The COVID-19 pandemic,caused by SARS-CoV-2,has seriously threatened human life and security in recent years and has had a serious impact on economic development.A range of strategies,including antibodies,smallmolecule...The COVID-19 pandemic,caused by SARS-CoV-2,has seriously threatened human life and security in recent years and has had a serious impact on economic development.A range of strategies,including antibodies,smallmolecule agents and vaccines,have been developed and widely used to combat SARS-CoV-2.However,the uncertain development and susceptibility to mutation of SARS-CoV-2 pose challenges to these approaches,making it necessary to develop a broader range of strategies to complement and expand the diversity of attacks against SARS-CoV-2.As promising tools against SARSCoV-2,aptamers have attracted wide attention due to their unique molecular properties.In this review,we survey SARS-CoV-2 aptamers and aptamer-based detection tools as well as aptamer-based therapeutics.In addition,we analyze the potential value of aptamers in the investigation of SARS-CoV-2 infection mechanism and vaccine design.Finally,we look forward to the future development direction of aptamers against SARS-CoV-2 or other viruses.展开更多
基金Program for Changjiang Scholars and Innovative Research Team in University,Grant/Award Number:IRT13036National Science Foundation of China,Grant/Award Numbers:22022409,992269114,22293031。
文摘The COVID-19 pandemic,caused by SARS-CoV-2,has seriously threatened human life and security in recent years and has had a serious impact on economic development.A range of strategies,including antibodies,smallmolecule agents and vaccines,have been developed and widely used to combat SARS-CoV-2.However,the uncertain development and susceptibility to mutation of SARS-CoV-2 pose challenges to these approaches,making it necessary to develop a broader range of strategies to complement and expand the diversity of attacks against SARS-CoV-2.As promising tools against SARSCoV-2,aptamers have attracted wide attention due to their unique molecular properties.In this review,we survey SARS-CoV-2 aptamers and aptamer-based detection tools as well as aptamer-based therapeutics.In addition,we analyze the potential value of aptamers in the investigation of SARS-CoV-2 infection mechanism and vaccine design.Finally,we look forward to the future development direction of aptamers against SARS-CoV-2 or other viruses.
