Traditional Chinese medicine(TCM)has been practiced in China and surrounding countries for thousands of years and has gradually attracted the attention of Western countries.After reasonable compatibility,TCMs could pl...Traditional Chinese medicine(TCM)has been practiced in China and surrounding countries for thousands of years and has gradually attracted the attention of Western countries.After reasonable compatibility,TCMs could play the key role of enhancing efficacy and reducing toxicity,which has significant therapeutic advantages in the treatment of complex diseases in clinical practice.While the TCM compatibility is not the simple addition of drugs.Under the appropriate dosage ratio,multiple TCMs can play a synergistic role to realize the overall regulation of TCM treatment.Therefore,it is of critical essential to study the compatibility of TCM formula to promote TCM modernization,new drug development and clinical application.Recently,under the guidance of TCM theory,many researches on the composition,pharmacodynamic activity and pharmacokinetic properties of TCM formula have emerged by integrating new technologies and new methods,revealing the scientific connotation of the compatibility of TCM formula from different perspectives and levels.This paper introduces the research progress of compatibility rules from different levels of compatibility,compatibility for synergistic enhancement and detoxification,and application of cutting-edge technology,with representative cases,in order to provide ideas and references for further study on TCM compatibility.展开更多
This study aims to evaluate the clinical outcomes of endoscopic vein harvesting (EVH) for coronary artery bypass grafting (CABG) in obese patients. Totally, 153 obese patients who underwent EVH (n=81) or standar...This study aims to evaluate the clinical outcomes of endoscopic vein harvesting (EVH) for coronary artery bypass grafting (CABG) in obese patients. Totally, 153 obese patients who underwent EVH (n=81) or standard bridging technique (SBT, n=72) in CABG surgery from May 2012 to October 2014 in our hospital were enrolled in this retrospective non-randomized controlled study. The general situation of operation, postoperative complications and short medium-term outcomes were analyzed. The baseline characteristics were similar between these two groups (P〉0.05). There were no statistical differences in total operation time (226±28 min vs. 224±30 min, P〉0.05), number of damaged vessels (0.12±0.05 vs. 0.16±0.06, P〉0.05) and short medium-term outcomes including revascularization rate (1.25% vs. 2.78%, P〉0.05), vessel dysfunction rate (11.25% vs. 11.11%, P〉0.05) and mortality (0.00% vs. 0.00%, P〉0.05). Use of EVH was associated with significant reduction of total harvesting time (41±6 min vs. 63±11 min, P〈0.05), incision length (4.4±1.1 cm vs. 18.2±4.5 cm, P〈0.05) and postoperative lower extremity complications (P〈0.05). EVH can reduce the risk of wound complications, whereas does not influence short- and medium-term outcomes in obese patients. It can be considered a reliable procedure of harvesting vessel conduits for obese patients undergoing CABG.展开更多
Pneumatic-hydraulic transmission has been developed for years. However, its dynamic properties are not good enough for application. In this paper, in order to increase the output characteristics, a late-model air-powe...Pneumatic-hydraulic transmission has been developed for years. However, its dynamic properties are not good enough for application. In this paper, in order to increase the output characteristics, a late-model air-powered vehicle using expansion energy is proposed which can boost energy through a pneumatic-hydraulic transmission. The dynamic characteristics of the air-powered vehicle is modeled and verified by conducting experiment. In addition,the influence of the key parameters of the air-powered vehicle is researched for the optimization of the system performance. Through the results, the author got the conclusion that, firstly, comparison of the results of model and experiment proves the built model to be effective; secondly, input air pressure should be set according to the request of the practical loads, and range of 0.65 to 0.75 MPa can be chosen; thirdly, as a key structure parameter of the airpowered vehicle, ratio of the areas is considered to be set to approximate 8; what’s more, a bigger orifice with a limit will promote the system dynamic characteristic property, and the limit is about 3.5 mm; last but not the least, not too farther position of the rings will increase the quality of output dynamic characteristics. This paper can be a reference for system design of air-powered vehicle and dynamic improvement.展开更多
