Optimizing FeCoNiCrTi high-entropy alloy with hydrogen pumping effect to boost de/hydrogenation performance of magnesium hydride

The exploration of efficient,long-lived and cost-effective transition metal catalysts is highly desirable for the practical hydrogen storage of magnesium hydride(MgH_(2)) in sustainable energy devices.Herein,FeCoNiCrTi high-entropy alloy(HEA) nanosheets were prepared via a facile wet chemical ball milling strategy and they were introduced into MgH_(2) to boost the hydrogen storage performance.The refined HEA exhibited superior catalytic activity on MgH_(2).In contrast to additive-free MgH_(2),the initial desorption temperature of the constructed MgH_(2)-HEA composite was reduced from 330.0 to 198.5℃ and a remarkable 51% reduction in the dehydrogenation activation energy was achieved.Besides,the MgH_(2)-HEA composite only required one-twentieth time of that consumed by pure MgH_(2) to absorb 5.0 wt% of H_(2) at 225℃.The synergy between the "hydrogen pumping" effect of Mg_2Ni/Mg_2NiH_4 and Mg_2Co/Mg_2CoH_5 couples,as well as the good dispersion of Fe,Cr and Ti on the surface of MgH_(2) contributed to the enhanced de/hydrogenation performance of the MgH_(2)-HEA composites.This study furnishes important steering for the design and fabrication of multiple transition metal catalysts and may push the commercial application of magnesium-based hydrides one step forward.

Visual Clues for the Histopathologic Diagnosis of Psoriasis:A Retrospective Case-Control Study

Objective:The histopathologic diagnosis of psoriasis remains challenging.This study aimed to uncover clues for the histopathologic diagnosis of psoriasis in patients whose lesions required differentiation from other inflammatory skin disorders.Methods:A retrospective analysis was conducted between psoriasis biopsy sections and other inflammatory skin diseases sections.The psoriasis and control groups were compared regarding the pathological characteristics,including the?sign,hypogranulosis,and neutrophilic infiltration or pustules within the epidermis.We also summarized the clinical information and the classic and non-classic histologic features of psoriasis.Comparisons between psoriasis and control groups were performed using the c-square test.Results:Biopsy sections from 190 patients were analyzed.Of these patients,100 had a confirmed clinicopathological diagnosis of psoriasis,while 90 were diagnosed with an inflammatory skin disorder other than psoriasis(control group).The classic histologic features included the mound of parakeratosis(68.0%),confluent parakera tosis(42.0%),hypogranulosis(86.0%),regular psoriasiform hyperplasia(79.0%),Munro microabscess(85.0%),spongiform pustule of Kogoj(43.0%),suprapapillary plate thinning(87.0%),and dermal papilla capillary ectasia(98.0%).The?sign was present in 79.0%and 21.1%,respectively,of the lesional biopsy samples from the psoriasis and control groups(P<0.001).The combination of the?sign and neutrophil infiltration in the upper epidermis was present in 74.0%and 10.0%,respectively,of the lesional biopsy samples from the psoriasis and control groups(P<0.001).The combination of these 2 features had a sensitivity of 0.89 and specificity of 0.76 in distinguishing between the psoriasis and control groups.Conclusion:The?sign is a useful visual clue for the histopathologic diagnosis of psoriasis.However,for some inflammatory skin disorders that are very similar to psoriasis,such as pityriasis rubra pilaris,the combination of the?sign and neutrophil infiltration in the upper epidermis is needed to distinguish the condition from psoriasis.

