Polymer composite fibers with superior properties such as excellent combined strength and toughness and biocompatibility can be used in high-tech applications of braided protective devices and smart wearable,however t...Polymer composite fibers with superior properties such as excellent combined strength and toughness and biocompatibility can be used in high-tech applications of braided protective devices and smart wearable,however the research of high-performance polymer composite fiber remains in the infant stage.Here we present a strategy to produce strong and tough anisotropic polymer nanocomposite fibers with orientedly aligned salt rods using mechanical stretching-assisted salting-out treatment.The prepared nanocomposite fibers have a tensile strength of up to 786±2.7 MPa and an elongation at break of 81%,and the anisotropic fibers exhibit good transmission of mechanical vibration in the longitudinal direction with high resolution.During the fabrication process,the salt builds up into oriented rods during the directional salting process,and the polymer is confined to the 150 nm domain between the rods after the solvent is completely evaporated,giving the nanocomposite fibers superior mechanical properties.The presented strategy can be applied to the continuous mass production of nanocomposite fibers and is also generalizable to other polymer nanocomposites,which could extend the applicability of nanocomposite fibers to conditions involving more demanding mechanical loading and mechanical vibration transmission.展开更多
Lysine-specific demethylase 1(LSD1),as a histone lysine demethylase,demethylates monomethyl and dimethyl of histone H3 on lysine 4(H3K4)and lysine 9(H3K9).Studies have reported that high LSD1 expression promotes cell ...Lysine-specific demethylase 1(LSD1),as a histone lysine demethylase,demethylates monomethyl and dimethyl of histone H3 on lysine 4(H3K4)and lysine 9(H3K9).Studies have reported that high LSD1 expression promotes cell proliferation,migration,and invasion by regulating chromatin morphology and gene expression,and is closely related to the development of non-small cell lung cancer(NSCLC).1 However,the underlying mechanism of LSD1 on cell proliferation and migration remains unclear.展开更多
Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation,thus stimulating ferroptosis may be a potential strategy for treating gastric cancer,therapeutic agents against which are urgently r...Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation,thus stimulating ferroptosis may be a potential strategy for treating gastric cancer,therapeutic agents against which are urgently required.Jiyuan oridonin A(JDA) is a natural compound isolated from Jiyuan Rabdosia rubescens with anti-tumor activity,unclear anti-tumor mechanisms and limited water solubility hamper its clinical application.Here,we showed a2,a new JDA derivative,inhibited the growth of gastric cancer cells.Subsequently,we discovered for the first time that a2 induced ferroptosis.Importantly,compound a2 decreased GPX4 expression and overexpressing GPX4 antagonized the anti-proliferative activity of a2.Furthermore,we demonstrated that a2 caused ferrous iron accumulation through the autophagy pathway,prevention of which rescued a2 induced ferrous iron elevation and cell growth inhibition.Moreover,a2 exhibited more potent anti-cancer activity than 5-fluorouracil in gastric canc er cell line-derived xenograft mice models.Patient-derived tumor xenograft models from different patients displayed varied sensitivity to a2,and GPX4 downregulation indicated the sensitivity of tumors to a2.Finally,a2 exhibited well pharmacokinetic characteristic s.Overall,our data suggest that inducing ferroptosis is the major mechanism mediating anti-tumor activity of a2,and a2 will hopefully serve as a promising compound for gastric cancer treatment.展开更多
