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原发性肝细胞癌抗血管生成治疗后血管内皮生长因子及血流灌注参数变化 被引量:4
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作者 仲康 张亦青 陈华 《世界华人消化杂志》 CAS 2019年第12期786-790,共5页
背景血管靶向药物是临床治疗肝脏肿瘤所取得的重大进步之一,尤其对于不能行手术切除的晚期原发性肝细胞癌(hepatocellular carcinoma, HCC)患者,其疗效确切.超声造影是一种无创性血流灌注显示方法,能实时动态反映肿瘤组织的微循环血流灌... 背景血管靶向药物是临床治疗肝脏肿瘤所取得的重大进步之一,尤其对于不能行手术切除的晚期原发性肝细胞癌(hepatocellular carcinoma, HCC)患者,其疗效确切.超声造影是一种无创性血流灌注显示方法,能实时动态反映肿瘤组织的微循环血流灌注,可为临床评估HCC抗血管生成疗效提供血流动力学参考信息.目的探讨超声造影在评估HCC抗血管生成疗效中的应用价值.方法选取经肝穿刺活检病理证实的72例HCC患者作为研究对象(共72个病灶),随机分为A组(36例)和B组(36例). A组接受经肝动脉化疗栓塞术(transcatheterarterial chemoembolization, TACE)治疗, B组接受TACE联合沙利度胺治疗.所有患者分别于治疗前、治疗12 wk后行超声造影检查,测量病灶血流灌注参数:曲线下面积(area under curve, AUC)、峰值强度(peak intensity, PI),同期测定血清血管内皮生长因子(vascular endothelial growth factor, VEGF)水平作比较分析.结果B组治疗后AUC、PI以及血清VEGF水平分别低于各组治疗前,差异有统计学意义(P <0.05);B组治疗后AUC、PI以及血清VEGF水平明显低于A组治疗后,差异有统计学意义(P <0.05).结论超声造影能定量分析HCC抗血管生成治疗后血流灌注参数变化,有效评估HCC抗血管生成疗效,具有一定应用价值. 展开更多
关键词 超声造影 原发性肝细胞癌 沙利度胺 血管生成抑制剂 血管内皮生长因子
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The analysis of acupoint selection rules for acupuncture treating functional constipation
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作者 Ai-Li Xu Xing-Hua Xiang +5 位作者 Hai-Xia Shi Deng-Ke Liu Ning-Juan Yan yi-qing zhang Wei Yang Wei Wei 《Journal of Hainan Medical University》 2020年第13期49-53,共5页
Objective: To analyze the prescription rule of acupuncture for functional constipation (FC), and explore the effective core clinical acupuncture prescriptions. Methods:The randomized controlled trials published in the... Objective: To analyze the prescription rule of acupuncture for functional constipation (FC), and explore the effective core clinical acupuncture prescriptions. Methods:The randomized controlled trials published in the PubMed, CNKI, Wanfang, and VIP databases were retrieved from January 1, 2010 to January 31, 2020. And the key information about acupuncture therapy for FC in these RCTs was collected according to the predetermined inclusion and exclusion criteria. Eventually, the statisticians analyzed the use frequency of single acupoints and meridian acupoints by descriptive statistical method and explored the combination rule between different acupoints by association rules. Results: Twenty six randomized controlled trials were included, with a total of 29 acupoints. Tianshu (ST25), Shangjuxu (ST37) and Zhongwan (RN12) were the top 3 frequency of acupuncture therapy for FC and the top 3 frequency meridian had been chosen were the stomach meridian of Foot-Yangming, the spleen meridian of Foot-Taiyin and Ren channel. The two acupoints with high support and compatibility frequency ranking in the top 3 are Tianshu (ST25) - Shangjuxu (ST37), Tianshu (ST25) - Zhongwan (RN12), Tianshu (ST25) - Zusanli (ST36). The three acupoints with compatibility frequency ranking in the top 2 are Tianshu (ST25) - Shangjuxu (ST37) - Zusanli (ST36), and Tianshu (ST25) - Shangjuxu (ST37) - Zhigou (SJ6). Conclusion: Tianshu (ST25) is the most common acupoint for acupuncture therapy of FC. Tianshu (ST25) and Shangjuxu (ST37) are the core acupoints to provide basis for clinical practice and future clinical research. 展开更多
关键词 ACUPUNCTURE Functional constipation ACUPOINT Randomized controlled trial Association rules
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Against Ebola: type Ⅰ interferon guard risk and mesenchymal stromal cell combat sepsis 被引量:1
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作者 Lei zhang Hao WANG yi-qing zhang 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2015年第1期1-9,共9页
The 2014 Ebola outbreak in West Africa trig- gered a global crisis. Nine countries have reported more than 20000 infection cases in total and nearly 8000 lives have been lost. The actual death toll is likely much high... The 2014 Ebola outbreak in West Africa trig- gered a global crisis. Nine countries have reported more than 20000 infection cases in total and nearly 8000 lives have been lost. The actual death toll is likely much higher than this figure; the death rate is as high as 70%, considering confirmed cases. The Ebola virus launches its destruction by shutting down the host's innate and adaptive immune systems. The virus then replicates itself out of control and causes a cytokine storm in the host. Consequently, the host's overdriven immune system attacks its own endothelial cells and this leads to multiple organ hemorrhagic damage, the host dies of septic shock finally. Under current circumstances where no spe- cific interventions have shown effectiveness against the virus, our opinions are justified in applying a non-specific anti-viral approach during the incubation period of virus infection as an essential protection to put the host's immune system into an alert state and henceforth to slow down the viral replication. 展开更多
关键词 埃博拉 非特异性策略 I型干扰素 间充质干细胞
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