With the great prosperity of national economy, there has been a dramatic rise of vehicles on city road, which makes increasing pressure of road transportation. Currently, many countries are confronting the severe situ...With the great prosperity of national economy, there has been a dramatic rise of vehicles on city road, which makes increasing pressure of road transportation. Currently, many countries are confronting the severe situation of traffic jam in different degrees. Nevertheless, there are many triggers contributing to this congestion, one of which is the blocking of residential quarters towards vital traffic line. Therefore, it is extremely necessary to study whether the opening of residential quarters can improve the road capacity of the entire city and remit the traffic pressure. Our paper is based on graph theory, density theory and random utility theory. First of all, we demonstrate a mathematical model of road traffic. Secondly, we explore the influence of residential quarters opening on urban traffic, taking three factors into account listed as road traffic capacity, road network density and network average running time. On the basis of above contents, the impact analysis of vehicle traffic caused by pedestrians is added afterwards. Finally, our paper takes three different types of residential areas into account as an example to empirically analyze the tangible impact of the opening, and finally come to the benefit of the traffic system after the opening.展开更多
Psoriasis is one of the most common immune-mediated chronic, inflammatory skin diseases characterized by hyperproliferative keratinocytes and infiltration of T cells, dendritic cells, macrophages and neutrophils. Alth...Psoriasis is one of the most common immune-mediated chronic, inflammatory skin diseases characterized by hyperproliferative keratinocytes and infiltration of T cells, dendritic cells, macrophages and neutrophils. Although the pathogenesis of psoriasis is not fully understood, there is ample evidence suggesting that the dysregulation of immune cells in the skin, particularly T cells, plays a critical role in psoriasis development. In this review, we mainly focus on the pathogenic T cells and discuss how these T cells are activated and involved in the disease pathogenesis. Newly identified ＇professional＇ IL-17-producing dermal γδ T cells and their potential role in psoriasis will also be included. Finally, we will briefly summarize the recent progress on the T cell and its related cytokine-targeted therapy for psoriasis treatment.展开更多
文摘With the great prosperity of national economy, there has been a dramatic rise of vehicles on city road, which makes increasing pressure of road transportation. Currently, many countries are confronting the severe situation of traffic jam in different degrees. Nevertheless, there are many triggers contributing to this congestion, one of which is the blocking of residential quarters towards vital traffic line. Therefore, it is extremely necessary to study whether the opening of residential quarters can improve the road capacity of the entire city and remit the traffic pressure. Our paper is based on graph theory, density theory and random utility theory. First of all, we demonstrate a mathematical model of road traffic. Secondly, we explore the influence of residential quarters opening on urban traffic, taking three factors into account listed as road traffic capacity, road network density and network average running time. On the basis of above contents, the impact analysis of vehicle traffic caused by pedestrians is added afterwards. Finally, our paper takes three different types of residential areas into account as an example to empirically analyze the tangible impact of the opening, and finally come to the benefit of the traffic system after the opening.
文摘Psoriasis is one of the most common immune-mediated chronic, inflammatory skin diseases characterized by hyperproliferative keratinocytes and infiltration of T cells, dendritic cells, macrophages and neutrophils. Although the pathogenesis of psoriasis is not fully understood, there is ample evidence suggesting that the dysregulation of immune cells in the skin, particularly T cells, plays a critical role in psoriasis development. In this review, we mainly focus on the pathogenic T cells and discuss how these T cells are activated and involved in the disease pathogenesis. Newly identified ＇professional＇ IL-17-producing dermal γδ T cells and their potential role in psoriasis will also be included. Finally, we will briefly summarize the recent progress on the T cell and its related cytokine-targeted therapy for psoriasis treatment.
