Engineering Spin States of Isolated Copper Species in a Metal-Organic Framework Improves Urea Electrosynthesis

The catalytic activities are generally believed to be relevant to the electronic states of their active center, but understanding this relationship is usually difficult. Here, we design two types of catalysts for electrocatalytic urea via a coordination strategy in a metal–organic frameworks: Cu^(Ⅲ)-HHTP and Cu^(Ⅱ)-HHTP. Cu^(Ⅲ)-HHTP exhibits an improved urea production rate of 7.78 mmol h^(−1)g^(−1) and an enhanced Faradaic efficiency of 23.09% at-0.6 V vs. reversible hydrogen electrode, in sharp contrast to Cu^(Ⅱ)-HHTP.Isolated CuⅢspecies with S = 0 spin ground state are demonstrated as the active center in Cu^(Ⅲ)-HHTP, different from Cu^(Ⅱ) with S = 1/2 in Cu^(Ⅱ)-HHTP. We further demonstrate that isolated Cu^(Ⅲ)with an empty dx2-y20orbital in Cu^(Ⅲ)-HHTP experiences a single-electron migration path with a lower energy barrier in the C–N coupling process, while Cu^(Ⅱ)with a single-spin state( d_(x2-y2)^(1)) in Cu^(Ⅱ)-HHTP undergoes a two-electron migration pathway.

Toward Quantifying the Increasing Accessibility of the Arctic Northeast Passage in the Past Four Decades

Sea ice,one of the most dominant barriers to Arctic shipping,has decreased dramatically over the past four decades.Arctic maritime transport is hereupon growing in recent years.To produce a long-term assessment of trans-Arctic accessibility,we systematically revisit the daily Arctic navigability with a view to the combined effects of sea ice thickness and concentration throughout the period 1979−2020.The general trends of Navigable Windows(NW)in the Northeast Passage show that the number of navigable days is steadily growing and reached 89±16 days for Open Water(OW)ships and 163±19 days for Polar Class 6(PC6)ships in the 2010s,despite high interannual and interdecadal variability in the NWs.More consecutive NWs have emerged annually for both OW ships and PC6 ships since 2005 because of the faster sea ice retreat.Since the 1980s,the number of simulated Arctic routes has continuously increased,and optimal navigability exists in these years of record-low sea ice extent(e.g.,2012 and 2020).Summertime navigability in the East Siberian and Laptev Seas,on the other hand,varies dramatically due to changing sea ice conditions.This systematic assessment of Arctic navigability provides a reference for better projecting the future trans-Arctic shipping routes.

Effect Evaluation of Cognitive Behavioral Intervention on Stress Response in Breast Cancer Patients

Objective: To investigate the effects of cognitive behavioral intervention on psychological stress response in breast cancer patients by cognitive behavioral intervention in breast cancer patients. Methods: Adopting the random comparison method, 100 patients with breast cancer were divided into comparison group and intervention group by 50 cases. The intervention group underwent cognitive behavioral intervention at the same time as the comparison group only received conventional treatment without cognitive behavioral intervention. Two groups of breast cancer patients were enrolled in the general questionnaire, the Self-Rating Anxiety Scale (SAS), and the Medical Coping Modes Questionnaire (MCMQ) within one week after admission and one month after treatment to understand the psychological stress levels of the two groups. Results: There was no significant difference in the scores of SAS and MCMQ between the intervention group and the comparison group before intervention (P > 0.05). But after intervention, the scores of SAS and MCMQ in the comparison group were significantly higher than those in the intervention group (P 0.05). It shows that the implementation of cognitive behavioral intervention therapy for breast cancer patients has the effect of improving their psychological status. Conclusion: Cognitive behavioral intervention therapy combined with psychology for breast cancer patients can effectively reduce their stress level, improve mental health status and improve their positive coping ability.

Estimation of reservoir temperature using silica and cationic solutes geothermometers:a case study in the Tengchong geothermal area

Reservoir temperature estimation is vitally important for assessing the exploitation potential of a geothermal field.In this study,the concentrations of major chemical constituents in geothermal water sampled from boiling and hot springs in the Tengchong hydrothermal area were measured,and quartz and cationic solutes geothermometers were used to calculate subsurface temperatures.Log(Q/K) diagrams and Na-K-Mg triangular diagrams were applied to evaluating the equilibrium status of geothermal water samples with regard to reservoir minerals,and results were used to select suitable geothermometers.The results show that samples RH01,RH03,RH04,RH05,and LL16 were in or very close to full equilibrium with the selected minerals,and therefore a NaK geothermometer is appropriate.A K/Mg geothermometer,however,is applicable to LP08 and PZH18 whose chemical compositions adjusted to the shallow reservoir temperatures during their re-equilibrium processes.In contrast,cationic solute geothermometers are unsuitable for SQ20 and RH07,which are categorized as immature water in the Na-K-Mg diagram;a quartz geothermometer was adopted to evaluate the corresponding subsurface temperatures of these samples.According to the reservoir temperature estimation made in this study,there is at least one high-temperature reservoir below Rehai with a possible temperature range of 210-270 ℃.

