A Review of Computing with Spiking Neural Networks

Artificial neural networks(ANNs)have led to landmark changes in many fields,but they still differ significantly fromthemechanisms of real biological neural networks and face problems such as high computing costs,excessive computing power,and so on.Spiking neural networks(SNNs)provide a new approach combined with brain-like science to improve the computational energy efficiency,computational architecture,and biological credibility of current deep learning applications.In the early stage of development,its poor performance hindered the application of SNNs in real-world scenarios.In recent years,SNNs have made great progress in computational performance and practicability compared with the earlier research results,and are continuously producing significant results.Although there are already many pieces of literature on SNNs,there is still a lack of comprehensive review on SNNs from the perspective of improving performance and practicality as well as incorporating the latest research results.Starting from this issue,this paper elaborates on SNNs along the complete usage process of SNNs including network construction,data processing,model training,development,and deployment,aiming to provide more comprehensive and practical guidance to promote the development of SNNs.Therefore,the connotation and development status of SNNcomputing is reviewed systematically and comprehensively from four aspects:composition structure,data set,learning algorithm,software/hardware development platform.Then the development characteristics of SNNs in intelligent computing are summarized,the current challenges of SNNs are discussed and the future development directions are also prospected.Our research shows that in the fields of machine learning and intelligent computing,SNNs have comparable network scale and performance to ANNs and the ability to challenge large datasets and a variety of tasks.The advantages of SNNs over ANNs in terms of energy efficiency and spatial-temporal data processing have been more fully exploited.And the development of programming and deployment tools has lowered the threshold for the use of SNNs.SNNs show a broad development prospect for brain-like computing.

FPGA Optimized Accelerator of DCNN with Fast Data Readout and Multiplier Sharing Strategy

With the continuous development of deep learning,Deep Convolutional Neural Network(DCNN)has attracted wide attention in the industry due to its high accuracy in image classification.Compared with other DCNN hard-ware deployment platforms,Field Programmable Gate Array(FPGA)has the advantages of being programmable,low power consumption,parallelism,and low cost.However,the enormous amount of calculation of DCNN and the limited logic capacity of FPGA restrict the energy efficiency of the DCNN accelerator.The traditional sequential sliding window method can improve the throughput of the DCNN accelerator by data multiplexing,but this method’s data multiplexing rate is low because it repeatedly reads the data between rows.This paper proposes a fast data readout strategy via the circular sliding window data reading method,it can improve the multiplexing rate of data between rows by optimizing the memory access order of input data.In addition,the multiplication bit width of the DCNN accelerator is much smaller than that of the Digital Signal Processing(DSP)on the FPGA,which means that there will be a waste of resources if a multiplication uses a single DSP.A multiplier sharing strategy is proposed,the multiplier of the accelerator is customized so that a single DSP block can complete multiple groups of 4,6,and 8-bit signed multiplication in parallel.Finally,based on two strategies of appeal,an FPGA optimized accelerator is proposed.The accelerator is customized by Verilog language and deployed on Xilinx VCU118.When the accelerator recognizes the CIRFAR-10 dataset,its energy efficiency is 39.98 GOPS/W,which provides 1.73×speedup energy efficiency over previous DCNN FPGA accelerators.When the accelerator recognizes the IMAGENET dataset,its energy efficiency is 41.12 GOPS/W,which shows 1.28×−3.14×energy efficiency compared with others.

Inverse design and realization of an optical cavity-based displacement transducer with arbitrary responses

Optical cavity has long been critical for a variety of applications ranging from precise measurement to spectral analysis.A number of theories and methods have been successful in describing the optical response of a stratified optical cavity,while the inverse problem,especially the inverse design of a displacement sensitive cavity,remains a significant challenge due to the cost of computation and comprehensive performance requirements.This paper reports a novel inverse design methodology combining the characteristic matrix method,mixed-discrete variables optimization algorithm,and Monte Carlo method-based tolerance analysis.The material characteristics are indexed to enable the mixed-discrete variables optimization,which yields considerable speed and efficiency improvements.This method allows arbitrary response adjustment with technical feasibility and gives a glimpse into the analytical characterization of the optical response.Two entirely different light-displacement responses,including an asymmetric sawtooth-like response and a highly symmetric response,are dug out and experimentally achieved,which fully confirms the validity of the method.The compact Fabry-Perot cavities have a good balance between performance and feasibility,making them promising candidates for displacement transducers.More importantly,the proposed inverse design paves the way for a universal design of optical cavities,or even nanophotonic devices.

