BACKGROUND Cellular myofibroma is a rare subtype of myofibroma that was first described in 2017.Its diagnosis is often challenging because of its relative rarity,lack of known genetic abnormalities,and expression of m...BACKGROUND Cellular myofibroma is a rare subtype of myofibroma that was first described in 2017.Its diagnosis is often challenging because of its relative rarity,lack of known genetic abnormalities,and expression of muscle markers that can be confused with sarcomas that have myogenic differentiation.Currently,scholars have limited knowledge of this disease,and published cases are few.Further accumulation of diagnostic and treatment experiences is required.CASE SUMMARY A 16-year-old girl experienced left upper limb swelling for 3 years.She sought medical attention at a local hospital 10 months ago,where magnetic resonance imaging revealed a 5-cm soft tissue mass.Needle biopsy performed at a local hospital resulted in the diagnosis of a spindle cell soft tissue sarcoma.The patient was referred to our hospital for limb salvage surgery with endoprosthetic replacement.She was initially diagnosed with a synovial sarcoma.Consequently,clinical management with chemotherapy was continued for the malignant sarcoma.Our pathology department also performed fluorescence in situ hybridization for result validation,which returned negative for SS18 gene breaks,indicating that it was not a synovial sarcoma.Next-generation sequencing was used to identify the SRF-RELA rearrangement.The final pathological diagnosis was a cellular/myofibroblastic neoplasm with an SRF-RELA gene fusion.The patient had initially received two courses of chemotherapy;however,chemotherapy was discontinued after the final diagnosis.CONCLUSION This case was misdiagnosed because of its rare occurrence,benign biological behavior,and pathological similarity to soft tissue sarcoma.展开更多
BACKGROUND Angiosarcoma(AS)is a rare and highly aggressive soft tissue disease that most commonly arises in deep soft tissues.There are only a few reported cases of AS involving the ovary and even fewer reports of the...BACKGROUND Angiosarcoma(AS)is a rare and highly aggressive soft tissue disease that most commonly arises in deep soft tissues.There are only a few reported cases of AS involving the ovary and even fewer reports of the underlying molecular abnormalities.Here,we briefly review two cases of primary ovarian AS(oAS)with specific molecular events and immune checkpoints.The clinical features and prognosis of the disease,diagnosis,differential diagnosis,and new treatment approaches are discussed based on a literature review.CASE SUMMARY Case 1:A 51-year-old female patient was admitted with right lower limb pain for 5 mo,and lower abdominal pain with hematuria for 1 mo.Partial removal of rectus abdominis muscle and fascia,partial hysterectomy,bilateral salpingooophorectomy,and inguinal and pelvic lymphadenectomy were performed.Pathology revealed primary oAS.Fluorescence in situ hybridization revealed c-MYC gene amplification.MESNA+ADM+IFO+DTIC(MAID)regimen was administered,but stable disease was achieved.The patient died 1 mo later.Case 2:A 41-year-old female patient presented with fatigue,nausea,decreased appetite,and diffuse abdominal pain.On physical examination,the abdomen was distended and a complex cystic mass was palpable in the right pelvic cavity.Pathology revealed primary oAS.MAID chemotherapy was administered and programmed death ligand 1(PD-L1)staining was performed on the tumor samples.The patient benefited from anti-PD-1 immunotherapy and is alive without any evidence of disease 27 mo off therapy in follow-up.CONCLUSION Long-term survival benefit for primary oAS can be achieved by alternative therapeutic strategies using pathological indicators to inform treatment.展开更多
In this paper, we demonstrate that the eco-industrial network equilibrium model of link flow version previously introduced can be reformulated as a transportation network equilibrium problem of path flow version. Then...In this paper, we demonstrate that the eco-industrial network equilibrium model of link flow version previously introduced can be reformulated as a transportation network equilibrium problem of path flow version. Then, some methodological tools mainly applied in the field of transportation science can be used to discuss the eco-industrial chain network problem. What the highlighted contribution lies in is that the paper not only expands theory of supply chain model with reducing path flow but also generalizes the traditional transportation network equilibrium problem by new applications.展开更多
