As a highly invasive carcinoma,esophageal cancer(EC)was the eighth most prevalent malignancy and the sixth leading cause of cancer-related death worldwide in 2020.Esophageal squamous cell carcinoma(ESCC)is the major h...As a highly invasive carcinoma,esophageal cancer(EC)was the eighth most prevalent malignancy and the sixth leading cause of cancer-related death worldwide in 2020.Esophageal squamous cell carcinoma(ESCC)is the major histological subtype of EC,and its incidence and mortality rates are decreasing globally.Due to the lack of specific early symptoms,ESCC patients are usually diagnosed with advanced-stage disease with a poor prognosis,and the incidence and mortality rates are still high in many countries,especially in China.Therefore,enormous challenges still exist in the management of ESCC,and novel strategies are urgently needed to further decrease the incidence and mortality rates of ESCC.Although the key molecular mechanisms underlying ESCC pathogenesis have not been fully elucidated,certain promising biomarkers are being investigated to facilitate clinical decision-making.With the advent and advancement of highthroughput technologies,such as genomics,proteomics and metabolomics,valuable biomarkers with high sensitivity,specificity and stability could be identified for ESCC.Herein,we aimed to determine the epidemiological features of ESCC in different regions of the world,especially in China,and focused on novel molecular biomarkers associated with ESCC screening,early diagnosis and prognosis prediction.展开更多
A remote-control tether-less isolation tool is a mechanical device that is normally used in pipelines to block the flow at a given position by transforming a blocking module. In this study, the interactions between th...A remote-control tether-less isolation tool is a mechanical device that is normally used in pipelines to block the flow at a given position by transforming a blocking module. In this study, the interactions between the fluid and the plug module of the isolation tool were investigated. Simulations of the plug process and particle image velocimetry measurements were performed to study the flow characteristics. Numerical solutions for the continuity, momentum, and energy equations were obtained by using commercial software based on finite-volume techniques. Box–Behnken design was applied, and response surface methodology(RSM)-based CFD simulation analysis was conducted. The dynamic model in the plug process was built by RSM and used to evaluate the influences of the main mechanical parameters on the pressure during the plug process. The diameter of the isolation tool and the diameter of the plug module have strong influences on the process, and the length of the isolation tool has only a little influence on the plug process.展开更多
Mine closure is associated with many negative impacts on society and the environment.If these effects are not rationally addressed,they would pose risks of mine closure.Thus,a risk management method is needed to mitig...Mine closure is associated with many negative impacts on society and the environment.If these effects are not rationally addressed,they would pose risks of mine closure.Thus,a risk management method is needed to mitigate these adverse impacts and address mine-closure issues.An integral framework for mine-closure risk management that includes risk assessment and risk treatment was proposed.Given the fuzziness and randomness of the transformation between qualitative and quantitative knowledge in the risk assessment process,a novel risk assessment method based on the cloud model was presented,which fully considers the uncertainty in risks themselves and in the reasoning process.Closed mine reutilization is an effective risk treatment option in response to the identified high risks,but it requires selecting optimal reutilization strategies for the successful implementation of the reuse plan.To this end,a hybrid semi-quantitative decision method is proposed to optimize decision-making.The results of a case study showed that this risk management methodology can help budget planning for risk treatment and provide an instructional framework to effectively reduce the negative effects of closed mines.展开更多
It is estimated that more than 3 million people die from chronic obstructive pulmonary disease(COPD)annually.Acute exacerbation of COPD(AECOPD)leads to an irreversible decline of pulmonary function,an increase of emer...It is estimated that more than 3 million people die from chronic obstructive pulmonary disease(COPD)annually.Acute exacerbation of COPD(AECOPD)leads to an irreversible decline of pulmonary function,an increase of emergency visits,hospitalization and length of stay in hospital,and an increase of the mortality.However,many exacerbations are not reported to healthcare professionals for therapy and yet these events,although often in short durations,have a significant impact on health status.111 Early detection and intervention of AECOPD as well as reducing of unreported episodes of AECOPD will potentially improve the prognosis.展开更多
基金Supported by Xi’an Municipal Health Commission of China,No.2022qn07 and No.2023ms11.
