Nicotine and nornicotine-typed compounds are well-known for its potential as insecticide.Some researches have shown that nicotine was highly toxic to Diaphorina citri Kuwayama,an invasive and fast spreading pest.Here ...Nicotine and nornicotine-typed compounds are well-known for its potential as insecticide.Some researches have shown that nicotine was highly toxic to Diaphorina citri Kuwayama,an invasive and fast spreading pest.Here we report the effects of nornicotine-typed insecticide against D.citri.Novel compounds A1-A8,B1-B28,C1-C18 and D1-D12 were synthesized by reported procedure.And bioassays indicated that some of these compounds exhibited good effects against D.citri.Compounds B2,B3,B8,B12,B13,B22,C5,C7,D5,and D9 exhibited the mortality up to 100%within 120 h in 50 mg/L.And further data shows that A2-5,A7,B1,B8,B20 and B22 showed rapid insecticidal activities against D.citri in 24 h with the low LC_(50)(LC_(50)<50 mg/L in 24 h,and LC_(50)<30 mg/L in 72 h).Nornicotine-typed derivatives exhibited activity against D.citri,and B8 and B22 exhibited the best insecticidal activity with an LC_(50)of 18.01.0,18.20.9 mg/L in 24 h,which had the lower cost than nicotine and showed the potential as powerful insecticides.展开更多
基金the financial support from the National Natural Science Foundation of China(31901786,22078263)the National Key R&D Program of China(2021YFC2101500)+2 种基金the National Key R&D Program of China(2021SF-116,2023-YBSF-396)the Natural Science Foundation of Shaanxi Province(2022JQ-112)the China Postdoctoral Science Foundation(2021M692610).
文摘Nicotine and nornicotine-typed compounds are well-known for its potential as insecticide.Some researches have shown that nicotine was highly toxic to Diaphorina citri Kuwayama,an invasive and fast spreading pest.Here we report the effects of nornicotine-typed insecticide against D.citri.Novel compounds A1-A8,B1-B28,C1-C18 and D1-D12 were synthesized by reported procedure.And bioassays indicated that some of these compounds exhibited good effects against D.citri.Compounds B2,B3,B8,B12,B13,B22,C5,C7,D5,and D9 exhibited the mortality up to 100%within 120 h in 50 mg/L.And further data shows that A2-5,A7,B1,B8,B20 and B22 showed rapid insecticidal activities against D.citri in 24 h with the low LC_(50)(LC_(50)<50 mg/L in 24 h,and LC_(50)<30 mg/L in 72 h).Nornicotine-typed derivatives exhibited activity against D.citri,and B8 and B22 exhibited the best insecticidal activity with an LC_(50)of 18.01.0,18.20.9 mg/L in 24 h,which had the lower cost than nicotine and showed the potential as powerful insecticides.