One-dimensional(1D)transition metal phosphides(TMPs)with large specific surface areas,high charge transfer efficiency and excellent electrical conductivity have attracted significant attention in hydrogen evolution re...One-dimensional(1D)transition metal phosphides(TMPs)with large specific surface areas,high charge transfer efficiency and excellent electrical conductivity have attracted significant attention in hydrogen evolution reaction(HER)as versatile and active catalysts.Herein,the sub-4 nm Mo-Co2 P ultrafine nanorods(NRs)anchored on reduced graphene oxide(rGO)were successfully synthesized by a colloidal mesostructured strategy.Electrochemical test results reveal that the Mo-Co2 P@rGO electrode exhibits superior activity with overpotentials of204 mV and Tafel slope of 88 mV/dec for HER at 10 mA/cm^2,relative to the Co2 P@rGO electrode in 0.5 M H2SO4 solution.This improvement could be ascribed to the Mo doping,which results in more active sites,higher electrical conductivity and faster electron-transfer rates.This versatile strategy will provide a promising pathway for transition metal-doped compounds as an efficient catalyst.展开更多
BACKGROUND Genetic variants of Helicobacter pylori(H. pylori) are involved in gastric cancer occurrence. Single nucleotide polymorphisms(SNPs) of H. pylori that are associated with gastric cancer have been reported. T...BACKGROUND Genetic variants of Helicobacter pylori(H. pylori) are involved in gastric cancer occurrence. Single nucleotide polymorphisms(SNPs) of H. pylori that are associated with gastric cancer have been reported. The combined effect of H. pylori SNPs on the risk of gastric cancer remains unclear.AIM To assess the performance of a polygenic risk score(PRS) based on H. pylori SNPs in predicting the risk of gastric cancer.METHODS A total of 15 gastric cancer-associated H. pylori SNPs were selected. The associations between these SNPs and gastric cancer were further validated in 1022 global strains with publicly available genome sequences. The PRS model was established based on the validated SNPs. The performance of the PRS for predicting the risk of gastric cancer was assessed in global strains using quintiles and random forest(RF) methods. The variation in the performance of the PRS among different populations of H. pylori was further examined.RESULTS Analyses of the association between selected SNPs and gastric cancer in the global dataset revealed that the risk allele frequencies of six SNPs were significantly higher in gastric cancer cases than non-gastric cancer cases. The PRS model constructed subsequently with these validated SNPs produced significantly higher scores in gastric cancer. The odds ratio(OR) value for gastric cancer gradually increased from the first to the fifth quintile of PRS, with the fifth quintile having an OR value as high as 9.76(95% confidence interval: 5.84-16.29). The results of RF analyses indicated that the area under the curve(AUC) value for classifying gastric cancer and non-gastric cancer was 0.75, suggesting that the PRS based on H. pylori SNPs was capable of predicting the risk of gastric cancer. Assessing the performance of the PRS among different H. pylori populations demonstrated that it had good predictive power for cancer risk for hp Europe strains, with an AUC value of 0.78.CONCLUSION The PRS model based on H. pylori SNPs had a good performance for assessment of gastric cancer risk. It would be useful in the prediction of final consequences of the H. pylori infection and beneficial for the management of the infection in clinical settings.展开更多
We study the connection between the compressible Navier-Stokes equations coupled by the Qtensor equation for liquid crystals with the incompressible system in the periodic case, when the Mach number is low. To be more...We study the connection between the compressible Navier-Stokes equations coupled by the Qtensor equation for liquid crystals with the incompressible system in the periodic case, when the Mach number is low. To be more specific, the convergence of the weak solutions of the compressible nematic liquid crystal model to the incompressible one is proved as the Mach number approaches zero, and we also obtain the similar results in the stochastic setting when the equations are driven by a stochastic force. Our approach is based on the uniform estimates of the weak solutions and the martingale solutions, then we justify the limits using various compactness criteria.展开更多
