(No.81770166,81720108002)Jiangsu Province’s Medical Elite Programme(China)(No.ZDRCA2016022)+1 种基金Project of National Key Clinical Specialty,Jiangsu Provincial Special Program of Medical Science(China)(No.BE2017751)National Science and Technology Major Project(China)(No.2018ZX09734007).
文摘EBV-positive diffuse large B-cell lymphoma(DLBCL),which has a clonal EBV carrying proliferation of B-cells,defines a new DLBCL subtype and predicts a poor prognosis.Further studies are needed to explore the underlying mechanisms in EBV lymphomagenesis.EBV encoded microRNAs(miRNAs)have been proven to contribute to the pathogenesis and oncogenesis of EBV-associated malignancies.^(1)In this study,research has focused on the pathological roles of miRNAs in EBV-positive DLBCL progression and survival,which might provide ideas for therapeutic decision to improve the prognosis.
