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Pathogenetic mechanisms in gastric cancer 被引量:9
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作者 Jing Shi yi-ping qu peng Hou 《World Journal of Gastroenterology》 SCIE CAS 2014年第38期13804-13819,共16页
Gastric cancer(GC) is a major public health issue as the fourth most common cancer and the second leading cause of cancer-related death. Recent advances have improved our understanding of its molecular pathogenesis,as... Gastric cancer(GC) is a major public health issue as the fourth most common cancer and the second leading cause of cancer-related death. Recent advances have improved our understanding of its molecular pathogenesis,as best exemplified by elucidating the fundamental role of several major signaling pathways and related molecular derangements. Central to these mechanisms are the genetic and epigenetic alterations in these signaling pathways,such as gene mutations,copy number variants,aberrant gene methylation and histone modification,nucleosome positioning,and microRNAs. Some of these genetic/epigenetic alterations represent effective diagnostic and prognostic biomarkers and therapeutic targets for GC. This information has now opened unprecedented opportunities for better understanding of the molecular mechanisms of gastric carcinogenesis and the development of novel therapeutic strategies for this cancer. The pathogenetic mechanisms of GC are the focus of this review. 展开更多
关键词 Gastric cancer Risk factors Genetic alterations Epigenetic alterations Signaling pathways
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Boosting the proton conduction in a magnetic dysprosium-organic framework by introducing conjugate NH_(4)^(+)-NH_(3)pairs
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作者 yi-ping qu Qian Zou +1 位作者 Song-Song Bao Li-Min Zheng 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第1期518-522,共5页
Metal-organic frameworks(MOFs)with inherent porosity and suspended acidic groups are promising proton conducting materials in water or aqua-ammonia media.Herein we report a new lanthanide phosphonate,namely,Dy_(2)(amp... Metal-organic frameworks(MOFs)with inherent porosity and suspended acidic groups are promising proton conducting materials in water or aqua-ammonia media.Herein we report a new lanthanide phosphonate,namely,Dy_(2)(amp_(2)H_(2))_(2)(mal)(H_(2)O)_(2)·5H2O(MDAF-6).It possesses a 3D open-framework structure,and shows a high NH_(3)adsorption capacity of 142.4 cm^(3)/g at P/P0=0.98 at 298 K due to acid-base interaction.Interestingly,the proton conductivity of MDAF-6-NH3 is enhanced by five orders of magnitude compared to MDAF-6 after 8.5 h exposure in saturated NH_(3)-H_(2)O vapor,indicating the importance of coexistent conjugate acid-base pairs of H_(3)O+-H_(2)O and NH_(4)^(+)-NH_(3)in promoting proton conduction.Magnetic studies of MDAF-6 revealed slow magnetization relaxation under zero dc field,characteristic of singlemolecule magnet behavior.This work provides not only a new multifunctional MOF material,but also a new strategy to improve proton conduction in aqua-ammonia medium. 展开更多
关键词 Metal-organic framework Proton conduction Ammonia adsorption Metal phosphonate Single molecule magnet
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