Fish Swimming Traces from the Upper Devonian of Wuhan,South China

0 INTRODUCTION Fishes can make diverse traces with various functions such as feeding, resting, dwelling, and nesting(mating). The most common fish trace fossil, however, may be the fish swimming trace Undichna Anderson, 1976, which is typified by singular or multiple sinusoidal trails on bedding surfaces(or as ridges on soles)。

PD-1 inhibitor plus anlotinib for metastatic castration-resistant prostate cancer: a real-world study

Management and treatment of terminal metastatic castration-resistant prostate cancer(mCRPC)remains heavily debated.We sought to investigate the efficacy of programmed cell death 1(PD-1)inhibitor plus anlotinib as a potential solution for terminal mCRPC and further evaluate the association of genomic characteristics with efficacy outcomes.We conducted a retrospective real-world study of 25 mCRPC patients who received PD-1 inhibitor plus anlotinib after the progression to standard treatments.The clinical information was extracted from the electronic medical records and 22 patients had targeted circulating tumor DNA(ctDNA)next-generation sequencing.Statistical analysis showed that 6(24.0%)patients experienced prostate-specific antigen(PSA)response and 11(44.0%)patients experienced PSA reduction.The relationship between ctDNA findings and outcomes was also analyzed.DNA-damage repair(DDR)pathways and homologous recombination repair(HRR)pathway defects indicated a comparatively longer PSA-progressionfree survival(PSA-PFS;2.5 months vs 1.2 months,P=0.027;3.3 months vs 1.2 months,P=0.017;respectively).This study introduces the PD-1 inhibitor plus anlotinib as a late-line therapeutic strategy for terminal mCRPC.PD-1 inhibitor plus anlotinib may be a new treatment choice for terminal mCRPC patients with DDR or HRR pathway defects and requires further investigation.

Palaeoecological Analysis of Trace Fossil Sinusichnus sinuosus from the Middle Triassic Guanling Formationin Southwestern China

The Luoping Biota discovered from the early Middle Triassic （Anisian） Guanling Formation of southwestern China represents a fully recovered shallow marine ecosystem, marking the end point of Early Triassic biotic recovery following the end-Permian mass extinction. Contemporaneously preserved are prolific trace fossils, which offer good opportunities to understand the palaeoecology of marine invertebrates from a fully recovered shallow marine ecosystem. Here we present a newly discovered sinuous branching burrow from the fossil-bearing unit in Member II of the Guanling Formation. Several features, including the horizontal regular sinuous nature, the branching pattern, typical H-junction, and the small wavelength/amplitude ratio of these sinuous structures within the burrow systems justify assignment of these traces as Sinusichnus sinuosus, a trace possibly produced by decapod crustaceans. Close association ofS. sinuosus with Rhizocorallium commune suggests a deposit-feeding strategy of these trace makers. The newly reported Anisian material from the Guanling Formation in Luoping represents first report of Sinusichnus from South China. The global record of Sinusichnus occurrence suggests that these burrows might have an older history than Early Middle Triassic.

Recent progress and focuses of ichnology:Outline of the 14^(th) International Ichnofabric Workshop

The 14^（th） International Ichnofabric Workshop was held successfully in Taipei, China from April 29 thto May 2^（nd）. From the oral presentations, posters, intra-and post-workshop field trips, and workshop discussions, a few promising aspects of ichnological study can be outlined：（1） Ichnotaxonomy is, and will be the major endeavour of ichnologists, supplying important behavioural information for palaeontological studies, and also providing reasonable, objective, and convenient taxonomical framework for further sedimentological and palaeoecological studies;（2） Ichnofabric analysis is widely applied to in-depth sedimentological, palaeoclimatical, and petroleum exploration studies, offering a wealth of biological information that cannot be properly obtained from traditional sedimentological and geochemical analyses;（3） Study of trace fossils in the context of evolutionary palaeoecology sheds light on some intriguing issues of the biological responses during certain critical periods in Earth＇s history;（4）Work on combining geomicrobiology and ichnology is under way;（5） Quantitative morphological characterization has become increasingly useful in grasping the finer ingredients of functional morphology.