Background:Texture analysis(TA)can quantify intra-tumor heterogeneity using standard medical images.The present study aimed to assess the application of positron emission tomography(PET)TA in the differential diagnosi...Background:Texture analysis(TA)can quantify intra-tumor heterogeneity using standard medical images.The present study aimed to assess the application of positron emission tomography(PET)TA in the differential diagnosis of gastric cancer and gastric lymphoma.Methods:The pre-treatment PET images of 79 patients(45 gastric cancer,34 gastric lymphoma)between January 2013 and February 2018 were retrospectively reviewed.Standard uptake values(SUVs),first-order texture features,and second-order texture features of the grey-level co-occurrence matrix(GLCM)were analyzed.The differences in features among different groups were analyzed by the two-way Mann-Whitney test,and receiver operating characteristic(ROC)analysis was used to estimate the diagnostic efficacy.Results:InertiaGLCM was significantly lower in gastric cancer than that in gastric lymphoma(4975.61 vs.11,425.30,z=-3.238,P=0.001),and it was found to be the most discriminating texture feature in differentiating gastric lymphoma and gastric cancer.The area under the curve(AUC)of inertiaGLCM was higher than the AUCs of SUVmax and SUVmean(0.714 vs.0.649 and 0.666,respectively).SUVmax and SUVmean were significantly lower in low-grade gastric lymphoma than those in high grade gastric lymphoma(3.30 vs.11.80,2.40 vs.7.50,z=-2.792 and-3.007,P=0.005 and 0.003,respectively).SUVs and first-order greylevel intensity features were not significantly different between low-grade gastric lymphoma and gastric cancer.EntropyGLCM12 was significantly lower in low-grade gastric lymphoma than that in gastric cancer(6.95 vs.9.14,z=-2.542,P=0.011)and had an AUC of 0.770 in the ROC analysis of differentiating low-grade gastric lymphoma and gastric cancer.Conclusions:InertiaGLCM and entropyGLCM were the most discriminating features in differentiating gastric lymphoma from gastric cancer and low-grade gastric lymphoma from gastric cancer,respectively.PET TA can improve the differential diagnosis of gastric neoplasms,especially in tumors with similar degrees of fluorodeoxyglucose uptake.展开更多
文摘BACKGROUND Cellular myofibroma is a rare subtype of myofibroma that was first described in 2017.Its diagnosis is often challenging because of its relative rarity,lack of known genetic abnormalities,and expression of muscle markers that can be confused with sarcomas that have myogenic differentiation.Currently,scholars have limited knowledge of this disease,and published cases are few.Further accumulation of diagnostic and treatment experiences is required.CASE SUMMARY A 16-year-old girl experienced left upper limb swelling for 3 years.She sought medical attention at a local hospital 10 months ago,where magnetic resonance imaging revealed a 5-cm soft tissue mass.Needle biopsy performed at a local hospital resulted in the diagnosis of a spindle cell soft tissue sarcoma.The patient was referred to our hospital for limb salvage surgery with endoprosthetic replacement.She was initially diagnosed with a synovial sarcoma.Consequently,clinical management with chemotherapy was continued for the malignant sarcoma.Our pathology department also performed fluorescence in situ hybridization for result validation,which returned negative for SS18 gene breaks,indicating that it was not a synovial sarcoma.Next-generation sequencing was used to identify the SRF-RELA rearrangement.The final pathological diagnosis was a cellular/myofibroblastic neoplasm with an SRF-RELA gene fusion.The patient had initially received two courses of chemotherapy;however,chemotherapy was discontinued after the final diagnosis.CONCLUSION This case was misdiagnosed because of its rare occurrence,benign biological behavior,and pathological similarity to soft tissue sarcoma.
