We report on ambipolar modulation doping of monolayer FeSe epitaxial films grown by molecular beam epitaxy and in situ spectroscopic measurements via a cryogenic scanning tunneling microscopy.It is found that hole dop...We report on ambipolar modulation doping of monolayer FeSe epitaxial films grown by molecular beam epitaxy and in situ spectroscopic measurements via a cryogenic scanning tunneling microscopy.It is found that hole doping kills superconductivity in monolayer FeSe films on metallic Ir(001)substrates,whereas electron doping from polycrystalline IrO_(2)/SrTiO_(3)substrate enhances significantly the superconductivity with an energy gap of 10.3 meV.By exploring substrate-dependent superconductivity,we elucidate the essential impact of substrate work functions on the superconductivity of monolayer FeSe films.Our results therefore offer a valuable reference guide for further enhancement of the transition temperature Tc in FeSe-based superconductors by interface engineering.展开更多
AIM:To compare efficacy of combined lamivudine(LAM)and adefovir dipivoxil(ADV)therapy with that of entecavir(ETV)monotherapy for hepatitis B virus(HBV)-related decompensated liver cirrhosis.METHODS:A total of 120 na v...AIM:To compare efficacy of combined lamivudine(LAM)and adefovir dipivoxil(ADV)therapy with that of entecavir(ETV)monotherapy for hepatitis B virus(HBV)-related decompensated liver cirrhosis.METHODS:A total of 120 na ve patients with HBVrelated decompensated cirrhosis participated in this study.Sixty patients were treated with combined LAM and ADV therapy(LAM+ADV group),while the other60 were treated with ETV monotherapy(ETV group)for two years.Tests for liver and kidney function,alpha-fetoprotein,HBV serum markers,HBV DNA load,prothrombin time(PT),and ultrasonography or computed tomography scan of the liver were performed every1 to 3 mo.Repeated measure ANOVA and theχ2test were performed to compare the efficacy,side effects,and the cumulative survival rates at 48 and 96 wk.RESULTS:Forty-five patients in each group were observed for 96 wk.No significant differences in HBV DNA negative rates and alanine aminotransferase(ALT)normalization rates at weeks 48(χ2=2.12 and 2.88)and96(χ2=3.21 and 3.24)between the two groups were observed.Hepatitis B e antigen seroconversion rate in the LAM+ADV group at week 96 was significantly higher in the ETV group(43.5%vs 36.4%,χ2=4.09,P<0.05).Viral breakthrough occurred in 2 cases(4.4%)by week 48 and in 3 cases(6.7%)by week 96 in the LAM+ADV group,and no viral mutation was detected.In the ETV group,viral breakthrough occurred in 1 case(2.2%)at the end of week 96.An increase in albumin(F=18.9 and 17.3),decrease in total bilirubin and in ALT(F=16.5,17.1 and 23.7,24.8),reduced PT(F=22.7 and 24.5),and improved Child-Turcotte-Pugh and the model for end-stage liver disease scores(F=18.5,17.8,and 24.2,23.8)were observed in both groups.The cumulative rates of mortality and liver transplantation were 16.7%(10/60)and 18.3%(11/60)in the LAM+ADV and ETV groups,respectively.CONCLUSION:Both LAM+ADV combination therapy and ETV monotherapy can effectively inhibit HBV replication,improve liver function,and decrease mortality.展开更多
AIM: To evaluate urine β2-microglobulin(β2-M), retinol-binding protein(RBP) excretion, and renal impairment with adefovir dipivoxil(ADV) for chronic hepatitis B. METHODS: We enrolled 165 patients with chronic hepati...AIM: To evaluate urine β2-microglobulin(β2-M), retinol-binding protein(RBP) excretion, and renal impairment with adefovir dipivoxil(ADV) for chronic hepatitis B. METHODS: We enrolled 165 patients with chronic hepatitis B infection who were treated with ADV monotherapy(n = 90) or ADV plus lamivudine combination therapy(n = 75). An additional 165 chronic hepatitis B patients treated with entecavir were recruited as controls. We detected serum creatinine, urine β2-M, and RBP levels, and estimated the glomerular filtration rate(e GFR) at the initiation of antiviral therapy and every 6 mo for a period of five years. RESULTS: Urine β2-M abnormalities were observed in patients during the first(n = 3), second(n = 7), third(n = 11), fourth(n = 16), and fifth(n = 21) year of ADV treatment. Urinary RBP abnormalities were observed in patients during the first(n = 2), second(n = 8), third(n = 12), fourth(n = 15), and fifth(n = 22) year of ADV treatment. e GFR decreased 20%-30% from baseline in 20 patients, 30%-50% in 12 patients, and > 50% in 3 patients during the five years of treatment. Further analysis indicated that decreases in e GFR of ≥ 30% relative to the baseline level correlated significantly with urine RBP and β2-M abnormalities. In contrast, both serum creatinine and e GFR remained stable in patients treated with entecavir, and only one of these patients developed a urine β2-M abnormality, and two developed urine RBP abnormalities during the five years of treatment. CONCLUSION: Urine RBP and β2-M are biomarkers of renal injury during long-term ADV treatment for chronic hepatitis B, and indicate when treatment should be switched to entecavir.展开更多
The mechanisms of aid-leaching reagent calcium fluoride in the extracting vanadium processes were researched by comparing the blank extraction with the extraction with calcium fluoride as aid-leaching reagent. The lea...The mechanisms of aid-leaching reagent calcium fluoride in the extracting vanadium processes were researched by comparing the blank extraction with the extraction with calcium fluoride as aid-leaching reagent. The leaching experiments were carried out under the conditions of 95 ~C, 6 h, 1.5 ml.g-1, 15 vol % H2SO4, and 5 % calcium fluoride (mass ratio of CaF2 to stone coal). The concentrations of hydrogen ion were adjusted from initial 1.82 and 4.79 mol.L-1 to the pH of 1.80 4- 0.05 by 200 g.L-1 lime milk, respectively. The solvent extraction experiments were carded out under the organic phase using 15 vol% D2EHPA, 5 vol% TBP, and 80 vol% sulfonated kerosene and O/A phase ratio of 1/4. The leaching rate of vanadium and six-stage countercurrent solvent extraction rate of vanadium can be remarkably improved from 66.71 to 92.97 % and 81.15 to 98.81%, respectively, when calcium fluoride was added as aid-leaching reagent. In the leaching process, fluorine can enhance the breakage of the structure of vanadium-bearing minerals. Meanwhile, fluoride ion can combine with iron ion to generate acid-insoluble iron fluoride hydrate (Fe2Fs.7H20) and consume all ferric ions and a portion of ferrous ions. In adjusting pH value process, the massive impurities are decreased to form KA1SO4 and FeA1Fs. In solvent extraction process, fluorine can prevent the formation of ferric hydroxide colloids and eliminate the formed unstable ferric hydroxide colloids and the silicon-containing colloids to promote the sufficient contact between the aqueous phase and the organic phase and the sufficient reaction.展开更多
