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Respective IL-17A production by γδ T and Th17 cells and its implication in host defense against chlamydial lung infection 被引量:8
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作者 Hong Bai Xiaoling Gao +9 位作者 Lei Zhao Ying Peng Jie Yang Sai Qiao Huili Zhao Shuhe Wang yijun fan Antony George Joyee Zhi Yao Xi Yang 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2017年第10期850-861,共12页
The role of IL-17A is important in protection against lung infection with Chlamydiae,an obligate intracellular bacterial pathogen.In this study,we explored the producers of IL-17A in chlamydial lung infection and spec... The role of IL-17A is important in protection against lung infection with Chlamydiae,an obligate intracellular bacterial pathogen.In this study,we explored the producers of IL-17A in chlamydial lung infection and specifically tested the role of major IL-17A producers in protective immunity.We found thatγδT cells and Th17 cells are the major producers of IL-17A at the early and later stages of chlamydial infection,respectively.Depletion ofγδT cells in vivo at the early postinfection(p.i.)stage,when mostγδT cells produce IL-17A,failed to alter Th1 responses and bacterial clearance.In contrast,the blockade of IL-17A at the time when IL-17A was mainly produced by Th17(day 7 p.i.)markedly reduced the Th1 response and increased chlamydial growth.The data suggest that theγδT cell is the highest producer of IL-17A in the very early stages of infection,but the protection conferred by IL-17A is mainly mediated by Th17 cells.In addition,we found that depletion ofγδT cells reduced IL-1αproduction by dendritic cells,which was associated with a reduced Th17 response.This finding is helpful to understand the variable role of IL-17A in different infections and to develop preventive and therapeutic approaches against infectious diseases by targeting IL-17A. 展开更多
关键词 CHLAMYDIA IL-17A γδT cell infection TH17
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