文摘BACKGROUND Angiosarcoma(AS)is a rare and highly aggressive soft tissue disease that most commonly arises in deep soft tissues.There are only a few reported cases of AS involving the ovary and even fewer reports of the underlying molecular abnormalities.Here,we briefly review two cases of primary ovarian AS(oAS)with specific molecular events and immune checkpoints.The clinical features and prognosis of the disease,diagnosis,differential diagnosis,and new treatment approaches are discussed based on a literature review.CASE SUMMARY Case 1:A 51-year-old female patient was admitted with right lower limb pain for 5 mo,and lower abdominal pain with hematuria for 1 mo.Partial removal of rectus abdominis muscle and fascia,partial hysterectomy,bilateral salpingooophorectomy,and inguinal and pelvic lymphadenectomy were performed.Pathology revealed primary oAS.Fluorescence in situ hybridization revealed c-MYC gene amplification.MESNA+ADM+IFO+DTIC(MAID)regimen was administered,but stable disease was achieved.The patient died 1 mo later.Case 2:A 41-year-old female patient presented with fatigue,nausea,decreased appetite,and diffuse abdominal pain.On physical examination,the abdomen was distended and a complex cystic mass was palpable in the right pelvic cavity.Pathology revealed primary oAS.MAID chemotherapy was administered and programmed death ligand 1(PD-L1)staining was performed on the tumor samples.The patient benefited from anti-PD-1 immunotherapy and is alive without any evidence of disease 27 mo off therapy in follow-up.CONCLUSION Long-term survival benefit for primary oAS can be achieved by alternative therapeutic strategies using pathological indicators to inform treatment.
基金Sponsored by the Fundamental Research Funds for the Central Universitiesthe Research Funds of Renmin University of China(Grant No.13XNH169)
文摘In this paper, we demonstrate that the eco-industrial network equilibrium model of link flow version previously introduced can be reformulated as a transportation network equilibrium problem of path flow version. Then, some methodological tools mainly applied in the field of transportation science can be used to discuss the eco-industrial chain network problem. What the highlighted contribution lies in is that the paper not only expands theory of supply chain model with reducing path flow but also generalizes the traditional transportation network equilibrium problem by new applications.
文摘Background:Texture analysis(TA)can quantify intra-tumor heterogeneity using standard medical images.The present study aimed to assess the application of positron emission tomography(PET)TA in the differential diagnosis of gastric cancer and gastric lymphoma.Methods:The pre-treatment PET images of 79 patients(45 gastric cancer,34 gastric lymphoma)between January 2013 and February 2018 were retrospectively reviewed.Standard uptake values(SUVs),first-order texture features,and second-order texture features of the grey-level co-occurrence matrix(GLCM)were analyzed.The differences in features among different groups were analyzed by the two-way Mann-Whitney test,and receiver operating characteristic(ROC)analysis was used to estimate the diagnostic efficacy.Results:InertiaGLCM was significantly lower in gastric cancer than that in gastric lymphoma(4975.61 vs.11,425.30,z=-3.238,P=0.001),and it was found to be the most discriminating texture feature in differentiating gastric lymphoma and gastric cancer.The area under the curve(AUC)of inertiaGLCM was higher than the AUCs of SUVmax and SUVmean(0.714 vs.0.649 and 0.666,respectively).SUVmax and SUVmean were significantly lower in low-grade gastric lymphoma than those in high grade gastric lymphoma(3.30 vs.11.80,2.40 vs.7.50,z=-2.792 and-3.007,P=0.005 and 0.003,respectively).SUVs and first-order greylevel intensity features were not significantly different between low-grade gastric lymphoma and gastric cancer.EntropyGLCM12 was significantly lower in low-grade gastric lymphoma than that in gastric cancer(6.95 vs.9.14,z=-2.542,P=0.011)and had an AUC of 0.770 in the ROC analysis of differentiating low-grade gastric lymphoma and gastric cancer.Conclusions:InertiaGLCM and entropyGLCM were the most discriminating features in differentiating gastric lymphoma from gastric cancer and low-grade gastric lymphoma from gastric cancer,respectively.PET TA can improve the differential diagnosis of gastric neoplasms,especially in tumors with similar degrees of fluorodeoxyglucose uptake.