The influence of roasting on the leaching rate and valence of vanadium was evaluated during vanadium extraction from stone coal. Vanadium in stone coal is hard to be leached and the leaching rate is less than 10% when...The influence of roasting on the leaching rate and valence of vanadium was evaluated during vanadium extraction from stone coal. Vanadium in stone coal is hard to be leached and the leaching rate is less than 10% when the raw ore is leached by 4 moUL H2SO4 at 90℃ for 2 h. After the sample is roasted at 900℃ for 2 h, the leaching rate of vanadium reaches the maximum, and more than 70% of vanadium can be leached. The crystal of vanadium-bearing mica minerals decomposes and the Content of V(V) increases with the rise of roasting temperature from 600 to 900℃, therefore the leaching rate of vanadium increases significantly with the decomposition of the mica minerals. Some new phases, anorthite for example, form when the roasting temperature reaches 1000℃. A part of vanadium may be enwrapped in the sintered materials and newly formed phases, which may impede the oxidation of low valent vanadium and make the leaching rate of vanadium drop dramatically. The leaching rate of vanadium is not only determined by the valence state of vanadium but also controlled by the decomposition of vanadium-bearing minerals and the existence state of vanadium to a large extent.展开更多
Industrial experiments were carried out to investigate the formation of CaS-bearing inclusion during Ca double modification in oil casting steels using polished cross sections and electrolytic extraction. Immediately ...Industrial experiments were carried out to investigate the formation of CaS-bearing inclusion during Ca double modification in oil casting steels using polished cross sections and electrolytic extraction. Immediately after Ca addition, the role of newly generated CaS as an intermediate reaction product, which modified the Al_2O_3 inclusion into a liquid calcium aluminate, was confirmed. The formation of transient CaS was attributed to the high surface segregation of S at the liquid steel-calcium vapor interface, where a simple site coverage model based upon the Langmuir adsorption equation was established. Moreover, a CaS outer layer surrounding the liquid calcium aluminate was attained mainly in the tundish, which was distributed unevenly on the surface of liquid particles according to the three-dimensional mapping results. The surface of a well-modified calcium aluminate with higher CaO activity and Al_2O_3 activity under bulk composition conditions in the tundish acted as a favorable site for the generation of CaS. Additionally, CaS could be precipitated directly onto existing inclusions during solidification of the steel, which led to various morphologies of CaS-bearing inclusions in slabs. Furthermore, the phase transformation of inclusions during solidification was strongly influenced both by the S content and the Ca/S ratio in the tundish via thermodynamics.展开更多
The morphological and mineralogical characterizations of a Chinese oolitic iron ore (Exi deposit) were studied by scanning electron microscopy and energy-dispersive X-ray spectroscopy in this work. It is shown that ...The morphological and mineralogical characterizations of a Chinese oolitic iron ore (Exi deposit) were studied by scanning electron microscopy and energy-dispersive X-ray spectroscopy in this work. It is shown that the Exi ore is mainly composed of hematite, quartz, apatite, and chlorite. The hematite is present as the oolitic layers and in the spaces between the aggregated ooids; quartz exists as granular particles in the spaces and as nucleuses in ooids; the harmful mineral, apatite, is associated with hematite as the oolitic layers, fine dissemination, granular particles in the spaces, and nucleuses in ooids. From the viewpoint of mineral beneficiation, it is hard to separate apatite and chlorite but easy to separate quartz from hematite in the Exi iron ore in recovering the iron values.展开更多
The purpose of this study was to assess the differences in clinical and sonographic features of papillary thyroid carcinoma(PTC) between cervical lymph node metastatic(CLNM) and nonmetastatic groups.Clinical data ...The purpose of this study was to assess the differences in clinical and sonographic features of papillary thyroid carcinoma(PTC) between cervical lymph node metastatic(CLNM) and nonmetastatic groups.Clinical data of PTC patients(414 patients with 624 malignant nodules) who underwent a preoperative ultrasonography and surgery between June 2010 and March 2015 at Renmin Hospital of Wuhan University were retrospectively analyzed.Clinical factors,preoperative ultrasound features and the final pathological findings were obtained.The differences in the sonographic features of PTC between the CLNM group and the non-CLNM group were analyzed.There were 187 CLNM and 227 non-CLNM patients.The median age at the diagnosis of this cohort was 45.4 years old(ranging from 18 to 77 years).Ultrasonographic parameters that were significantly associated with CLNM [OR=2.569(1.502,4.393),P〈0.001)] were as follows:the mulifocality of the nodules,size over 2 cm,the presence of microcalcifications,the distance ratio(DR) pattern showing the contact of the nodules with the thyroid capsule,and the extracapsular spread of the nodules.No significant differences in age,gender,thyroid stimulating hormone(TSH) levels and other ultrasonography parameters were found between the CLNM and the non-CLNM groups.Therefore,our results suggest that a larger size,microcalcifications,mulifocality,and the DR pattern showing the contact of the nodules with the thyroid capsule and extracapsular spread are significantly more indicative of CLNM in PTC.展开更多