High throughput N-modular redundancy for error correction design of memristive stateful logic

Memristive stateful logic is one of the most promising candidates to implement an in-memory computing system that computes within the storage unit.It can eliminate the costs for the data movement in the traditional von Neumann system.However,the instability in the memristors is inevitable due to the limitation of the current fabrication technology,which incurs a great challenge for the reliability of the memristive stateful logic.In this paper,the implication of device instability on the reliability of the logic event is simulated.The mathematical relationship between logic reliability and redundancy has been deduced.By combining the mathematical relationship with the vector-matrix multiplication in a memristive crossbar array,the logic error correction scheme with high throughput has been proposed.Moreover,a universal design paradigm has been put forward for complex logic.And the circuit schematic and the flow of the scheme have been raised.Finally,a 1-bit full adder(FA)based on the NOR logic and NOT logic is simulated and the mathematical evaluation is performed.It demonstrates the scheme can improve the reliability of the logic significantly.And compared with other four error corrections,the scheme which can be suitable for all kinds of R–R logics and V–R logics has the best universality and throughput.Compared with the other two approaches which also need additional complementary metal–oxide semiconductor(CMOS)circuits,it needs fewer transistors and cycles for the error correction.

利用Ka波段云雷达对青藏高原三类重要天气系统云宏观参数日变化特征的研究

青藏高原上空云宏观参数的日变化受大尺度环流、当地太阳辐射和地表过程的联合作用,对辐射收支、辐射传输及感热、潜热的分布等有重要影响。由于缺乏持续定量的观测,对各类天气系统云宏观参数日变化特征的了解还十分不足。多波段多大气成分主被动综合探测系统APSOS(Atmospheric Profiling Synthetic Observation System)的Ka波段云雷达是首部在青藏高原实现长期观测云的雷达。本文基于2019年全年APSOS的Ka波段云雷达资料,采用统计和快速傅里叶变换方法研究了西风槽、切变线和低涡三类重要天气系统影响下的有云频率、单层非降水云或者降水云非降水时段的云顶高度、云底高度和云厚日变化的时域和频域特征,得到了统计回归方程。主要结论有:(1)西风槽系统日均有云频率为56.9%,切变线系统为50.8%,低涡系统达73%。(2)尽管西风槽和切变线系统的成因不同,但两类系统云宏观参数的日变化趋势和主要谐波周期相似:日变化趋势基本为单峰单谷型,日出前最低,日落前最高。有云频率表现为日变化和半日变化,单层云云顶高度、云底高度和云厚主要表现为日变化。(3)低涡系统云宏观参数的日变化特征与前两类系统明显不同:日变化趋势表现为多峰多谷型,虽然有云频率和单层云云顶高度、云底高度主要谐波中均以日变化振幅最大,但频谱分布分散,云厚主要变化中振幅最大的是周期为4.8 h的波动。(4)得到了各系统有云频率、单层云云顶高度、云底高度和云厚日变化的统计回归方程。

Atmospheric Profiling Synthetic Observation System in Tibet

1. Introduction The Atmosphere Profiling Synthetic Observation System （APSOS） is the first ground-based facility for profiling atmospheric variables and multiple constituents in the whole （neutral） atmosphere from the surface up to the lower thermosphere. It enables simultaneous observations and extensive studies of the atmospheric vertical structure and constituent transport.

Activin A maintains cerebral cortex neuronal survival and increases voltage-gated Na^+ neuronal current

Activin A, which was first described in 1986, has been shown to maintain hippocampal neuronal survival. Activin A increases intracellular free Ca2＋ via L-type Ca2＋ channels. Our previous study showed that activin A promotes neurite growth of dorsal root ganglia in embryonic chickens and inhibits nitric oxide secretion. The present study demonstrated for the first time that activin A could maintain cerebral cortex neuronal survival in vitro for a long period, and that activin A was shown to increase voltage-gated Na＋ current （/Na） in Neuro-2a cells, which was recorded by patch clamp technique. The present study revealed a novel mechanism for activin A, as well as the influence of activin A on neurons by regulating expressions of vasoactive intestine peptide and inducible nitric oxide synthase.

