Objective: To analyze the prescription rule of acupuncture for functional constipation (FC), and explore the effective core clinical acupuncture prescriptions. Methods:The randomized controlled trials published in the...Objective: To analyze the prescription rule of acupuncture for functional constipation (FC), and explore the effective core clinical acupuncture prescriptions. Methods:The randomized controlled trials published in the PubMed, CNKI, Wanfang, and VIP databases were retrieved from January 1, 2010 to January 31, 2020. And the key information about acupuncture therapy for FC in these RCTs was collected according to the predetermined inclusion and exclusion criteria. Eventually, the statisticians analyzed the use frequency of single acupoints and meridian acupoints by descriptive statistical method and explored the combination rule between different acupoints by association rules. Results: Twenty six randomized controlled trials were included, with a total of 29 acupoints. Tianshu (ST25), Shangjuxu (ST37) and Zhongwan (RN12) were the top 3 frequency of acupuncture therapy for FC and the top 3 frequency meridian had been chosen were the stomach meridian of Foot-Yangming, the spleen meridian of Foot-Taiyin and Ren channel. The two acupoints with high support and compatibility frequency ranking in the top 3 are Tianshu (ST25) - Shangjuxu (ST37), Tianshu (ST25) - Zhongwan (RN12), Tianshu (ST25) - Zusanli (ST36). The three acupoints with compatibility frequency ranking in the top 2 are Tianshu (ST25) - Shangjuxu (ST37) - Zusanli (ST36), and Tianshu (ST25) - Shangjuxu (ST37) - Zhigou (SJ6). Conclusion: Tianshu (ST25) is the most common acupoint for acupuncture therapy of FC. Tianshu (ST25) and Shangjuxu (ST37) are the core acupoints to provide basis for clinical practice and future clinical research.展开更多
The 2014 Ebola outbreak in West Africa trig- gered a global crisis. Nine countries have reported more than 20000 infection cases in total and nearly 8000 lives have been lost. The actual death toll is likely much high...The 2014 Ebola outbreak in West Africa trig- gered a global crisis. Nine countries have reported more than 20000 infection cases in total and nearly 8000 lives have been lost. The actual death toll is likely much higher than this figure; the death rate is as high as 70%, considering confirmed cases. The Ebola virus launches its destruction by shutting down the host's innate and adaptive immune systems. The virus then replicates itself out of control and causes a cytokine storm in the host. Consequently, the host's overdriven immune system attacks its own endothelial cells and this leads to multiple organ hemorrhagic damage, the host dies of septic shock finally. Under current circumstances where no spe- cific interventions have shown effectiveness against the virus, our opinions are justified in applying a non-specific anti-viral approach during the incubation period of virus infection as an essential protection to put the host's immune system into an alert state and henceforth to slow down the viral replication.展开更多
基金This study was supported by Beijing Municipal Science&Technology Commission(No.BZ0374)Beijing Administration of Traditional Chinese Medicine(No.JJ2018-70)
文摘Objective: To analyze the prescription rule of acupuncture for functional constipation (FC), and explore the effective core clinical acupuncture prescriptions. Methods:The randomized controlled trials published in the PubMed, CNKI, Wanfang, and VIP databases were retrieved from January 1, 2010 to January 31, 2020. And the key information about acupuncture therapy for FC in these RCTs was collected according to the predetermined inclusion and exclusion criteria. Eventually, the statisticians analyzed the use frequency of single acupoints and meridian acupoints by descriptive statistical method and explored the combination rule between different acupoints by association rules. Results: Twenty six randomized controlled trials were included, with a total of 29 acupoints. Tianshu (ST25), Shangjuxu (ST37) and Zhongwan (RN12) were the top 3 frequency of acupuncture therapy for FC and the top 3 frequency meridian had been chosen were the stomach meridian of Foot-Yangming, the spleen meridian of Foot-Taiyin and Ren channel. The two acupoints with high support and compatibility frequency ranking in the top 3 are Tianshu (ST25) - Shangjuxu (ST37), Tianshu (ST25) - Zhongwan (RN12), Tianshu (ST25) - Zusanli (ST36). The three acupoints with compatibility frequency ranking in the top 2 are Tianshu (ST25) - Shangjuxu (ST37) - Zusanli (ST36), and Tianshu (ST25) - Shangjuxu (ST37) - Zhigou (SJ6). Conclusion: Tianshu (ST25) is the most common acupoint for acupuncture therapy of FC. Tianshu (ST25) and Shangjuxu (ST37) are the core acupoints to provide basis for clinical practice and future clinical research.
文摘The 2014 Ebola outbreak in West Africa trig- gered a global crisis. Nine countries have reported more than 20000 infection cases in total and nearly 8000 lives have been lost. The actual death toll is likely much higher than this figure; the death rate is as high as 70%, considering confirmed cases. The Ebola virus launches its destruction by shutting down the host's innate and adaptive immune systems. The virus then replicates itself out of control and causes a cytokine storm in the host. Consequently, the host's overdriven immune system attacks its own endothelial cells and this leads to multiple organ hemorrhagic damage, the host dies of septic shock finally. Under current circumstances where no spe- cific interventions have shown effectiveness against the virus, our opinions are justified in applying a non-specific anti-viral approach during the incubation period of virus infection as an essential protection to put the host's immune system into an alert state and henceforth to slow down the viral replication.