BACKGROUND: Linezolid is an effective antibiotic reagent for Gram-positive bacterial infection; its most common side effect is thrombocytopenia. However, the incidence of throm- bocytopenia in patients with acute-on-...BACKGROUND: Linezolid is an effective antibiotic reagent for Gram-positive bacterial infection; its most common side effect is thrombocytopenia. However, the incidence of throm- bocytopenia in patients with acute-on-chronic liver failure (ACLF) who underwent linezolid therapy was unclear. The present study was to evaluate the incidence of thrombocyto- penia in ACLF and non-ACLF patients treated with linezolid and the risk factors of thrombocytopenia in these patients.展开更多
The current research of reliability allocation of CNC lathes always treat CNC lathes as independent series systems. However, CNC lathes are complex systems in the actual situation. Failure correlation is rarely consid...The current research of reliability allocation of CNC lathes always treat CNC lathes as independent series systems. However, CNC lathes are complex systems in the actual situation. Failure correlation is rarely considered when reliabil?ity allocation is conducted. In this paper, drawbacks of reliability model based on failure independence assumption are illustrated, after which, reliability model of CNC lathes considering failure correlation of subsystems is established based on Copula theory, which is an improvement of traditional reliability model of series systems. As the failure time of CNC lathes often obeys Weibull or exponential distribution, Gumbel Copula is selected to build correlation model. After that, a reliability allocation method considering failure correlation is analyzed based on the model established before. Reliability goal is set first and then failure rates are allocated to subsystems according to the allocation vector through solving the correlation model. Reliability allocation is conducted for t = 1. A real case of a CNC lathe and a numerical case are presented together to illustrate the advantages of the reliability model established consider?ing failure correlation and the corresponding allocation method. It shows that the model accords to facts and real working condition more, and failure rates allocated to all the subsystems are increased to some extent. This research proposes a reliability allocation method which takes failure correlation among subsystems of CNC lathes into consid?eration, and costs for design and manufacture could be decreased.展开更多
The effect and mechanism of microwave irradiation on vanadium leaching were studied via a comparison between microwave heating and conventional heating. The results show a synergistic effect of microwave irradiation a...The effect and mechanism of microwave irradiation on vanadium leaching were studied via a comparison between microwave heating and conventional heating. The results show a synergistic effect of microwave irradiation and calcium fluoride (CaF2) on the vana- dium leaching efficiency. It is confirmed that the vanadium leaching process can be improved by microwave irradiation when CaF2 is present. The leaching rate of vanadium under microwave irradiation is increased by 8%-15% when 5wt% CaF2 is added; by contrast, in the absence of CaF2, the leaching rate is almost unaffected compared to that by conventional heating. Morphological analysis reveals that the particles are gradually eroded by acid under microwave irradiation, whereas some of the fine particles in samples subjected to conventional heating are tightly covered by a flocculent silicate product. Moreover, a large amount of A1 and V and a small amount of Si are dissolved from samples under microwave heating, as revealed by the elemental analysis of leachates. Fourier transform infrared spectroscopic analysis also indicates a higher mass transfer coefficient in the diffusion layer of the raw material by microwave irradiation. When CaF2 is present, the reaction energy barrier is lowered and the leaching process is controlled by the tightly covered product layer, resulting in a prominent effect of mi- crowave irradiation.展开更多
Experiments comparing microwave blank roasting and conventional blank roasting for typical vanadium-bearing stone coal from Hubei Province in central China, in which vanadium is present in muscovite, were conducted to...Experiments comparing microwave blank roasting and conventional blank roasting for typical vanadium-bearing stone coal from Hubei Province in central China, in which vanadium is present in muscovite, were conducted to investigate the effects of roasting tempera- ture, roasting time, H2SO4 concentration, and leaching time on vanadium extraction. The results show that the vanadium leaching efficiency is 84% when the sample is roasted at 800℃ for 30 min by microwave irradiation and the H2SO4 concentration, liquid/solid ratio, leaching temperature, and leaching time are set as 20vo1%, 1.5:1 mL.g-1, 95℃, and 8 h, respectively. However, the vanadium leaching efficiency achieved for the sample subjected to conventional roasting at 900℃ for 60 min is just 71% under the same leaching conditions. Scanning electron microscopy (SEM) analysis shows that the microwave roasted samples contain more cracks and that the particles are more porous compared to the conventionally roasted samples. According to the results of X-ray diffraction (XRD) and Fourier-transform infrared (FTIR) analyses, neither of these roasting methods could completely destroy the mica lattice structure under the experimental conditions; however, both methods deformed the muscovite structure and facilitated the leaching process. Comparing with conventional roasting, microwave roasting causes a greater deformation of the mineral structure at a lower temperature for a shorter roasting time.展开更多
AIM: To investigate hepatitis B surface antigen (HBsAg) levels in patients with HBeAg-positive chronic hepatitis B (CHB) and different immune conditions.