Review of micromachined optical accelerometers:from mg to sub-μg

Micro-Opto-Electro-Mechanical Systems(MOEMS)accelerometer is a new type of accelerometer which combines the merits of optical measurement and Micro-Electro-Mechanical Systems(MEMS)to enable high precision,small volume and anti-electromagnetic disturbance measurement of acceleration.In recent years,with the in-depth research and development of MOEMS accelerometers,the community is flourishing with the possible applications in seismic monitoring,inertial navigation,aerospace and other industrial and military fields.There have been a variety of schemes of MOEMS accelerometers,whereas the performances differ greatly due to different measurement principles and corresponding application requirements.This paper aims to address the pressing issue of the current lack of systematic review of MOEMS accelerometers.According to the optical measurement principle,we divide the MOEMS accelerometers into three categories:the geometric optics based,the wave optics based,and the new optomechanical accelerometers.Regarding the most widely studied category,the wave optics based accelerometers are further divided into four sub-categories,which is based on grating interferometric cavity,Fiber Bragg Grating(FBG),Fabry-Perot cavity,and photonic crystal,respectively.Following a brief introduction to the measurement principles,the typical performances,advantages and disadvantages as well as the potential application scenarios of all kinds of MOEMS accelerometers are discussed on the basis of typical demonstrations.This paper also presents the status and development tendency of MOEMS accelerometers to meet the ever-increasing demand for high-precision acceleration measurement.

Process operation performance of PDMS membrane pervaporation coupled with fermentation for efficient bioethanol production

There would be strong product inhibition on ethanol fermentation process if ethanol is not removed in situ from broth. PDMS membrane pervaporation coupled with fermentation is a promising process for efficient bioethanol production since ethanol inhibition is relieved or eliminated. From the perspective of process operation, membrane separation performance, ethanol fermentation performance and the subsequent processing on membrane downstream are the three key issues. This review aims at contributing a comprehensive overview on the operation performance of the integrated process. The state-of-the-art of the three key issues related to the operation performance is focused. Finally, the tentative perspective on the possible future prospects of the integrated process is briefly presented.

A multi-location joint field observation of the stratosphere and troposphere over the Tibetan Plateau

The unique geographical location and high altitude of the Tibetan Plateau can greatly influence regional weather and climate.In particular, the Asian summer monsoon(ASM) anticyclone circulation system over the Tibetan Plateau is recognized to be a significant transport pathway for water vapor and pollutants to enter the stratosphere. To improve understanding of these physical processes, a multi-location joint atmospheric experiment was performed over the Tibetan Plateau from late July to August in 2018, funded by the fiveyear(2018–2022) STEAM(stratosphere and troposphere exchange experiment during ASM) project, during which multiple platforms/instruments—including long-duration stratospheric balloons, dropsondes, unmanned aerial vehicles, special sounding systems, and ground-based and satellite-borne instruments—will be deployed. These complementary methods of data acquisition are expected to provide comprehensive atmospheric parameters(aerosol, ozone, water vapor, CO_2, CH_4, CO, temperature, pressure,turbulence, radiation, lightning and wind); the richness of this approach is expected to advance our comprehension of key mechanisms associated with thermal, dynamical, radiative, and chemical transports over the Tibetan Plateau during ASM activity.

简单形状的情绪效应

本研究采用情绪启动范式,以首都师范大学在校生为被试,检验了简单形状的情绪效应。实验一发现快乐表情的情绪一致性效应,圆形启动刺激促进对快乐表情的判断,倒三角形启动刺激干扰表情判断。实验二发现形状的情绪一致性影响,倒三角形促进对消极词语的加工,干扰对积极词语的加工,圆形产生相反的作用。实验表明,圆形表征着积极意义,倒三角形表征消极意义,且这种情绪意义可以被自动激活,对认知操作产生不同的影响。

Duplex micro RNAs assay based on target-triggered universal reporter hybridization

In this paper, we designed and evaluated a duplex detection strategy for micro RNAs（mi RNAs） using universal probe-based target-triggered double hybridization and fluorescent microsphere-based assay system（x MAP array）. In the absence of target mi RNA, reporter DNA cannot hybridize stably with the immobilized capture DNA due to its low melting temperature. Only after adding target mi RNA, can reporter probe hybridize with capture probe to form a stable three-component complex. This targettriggered stable hybridization makes this method possible for highly selective and sensitive detection of multiple mi RNAs. We exemplified a quantitative detection of duplex mi RNAs with a limit of detection of40 p M. The x MAP array platform holds the potential of extending this approach to simultaneous detection of up to 100 mi RNA targets. Considering the simplicity, rapidity and multiplexing, this work promised a potential detection of multiple mi RNA biomarkers for early disease diagnosis and prognosis.