Synthetic materials with tunable mechanical properties have great potential in soft robotics and biomedical engineering.However,current materials are limited to the mechanical duality altering their mechanical propert...Synthetic materials with tunable mechanical properties have great potential in soft robotics and biomedical engineering.However,current materials are limited to the mechanical duality altering their mechanical properties only between soft and hard states and lack of consecutively programmable mechanics.Herein,the magnetic-programmable organohydrogels with heterogeneous dynamic architecture are designed by encasing oleophilic ferrofluid droplets into hydrogel matrix.As magnetic field increases,the mechanical properties of organohydrogels can be consecutively modulated owing to the gradual formation of chain-like assembly structures of nanoparticles.The storage modulus G'increases by 2.5 times when magnetic field goes up to 0.35 T.Small-Angle X-ray Scattering(SAXS)confirms the reconfigurable orientation of nanoparticles and the organohydrogels show reversible modulus switching.Besides,the materials also exhibit high stretchability,magnetic actuation behavior and effective self-healing capability.Furthermore,the organohydrogels are applied into the design of effectors with mechanical adaptivity.When subjected to serious external perturbations,the effector can maintain mechanical homeostasis by regulating modulus of organohydrogel under applied magnetic field.Such materials are applicable to homeostatic systems with mechanically adaptive behaviors and programmed responses to external force stimuli.展开更多
Background:Severe burn sepsis can lead to high mortality. We explored the valuable prognostic indicators for severe burn sepsis with inhalation lesion. Methods:Thirty-eight severe burn patients with sepsis who were ad...Background:Severe burn sepsis can lead to high mortality. We explored the valuable prognostic indicators for severe burn sepsis with inhalation lesion. Methods:Thirty-eight severe burn patients with sepsis who were admitted to the Third Affiliated Hospital of Soochow University from August 2014 to December 2017 were retrospectively analyzed. Among them, 22 patients were assigned to the death group and 16 patients to the survival group. Their general information, vital signs, and blood index including serum procalcitonin (PCT) and C-reactive protein (CRP) levels at admission, diagnosis of sepsis, and 1-week post-diagnosis of sepsis were compared. Results:Patients in the death group were older and had lower platelet count (PLT) at diagnosis of sepsis and 1-week post-diagnosis as well as higher PCT level at 1-week post-diagnosis than patients in the survival group (all p<0.05). According to receiver operating characteristic (ROC) curves, the above four indicators could be used to predict the prognosis, and the area under the curve (AUC) of PLT at diagnosis and 1-week post-diagnosis was larger (0.888 and 0.911), and PLT at diagnosis had the highest sensitivity and specificity (0.842 and 0.937). In addition, these patients were divided into two groups by the optimal cutoff age of 38 years. According to multivariate logistic regression analysis and COX regression analysis, only age group and PLT at diagnosis were statistically significant (all p<0.05). The risk of death in the older group was 28 times higher than that in the younger group, and the risk of death increased by 3%for each unit reduction in PLT at diagnosis. Moreover, age group was an independent factor affecting the patients' survival (β=?1.370, p=0.026). Considering the survival time after sepsis, the mortality risk was lower for patients in the older group than for patients in the younger group (hazard ratio (HR)=0.254, 95%confidence interval (CI) 0.076–0.851). Conclusion:Age, PLT at diagnosis of sepsis, and 1-week post-diagnosis as well as PCT level at 1-week post-diagnosis are indicators for the evaluation of prognosis of severe burn sepsis with inhalation lesion. Among them, PLT at diagnosis has the greatest prognostic value. In addition, age can predict the patients' mortality and survival time after sepsis.展开更多
Let D be a bounded positive(m, p)-circle domain in C^2. The authors prove that if dim(Iso(D)~0) = 2, then D is holomorphically equivalent to a Reinhardt domain; if dim(Iso(D)~0) = 4, then D is holomorphically equivale...Let D be a bounded positive(m, p)-circle domain in C^2. The authors prove that if dim(Iso(D)~0) = 2, then D is holomorphically equivalent to a Reinhardt domain; if dim(Iso(D)~0) = 4, then D is holomorphically equivalent to the unit ball in C^2. Moreover,the authors prove the Thullen's classification on bounded Reinhardt domains in C^2 by the Lie group technique.展开更多
基金supported by the National Key Research and Development Project(No.2022YFA1503000)the National Natural Science Foundation of China(Nos.22161142021 and 22175010).
