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樟叶提取物作为新型环境友好抑制剂在白钨矿与方解石浮选分离中的应用 被引量:3
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作者 潘祖超 张伊升 +2 位作者 胡俊杰 焦芬 覃文庆 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2023年第1期275-284,共10页
采用简单的物理方法,直接榨取樟叶汁液作为白钨矿和方解石分离的抑制剂。通过接触角测量、傅里叶转换红外光谱测试和原子力显微镜研究樟叶提取物中活性成分及其抑制机理。浮选试验表明,樟叶提取物对方解石有较强的抑制作用,对白钨矿的... 采用简单的物理方法,直接榨取樟叶汁液作为白钨矿和方解石分离的抑制剂。通过接触角测量、傅里叶转换红外光谱测试和原子力显微镜研究樟叶提取物中活性成分及其抑制机理。浮选试验表明,樟叶提取物对方解石有较强的抑制作用,对白钨矿的抑制作用较小。原子力显微镜检测证实方解石表面吸附有樟叶提取物的有效成分。红外光谱结果表明,吸附在方解石表面的组分含有大量的羟基,这些羟基使方解石疏水。Zeta电位和红外光谱结果表明,樟树叶提取物在方解石表面的吸附量远大于在白钨矿表面的吸附量。樟叶提取物在白钨矿和方解石浮选分离中具有潜在的应用价值。 展开更多
关键词 白钨矿 方解石 浮选 樟叶提取物 抑制剂
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基于网络药理学和指纹图谱的温经止痛合剂质量标准研究
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作者 田永强 邹戬 +1 位作者 张义生 黄艳辉 《中国药师》 CAS 2023年第10期22-34,共13页
目的基于网络药理学和指纹图谱,筛选温经止痛合剂质量指标成分,建立薄层鉴别和含量测定方法,为评价温经止痛合剂的质量提供依据。方法构建“温经止痛合剂饮片-主要活性成分-靶点”图,筛选用于质量控制的主要饮片和成分;采用TLC法对其进... 目的基于网络药理学和指纹图谱,筛选温经止痛合剂质量指标成分,建立薄层鉴别和含量测定方法,为评价温经止痛合剂的质量提供依据。方法构建“温经止痛合剂饮片-主要活性成分-靶点”图,筛选用于质量控制的主要饮片和成分;采用TLC法对其进行定性分析;用HPLC法建立温经止痛合剂的指纹图谱,标定共有峰并进行相似度评价,并对确认的成分进行含量测定。结果通过温经止痛合剂“饮片-主要活性成分-靶点”图,筛选出甘草、蒲黄、吴茱萸、乌药、延胡索、赤芍为主要活性成分饮片。赤芍、吴茱萸、延胡索的TCL鉴别结果分离度好、专属性强;指纹图谱指认了5个共有峰,并以去甲异波尔定、芍药苷、甘草酸铵建立了温经止痛合剂含量测定的质量标准。结论基于网络药理学和指纹图谱,建立了TLC定性分析和HPLC含量测定方法,该法准确可靠,重复性好,可用于温经止痛合剂的质量控制。 展开更多
关键词 温经止痛合剂 网络药理学 指纹图谱 含量测定 薄层色谱法 质量标准
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铜离子对铁闪锌矿溶解机制的影响
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作者 孟晓宇 赵红波 +3 位作者 张伊升 王帅 顾帼华 邱冠周 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2022年第12期4099-4112,共14页
通过实验和密度泛函理论(DFT)模拟计算研究铜离子存在下铁闪锌矿的溶解机制。浸出实验结果表明,铜离子在高温条件下(高于55℃)加速铁闪锌矿的溶解,但在低温条件下(低于45℃)抑制其溶解。导致该现象的原因可能是铜离子与铁闪锌矿间的反... 通过实验和密度泛函理论(DFT)模拟计算研究铜离子存在下铁闪锌矿的溶解机制。浸出实验结果表明,铜离子在高温条件下(高于55℃)加速铁闪锌矿的溶解,但在低温条件下(低于45℃)抑制其溶解。导致该现象的原因可能是铜离子与铁闪锌矿间的反应机制随反应温度的升高从表面吸附反应转变为体相取代反应。体相取代反应使铁闪锌矿晶格中更多的锌原子被释放,并且取代反应产物,增强铁闪锌矿表面的电化学反应活性;然而,低温条件下铜离子的吸附会使铁闪锌矿表面钝化,从而阻碍电化学反应的进行。DFT模拟计算表明,高温条件下取代反应的反应能比表面吸附反应能更负,进一步验证了所提出的反应机制。 展开更多
关键词 溶解机制 闪锌矿 铁闪锌矿 铜离子
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Potential of Arbidol for Post-exposure Prophylaxis of COVID-19 Transmission:A Preliminary Report of a Retrospective Cohort Study 被引量:11
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作者 Jin-nong zhang Wen-jing WANG +10 位作者 Bo PENG Wei PENG yi-sheng zhang Ya-ling WANG Yan WAN Jiang CHANG Ling MAO Xiao-ping MIAO Ya-nan LI Yi-fan ZHOU Bo HU 《Current Medical Science》 SCIE CAS 2020年第3期480-485,共6页
The efficient transmission of severe acute respiratory syndrome-2 coronavirus(SARS-CoV-2)from patients to health care workers or family members has been a worrisome and prominent feature of the ongoing outbreak.On the... The efficient transmission of severe acute respiratory syndrome-2 coronavirus(SARS-CoV-2)from patients to health care workers or family members has been a worrisome and prominent feature of the ongoing outbreak.On the basis of clinical practice and in-vitro studies,we postulated that post-exposure prophylaxis(PEP)using Arbidol is associated with decreased infection among