Determination of Triclocarban, Triclosan and Methyl-Triclosan in Environmental Water by Silicon Dioxide/Polystyrene Composite Microspheres Solid-Phase Extraction Combined with HPLC-ESI-MS

This paper developed a sensitive and efficient analytical method for triclocarban (TCC), triclosan (TCS) and Methyl-triclosan (MTCS) determination in environmental water, which involves enrichment by using silicon dioxide/polystyrene composite microspheres solid-phase extraction and detection with HPLC-ESI-MS. The influence of several operational parameters, including the eluant and its volume, the flow rate and acidity of water sample were investigated and optimized. Under the optimum conditions, the limits of detection were 1.0 ng/L, 2.5 and 4.5 ng/L for TCC, TCS, and MTCS, respectively. The linearity of the method was observed in the range of 5-2000 ng/L, with correlation coefficients (r2) >.99. The spiked recoveries of TCC, TCS and MTCS in water sampleswereachieved in the range of 89.5% -96.8% with RSD below 5.7%. The proposed method has been successfully applied to analyze real water samples and satisfactory results were achieved.

Proteomic analysis provides insights into the function of Polian vesicles in the sea cucumber A postichopus japonicus post-evisceration

The Polian vesicle is the main accessory structure in the water vascular system of sea cucumbers.It can function to hold water vascular fluid under slight pressure and act as a hematopoiesis,excretory,and inflammatory response organ.Being the only organ to remain after evisceration,the Polian vesicle may function in the survival and regeneration of sea cucumber.We performed Tandem Mass Tag(TMT)-based proteomics to identify how proteins in the Polian vesicle of Apostichopus japonicus respond to evisceration.Among the 8453 proteins identified from vesicle samples before evisceration(PVOh)and at 6-h post-evisceration(PV6h)and 3-d post-evisceration(PV3d),we detected 222 differentially abundant proteins(DAPs).Most of the annotated DAPs were associated with cell growth and proliferation,immune response and wound healing,substance transport and metabolism,cytoskeleton/cilia/flagella,extracellular matrix,energy production and conversion,protein synthesis and modification,and signal recognition and transduction.Compared with PVOh,fewer DAPs were identified at PV6h,and more DAPs were found at PV3d,and these DAPs were widely distributed among multiple biological processes.Our results indicate that a wide range of biological processes was induced in Polian vesicles in response to evisceration.In particular,Polian vesicles may play important roles in the re storation of coelomocyte s,immune defense,and wound healing in sea cucumber.We propose that the Polian vesicle may be involved in visceral regeneration through nutrition and energy supply and by promoting dedifferentiation and migration.Together,these results provided new insights into the function of the Polian vesicle in A.japonicus post-evisceration.

A Solely Radiance-based Spectral Angular Distribution Model and Its Application in Deriving Clear-Sky Spectral Fluxes over Tropical Oceans

The radiation budget at the top of the atmosphere plays a critical role in climate research. Compared to the broadband flux, the spectrally resolved outgoing longwave radiation or flux （OLR）, with rich atmospheric information in different bands, has obvious advantages in the evaluation of GCMs. Unlike methods that need auxiliary measurements and information, here we take atmospheric infrared sounder （AIRS） observations as an example to build a self-consistent algorithm by an angular distribution model （ADM）, based solely on radiance observations, to estimate clear-sky spectrally resolved fluxes over tropical oceans. As the key step for such an ADM, scene type estimations are obtained from radiance and brightness temperature in selected AIRS channels. Then, broadband OLR as well as synthetic spectral fluxes are derived by the spectral ADM and validated using both synthetic spectra and CERES （Clouds and the Earth＇s Radiant Energy System） observations. In most situations, the mean OLR differences between the spectral ADM products and the CERES observations are within -4-2 W m-2, which is less than 1% of the typical mean clear-sky OLR over tropical oceans. The whole algorithm described in this study can be easily extended to other similar hyperspectral radiance measurements.