文摘Polymer composite fibers with superior properties such as excellent combined strength and toughness and biocompatibility can be used in high-tech applications of braided protective devices and smart wearable,however the research of high-performance polymer composite fiber remains in the infant stage.Here we present a strategy to produce strong and tough anisotropic polymer nanocomposite fibers with orientedly aligned salt rods using mechanical stretching-assisted salting-out treatment.The prepared nanocomposite fibers have a tensile strength of up to 786±2.7 MPa and an elongation at break of 81%,and the anisotropic fibers exhibit good transmission of mechanical vibration in the longitudinal direction with high resolution.During the fabrication process,the salt builds up into oriented rods during the directional salting process,and the polymer is confined to the 150 nm domain between the rods after the solvent is completely evaporated,giving the nanocomposite fibers superior mechanical properties.The presented strategy can be applied to the continuous mass production of nanocomposite fibers and is also generalizable to other polymer nanocomposites,which could extend the applicability of nanocomposite fibers to conditions involving more demanding mechanical loading and mechanical vibration transmission.
基金This work was financially supported by the National Key Research and Development Project(2022YFA1503000)the National Natural Science Foundation of China(22161142021).
基金financially supported by the National Natural Science Funds for Distinguished Young Scholars(21725401)the National Key R&D Program of China(2017YFA0207800)the National Natural Science Foundation of China(22161142021)。
基金supported by the National Natural Science Foundation of China(No.U2004101 for Peng-xing He,No.U21A20416 for Hong-min Liu).
文摘Lysine-specific demethylase 1(LSD1),as a histone lysine demethylase,demethylates monomethyl and dimethyl of histone H3 on lysine 4(H3K4)and lysine 9(H3K9).Studies have reported that high LSD1 expression promotes cell proliferation,migration,and invasion by regulating chromatin morphology and gene expression,and is closely related to the development of non-small cell lung cancer(NSCLC).1 However,the underlying mechanism of LSD1 on cell proliferation and migration remains unclear.
基金supported by grants from the National Natural Science Foundation of China (Nos. 81773562, 82020108030, and U1904163)National Key Research and Development Project (No. 2018YFE0195100, China)the Science and Technology Program of Henan Province (No. 202102310152, China)。
文摘Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation,thus stimulating ferroptosis may be a potential strategy for treating gastric cancer,therapeutic agents against which are urgently required.Jiyuan oridonin A(JDA) is a natural compound isolated from Jiyuan Rabdosia rubescens with anti-tumor activity,unclear anti-tumor mechanisms and limited water solubility hamper its clinical application.Here,we showed a2,a new JDA derivative,inhibited the growth of gastric cancer cells.Subsequently,we discovered for the first time that a2 induced ferroptosis.Importantly,compound a2 decreased GPX4 expression and overexpressing GPX4 antagonized the anti-proliferative activity of a2.Furthermore,we demonstrated that a2 caused ferrous iron accumulation through the autophagy pathway,prevention of which rescued a2 induced ferrous iron elevation and cell growth inhibition.Moreover,a2 exhibited more potent anti-cancer activity than 5-fluorouracil in gastric canc er cell line-derived xenograft mice models.Patient-derived tumor xenograft models from different patients displayed varied sensitivity to a2,and GPX4 downregulation indicated the sensitivity of tumors to a2.Finally,a2 exhibited well pharmacokinetic characteristic s.Overall,our data suggest that inducing ferroptosis is the major mechanism mediating anti-tumor activity of a2,and a2 will hopefully serve as a promising compound for gastric cancer treatment.
基金supported by the National Key R&D Program of China(2017YFA0207800)the National Natural Science Foundation of China(21574004)+4 种基金the National Natural Science Funds for Distinguished Young Scholar(21725401)the 111 project(B14009)the Fundamental Research Funds for the Central Universitiesthe National “Young Thousand Talents Program”the China Postdoctoral Science Foundation(2017M620012)
基金the National Natural Science Funds for Distinguished Young Scholar(No.21725401)the National Key R&D Program of China(No.2017YFA0207800)+1 种基金the 111 project(No.B14009)the Fundamental Research Funds for the Central Universities.
