BACKGROUND Porokeratosis(PK)is a common autosomal dominant chronic progressive dyskeratosis with various clinical manifestations.Based on clinical manifestations,porokeratosis can be classified as porokeratosis of mib...BACKGROUND Porokeratosis(PK)is a common autosomal dominant chronic progressive dyskeratosis with various clinical manifestations.Based on clinical manifestations,porokeratosis can be classified as porokeratosis of mibelli,disseminated superficial porokeratosis,disseminated superficial actinic porokeratosis,linear porokeratosis(LP),porokeratosis palmaris et plantaris disseminata,porokeratosis punctata,popular PK,hyperkeratosis PK,inflammatory PK,verrucous PK,and mixed types.We report a case of LP in a child and describe its dermoscopic findings.CASE SUMMARY Linear porokeratosis is a rare PK.The patient presented with unilateral keratinizing maculopapular rash of the foot in childhood.The patient underwent skin pathology and dermoscopy,and was treated with liquid nitrogen freezing and topical drugs.CONCLUSION From this case we take-away that LP is a rare disease,by the dermoscopic we can identify it.展开更多
Clear cell renal cell carcinoma(ccRCC)is the most common subtype of renal cell carcinoma,accounting for approximately 80%of cases.Although most patients in the early stages of ccRCC can be cured by surgery,ccRCC is of...Clear cell renal cell carcinoma(ccRCC)is the most common subtype of renal cell carcinoma,accounting for approximately 80%of cases.Although most patients in the early stages of ccRCC can be cured by surgery,ccRCC is often in the advanced stage when patients are diagnosed,.with:>30%of the patients presenting with distant metastases at the time of diagnosis.For ccRCC patients with distant metastases,the 5-year survival is only 12%.Immunotherapy selectively corrects tumor microenviron-ment(TME)immunity,which is of great significance for patients with advanced ccRCC.展开更多
Hemorrhagic cystitis(HC),which is characterized by a congested vasculature and extensive hemorrhage in the bladder lamina propria,is often secondary to chemotherapy,external radiation therapy,allogeneic hematopoietic ...Hemorrhagic cystitis(HC),which is characterized by a congested vasculature and extensive hemorrhage in the bladder lamina propria,is often secondary to chemotherapy,external radiation therapy,allogeneic hematopoietic stem cell transplantation(Allo-HSCT),and/or opportunistic infection.[1]The incidence of HC after Allo-HSCT has been reported to range between 1.3%and 20%.[2]The severity of HC may vary from bladder irritation symptoms with mild hematuria,which is observed in most cases and is resolved with conservative management,such as adequate hydration and bladder irrigation,to transfusion-dependent hemorrhage and/or a lower urinary tract obstruction post renal failure.Other strategies,including bladder irrigation with intravesical alum,formalin,aminocaproic acid,or prostaglandin and hyperbaric oxygen therapy,have been reported,with the resolution of bleeding in the majority of cases.[3]However,for patients in whom these measures fail and the lower urinary tract becomes obstructed by numerous blood clots,further surgery,including internal iliac angioembolization,cystoscopy with control of bladder hemorrhage and cystectomy,should be considered.[4]展开更多
文摘BACKGROUND Porokeratosis(PK)is a common autosomal dominant chronic progressive dyskeratosis with various clinical manifestations.Based on clinical manifestations,porokeratosis can be classified as porokeratosis of mibelli,disseminated superficial porokeratosis,disseminated superficial actinic porokeratosis,linear porokeratosis(LP),porokeratosis palmaris et plantaris disseminata,porokeratosis punctata,popular PK,hyperkeratosis PK,inflammatory PK,verrucous PK,and mixed types.We report a case of LP in a child and describe its dermoscopic findings.CASE SUMMARY Linear porokeratosis is a rare PK.The patient presented with unilateral keratinizing maculopapular rash of the foot in childhood.The patient underwent skin pathology and dermoscopy,and was treated with liquid nitrogen freezing and topical drugs.CONCLUSION From this case we take-away that LP is a rare disease,by the dermoscopic we can identify it.
基金funded by the General Project of China’s National Natural Science Foundation(No.81872086)。
文摘Clear cell renal cell carcinoma(ccRCC)is the most common subtype of renal cell carcinoma,accounting for approximately 80%of cases.Although most patients in the early stages of ccRCC can be cured by surgery,ccRCC is often in the advanced stage when patients are diagnosed,.with:>30%of the patients presenting with distant metastases at the time of diagnosis.For ccRCC patients with distant metastases,the 5-year survival is only 12%.Immunotherapy selectively corrects tumor microenviron-ment(TME)immunity,which is of great significance for patients with advanced ccRCC.
基金supported by the General Project of the National Natural Science Foundation of China(No.81872086).
文摘Hemorrhagic cystitis(HC),which is characterized by a congested vasculature and extensive hemorrhage in the bladder lamina propria,is often secondary to chemotherapy,external radiation therapy,allogeneic hematopoietic stem cell transplantation(Allo-HSCT),and/or opportunistic infection.[1]The incidence of HC after Allo-HSCT has been reported to range between 1.3%and 20%.[2]The severity of HC may vary from bladder irritation symptoms with mild hematuria,which is observed in most cases and is resolved with conservative management,such as adequate hydration and bladder irrigation,to transfusion-dependent hemorrhage and/or a lower urinary tract obstruction post renal failure.Other strategies,including bladder irrigation with intravesical alum,formalin,aminocaproic acid,or prostaglandin and hyperbaric oxygen therapy,have been reported,with the resolution of bleeding in the majority of cases.[3]However,for patients in whom these measures fail and the lower urinary tract becomes obstructed by numerous blood clots,further surgery,including internal iliac angioembolization,cystoscopy with control of bladder hemorrhage and cystectomy,should be considered.[4]