An innovative method for recovering valuable elements from vanadium-bearing titanomagnetite is proposed. This method involves two procedures: low-temperature roasting of vanadium-bearing titanomagnetite and water lea...An innovative method for recovering valuable elements from vanadium-bearing titanomagnetite is proposed. This method involves two procedures: low-temperature roasting of vanadium-bearing titanomagnetite and water leaching of roasting slag. During the roasting process, the reduction of iron oxides to metallic iron, the sodium oxidation of vanadium oxides to water-soluble sodium vanadate, and the smelting separation of metallic iron and slag were accomplished simultaneously. Optimal roasting conditions for iron/slag separation were achieved with a mixture thickness of 42.5 mm, a roasting temperature of 1200°C, a residence time of 2 h, a molar ratio of C/O of 1.7, and a sodium carbonate addition of 70 wt%, as well as with the use of anthracite as a reductant. Under the optimal conditions, 93.67% iron from the raw ore was recovered in the form of iron nugget with 95.44% iron grade. After a water leaching process, 85.61% of the vanadium from the roasting slag was leached, confirming the sodium oxidation of most of the vanadium oxides to water-soluble sodium vanadate during the roasting process. The total recoveries of iron, vanadium, and titanium were 93.67%, 72.68%, and 99.72%, respectively.展开更多
Solution-phase hydrogen reduction(Sp HR)was introduced into V_(2)O_(3)preparation to overcome disadvantages of traditional reduction roasting,which include a long process,high energy consumption,and generation of poll...Solution-phase hydrogen reduction(Sp HR)was introduced into V_(2)O_(3)preparation to overcome disadvantages of traditional reduction roasting,which include a long process,high energy consumption,and generation of pollution.The research mainly focuses onφ-pH diagrams and kinetics of SpHR.Thermodynamic analysis ofφ-pH diagrams for the V-H_(2)O system demonstrates that V_(2)O_(3)preparation via Sp HR requires a high temperature,a high vanadium concentration,and sufficient hydrogen in acidic solution.Kinetic analyses show that the activation energy of V_(2)O_(3)preparation via SpHR is 38.0679 k J/mol,indicating that the reduction is controlled by a combination of interfacial chemical reaction and internal diffusion.Effects of H;partial pressure(slope K=0.05246)on the reaction rate is not as significant as the vanadium concentration(K=1.58872).V_(2)O_(3)crystals with a purity of 99.59%and a vanadium precipitation rate of 99.83%were obtained under the following conditions:pH=5-6,c(V_(2)O_(3))=0.5 mol/L,p(H;)=4 MPa,m(PdCl;)=10 mg,T=250℃,and t=2.5 h.展开更多
BACKGROUND: Differentiation of liver progenitor cells(LPCs) to functional hepatocytes holds great potential to develop new strategies for hepatocyte transplantation and the screening of drug-induced cytotoxicity. H...BACKGROUND: Differentiation of liver progenitor cells(LPCs) to functional hepatocytes holds great potential to develop new strategies for hepatocyte transplantation and the screening of drug-induced cytotoxicity. However, reports on the efficient and convenient hepatic differentiation of LPCs to hepatocytes are few. The present study aims to investigate the possibility of generating functional hepatocytes from LPCs in an indirect co-culture system.METHODS: Mouse LPCs were co-cultured in Transwell plates with an immortalized human hepatic stellate cell line(HSCLi) we previously established. The morphology, expression of hepatic markers, and functions of mouse LPC-derived cells were monitored and compared with those of conventionally cultured LPCs. RESULTS: Co-culturing with HSC-Li cells induced differentiation of mouse LPCs into functional hepatocyte-like cells. The differentiated cells were morphologically transformed into hepatocyte-like cells 3 days after co-culture initiation. In addition, the differentiated cells expressed liver-specific genes and possessed hepatic functions, including glycogen storage, lowdensity lipoprotein uptake, albumin secretion, urea synthesis, and cytochrome P450 1A2 enzymatic activity.CONCLUSIONS: Our method, which employs indirect co-culture with HSC-Li cells, can efficiently induce the differentiation of LPCs into functional hepatocytes. This finding suggests that this co-culture system can be a useful method for the efficient generation of functional hepatocytes from LPCs.展开更多
Composite electrodes prepared by cation exchange resins and activated carbon(AC)were used to adsorb Ⅴ(Ⅳ)in capacitive deionization(CDI).The electrode made of middle resin size(D860/AC M)had the largest specific surf...Composite electrodes prepared by cation exchange resins and activated carbon(AC)were used to adsorb Ⅴ(Ⅳ)in capacitive deionization(CDI).The electrode made of middle resin size(D860/AC M)had the largest specific surface area and mesoporous content than two other composite electrodes.Electrochemical analysis showed that D860/AC M presents higher specific capacitance and electrical double layer capacitor than the others,and significantly lower internal diffusion impedance.Thus,D860/AC M exhibits the highest adsorption capacity and rate of Ⅴ(Ⅳ)among three electrodes.The intra-particle diffusion model fits well in the initial adsorption stage,while the liquid film diffusion model is more suitable for fitting at the later stage.The pseudo-second-order kinetic model is suited for the entire adsorption process.The adsorption of Ⅴ(Ⅳ)on the composite electrode follows that of the Freundlich isotherm.Thermodynamic analysis indicates that the adsorption of Ⅴ(Ⅳ)is an exothermic process with entropy reduction,and the electric field force plays a dominant role in the CDI process.This work aims to improve our understanding of the ion adsorption behaviors and mechanisms on the composite electrodes in CDI.展开更多
基金the National Key Research and Development Program of China(No.2020YFC1909700)the National Natural Science Foundation of China(Nos.51974207,51774215).
基金financially supported by the National Natural Science Foundation of China(Grant No.12141403)the National Key R&D Program of China(Grant No.2022YFA1403100)。
文摘We report on ambipolar modulation doping of monolayer FeSe epitaxial films grown by molecular beam epitaxy and in situ spectroscopic measurements via a cryogenic scanning tunneling microscopy.It is found that hole doping kills superconductivity in monolayer FeSe films on metallic Ir(001)substrates,whereas electron doping from polycrystalline IrO_(2)/SrTiO_(3)substrate enhances significantly the superconductivity with an energy gap of 10.3 meV.By exploring substrate-dependent superconductivity,we elucidate the essential impact of substrate work functions on the superconductivity of monolayer FeSe films.Our results therefore offer a valuable reference guide for further enhancement of the transition temperature Tc in FeSe-based superconductors by interface engineering.