Traditional Chinese medicine,as a complementary and alternative medicine,has been practiced for thousands of years in China and possesses remarkable clinical efficacy.Thus,systematic analysis and examination of the me...Traditional Chinese medicine,as a complementary and alternative medicine,has been practiced for thousands of years in China and possesses remarkable clinical efficacy.Thus,systematic analysis and examination of the mechanistic links between Chinese herbal medicine(CHM)and the complex human body can benefit contemporary understandings by carrying out qualitative and quantitative analysis.With increasing attention,the approach of network pharmacology has begun to unveil the mystery of CHM by constructing the heterogeneous network relationship of“herb-compound-target-pathway,”which corresponds to the holistic mechanisms of CHM.By integrating computational techniques into network pharmacology,the efficiency and accuracy of active compound screening and target fishing have been improved at an unprecedented pace.This review dissects the core innovations to the network pharmacology approach that were developed in the years since 2015 and highlights how this tool has been applied to understanding the coronavirus disease 2019 and refining the clinical use of CHM to combat it.展开更多
Holographic optical elements(HOEs)based on polymer composites have become a research hot spot in recent years for augmented reality(AR)due to the significant improvement of optical performance,dynamic range,ease of pr...Holographic optical elements(HOEs)based on polymer composites have become a research hot spot in recent years for augmented reality(AR)due to the significant improvement of optical performance,dynamic range,ease of processing and high yield rate.Nevertheless,it remains a formidable challenge to obtain a large field of view(FOV)and brightness due to the limited refractive index modulation.Herein,we report an effective method to tackle the challenge by doping an epoxy liquid crystal termed E6M,which enables a large refractive index modulation of 0.050@633 nm and low haze of 5.0%at a doping concentration of 5 wt%.This achievement may be ascribed to the improved molecular ordering of liquid crystals within the holographic polymer composites.The high refractive index modulation can endow transmission-type holographic polymer composites with a high diffraction efficiency of 96.2%at a small thickness of 5μm,which would promise the design of thin and lightweight AR devices.展开更多
Objective: Huazhi Rougan granules(HRGs) are a promising drug to improve alcoholic liver disease(ALD), but its mechanism remains unclear. Materials and Methods: Network pharmacology, molecular docking, and animal exper...Objective: Huazhi Rougan granules(HRGs) are a promising drug to improve alcoholic liver disease(ALD), but its mechanism remains unclear. Materials and Methods: Network pharmacology, molecular docking, and animal experiments were used to reveal the potential mechanism of HRG against ALD. Results: A total of 245 potential targets of HRG against ALD were obtained. Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD. Molecular docking showed that the key targets exhibited the good binding ability with the key compounds. The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue, improve blood lipid levels, antioxidant stress ability, and liver function, and reduce the release of inflammatory cytokines in the liver. Conclusions: This study reflects that HRG is an effective strategy for treating ALD, providing a basis for revealing the prevention and treatment mechanisms of ALD.展开更多
基金supported by grants from the Shaanxi Key Laboratory of Research on TCM Physical Constitution and Disease Prevention and Treatment (Program No.KF2207)the Key Research and Development Program of Shaanxi (Program No.2020GXLH-Y-019,2022KXJ-141)+1 种基金the Innovation Capability Support Program of Shaanxi (Program No.2019GHJD-14,2021TD-40)Science and Technology Talent Support Program of Shaanxi Provincial People’s Hospital (Program No.2021LJ-05).
文摘Traditional Chinese medicine(TCM)has been practiced in China and surrounding countries for thousands of years and has gradually attracted the attention of Western countries.After reasonable compatibility,TCMs could play the key role of enhancing efficacy and reducing toxicity,which has significant therapeutic advantages in the treatment of complex diseases in clinical practice.While the TCM compatibility is not the simple addition of drugs.Under the appropriate dosage ratio,multiple TCMs can play a synergistic role to realize the overall regulation of TCM treatment.Therefore,it is of critical essential to study the compatibility of TCM formula to promote TCM modernization,new drug development and clinical application.Recently,under the guidance of TCM theory,many researches on the composition,pharmacodynamic activity and pharmacokinetic properties of TCM formula have emerged by integrating new technologies and new methods,revealing the scientific connotation of the compatibility of TCM formula from different perspectives and levels.This paper introduces the research progress of compatibility rules from different levels of compatibility,compatibility for synergistic enhancement and detoxification,and application of cutting-edge technology,with representative cases,in order to provide ideas and references for further study on TCM compatibility.
