3,3-二苯基-3H-萘并吡喃化合物的合成与光致变色性质——一个综合有机化学实验设计与教学实践

将Claisen重排、光化学反应及固相合成等引入有机化学实验,开发了一个综合有机化学试验——3,3-二苯基-3H-萘并吡喃(3H-NP)的合成与光致变色性质研究。采用液相及固相合成两种方法合成了产物,对比考查了合成方法对收率的影响,并通过紫外-可见吸收光谱研究了产物的光致变色性质的影响。本实验将科学研究过程融入教学实践,有利于培养本科生的科学素质和创新能力。

Trends and Distribution of Life Expectancy and Health-Adjusted Life Expectancy—Asia-Pacific Region,1990-2021

What is already known about this topic?The Asia-Pacific region is the most populous and diverse globally,encompassing nations with both the longest and shortest life expectancies(LE).However,less is known about the health-adjusted life expectancy(HALE)situation in this region.What is added by this report?This study found diversity in the levels and trends of HALE among countries in the Asia-Pacific region,with HALE in 2021 ranging from 49.87 years in Afghanistan to 74.96 years in Singapore.The largest HALE increase from 1990 to 2021 was observed in the Lao People’s Democratic Republic and the smallest in Fiji.HALE continually increased as SDI increased,but different patterns of HALE across countries varied by SDI level.What are the implications for public health practice?The diversity among these countries provides a prerequisite and scientific basis for promoting the achievement of health goals in the Asia-Pacific region through multilateral and bilateral cooperation.

Foundations and implications of Human Aging Omics:A framework for identifying cumulative health risks from embryo to senescence

We are witnessing a global demographic shift towards an aging society,driven by significant improvements in life expectancy.Over the past two decades,the average life expectancy has increased by more than 6 years from 66.8 years in 2000 to73.3 years in 2019,and is projected to reach 74.6 years by 2030[1].

Trends and Patterns of Respiratory Tuberculosis Mortality in Rural and Urban——China,1987-2021

Summary What is already known about this topic?In China,an estimated 780,000 individuals contract tuberculosis(TB)every year.With TB ranked as the second most prevalent disease in terms of the morbidity and mortality rates for legally infectious diseases,it imparts a substantial disease burden on families and society.What is added by this report?This study identifies specific periods and cohort effects related to trends in respiratory TB mortality in both rural and urban regions of China.The mortality rates have been found to decrease at an annual rate of 5.5%in urban regions and 6.6%in rural ones,with a more marked decline evident in rural areas.These findings represent a significant milestone in the prevention and treatment of respiratory TB in China,especially in its rural locales.

Healthy Lifestyles and Chronic Pain with New-Onset Metabolic-Related Multimorbidity among Older Adults—China,2011–2018

Summary What is already known about this topic?Chronic pain has been identified as a risk factor for cardiovascular diseases.Evidence shows that adopting a healthy lifestyle can help reduce the cardiometabolic risks associated with chronic pain.What is added by this report?Results from this cohort study suggest a positive association between chronic pain and the development of new-onset metabolic-related multimorbidity,specifically metabolic multimorbidity and cardiometabolic comorbidity,within middle-aged and older Chinese adults.Furthermore,adopting healthy lifestyles can potentially mitigate or even reverse these associations.What are the implications for public health practice?The results of our study emphasize the importance of promoting healthy lifestyles among older Chinese adults as a preventative measure against the medical burdens and cardiometabolic risks associated with chronic pain.

Urban-Rural Disparity in Mortality Patterns of Respiratory Diseases Among Older Adults—China,1987-2021

What is already known about this topic?Respiratory diseases(RDs)are the primary cause of death in older adults in China.However,there is limited evidence regarding the disparity in mortality rates of RDs between urban and rural areas among the elderly population.What is added by this report?The age-standardized mortality rate(ASMR)due to RDs in the elderly population in both urban and rural areas of China has shown a consistent decrease.This trend is observed in both males and females.However,there was no significant change in the average annual percentage of ASMR for pneumonia among the urban elderly population and rural elderly men throughout the study period.What are the implications for public health practice?Efforts should be made in China to reduce mortality from chronic lower respiratory disease and pneumonia among the elderly,particularly in urban populations.

Changing Patterns of Mortality in Diabetes Mellitus Among Older Adults—China,1987-2021

What is already known about this topic?Diabetes mellitus poses a significant public health concern for older adults in China,resulting in increased mortality rates.What is added by this report?This study investigates the evolving pattern of mortality associated with diabetes mellitus and analyzes the contributions of age,period,and cohort effects from 1987 to 2021.The results demonstrate a consistent rise in diabetes mellitus mortality over the last 30 years,notably in rural regions.What are the implications for public health practice?This research offers valuable insights to aid policymakers in developing targeted intervention strategies that address the specific needs of higher-risk populations,such as women,older adults,and individuals in rural areas.

The RIP3-RIP1-NF-κB signaling axis is dispensable for necroptotic cells to elicit cross-priming of CD8^(+) T cells

Apoptosis and necroptosis are two types of programmed cell death with distinct morphological features.Necroptosis has been assumed to be more inflammatory than apoptosis,but a recent paper1 concluded that necroptotic cells cannot elicit cross-priming of CD8^(+)T cells and that NF-κB activation in necroptotic cells is required for maximal CD8^(+)T-cell cross-priming.