基金Supported by the National Key Program for Infectious Diseases of China to Yang YD,2013ZX1000200112th Five-Year Significant New Drugs Creation Plan of the Ministry of Science and Technology of China toYangYD,2011ZX09302-003-03
文摘AIM:To compare efficacy of combined lamivudine(LAM)and adefovir dipivoxil(ADV)therapy with that of entecavir(ETV)monotherapy for hepatitis B virus(HBV)-related decompensated liver cirrhosis.METHODS:A total of 120 na ve patients with HBVrelated decompensated cirrhosis participated in this study.Sixty patients were treated with combined LAM and ADV therapy(LAM+ADV group),while the other60 were treated with ETV monotherapy(ETV group)for two years.Tests for liver and kidney function,alpha-fetoprotein,HBV serum markers,HBV DNA load,prothrombin time(PT),and ultrasonography or computed tomography scan of the liver were performed every1 to 3 mo.Repeated measure ANOVA and theχ2test were performed to compare the efficacy,side effects,and the cumulative survival rates at 48 and 96 wk.RESULTS:Forty-five patients in each group were observed for 96 wk.No significant differences in HBV DNA negative rates and alanine aminotransferase(ALT)normalization rates at weeks 48(χ2=2.12 and 2.88)and96(χ2=3.21 and 3.24)between the two groups were observed.Hepatitis B e antigen seroconversion rate in the LAM+ADV group at week 96 was significantly higher in the ETV group(43.5%vs 36.4%,χ2=4.09,P<0.05).Viral breakthrough occurred in 2 cases(4.4%)by week 48 and in 3 cases(6.7%)by week 96 in the LAM+ADV group,and no viral mutation was detected.In the ETV group,viral breakthrough occurred in 1 case(2.2%)at the end of week 96.An increase in albumin(F=18.9 and 17.3),decrease in total bilirubin and in ALT(F=16.5,17.1 and 23.7,24.8),reduced PT(F=22.7 and 24.5),and improved Child-Turcotte-Pugh and the model for end-stage liver disease scores(F=18.5,17.8,and 24.2,23.8)were observed in both groups.The cumulative rates of mortality and liver transplantation were 16.7%(10/60)and 18.3%(11/60)in the LAM+ADV and ETV groups,respectively.CONCLUSION:Both LAM+ADV combination therapy and ETV monotherapy can effectively inhibit HBV replication,improve liver function,and decrease mortality.
基金Supported by National Key Program for Infectious Diseases of China(to Yang YD),No.2013ZX1000200112th FiveYear Significant New Drugs Creation Plan of the Ministry of Science and Technology of China(to Yang YD),No.2011ZX09302-003-03
文摘AIM: To evaluate urine β2-microglobulin(β2-M), retinol-binding protein(RBP) excretion, and renal impairment with adefovir dipivoxil(ADV) for chronic hepatitis B. METHODS: We enrolled 165 patients with chronic hepatitis B infection who were treated with ADV monotherapy(n = 90) or ADV plus lamivudine combination therapy(n = 75). An additional 165 chronic hepatitis B patients treated with entecavir were recruited as controls. We detected serum creatinine, urine β2-M, and RBP levels, and estimated the glomerular filtration rate(e GFR) at the initiation of antiviral therapy and every 6 mo for a period of five years. RESULTS: Urine β2-M abnormalities were observed in patients during the first(n = 3), second(n = 7), third(n = 11), fourth(n = 16), and fifth(n = 21) year of ADV treatment. Urinary RBP abnormalities were observed in patients during the first(n = 2), second(n = 8), third(n = 12), fourth(n = 15), and fifth(n = 22) year of ADV treatment. e GFR decreased 20%-30% from baseline in 20 patients, 30%-50% in 12 patients, and > 50% in 3 patients during the five years of treatment. Further analysis indicated that decreases in e GFR of ≥ 30% relative to the baseline level correlated significantly with urine RBP and β2-M abnormalities. In contrast, both serum creatinine and e GFR remained stable in patients treated with entecavir, and only one of these patients developed a urine β2-M abnormality, and two developed urine RBP abnormalities during the five years of treatment. CONCLUSION: Urine RBP and β2-M are biomarkers of renal injury during long-term ADV treatment for chronic hepatitis B, and indicate when treatment should be switched to entecavir.
基金financially supported by the Key Science and Technology Support Program (No. 2011BAB05B01) from the Ministry of ScienceTechnology of China and the Special Science and Technology Program (No. 201009013) from the Ministry of Environmental Protection of China
文摘The mechanisms of aid-leaching reagent calcium fluoride in the extracting vanadium processes were researched by comparing the blank extraction with the extraction with calcium fluoride as aid-leaching reagent. The leaching experiments were carried out under the conditions of 95 ~C, 6 h, 1.5 ml.g-1, 15 vol % H2SO4, and 5 % calcium fluoride (mass ratio of CaF2 to stone coal). The concentrations of hydrogen ion were adjusted from initial 1.82 and 4.79 mol.L-1 to the pH of 1.80 4- 0.05 by 200 g.L-1 lime milk, respectively. The solvent extraction experiments were carded out under the organic phase using 15 vol% D2EHPA, 5 vol% TBP, and 80 vol% sulfonated kerosene and O/A phase ratio of 1/4. The leaching rate of vanadium and six-stage countercurrent solvent extraction rate of vanadium can be remarkably improved from 66.71 to 92.97 % and 81.15 to 98.81%, respectively, when calcium fluoride was added as aid-leaching reagent. In the leaching process, fluorine can enhance the breakage of the structure of vanadium-bearing minerals. Meanwhile, fluoride ion can combine with iron ion to generate acid-insoluble iron fluoride hydrate (Fe2Fs.7H20) and consume all ferric ions and a portion of ferrous ions. In adjusting pH value process, the massive impurities are decreased to form KA1SO4 and FeA1Fs. In solvent extraction process, fluorine can prevent the formation of ferric hydroxide colloids and eliminate the formed unstable ferric hydroxide colloids and the silicon-containing colloids to promote the sufficient contact between the aqueous phase and the organic phase and the sufficient reaction.