文摘Synthetic materials with tunable mechanical properties have great potential in soft robotics and biomedical engineering.However,current materials are limited to the mechanical duality altering their mechanical properties only between soft and hard states and lack of consecutively programmable mechanics.Herein,the magnetic-programmable organohydrogels with heterogeneous dynamic architecture are designed by encasing oleophilic ferrofluid droplets into hydrogel matrix.As magnetic field increases,the mechanical properties of organohydrogels can be consecutively modulated owing to the gradual formation of chain-like assembly structures of nanoparticles.The storage modulus G'increases by 2.5 times when magnetic field goes up to 0.35 T.Small-Angle X-ray Scattering(SAXS)confirms the reconfigurable orientation of nanoparticles and the organohydrogels show reversible modulus switching.Besides,the materials also exhibit high stretchability,magnetic actuation behavior and effective self-healing capability.Furthermore,the organohydrogels are applied into the design of effectors with mechanical adaptivity.When subjected to serious external perturbations,the effector can maintain mechanical homeostasis by regulating modulus of organohydrogel under applied magnetic field.Such materials are applicable to homeostatic systems with mechanically adaptive behaviors and programmed responses to external force stimuli.
文摘Background:Severe burn sepsis can lead to high mortality. We explored the valuable prognostic indicators for severe burn sepsis with inhalation lesion. Methods:Thirty-eight severe burn patients with sepsis who were admitted to the Third Affiliated Hospital of Soochow University from August 2014 to December 2017 were retrospectively analyzed. Among them, 22 patients were assigned to the death group and 16 patients to the survival group. Their general information, vital signs, and blood index including serum procalcitonin (PCT) and C-reactive protein (CRP) levels at admission, diagnosis of sepsis, and 1-week post-diagnosis of sepsis were compared. Results:Patients in the death group were older and had lower platelet count (PLT) at diagnosis of sepsis and 1-week post-diagnosis as well as higher PCT level at 1-week post-diagnosis than patients in the survival group (all p<0.05). According to receiver operating characteristic (ROC) curves, the above four indicators could be used to predict the prognosis, and the area under the curve (AUC) of PLT at diagnosis and 1-week post-diagnosis was larger (0.888 and 0.911), and PLT at diagnosis had the highest sensitivity and specificity (0.842 and 0.937). In addition, these patients were divided into two groups by the optimal cutoff age of 38 years. According to multivariate logistic regression analysis and COX regression analysis, only age group and PLT at diagnosis were statistically significant (all p<0.05). The risk of death in the older group was 28 times higher than that in the younger group, and the risk of death increased by 3%for each unit reduction in PLT at diagnosis. Moreover, age group was an independent factor affecting the patients' survival (β=?1.370, p=0.026). Considering the survival time after sepsis, the mortality risk was lower for patients in the older group than for patients in the younger group (hazard ratio (HR)=0.254, 95%confidence interval (CI) 0.076–0.851). Conclusion:Age, PLT at diagnosis of sepsis, and 1-week post-diagnosis as well as PCT level at 1-week post-diagnosis are indicators for the evaluation of prognosis of severe burn sepsis with inhalation lesion. Among them, PLT at diagnosis has the greatest prognostic value. In addition, age can predict the patients' mortality and survival time after sepsis.
基金supported by the National Natural Science Foundation of China(Nos.11571288,11671330,11771357)
文摘Let D be a bounded positive(m, p)-circle domain in C^2. The authors prove that if dim(Iso(D)~0) = 2, then D is holomorphically equivalent to a Reinhardt domain; if dim(Iso(D)~0) = 4, then D is holomorphically equivalent to the unit ball in C^2. Moreover,the authors prove the Thullen's classification on bounded Reinhardt domains in C^2 by the Lie group technique.
