Discovering metastasis genes that are clinically relevant and functionally important are critical for the development of novel therapeutics for high-risk breast cancer patients. Application of genomic profiling techno...Discovering metastasis genes that are clinically relevant and functionally important are critical for the development of novel therapeutics for high-risk breast cancer patients. Application of genomic profiling technology展开更多
In a recent study published in Nature,Seki et al.reported that cold-induced brown fat activation impedes glycolysis and reduces tumor growth in multiple cancers,1 deepening our understanding of the complex role of fat...In a recent study published in Nature,Seki et al.reported that cold-induced brown fat activation impedes glycolysis and reduces tumor growth in multiple cancers,1 deepening our understanding of the complex role of fat metabolism in cancer.展开更多
Tumor microenvironment （TME） is comprised of cellular and non-cellular components that exist within and around the tumor mass. The TME is highly dynamic and its importance in different stages of cancer progression h...Tumor microenvironment （TME） is comprised of cellular and non-cellular components that exist within and around the tumor mass. The TME is highly dynamic and its importance in different stages of cancer progression has been well recognized. A growing body of evidence suggests that TME also plays pivotal roles in cancer treatment responses. TME is significantly remodeled upon cancer therapies, and such change either enhances the responses or induces drug resistance. Given the importance of TME in tumor progression and therapy resistance, strategies that remodel TME to improve therapeutic responses are under developing. In this review, we provide an overview of the essential components in TME and the remodeling of TME in response to anti-cancer treatments. We also summarize the strategies that aim to enhance therapeutic efficacy by modulating TME.展开更多
文摘Discovering metastasis genes that are clinically relevant and functionally important are critical for the development of novel therapeutics for high-risk breast cancer patients. Application of genomic profiling technology
基金The authors gratefully acknowledge the support of postdoctoral fellowship form NJCCR(no.COCR23PDF017)to Z.C.and Ludwig Institute for Cancer Research,the Brewster Foundation,and grants from the Breast Cancer Research Foundation,American Cancer Society,and Susan G.Komen Foundation to Y.K.
文摘In a recent study published in Nature,Seki et al.reported that cold-induced brown fat activation impedes glycolysis and reduces tumor growth in multiple cancers,1 deepening our understanding of the complex role of fat metabolism in cancer.
文摘Tumor microenvironment （TME） is comprised of cellular and non-cellular components that exist within and around the tumor mass. The TME is highly dynamic and its importance in different stages of cancer progression has been well recognized. A growing body of evidence suggests that TME also plays pivotal roles in cancer treatment responses. TME is significantly remodeled upon cancer therapies, and such change either enhances the responses or induces drug resistance. Given the importance of TME in tumor progression and therapy resistance, strategies that remodel TME to improve therapeutic responses are under developing. In this review, we provide an overview of the essential components in TME and the remodeling of TME in response to anti-cancer treatments. We also summarize the strategies that aim to enhance therapeutic efficacy by modulating TME.