基金financially supported by the National Key Technologies R&D Program of China(Nos.2011BAB05B01 and 2011BAB05B04)the Exclusive Research Fund of Environmental Protection for the Commonweal of China(No.201009013)
文摘The influence of roasting on the leaching rate and valence of vanadium was evaluated during vanadium extraction from stone coal. Vanadium in stone coal is hard to be leached and the leaching rate is less than 10% when the raw ore is leached by 4 moUL H2SO4 at 90℃ for 2 h. After the sample is roasted at 900℃ for 2 h, the leaching rate of vanadium reaches the maximum, and more than 70% of vanadium can be leached. The crystal of vanadium-bearing mica minerals decomposes and the Content of V(V) increases with the rise of roasting temperature from 600 to 900℃, therefore the leaching rate of vanadium increases significantly with the decomposition of the mica minerals. Some new phases, anorthite for example, form when the roasting temperature reaches 1000℃. A part of vanadium may be enwrapped in the sintered materials and newly formed phases, which may impede the oxidation of low valent vanadium and make the leaching rate of vanadium drop dramatically. The leaching rate of vanadium is not only determined by the valence state of vanadium but also controlled by the decomposition of vanadium-bearing minerals and the existence state of vanadium to a large extent.
基金financially supported by the National Basic Research Program of China(Nos.2013CB632601 and 2013CB632604)the National Science Foundation for Distinguished Young Scholars of China(Nos.51125018 and 51504230)+2 种基金the Key Research Program of Chinese Academy of Sciences(No.KGZD-EW-201-2)the National Natural Science Foundation of China(Nos.51374191 and 2110616751104139)China Postdoctoral Science Foundation(Nos.2012M510552 and 2013T60175)
基金financially supported by the National Natural Science Foundation of China (No. 51574026)
文摘Industrial experiments were carried out to investigate the formation of CaS-bearing inclusion during Ca double modification in oil casting steels using polished cross sections and electrolytic extraction. Immediately after Ca addition, the role of newly generated CaS as an intermediate reaction product, which modified the Al_2O_3 inclusion into a liquid calcium aluminate, was confirmed. The formation of transient CaS was attributed to the high surface segregation of S at the liquid steel-calcium vapor interface, where a simple site coverage model based upon the Langmuir adsorption equation was established. Moreover, a CaS outer layer surrounding the liquid calcium aluminate was attained mainly in the tundish, which was distributed unevenly on the surface of liquid particles according to the three-dimensional mapping results. The surface of a well-modified calcium aluminate with higher CaO activity and Al_2O_3 activity under bulk composition conditions in the tundish acted as a favorable site for the generation of CaS. Additionally, CaS could be precipitated directly onto existing inclusions during solidification of the steel, which led to various morphologies of CaS-bearing inclusions in slabs. Furthermore, the phase transformation of inclusions during solidification was strongly influenced both by the S content and the Ca/S ratio in the tundish via thermodynamics.
基金Supported by National Key Program for Infectious Diseases of China to Yang YD,No.2013ZX10002001the 12th Five-Year Significant New Drugs Creation Plan of the Ministry of Science and Technology of China to Li LJ,No.2011ZX09302-003-03
文摘AIM: To determine the baseline hepatitis B surface antigen (HBsAg) levels during the different phases of chronic hepatitis B (CHB) patients in China.
基金supports for this work from the National Council of Science and Technology (CONACyT) of Mexico (Nos. 92506, 123487,and 155148)
文摘The morphological and mineralogical characterizations of a Chinese oolitic iron ore (Exi deposit) were studied by scanning electron microscopy and energy-dispersive X-ray spectroscopy in this work. It is shown that the Exi ore is mainly composed of hematite, quartz, apatite, and chlorite. The hematite is present as the oolitic layers and in the spaces between the aggregated ooids; quartz exists as granular particles in the spaces and as nucleuses in ooids; the harmful mineral, apatite, is associated with hematite as the oolitic layers, fine dissemination, granular particles in the spaces, and nucleuses in ooids. From the viewpoint of mineral beneficiation, it is hard to separate apatite and chlorite but easy to separate quartz from hematite in the Exi iron ore in recovering the iron values.
基金supported by the National Natural Science Foundation of China(No.81471781,No.81502665 and No.81302314/H1622)the Fundamental Research Funds of Health and Family Planning Commission of Hubei Province(No.JS-20110118)the Fundamental Research Funds for the Central Universities of China(No.2042014kf0189)
文摘The purpose of this study was to assess the differences in clinical and sonographic features of papillary thyroid carcinoma(PTC) between cervical lymph node metastatic(CLNM) and nonmetastatic groups.Clinical data of PTC patients(414 patients with 624 malignant nodules) who underwent a preoperative ultrasonography and surgery between June 2010 and March 2015 at Renmin Hospital of Wuhan University were retrospectively analyzed.Clinical factors,preoperative ultrasound features and the final pathological findings were obtained.The differences in the sonographic features of PTC between the CLNM group and the non-CLNM group were analyzed.There were 187 CLNM and 227 non-CLNM patients.The median age at the diagnosis of this cohort was 45.4 years old(ranging from 18 to 77 years).Ultrasonographic parameters that were significantly associated with CLNM [OR=2.569(1.502,4.393),P〈0.001)] were as follows:the mulifocality of the nodules,size over 2 cm,the presence of microcalcifications,the distance ratio(DR) pattern showing the contact of the nodules with the thyroid capsule,and the extracapsular spread of the nodules.No significant differences in age,gender,thyroid stimulating hormone(TSH) levels and other ultrasonography parameters were found between the CLNM and the non-CLNM groups.Therefore,our results suggest that a larger size,microcalcifications,mulifocality,and the DR pattern showing the contact of the nodules with the thyroid capsule and extracapsular spread are significantly more indicative of CLNM in PTC.
