Helicobacter pylori plays a key role in gastric adenocarcinoma induced by spasmolytic polypeptide-expressing metaplasia

Heliobacter pylori(H. pylori), a group 1 human gastric carcinogen, is significantly associated with chronic gastritis, gastric mucosal atrophy, and gastric cancer.Approximately 20% of patients infected with H. pylori develop precancerous lesions, among which metaplasia is the most critical. Except for intestinal metaplasia(IM), which is characterized by goblet cells appearing in the stomach glands, one type of mucous cell metaplasia, spasmolytic polypeptide-expressing metaplasia(SPEM), has attracted much attention. Epidemiological and clinicopathological studies suggest that SPEM may be more strongly linked to gastric adenocarcinoma than IM. SPEM, characterized by abnormal expression of trefoil factor 2, mucin 6, and Griffonia simplicifolia lectin II in the deep glands of the stomach, is caused by acute injury or inflammation. Although it is generally believed that the loss of parietal cells alone is a sufficient and direct cause of SPEM, further in-depth studies have revealed the critical role of immunosignals.There is controversy regarding whether SPEM cells originate from the transdifferentiation of mature chief cells or professional progenitors. SPEM plays a functional role in the repair of gastric epithelial injury. However, chronic inflammation and immune responses caused by H. pylori infection can induce further progression of SPEM to IM, dysplasia, and adenocarcinoma. SPEM cells upregulate the expression of whey acidic protein 4-disulfide core domain protein 2 and CD44 variant 9, which recruit M2 macrophages to the wound. Studies have revealed that interleukin-33, the most significantly upregulated cytokine in macrophages, promotes SPEM toward more advanced metaplasia. Overall, more effort is needed to reveal the specific mechanism of SPEM malignant progression driven by H.pylori infection.

Physics performance of the STAR zero degree calorimeter at relativistic heavy ion collider

The zero degree calorimeter(ZDC) at RHICSTAR was installed in the year 2000.After running for more than 10 years,the performance of the STAR-ZDC cannot maintain a proper status because of the radiation damage.The ZDC on RHIC-BRAHMS had been moved to STAR in 2011 after some tests.We present here the result of the tests as well as the physical performance of those ZDC modules between the 2011 and 2015 RHIC runs.The excellent energy resolution of the ZDC in heavy ion collision provides a good candidate for future detector development,such as the CSR experiment at CAS-Lanzhou facility.

黄彬治疗慢性萎缩性胃炎之经验

慢性萎缩性胃炎(chronic atrophic gastritis,CAG)是消化系统的一种常见病,属于癌前疾病,与胃癌的发生密切相关。目前西医暂无阻断或逆转萎缩的特效药,中医药在改善临床症状、控制疾病进展,甚至逆转萎缩等方面具有显著优势。黄彬教授认为脾胃虚弱是CAG的发病基础,痰瘀、热毒互结是病机关键,以益气健脾、化痰散瘀、解毒散结为法,运用自拟方消萎化肠方作为基础方,别脉遣方,识症用药,形成“验方+时方+识症”的用药模式,并重视药后调护,常能有效控制CAG的发展,甚至逆转萎缩。

Low-mass vector meson production at forward rapidity in p+p and d+Au collisions at (~SNN)^(1/2)=200 GeV from a multiphase transport model

Low-mass vector meson(ρ, ω, and Ф) production at forward rapidity in p+p and d+Au collisions at (~SNN)^(1/2)=200 Ge V is studied within the framework of a multiphase transport model(AMPT). Detailed investigations, including the transverse momentum and the rapidity dependence of low-mass vector meson production in the AMPT model, show that the hadron interaction process is important for a quantitative description of the ρ and ω data.But for the Ф meson, the strange quark production in the AMPT model with the string melting scenario describes the data reasonably well, while the default AMPT model under-predicts the data. The N(Ф)=N(ρ+ω) ratio from the AMPT model with the string melting scenario perfectly describes the data in p+p collisions. For the d+Au collisions, an increased trend of this ratio vs. transverse momentum and the number of participants are observed from the AMPT model. Our results indicate that a precise measurement of the N(Ф)=N(ρ+ω) ratio in d+Au and Au+Au collisions will shed more light on the strangeness production and its dynamics in quark–gluon plasma.

Intracellular Self-assembly of TPE-biotin Nanoparticles Enables Aggregation-Induced Emission Fluorescence for Cancer-Targeted Imaging

Fluorogens with aggregation-induced emission (AIE) characteristics have recently been widely applied for studying biological events, and fluorogens with “smart” properties are especially desirable. Herein, we rationally designed and synthesized a biotinylated and reduction-activatable probe (Cys(StBu)-Lys(biotin)-Lys(TPE)-CBT (1)) with AIE properties for cancer-targeted imaging. The biotinylated probe 1 can be actively uptaken by the biotin receptor-overexpressing cancer cells, and then “smartly” self-assemble into nanoparticles inside cells and turn the fluorescence “On”. Employing this “smart” strategy, we successfully applied probe 1 for cancer-targeted imaging. We envision that this biotinylated intelligent probe 1 might be further developed for cancer-targeted imaging in routine clinical studies in the near future.

Recurrence of non-cardiogenic pulmonary edema and sustained hypotension shock in cystic pheochromocytoma

本文介绍一例以胸痛、呼吸困难为主要表现,反复发生非心源性肺水肿、持续性低血压和急性冠脉综合征的囊性嗜铬细胞瘤患者。囊性嗜铬细胞瘤合并多种严重并发症临床上少有报道,容易误诊和漏诊。对于出现肺水肿、持续性低血压和急性冠脉综合征等严重体征,临床诊断又不明确的患者,需要考虑嗜铬细胞瘤的可能。