文摘This study aims to evaluate the clinical outcomes of endoscopic vein harvesting (EVH) for coronary artery bypass grafting (CABG) in obese patients. Totally, 153 obese patients who underwent EVH (n=81) or standard bridging technique (SBT, n=72) in CABG surgery from May 2012 to October 2014 in our hospital were enrolled in this retrospective non-randomized controlled study. The general situation of operation, postoperative complications and short medium-term outcomes were analyzed. The baseline characteristics were similar between these two groups (P〉0.05). There were no statistical differences in total operation time (226±28 min vs. 224±30 min, P〉0.05), number of damaged vessels (0.12±0.05 vs. 0.16±0.06, P〉0.05) and short medium-term outcomes including revascularization rate (1.25% vs. 2.78%, P〉0.05), vessel dysfunction rate (11.25% vs. 11.11%, P〉0.05) and mortality (0.00% vs. 0.00%, P〉0.05). Use of EVH was associated with significant reduction of total harvesting time (41±6 min vs. 63±11 min, P〈0.05), incision length (4.4±1.1 cm vs. 18.2±4.5 cm, P〈0.05) and postoperative lower extremity complications (P〈0.05). EVH can reduce the risk of wound complications, whereas does not influence short- and medium-term outcomes in obese patients. It can be considered a reliable procedure of harvesting vessel conduits for obese patients undergoing CABG.
基金Supported by National Natural Science Foundation of China(Grant No.51375028)
文摘Pneumatic-hydraulic transmission has been developed for years. However, its dynamic properties are not good enough for application. In this paper, in order to increase the output characteristics, a late-model air-powered vehicle using expansion energy is proposed which can boost energy through a pneumatic-hydraulic transmission. The dynamic characteristics of the air-powered vehicle is modeled and verified by conducting experiment. In addition,the influence of the key parameters of the air-powered vehicle is researched for the optimization of the system performance. Through the results, the author got the conclusion that, firstly, comparison of the results of model and experiment proves the built model to be effective; secondly, input air pressure should be set according to the request of the practical loads, and range of 0.65 to 0.75 MPa can be chosen; thirdly, as a key structure parameter of the airpowered vehicle, ratio of the areas is considered to be set to approximate 8; what’s more, a bigger orifice with a limit will promote the system dynamic characteristic property, and the limit is about 3.5 mm; last but not the least, not too farther position of the rings will increase the quality of output dynamic characteristics. This paper can be a reference for system design of air-powered vehicle and dynamic improvement.
基金National Natural Science Foundation of China(Grant Nos.11874027,11774124,and 11504126)China Postdoctoral Science Foundation(Grant Nos.2019T120233 and 2017M621198)。
文摘One-dimensional(1D)transition metal phosphides(TMPs)with large specific surface areas,high charge transfer efficiency and excellent electrical conductivity have attracted significant attention in hydrogen evolution reaction(HER)as versatile and active catalysts.Herein,the sub-4 nm Mo-Co2 P ultrafine nanorods(NRs)anchored on reduced graphene oxide(rGO)were successfully synthesized by a colloidal mesostructured strategy.Electrochemical test results reveal that the Mo-Co2 P@rGO electrode exhibits superior activity with overpotentials of204 mV and Tafel slope of 88 mV/dec for HER at 10 mA/cm^2,relative to the Co2 P@rGO electrode in 0.5 M H2SO4 solution.This improvement could be ascribed to the Mo doping,which results in more active sites,higher electrical conductivity and faster electron-transfer rates.This versatile strategy will provide a promising pathway for transition metal-doped compounds as an efficient catalyst.
基金Supported by the National Natural Science Foundation of China,No. 31870777。
文摘BACKGROUND Genetic variants of Helicobacter pylori(H. pylori) are involved in gastric cancer occurrence. Single nucleotide polymorphisms(SNPs) of H. pylori that are associated with gastric cancer have been reported. The combined effect of H. pylori SNPs on the risk of gastric cancer remains unclear.AIM To assess the performance of a polygenic risk score(PRS) based on H. pylori SNPs in predicting the risk of gastric cancer.METHODS A total of 15 gastric cancer-associated H. pylori SNPs were selected. The associations between these SNPs and gastric cancer were further validated in 1022 global strains with publicly available genome sequences. The PRS model was established based on the validated SNPs. The performance of the PRS for predicting the risk of gastric cancer was assessed in global strains using quintiles and random forest(RF) methods. The variation in the performance of the PRS among different populations of H. pylori was further examined.RESULTS Analyses of the association between selected SNPs and gastric cancer in the global dataset revealed that the risk allele frequencies of six SNPs were significantly higher in gastric cancer cases than non-gastric cancer cases. The PRS model constructed subsequently with these validated SNPs produced significantly higher scores in gastric cancer. The odds ratio(OR) value for gastric cancer gradually increased from the first to the fifth quintile of PRS, with the fifth quintile having an OR value as high as 9.76(95% confidence interval: 5.84-16.29). The results of RF analyses indicated that the area under the curve(AUC) value for classifying gastric cancer and non-gastric cancer was 0.75, suggesting that the PRS based on H. pylori SNPs was capable of predicting the risk of gastric cancer. Assessing the performance of the PRS among different H. pylori populations demonstrated that it had good predictive power for cancer risk for hp Europe strains, with an AUC value of 0.78.CONCLUSION The PRS model based on H. pylori SNPs had a good performance for assessment of gastric cancer risk. It would be useful in the prediction of final consequences of the H. pylori infection and beneficial for the management of the infection in clinical settings.