Effects of HF frequency on plasma characteristics in dual-frequency helium discharge at atmospheric pressure by fluid modeling

On the basis of the fluid theory and the drift-diffusion approximation, a numerical model for dual-frequency atmospheric pressure helium discharge is established, in order to investigate the effects of the high frequency source （HF） on the characteristics of dual-frequency atmospheric pressure helium discharge. The numerical results showed that the electron heating rate increases with enhancing HF frequency, as well as the particles densities, electron dissipation rate, current density, net electron generation and bulk plasma region. Moreover, it is also observed that the efficient electron heating region moves when the HF frequency has been changed. The plasma parameters are not linear change with the HF frequency linearly increasing.

Review on multi-dimensional assembled S-scheme heterojunction photocatalysts

S-scheme heterostructure photocatalysts utilize the synergistic and superposition effects of materials,ef-fectively separating electrons and holes,maintaining strong redox capacity,and addressing issues en-countered by current photocatalytic reactions.This review explores the origins and unique benefits of S-scheme heterojunctions.Specifically,we summarized and discussed the effects of different dimensions of semiconductors constituting S-scheme heterojunctions and the similarities and differences in elec-tron transfer processes when constructing heterojunctions.Additionally,we analyzed several methods for proving the formation of S-scheme heterojunctions and the electron transfer process,both directly and indirectly.Finally,we review the applications of S-scheme heterojunctions in various fields of photo-catalysis,including photocatalytic water splitting,pollution degradation,CO_(2) reduction and other related photocatalytic applications.Our hope is that this review will provide an essential reference for the devel-opment and application of S-scheme heterojunction photocatalysis.

The highest melting point material:Searched by Bayesian global optimization with deep potential molecular dynamics

The interest in refractory materials is increasing rapidly in recent decades due to the development of hypersonic vehicles.However,the substance that has the highest melting point(Tm)keeps a secret,since precise measurements in extreme conditions are overwhelmingly difficult.In the present work,an accurate deep potential(DP)model of a Hf-Ta-C-N system was first trained,and then applied to search for the highest melting point material by molecular dynamics(MD)simulation and Bayesian global optimization(BGO).The predicted melting points agree well with the experiments and confirm that carbon site vacancies can enhance the melting point of rock-saltstructure carbides.The solid solution with N is verified as another new and more effective melting point enhancing approach for HfC,while a conventional routing of the solid solution with Ta(e.g.,HfTa_(4)C_(5))is not suggested to result in a maximum melting point.The highest melting point(~4236 K)is achieved with the composition of HfCo.638No.271,which is~80 K higher than the highest value in a Hf-C binary system.Dominating mechanism of the N addition is believed to be unstable C-N and N-N bonds in liquid phase,which reduces liquid phase entropy and renders the liquid phase less stable.The improved melting point and less gas generation during oxidation by the addition of N provide a new routing to modify thermal protection materials for the hypersonic vehicles.

The Classical and Regulatory Functions of C1q in Immunity and Autoimmunity

A classical function of Clq is to bind immune complexes and initiate complement activation producing membrane lytic complexes, opsonins and anaphylatoxins. This classical pathway of complement activation is also elicited when Clq binds some other ligands. Besides complement activation, Clq also regulates cell differentiation, adhesion, migration, activation and survival. Clq deficiency is associated with autoimmunity as well as increased susceptibility to infections. In this article, we discuss the basic properties of Clq, its expression, and classical and regulatory functions. Cellular ＆ Molecular Immunology.

Direct Effects of Activin A on the Activation of Mouse Macrophage RAW264.7 Cells

Macrophages play critical roles in innate immune and acquired immune v/a secreting pro-inflammatory mediators, phagocytosing microorganisms and presenting antigens. Activin A, a member of transforming growth factor （TGF-β） superfamily, is produced by macrophages and microglia cells. In this study, we reported a direct effect of activin A as a pro-inflammatory factor on mouse macrophage cell line RAW264.7 cells. Our data revealed that activin A could not only increase IL-1β and IL-6 production from RAW264.7 cells, but also promote pinocytic and phagocytic activities of RAW264.7 cells. In addition, activin A obviously up-regulated MHC Ⅱ expression on the surface of RAW264.7 cells, whereas did not influence MHC I expression. Activin A also enhanced CD80 expression, which is a marker of activated macrophages, but did not influence RAW264.7 cell proliferation. These data suggest that activin A may regulate primary macrophage-mediated innate and acquired immune response via promoting the activation of rest macrophages.