individuals exposed to confirmed cases of COVID-19 infection.We conducted a retrospective cohort study on family members and health care workers who were exposed to patients confirmed to have SARS-CoV-2 infection by real-time RT-PCR and chest computed tomography(CT)from January 1 to January 16,2020.The last follow-up date was Feb.26,2020.The emergence of fever and/or respiratory symptoms after exposure to the primary case was collected.The correlations between post-exposure prophylaxis and infection in household contacts and health care workers were respectively analyzed.A total of 66 members in 27 families and 124 health care workers had evidence of close exposure to patients with confirmed COVID-19.The Cox regression based on the data of the family members and health care workers with Arbidol or not showed that Arbidol PEP was a protective factor against the development of COVID-19(HR 0.025,95%CI 0.003-0.209,P=0.0006 for family members and HR 0.056,95%CI 0.005-0.662,P=0.0221 for health care workers).Our findings suggest Arbidol could reduce the infection risk of the novel coronavirus in hospital and family settings.This treatment should be promoted for PEP use and should be the subject of further investigation. 展开更多
关键词 ARBIDOL COVID-19 SARS-CoV-2 post-exposure prophylaxis
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Expression of insulin-like growth factor binding protein-2 in gastric carcinoma and its relationship with cell proliferation 被引量:2
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作者 Liang-Hui Shi Xiao-Qun Zhu +2 位作者 Guo-Hai Zhao Ya-Bin Xia yi-sheng zhang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第39期6285-6289,共5页
AIM: To investigate the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in gastric carcinoma and its clinical significance and to explore its relationship with cell proliferation. METHODS: Express... AIM: To investigate the expression of insulin-like growth factor binding protein-2 (IGFBP-2) in gastric carcinoma and its clinical significance and to explore its relationship with cell proliferation. METHODS: Expressions of IGFBP-2 and Ki-67 in 118 cases of gastric carcinoma and 40 cases of normal gastric mucosa were detected by EnVision immunohistochemical technique. RESULTS: Expression of IGFBP-2 in gastric carcinoma was higher than that in normal gastric mucosa (P < 0.01). There was no difference between high- and low-grade gastric carcinoma (P > 0.05). Expression of IGFBP-2 in advanced gastric carcinoma was higher than that in early gastric carcinoma (P < 0.05). Expression of IGFBP-2 in gastric carcinoma with lymph node metastasis was higher than that without lymph node metastasis (P < 0.01). IGFBP-2 expression was a positively related to the clinical stage of gastric carcinoma (P < 0.01). There was a positive correlation between IGFBP-2 and Ki-67 (P < 0.05). CONCLUSION: IGFBP-2 may be involved in carcino- genesis and progression of gastric carcinoma by promoting cell proliferation. 展开更多
关键词 胰岛素样生长因子 胃癌 免疫组织学 细胞增殖
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