基金supported by grants from the China National Science and Technology Major Project(2012ZX10002004 and 2013ZX10002001)Zhejiang CTM Science and Technology Project(2011ZB061)
文摘BACKGROUND: Linezolid is an effective antibiotic reagent for Gram-positive bacterial infection; its most common side effect is thrombocytopenia. However, the incidence of throm- bocytopenia in patients with acute-on-chronic liver failure (ACLF) who underwent linezolid therapy was unclear. The present study was to evaluate the incidence of thrombocyto- penia in ACLF and non-ACLF patients treated with linezolid and the risk factors of thrombocytopenia in these patients.
基金National Natural Science Foundation of China(Grant Nos.51135003,U1234208)National Basic Research Program of China(973 Program,Grant No.2014CB046303)+3 种基金High-class CNC Machine Tools and Basic Manufacturing Equipment of Important National Science and Technology Specific Projects(Grant No.2013ZX04011-011)National Key Laboratory of Mechanical System and Vibration Project(Grant No.MSV201402)Scientific Research Business Fund of Central Colleges and Universities(Grant No.N150304006)Excellent Talents Support Program for Colleges and Universities in Liaoning Province of China(Grant No.LJQ2014030)
文摘The current research of reliability allocation of CNC lathes always treat CNC lathes as independent series systems. However, CNC lathes are complex systems in the actual situation. Failure correlation is rarely considered when reliabil?ity allocation is conducted. In this paper, drawbacks of reliability model based on failure independence assumption are illustrated, after which, reliability model of CNC lathes considering failure correlation of subsystems is established based on Copula theory, which is an improvement of traditional reliability model of series systems. As the failure time of CNC lathes often obeys Weibull or exponential distribution, Gumbel Copula is selected to build correlation model. After that, a reliability allocation method considering failure correlation is analyzed based on the model established before. Reliability goal is set first and then failure rates are allocated to subsystems according to the allocation vector through solving the correlation model. Reliability allocation is conducted for t = 1. A real case of a CNC lathe and a numerical case are presented together to illustrate the advantages of the reliability model established consider?ing failure correlation and the corresponding allocation method. It shows that the model accords to facts and real working condition more, and failure rates allocated to all the subsystems are increased to some extent. This research proposes a reliability allocation method which takes failure correlation among subsystems of CNC lathes into consid?eration, and costs for design and manufacture could be decreased.
基金financially supported by the National Natural Science Foundation of China(Nos.51474162 and 51404174)the Research Project of the Ministry of Education of China(No.213025A)
文摘The effect and mechanism of microwave irradiation on vanadium leaching were studied via a comparison between microwave heating and conventional heating. The results show a synergistic effect of microwave irradiation and calcium fluoride (CaF2) on the vana- dium leaching efficiency. It is confirmed that the vanadium leaching process can be improved by microwave irradiation when CaF2 is present. The leaching rate of vanadium under microwave irradiation is increased by 8%-15% when 5wt% CaF2 is added; by contrast, in the absence of CaF2, the leaching rate is almost unaffected compared to that by conventional heating. Morphological analysis reveals that the particles are gradually eroded by acid under microwave irradiation, whereas some of the fine particles in samples subjected to conventional heating are tightly covered by a flocculent silicate product. Moreover, a large amount of A1 and V and a small amount of Si are dissolved from samples under microwave heating, as revealed by the elemental analysis of leachates. Fourier transform infrared spectroscopic analysis also indicates a higher mass transfer coefficient in the diffusion layer of the raw material by microwave irradiation. When CaF2 is present, the reaction energy barrier is lowered and the leaching process is controlled by the tightly covered product layer, resulting in a prominent effect of mi- crowave irradiation.
基金financially supported by the Research Project from the Chinese Ministry of Education (No. 213025A)
文摘Experiments comparing microwave blank roasting and conventional blank roasting for typical vanadium-bearing stone coal from Hubei Province in central China, in which vanadium is present in muscovite, were conducted to investigate the effects of roasting tempera- ture, roasting time, H2SO4 concentration, and leaching time on vanadium extraction. The results show that the vanadium leaching efficiency is 84% when the sample is roasted at 800℃ for 30 min by microwave irradiation and the H2SO4 concentration, liquid/solid ratio, leaching temperature, and leaching time are set as 20vo1%, 1.5:1 mL.g-1, 95℃, and 8 h, respectively. However, the vanadium leaching efficiency achieved for the sample subjected to conventional roasting at 900℃ for 60 min is just 71% under the same leaching conditions. Scanning electron microscopy (SEM) analysis shows that the microwave roasted samples contain more cracks and that the particles are more porous compared to the conventionally roasted samples. According to the results of X-ray diffraction (XRD) and Fourier-transform infrared (FTIR) analyses, neither of these roasting methods could completely destroy the mica lattice structure under the experimental conditions; however, both methods deformed the muscovite structure and facilitated the leaching process. Comparing with conventional roasting, microwave roasting causes a greater deformation of the mineral structure at a lower temperature for a shorter roasting time.
基金Supported by China National Science and Technology Major Project,No.2012ZX10002004 and No.2013ZX10002001the Chinese High Tech Research and Development(863)Program,No.2011AA020104Zhejiang CTM Science and Technology Project,No.2011ZB061
文摘AIM: To investigate hepatitis B surface antigen (HBsAg) levels in patients with HBeAg-positive chronic hepatitis B (CHB) and different immune conditions.