文摘We study the connection between the compressible Navier-Stokes equations coupled by the Qtensor equation for liquid crystals with the incompressible system in the periodic case, when the Mach number is low. To be more specific, the convergence of the weak solutions of the compressible nematic liquid crystal model to the incompressible one is proved as the Mach number approaches zero, and we also obtain the similar results in the stochastic setting when the equations are driven by a stochastic force. Our approach is based on the uniform estimates of the weak solutions and the martingale solutions, then we justify the limits using various compactness criteria.
基金supported by grants from the National Natural Science Foundation of China(No.81903786)the Shaanxi Natural Science Foundation of China(No.2021JQ-731)Subject Innovation Team of Shaanxi University of Chinese Medicine(No.2019-YL10)。
文摘Traditional Chinese medicine,as a complementary and alternative medicine,has been practiced for thousands of years in China and possesses remarkable clinical efficacy.Thus,systematic analysis and examination of the mechanistic links between Chinese herbal medicine(CHM)and the complex human body can benefit contemporary understandings by carrying out qualitative and quantitative analysis.With increasing attention,the approach of network pharmacology has begun to unveil the mystery of CHM by constructing the heterogeneous network relationship of“herb-compound-target-pathway,”which corresponds to the holistic mechanisms of CHM.By integrating computational techniques into network pharmacology,the efficiency and accuracy of active compound screening and target fishing have been improved at an unprecedented pace.This review dissects the core innovations to the network pharmacology approach that were developed in the years since 2015 and highlights how this tool has been applied to understanding the coronavirus disease 2019 and refining the clinical use of CHM to combat it.
基金financially supported by the National Natural Science Foundation of China(Nos.52122316,52073108 and 52233005)the Innovation and Talent Recruitment Base of New Energy Chemistry and Device(No.B21003)。
文摘Holographic optical elements(HOEs)based on polymer composites have become a research hot spot in recent years for augmented reality(AR)due to the significant improvement of optical performance,dynamic range,ease of processing and high yield rate.Nevertheless,it remains a formidable challenge to obtain a large field of view(FOV)and brightness due to the limited refractive index modulation.Herein,we report an effective method to tackle the challenge by doping an epoxy liquid crystal termed E6M,which enables a large refractive index modulation of 0.050@633 nm and low haze of 5.0%at a doping concentration of 5 wt%.This achievement may be ascribed to the improved molecular ordering of liquid crystals within the holographic polymer composites.The high refractive index modulation can endow transmission-type holographic polymer composites with a high diffraction efficiency of 96.2%at a small thickness of 5μm,which would promise the design of thin and lightweight AR devices.
文摘Objective: Huazhi Rougan granules(HRGs) are a promising drug to improve alcoholic liver disease(ALD), but its mechanism remains unclear. Materials and Methods: Network pharmacology, molecular docking, and animal experiments were used to reveal the potential mechanism of HRG against ALD. Results: A total of 245 potential targets of HRG against ALD were obtained. Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD. Molecular docking showed that the key targets exhibited the good binding ability with the key compounds. The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue, improve blood lipid levels, antioxidant stress ability, and liver function, and reduce the release of inflammatory cytokines in the liver. Conclusions: This study reflects that HRG is an effective strategy for treating ALD, providing a basis for revealing the prevention and treatment mechanisms of ALD.