A free-standing paper-like three-dimensional graphene framework(3DGF) with orientated laminar structure and interconnected macropores, was obtained by the hard template-directed ordered assembly. As the sacrificial ...A free-standing paper-like three-dimensional graphene framework(3DGF) with orientated laminar structure and interconnected macropores, was obtained by the hard template-directed ordered assembly. As the sacrificial templates, polystyrene(PS) latex spheres were assembled with graphene oxide(GO) to build up a sandwich type composite film, followed by heat removal of which with a simultaneous reduction of GO. The 3DGF exhibited high specific surface area of 402.5 m2/g, controllable pores and mechanical flexibility, which was employed as the binder-free supercapacitor electrode and shows high specific gravimetric capacitance of 95 F/g at 0.5 A/g, with enhanced rate capability in 3 electrode KOH system.展开更多
Human phenomics is defned as the comprehensive collection of observable phenotypes and characteristics infuenced by a complex interplay among factors at multiple scales.These factors include genes,epigenetics at the m...Human phenomics is defned as the comprehensive collection of observable phenotypes and characteristics infuenced by a complex interplay among factors at multiple scales.These factors include genes,epigenetics at the microscopic level,organs,microbiome at the mesoscopic level,and diet and environmental exposures at the macroscopic level.“Phenomic imaging”utilizes various imaging techniques to visualize and measure anatomical structures,biological functions,metabolic processes,and biochemical activities across diferent scales,both in vivo and ex vivo.Unlike conventional medical imaging focused on disease diagnosis,phenomic imaging captures both normal and abnormal traits,facilitating detailed correlations between macro-and micro-phenotypes.This approach plays a crucial role in deciphering phenomes.This review provides an overview of diferent phenomic imaging modalities and their applications in human phenomics.Additionally,it explores the associations between phenomic imaging and other omics disciplines,including genomics,transcriptomics,proteomics,immunomics,and metabolomics.By integrating phenomic imaging with other omics data,such as genomics and metabolomics,a comprehensive understanding of biological systems can be achieved.This integration paves the way for the development of new therapeutic approaches and diagnostic tools.展开更多
New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design.Here,we identified a receptorbind...New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design.Here,we identified a receptorbinding domain(RBD)-binding antibody,XG014,which potently neutralizesβ-coronavirus lineage B(β-CoV-B),including SARS-CoV-2,its circulating variants,SARSCoV and bat SARSr-CoV WIV1.Interestingly,antibody family members competing with XG014 binding show reduced levels of cross-reactivity and induce antibodydependent SARS-CoV-2 spike(S)protein-mediated cellcell fusion,suggesting a unique mode of recognition by XG014.Structural analyses reveal that XG014 recognizes a conserved epitope outside the ACE2 binding site and completely locks RBD in the non-functional“down”conformation,while its family member XG005 directly competes with ACE2 binding and position the RBD“up”.Single administration of XG014 is effective in protection against and therapy of SARS-CoV-2 infection in vivo.Our findings suggest the potential to develop XG014 as pan-β-CoV-B therapeutics and the importance of the XG014 conserved antigenic epitope for designing broadly protective vaccines againstβ-CoV-B and newly emerging SARS-CoV-2 variants of concern.展开更多
The lump solution is one of the exact solutions of the nonlinear evolution equation.In this paper,we study the lump solution and lump-type solutions of(2+1)-dimensional dissipative Ablowitz-Kaup-Newell-Segure(AKNS)equ...The lump solution is one of the exact solutions of the nonlinear evolution equation.In this paper,we study the lump solution and lump-type solutions of(2+1)-dimensional dissipative Ablowitz-Kaup-Newell-Segure(AKNS)equation by the Hirota bilinear method and test function method.With the help of Maple,we draw three-dimensional plots of the lump solution and lump-type solutions,and by observing the plots,we analyze the dynamic behavior of the(2+1)-dimensional dissipative AKNS equation.We find that the interaction solutions come in a variety of interesting forms.展开更多
The invention of printing technologies has revolutionized the manner in which information is transmitted and reproduced.In the modern era,printing technologies,which are equipped with computerized control and de-sign ...The invention of printing technologies has revolutionized the manner in which information is transmitted and reproduced.In the modern era,printing technologies,which are equipped with computerized control and de-sign methods,have become considerably efficient and effective,facilitating A significant breakthrough in the manufacture of high-performance electrochemical energy storage systems.Through careful design and execu-tion,the components of energy storage devices,particularly electrodes,can be formulated into functional inks,enabling the use of divers materials and devices in high-performance energy storage applications.This review-focuses on three major printing technologies:inkjet printing,screen printing,and 3D printing,introducing the principles of each printing technology,the design and preparation of various electrode inks,and their applica-tions in supercapacitors.Finally,the challenges and scope for the future development of printing technologies forhigh-performance supercapacitors are presented.展开更多
基金supported by the National Natural Science Foundation of China (21922815, 51802325)the Natural Science Foundation of Shanxi Province (201901D211585)+2 种基金the Scientific and Technological Key Project of Shanxi Province (20191102003)the Patent Promotion and Implementation Project of Shanxi Province (20200716)the Key Research and Development (R&D) Projects of Shanxi Province (201903D121007)。
基金financial support from the Natural Science Foundation of China(51302281 and 51402324)Natural Science Foundation of Shanxi Province(2013011012–7)
文摘A free-standing paper-like three-dimensional graphene framework(3DGF) with orientated laminar structure and interconnected macropores, was obtained by the hard template-directed ordered assembly. As the sacrificial templates, polystyrene(PS) latex spheres were assembled with graphene oxide(GO) to build up a sandwich type composite film, followed by heat removal of which with a simultaneous reduction of GO. The 3DGF exhibited high specific surface area of 402.5 m2/g, controllable pores and mechanical flexibility, which was employed as the binder-free supercapacitor electrode and shows high specific gravimetric capacitance of 95 F/g at 0.5 A/g, with enhanced rate capability in 3 electrode KOH system.
