Downregulation of serum mi R-17 and mi R-106b levels in gastric cancer and benign gastric diseases

Altered micro RNA（mi RNA） associated with gastric cancer（GC） development and mi R-17 and mi R-106 b were differentially expressed in GC tissues. This study detected serum levels of mi R-17 and mi R-106 b expression in GC, benign gastric disease（BGD） and healthy controls to assess them as tumor markers for GC. Serum samples from 40 GC, 32 BGD（10 gastric ulcer, 14 gastric polyps, and 8 gastric ulcer with polyps） and 36 healthy individuals were subjected to quantitative reverse transcription polymerase chain reaction（q RT-PCR） analysis of mi R-17 and mi R-106 b expression. The data showed that the serum levels of mi R-17 and mi R-106 b were significantly reduced in healthy individuals and BGD patients compared to GC patients. There was a significant association of mi R-17 and mi R-106 b expression with age, but not with other clinicopathological features, such as gender, tumor differentiation, stage and lymphatic metastasis. Further analysis showed that, in discriminating GC patients from healthy controls, mi R-17 could yield a receiver-operating characteristic（ROC） area under the curve（AUC） of 0.879 with 80.6% sensitivity and 87.5% specificity and mi R-106 b could yield an AUC of 0.856 with 75.0% sensitivity and 92.5% specificity. The combined AUC of mi R-17 and mi R-106 b was 0.913 with 83.3% sensitivity and 87.5% specificity. Collectively, these data suggest that detection of serum mi R-17 and mi R-106 b levels should be further evaluated as novel non-invasive biomarkers in early GC detection and surveillance of disease progression.

Fast-Response Fiber-Optic FPI Temperature Sensing System Based on Modulated Grating Y-Branch Tunable Laser

In this paper,a cost-effective and miniaturized instrument is proposed,which is based on a tunable modulated grating Y-branch(MG-Y)laser for rapid temperature measurement using a Fabry-Perot interferometer(FPI)sensor.The FPI sensor with a 1463-μm cavity length is a short segment of a capillary tube sandwiched by two sections of single-mode fibers(SMFs).This system has a broad tunable range(1527 nm-1567 nm)with a wavelength interval of 8 pm and a tuning rate of 100 Hz.Temperature sensing experiments are carried out to investigate the performance of the system by demodulating the absolute cavity length of the FPI sensor using a cross-correlation algorithm.Experimental results show that the sensor can reach the response time as short as 94 ms with the sensitivity of 802 pm/C.Benefiting from the homemade and integrated essential electrical circuits,the entire system has the small size,low cost,and practical application potential to be used in the harsh environment for rapid temperature measurement.

Patterning of large area nanoscale domains in as-grown epitaxial ferroelectric PbTiO_(3)films

Effective tuning of nanoscale domain structures provides fundamental basis for controlling and engineering of various functionalities in ferroelectric materials.In this work,we demonstrate the precise patterning of nanoscopic domain structures in as-grown epitaxial PbTiO_(3)(PTO)films by merely introducing an ultrathin pre-patterned doping layer(e.g.,Fe-doped PTO).The doping layer can effectively reverse the interfacial built-in bias,consequent to a reversed initial polarization reorientation in the as-grown film,which makes it possible to transfer the nano-patterns in the doping layer into the domain structure of ferroelectric films.For instance,we have successfully fabricated large area ordered array of nanoscale cylindrical domains(downward polarization)embedded in the matrix domain with opposite polarization(upward polarization)in PTO film.These nanoscale cylinder domains also allow deterministic and reversible erasure and creation induced by biased tip scanning.The results provide an effective pathway for on-demand patterning of large area nanoscale domains in the as-grown films,which may find applications in a wide range of nanoelectronic devices.

典型介孔硅基固体酸催化剂的新进展

无机酸在化学化工领域有着广泛应用,由此带来的诸多环保与安全问题已经引发了国内外科学和产业界的高度重视,创制高效固体酸催化剂替代无机酸成为当前研究的重点和热点.与其他固体酸催化剂相比,硅材料耐酸性强、具有良好的孔隙率,其组成、物理化学性质及形貌等均可调控,被认为是一类理想的固体酸载体.将活性组分负载至硅材料载体上,创制高效硅基固体酸催化剂,一方面,通过调控硅材料载体形貌结构,促进活性组分的分散,提升传质效果;另一方面,硅基固体酸催化剂环境友好,符合绿色化学发展的要求,且催化剂经多次循环利用活性无明显降低,具有重要的应用价值.本文概述了近年来通过形貌控制制备介孔硅基固体酸催化剂及其在催化领域应用的新进展,为创制新型固体酸催化剂提供了新的思路.