基金financially supported by the National Basic Research Program of China(Nos.2013CB632601 and 2013CB632604)the National Science Foundation for Distinguished Young Scholars of China(Nos.51125018 and 51504230)+3 种基金the Key Research Program of the Chinese Academy of Sciences(No.KGZD-EW-201-2)the National Natural Science Foundation of China(Nos.51374191,21106167,2160624,and 51104139)the Financial Grant from the China Postdoctoral Science Foundation(Nos.2012M510552 and 2013T60175)the Nonprofit Industry Research Subject of Environmental Projection(No.201509053)
文摘An innovative method for recovering valuable elements from vanadium-bearing titanomagnetite is proposed. This method involves two procedures: low-temperature roasting of vanadium-bearing titanomagnetite and water leaching of roasting slag. During the roasting process, the reduction of iron oxides to metallic iron, the sodium oxidation of vanadium oxides to water-soluble sodium vanadate, and the smelting separation of metallic iron and slag were accomplished simultaneously. Optimal roasting conditions for iron/slag separation were achieved with a mixture thickness of 42.5 mm, a roasting temperature of 1200°C, a residence time of 2 h, a molar ratio of C/O of 1.7, and a sodium carbonate addition of 70 wt%, as well as with the use of anthracite as a reductant. Under the optimal conditions, 93.67% iron from the raw ore was recovered in the form of iron nugget with 95.44% iron grade. After a water leaching process, 85.61% of the vanadium from the roasting slag was leached, confirming the sodium oxidation of most of the vanadium oxides to water-soluble sodium vanadate during the roasting process. The total recoveries of iron, vanadium, and titanium were 93.67%, 72.68%, and 99.72%, respectively.
基金financially supported by the National Key R&D Program of China(No.2020YFC1909700)Outstanding Young and Middle-aged Science and Technology Innovation Team Project of Hubei Province,China(No.T201802)the National Natural Science Foundation of China(No.52004187)。
文摘Solution-phase hydrogen reduction(Sp HR)was introduced into V_(2)O_(3)preparation to overcome disadvantages of traditional reduction roasting,which include a long process,high energy consumption,and generation of pollution.The research mainly focuses onφ-pH diagrams and kinetics of SpHR.Thermodynamic analysis ofφ-pH diagrams for the V-H_(2)O system demonstrates that V_(2)O_(3)preparation via Sp HR requires a high temperature,a high vanadium concentration,and sufficient hydrogen in acidic solution.Kinetic analyses show that the activation energy of V_(2)O_(3)preparation via SpHR is 38.0679 k J/mol,indicating that the reduction is controlled by a combination of interfacial chemical reaction and internal diffusion.Effects of H;partial pressure(slope K=0.05246)on the reaction rate is not as significant as the vanadium concentration(K=1.58872).V_(2)O_(3)crystals with a purity of 99.59%and a vanadium precipitation rate of 99.83%were obtained under the following conditions:pH=5-6,c(V_(2)O_(3))=0.5 mol/L,p(H;)=4 MPa,m(PdCl;)=10 mg,T=250℃,and t=2.5 h.
基金supported by grants from the Chinese High-Tech Research&Development(863)Program(2013AA020102 and 2012AA020204)Science Fund for Creative Research Groups of the National Natural Science Foundation of China(81121002)+3 种基金Fundamental Research Funds for the Central Universities(2014XZZX008 and 2014FZA7010)Zhejiang CTM Science and Technology Project(2011ZB061)Zhejiang Health Science Foundation(2016KYA148)the National Health and Medical Research Council of Australia and Cancer Council of Western Australia
文摘BACKGROUND: Differentiation of liver progenitor cells(LPCs) to functional hepatocytes holds great potential to develop new strategies for hepatocyte transplantation and the screening of drug-induced cytotoxicity. However, reports on the efficient and convenient hepatic differentiation of LPCs to hepatocytes are few. The present study aims to investigate the possibility of generating functional hepatocytes from LPCs in an indirect co-culture system.METHODS: Mouse LPCs were co-cultured in Transwell plates with an immortalized human hepatic stellate cell line(HSCLi) we previously established. The morphology, expression of hepatic markers, and functions of mouse LPC-derived cells were monitored and compared with those of conventionally cultured LPCs. RESULTS: Co-culturing with HSC-Li cells induced differentiation of mouse LPCs into functional hepatocyte-like cells. The differentiated cells were morphologically transformed into hepatocyte-like cells 3 days after co-culture initiation. In addition, the differentiated cells expressed liver-specific genes and possessed hepatic functions, including glycogen storage, lowdensity lipoprotein uptake, albumin secretion, urea synthesis, and cytochrome P450 1A2 enzymatic activity.CONCLUSIONS: Our method, which employs indirect co-culture with HSC-Li cells, can efficiently induce the differentiation of LPCs into functional hepatocytes. This finding suggests that this co-culture system can be a useful method for the efficient generation of functional hepatocytes from LPCs.
基金financially supported by the National Natural Science Foundation of China(No.51874222).
文摘Composite electrodes prepared by cation exchange resins and activated carbon(AC)were used to adsorb Ⅴ(Ⅳ)in capacitive deionization(CDI).The electrode made of middle resin size(D860/AC M)had the largest specific surface area and mesoporous content than two other composite electrodes.Electrochemical analysis showed that D860/AC M presents higher specific capacitance and electrical double layer capacitor than the others,and significantly lower internal diffusion impedance.Thus,D860/AC M exhibits the highest adsorption capacity and rate of Ⅴ(Ⅳ)among three electrodes.The intra-particle diffusion model fits well in the initial adsorption stage,while the liquid film diffusion model is more suitable for fitting at the later stage.The pseudo-second-order kinetic model is suited for the entire adsorption process.The adsorption of Ⅴ(Ⅳ)on the composite electrode follows that of the Freundlich isotherm.Thermodynamic analysis indicates that the adsorption of Ⅴ(Ⅳ)is an exothermic process with entropy reduction,and the electric field force plays a dominant role in the CDI process.This work aims to improve our understanding of the ion adsorption behaviors and mechanisms on the composite electrodes in CDI.