文摘As a highly invasive carcinoma,esophageal cancer(EC)was the eighth most prevalent malignancy and the sixth leading cause of cancer-related death worldwide in 2020.Esophageal squamous cell carcinoma(ESCC)is the major histological subtype of EC,and its incidence and mortality rates are decreasing globally.Due to the lack of specific early symptoms,ESCC patients are usually diagnosed with advanced-stage disease with a poor prognosis,and the incidence and mortality rates are still high in many countries,especially in China.Therefore,enormous challenges still exist in the management of ESCC,and novel strategies are urgently needed to further decrease the incidence and mortality rates of ESCC.Although the key molecular mechanisms underlying ESCC pathogenesis have not been fully elucidated,certain promising biomarkers are being investigated to facilitate clinical decision-making.With the advent and advancement of highthroughput technologies,such as genomics,proteomics and metabolomics,valuable biomarkers with high sensitivity,specificity and stability could be identified for ESCC.Herein,we aimed to determine the epidemiological features of ESCC in different regions of the world,especially in China,and focused on novel molecular biomarkers associated with ESCC screening,early diagnosis and prognosis prediction.
基金Supported by the Major State Basic Research Development Program Fund (2010CB226801) the National Natural Science Foundation of China (50704034) the State Key Laboratory of Coal Resources and Safe Mining Open Research Fund (SKLCRSM11KFB08)
基金supported by the National Natural Science Foundation of China (Grant No. 51575528)the Scientific Research Foundation of the Education Ministry for Returned Chinese Scholars (China)+1 种基金the State Key Laboratory for Coal Resources and Safe Mining, China University of Mining and Technology (No. SKLCRSM10KFB04)the Science Foundation of China University of Petroleum, Beijing (No. YXQN-2014-02)
文摘A remote-control tether-less isolation tool is a mechanical device that is normally used in pipelines to block the flow at a given position by transforming a blocking module. In this study, the interactions between the fluid and the plug module of the isolation tool were investigated. Simulations of the plug process and particle image velocimetry measurements were performed to study the flow characteristics. Numerical solutions for the continuity, momentum, and energy equations were obtained by using commercial software based on finite-volume techniques. Box–Behnken design was applied, and response surface methodology(RSM)-based CFD simulation analysis was conducted. The dynamic model in the plug process was built by RSM and used to evaluate the influences of the main mechanical parameters on the pressure during the plug process. The diameter of the isolation tool and the diameter of the plug module have strong influences on the process, and the length of the isolation tool has only a little influence on the plug process.
基金financially supported by the National Key R&D Program of China(No.2018YFC0831800)the National Natural Science Foundation of China(No.71704178)+3 种基金the Beijing Excellent Talent Program(No.2017000020124G133)the Major Consulting Project of Chinese Academy of Engineering(No.2017-ZD-03)the National Statistical Science Research Project by National Bureau of Statistics of China(No.2017LY10)the Fundamental Research Funds for the Central Universities(No.2020YQNY08)。
文摘Mine closure is associated with many negative impacts on society and the environment.If these effects are not rationally addressed,they would pose risks of mine closure.Thus,a risk management method is needed to mitigate these adverse impacts and address mine-closure issues.An integral framework for mine-closure risk management that includes risk assessment and risk treatment was proposed.Given the fuzziness and randomness of the transformation between qualitative and quantitative knowledge in the risk assessment process,a novel risk assessment method based on the cloud model was presented,which fully considers the uncertainty in risks themselves and in the reasoning process.Closed mine reutilization is an effective risk treatment option in response to the identified high risks,but it requires selecting optimal reutilization strategies for the successful implementation of the reuse plan.To this end,a hybrid semi-quantitative decision method is proposed to optimize decision-making.The results of a case study showed that this risk management methodology can help budget planning for risk treatment and provide an instructional framework to effectively reduce the negative effects of closed mines.
基金a grant from the National Key Research and Development Program of China(No.2018YFC1313600).
文摘It is estimated that more than 3 million people die from chronic obstructive pulmonary disease(COPD)annually.Acute exacerbation of COPD(AECOPD)leads to an irreversible decline of pulmonary function,an increase of emergency visits,hospitalization and length of stay in hospital,and an increase of the mortality.However,many exacerbations are not reported to healthcare professionals for therapy and yet these events,although often in short durations,have a significant impact on health status.111 Early detection and intervention of AECOPD as well as reducing of unreported episodes of AECOPD will potentially improve the prognosis.
基金The present study was funded by grants from the National Natural Science Foundation of China[No.81772595]the Sun Yat-sen University Clinical Research 5010 Program[No.2015024 and 2013013]。