基金Shanghai Municipal Science and Technology Major Project(2017SHZDZX01).
文摘Human phenomics is defned as the comprehensive collection of observable phenotypes and characteristics infuenced by a complex interplay among factors at multiple scales.These factors include genes,epigenetics at the microscopic level,organs,microbiome at the mesoscopic level,and diet and environmental exposures at the macroscopic level.“Phenomic imaging”utilizes various imaging techniques to visualize and measure anatomical structures,biological functions,metabolic processes,and biochemical activities across diferent scales,both in vivo and ex vivo.Unlike conventional medical imaging focused on disease diagnosis,phenomic imaging captures both normal and abnormal traits,facilitating detailed correlations between macro-and micro-phenotypes.This approach plays a crucial role in deciphering phenomes.This review provides an overview of diferent phenomic imaging modalities and their applications in human phenomics.Additionally,it explores the associations between phenomic imaging and other omics disciplines,including genomics,transcriptomics,proteomics,immunomics,and metabolomics.By integrating phenomic imaging with other omics data,such as genomics and metabolomics,a comprehensive understanding of biological systems can be achieved.This integration paves the way for the development of new therapeutic approaches and diagnostic tools.
基金the National Natural Science Foundation of China(81822045 and 82041036 to L.L.,81900729 to L.S.,31872730 and 32070947 to Q.W.)the Program of Shanghai Academic/Technology Research Leader(20XD1420300 to L.L.).
文摘New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design.Here,we identified a receptorbinding domain(RBD)-binding antibody,XG014,which potently neutralizesβ-coronavirus lineage B(β-CoV-B),including SARS-CoV-2,its circulating variants,SARSCoV and bat SARSr-CoV WIV1.Interestingly,antibody family members competing with XG014 binding show reduced levels of cross-reactivity and induce antibodydependent SARS-CoV-2 spike(S)protein-mediated cellcell fusion,suggesting a unique mode of recognition by XG014.Structural analyses reveal that XG014 recognizes a conserved epitope outside the ACE2 binding site and completely locks RBD in the non-functional“down”conformation,while its family member XG005 directly competes with ACE2 binding and position the RBD“up”.Single administration of XG014 is effective in protection against and therapy of SARS-CoV-2 infection in vivo.Our findings suggest the potential to develop XG014 as pan-β-CoV-B therapeutics and the importance of the XG014 conserved antigenic epitope for designing broadly protective vaccines againstβ-CoV-B and newly emerging SARS-CoV-2 variants of concern.
文摘The lump solution is one of the exact solutions of the nonlinear evolution equation.In this paper,we study the lump solution and lump-type solutions of(2+1)-dimensional dissipative Ablowitz-Kaup-Newell-Segure(AKNS)equation by the Hirota bilinear method and test function method.With the help of Maple,we draw three-dimensional plots of the lump solution and lump-type solutions,and by observing the plots,we analyze the dynamic behavior of the(2+1)-dimensional dissipative AKNS equation.We find that the interaction solutions come in a variety of interesting forms.
基金This work was supported by the National Natural Science Foundation of China(U1904215)Natural Science Foundation of Jiangsu Province(BK20200044)and Changjiang scholars program of the Ministry of Ed-ucation(Q2018270).
文摘The invention of printing technologies has revolutionized the manner in which information is transmitted and reproduced.In the modern era,printing technologies,which are equipped with computerized control and de-sign methods,have become considerably efficient and effective,facilitating A significant breakthrough in the manufacture of high-performance electrochemical energy storage systems.Through careful design and execu-tion,the components of energy storage devices,particularly electrodes,can be formulated into functional inks,enabling the use of divers materials and devices in high-performance energy storage applications.This review-focuses on three major printing technologies:inkjet printing,screen printing,and 3D printing,introducing the principles of each printing technology,the design and preparation of various electrode inks,and their applica-tions in supercapacitors.Finally,the challenges and scope for the future development of printing technologies forhigh-performance supercapacitors are presented.