Effects of abnormal zona pellucida on fertilization and pregnancy in IVF/ICSI-ET

Objective To analyze the fertilization rate, embryo development and clinical outcome of oocytes with abnormal zona pellucida after in vitro fertilization （IVF） or intracytoplasmic sperm injection （1CS1）. Methods A retrospective analysis included a total of 43 cycles （27 IVF cycles and 16 ICSI cycles） in which oocytes displaying abnormal zona pellucida were retrieved between January 2006 and December 2011. The fertilization rate, embryo quality, and the cumulative clinical pregnancy rate were analyzed. Results Rescue ICSI was applied in 2 7 IVF cycles in which failed extrusion of the second polar body after conventional IVF was observed, and of them, complete failure to fertilize occurred in 23 IVF cycles. The fertilization rate and the normal fertilization rate for IVF （64.83% and 59.32%, respectively） were significantly lower than those for ICS1 （85.19% and 79.01%, respectively）, whereas the cleavage rate （94.12%） with IVF did not differ significantly from that with ICSI （95.65%, P〉0. 05）. The percentages of good-quality embryos in 1VF group （52. 67%） and 1CSl group （43.75%） also did not differ significantly （P〉0.05）. Although the rates of implantation and pregnancy appeared to be greater in IVF group （33.33% and 40.00%, respectively） compared with those in ICSI group （25.00% and 35. 71%, respectively）, the differences were not significant （P〉0.05）.Conclusions ICSI should be carried out for oocytes with abnormal zona pellucida, for which the risk of lVF failure is high. Rescue ICSI improves the likelihood of fertilization of oocytes with abnormal zona pellucida, but cannot improve the clinical outcome.

Papular acantholytic dyskeratosis of the anogenital area with novel ATP2C1 gene mutations

To the Editor:Focal acantholytic dyskeratosis(FAD)is used to describe a group of diseases with diverse clinical manifestations but characteristic histological structures.In 1984,the first case of“papular acantholytic dyskeratosis(PAD)of the vulvocrural area”was reported in a 23-year-old female with pathological manifestations of FAD and the researchers believed that it might be a new independent disease.[1]Recently,the relationship between PAD and Hailey-Hailey disease(HHD)as well as Darier disease(DD)is receiving increasing attention from scholars.We performed gene mutation screening in two patients with sporadic PAD and explored the nature of PAD.

Toe Absence Related to Verrucous Carcinoma

Introduction:Verrucous carcinoma is a rare variant of squamous cell carcinoma.It generally grows exogenously and bone erosion is rare.Here we present a case of verrucous carcinoma on the foot with toe absence.Case presentation:A 64-year-old man presented with a 6-year history of a slowly growing exogenous hyperkeratotic verrucous lesion on the right fifth toe,which had been absent for 1year.Before the lesion appeared,he had undergone nail extraction on this toe.The culture of fungi and mycobacteria were negative.Three-dimensional computed tomography showed that the fifth toe of the right foot was absent.Histopathological examination showed that the lesion was exogenous and verrucous and exhibited moderate keratinocyte hyperplasia.Combined with clinical manifestation and histopathological examination,verrucous carcinoma is suggested.The lesion was surgically excised,and the patient was followed up for more than 6months without recurrence.Discussion:Verrucous carcinoma is an exophytic tumor with verrucous growth at the beginning,which can invade deep tissues and even cause limb mutilation.When encountering a patient with a wart-like plaque on the foot that responds poorly to conventional treatments,clinicians should maintain a high degree of clinical vigilance and a low threshold for biopsy.Conclusion:We observed a rare outcome of toe absence associated with verrucous carcinoma.Therefore,early diagnosis of verrucous carcinoma is very important.Surgical excision is an effective treatment at present.Extensive resection is usually required to avoid recurrence.

Primary vulvar melanoma in a 27-year-old pregnant woman: a case report and literature review

Introduction Vulvar melanoma is the second most common vulvar malignancy and a significant health issue in women.Despite its low incidence,vulvar melanoma has a poor prognosis with a high tendency to metastasize due to delayed diagnosis.Most women are postmenopausal and aged 50 to 70 years at the time of diagnosis[1].The occurrence of vulvar malignant melanoma (MM) at <30 years of age is extremely rare.We herein describe a case of primary vulvar MM in a 27-year-old woman during her first pregnancy.