In this paper,we investigate the problem of key radar signal sorting and recognition in electronic intelligence(ELINT).Our major contribution is the development of a combined approach based on clustering and pulse rep...In this paper,we investigate the problem of key radar signal sorting and recognition in electronic intelligence(ELINT).Our major contribution is the development of a combined approach based on clustering and pulse repetition interval(PRI)transform algorithm,to solve the problem that the traditional methods based on pulse description word(PDW)were not exclusively targeted at tiny particular signals and were less time-efficient.We achieve this in three steps:firstly,PDW presorting is carried out by the DBSCAN(Density-Based Spatial Clustering of Applications with Noise)clustering algorithm,and then PRI estimates of each cluster are obtained by the PRI transform algorithm.Finally,by judging the matching between various PRI estimates and key targets,it is determined whether the current signal contains key target signals or not.Simulation results show that the proposed method should improve the time efficiency of key signal recognition and deal with the complex signal environment with noise interference and overlapping signals.展开更多
Sirtuins(SIRTs)are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes,and are involved in numerous biological processes.Currently,seven...Sirtuins(SIRTs)are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes,and are involved in numerous biological processes.Currently,seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified.Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions.Notably,this protein family plays a variety of important roles in cellular biology such as inflammation,metabolism,oxidative stress,and apoptosis,etc.,thus,it is considered a potential therapeutic target for different kinds of pathologies including cancer,cardiovascular disease,respiratory disease,and other conditions.Moreover,identification of SIRT modulators and exploring the functions of these different modulators have prompted increased efforts to discover new small molecules,which can modify SIRT activity.Furthermore,several randomized controlled trials have indicated that different interventions might affect the expression of SIRT protein in human samples,and supplementation of SIRT modulators might have diverse impact on physiological function in different participants.In this review,we introduce the history and structure of the SIRT protein family,discuss the molecular mechanisms and biological functions of seven members of the SIRT protein family,elaborate on the regulatory roles of SIRTs in human disease,summarize SIRT inhibitors and activators,and review related clinical studies.展开更多
A concise and efficient approach was developed for the synthesis of mono-substituted and di-substituted pyrimidines products via palladium-catalyzed amination of chloro-substituted 5-nitropyrimidines and amines. This ...A concise and efficient approach was developed for the synthesis of mono-substituted and di-substituted pyrimidines products via palladium-catalyzed amination of chloro-substituted 5-nitropyrimidines and amines. This synthetic methodology can produce various di-substituted pyrimidines in high yields with good functional group tolerance, and provide a complementary tool for the syntheses of important intermediates of nucleosides and purines with bioactivities.展开更多
文摘In this paper,we investigate the problem of key radar signal sorting and recognition in electronic intelligence(ELINT).Our major contribution is the development of a combined approach based on clustering and pulse repetition interval(PRI)transform algorithm,to solve the problem that the traditional methods based on pulse description word(PDW)were not exclusively targeted at tiny particular signals and were less time-efficient.We achieve this in three steps:firstly,PDW presorting is carried out by the DBSCAN(Density-Based Spatial Clustering of Applications with Noise)clustering algorithm,and then PRI estimates of each cluster are obtained by the PRI transform algorithm.Finally,by judging the matching between various PRI estimates and key targets,it is determined whether the current signal contains key target signals or not.Simulation results show that the proposed method should improve the time efficiency of key signal recognition and deal with the complex signal environment with noise interference and overlapping signals.
基金supported by the National Key R&D Program of China(No.2017YFC0907401 to Y.-H.Z.and No.2022YFC2704200 to Q.-J.W.)Natural Science Foundation of China(No.82073647 to Q.-J.-W.No.82102254 to T.-N.Z.,and No.81902607 to Y.-X.Z.)+3 种基金LiaoNing Revitalization Talents Program(No.XLYC1907102 to Q.-J.W.and No.XLYC1802095 to Y.-H.Z.)the JieBangGuaShuai Project of Liaoning Province(No.2021JH1/1040050 to Y.-H.Z.)Outstanding Scientific Fund of Shengjing Hospital(Q.-J.W.and Y.-H.Z.)345 Talent Project of Shengjing Hospital of China Medical University(Q.-J.W.,T.N.Z.,and Y.-X.Z.).
文摘Sirtuins(SIRTs)are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes,and are involved in numerous biological processes.Currently,seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified.Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions.Notably,this protein family plays a variety of important roles in cellular biology such as inflammation,metabolism,oxidative stress,and apoptosis,etc.,thus,it is considered a potential therapeutic target for different kinds of pathologies including cancer,cardiovascular disease,respiratory disease,and other conditions.Moreover,identification of SIRT modulators and exploring the functions of these different modulators have prompted increased efforts to discover new small molecules,which can modify SIRT activity.Furthermore,several randomized controlled trials have indicated that different interventions might affect the expression of SIRT protein in human samples,and supplementation of SIRT modulators might have diverse impact on physiological function in different participants.In this review,we introduce the history and structure of the SIRT protein family,discuss the molecular mechanisms and biological functions of seven members of the SIRT protein family,elaborate on the regulatory roles of SIRTs in human disease,summarize SIRT inhibitors and activators,and review related clinical studies.
基金financially supported by the National Natural Science Foundation of China(No.21202116)Independent Innovation Foundation of Tianjin Universityof China(No.2016XZC-0071)Natural Science Foundation of Tianjin of China(No.16JCYBJC20300)
文摘A concise and efficient approach was developed for the synthesis of mono-substituted and di-substituted pyrimidines products via palladium-catalyzed amination of chloro-substituted 5-nitropyrimidines and amines. This synthetic methodology can produce various di-substituted pyrimidines in high yields with good functional group tolerance, and provide a complementary tool for the syntheses of important intermediates of nucleosides and purines with bioactivities.