Study on the Relationship between Psychological Stress and Doctor-Patient Relationship of Cancer Patients and Their Families

Objective: To research the relationship between psychological stress and doctor-patient relationship of cancer patients and their families. Methods: The patients were randomly divided into the intervention group and the control group, and PDRQ-15, pcl-c, SAS and SDS scales were selected as evaluation indexes, and the levels of norepinephrine and dopamine were compared between the patients diagnosed with PTSD cancer and those without PTSD. Results: 1) The total score of PCL-C, SAS, SDS, PDRQ-15 scale of the cancer patients and their families after the intervention of clinical psychological care was significantly lower than that of before intervention and the control group. 2) The correlation coefficients between PCL-C, SAS, SDS and PDRQ-15 of cancer patients and their relatives were 0.971, 0.952 and 0.939 respectively. The significant test P value was less than 0.05 and the difference was statistically significant. 3) The plasma levels of dopamine and norepinephrine in cancer patients under stress were significantly higher than those in cancer patients without stress (P Conclusion: After psychological Intervention of cancer patients and their families, post-traumatic stress disorder, anxiety, depression and doctor-patient relationship were all improved.

An Associated Research for Genetic Polymorphism of 5-HTTLPR with Post-Traumatic Stress Disorder

The aim of this study was to investigate the influence of a polymorphism in the serotonin transporter gene (5-HTTLPR) in patients diagnosed with posttraumatic stress disorder (PTSD) in a Chinese sample of earthquake survivors. Polymerase chain reaction (PCR) amplification and amplified fragment length polymorphism (AFLP) were performed to type 5-HTTLPR promoter polymorphism in 57 PTSD patients and an equal number of healthy controls. The genotype and allele frequency distribution were analyzed and compared using various statistical methods. The frequency of LL, SL and SS genotypes in patients was found to be 5, 16 and 36 respectively, in comparison to 16, 22 and 19 in healthy controls. Fewer patients tended to be L genotype (22.8%) than controls (47.4%), but the number of patients with the S genotype was higher (77.2%) compared to controls (52.6%). The results show a statistically significant difference in genotype and allele frequency distribution between patients and controls. This research suggests that PTSD symptoms are significantly associated with 5-HTTLPR genetic polymorphism. These results add to the important research of genetics of psychiatric disorders, particularly in a Chinese context that has not been previously studied.

Research Progress on Post-Traumatic Stress Disorder and Its Animal Model

Posttraumatic stress disorder (PTSD) is to a persistently severe mental disorder which is caused by individual exposure to some unusual threatening or catastrophic stressful events. Its essential clinical manifestations refer to repeated playback of traumatic experience, durative avoidance of related clues, mental numbness or affection paralysis, and persistent increase of vigilance level. At present, the pathogenesis of PTSD has not been fully elucidated, and the clinical therapeutic effect has not been ideal. Generally, the classical animal model of PTSD is mouse;the domestic and international researches in the animal model of PTSD in recent years remain active, which are summarized as follows.

Correlation between Serotonin Transporter Promoter Gene Polymorphism and PTSD in Children

Objective: To study the association between post-traumatic stress disorder (PTSD) and serotonin transporter promoter (5-HTTLPR) gene polymorphism in Han children in Hainan;to explore the genetic mechanism of PTSD in children. Methods: 50 patients with post-traumatic stress disorder and healthy children in Han nationality in Hainan were selected. Detection of 5-HTTLPR gene polymorphism by polymerase chain reaction (PCR) and amplified fragment length polymorphism, the genotype and allele frequencies were analyzed using a case-control association analysis method. Results: There were 4, 14 and 32 cases of LL, SL and SS in the post-traumatic stress disorder group of Hainan Han children, and 13, 20 and 17 cases in the control group. From the perspective of gene frequency, the L gene of post-traumatic stress disorder appeared 22.0%, and S appeared 78.0%. In the control group, L appeared 46.0%, and S appeared 54.0%. There were significant differences in genotype and gene frequency (P Conclusion: The 5-HTTLPR gene polymorphism in Hainan Han children may be associated with post-traumatic stress disorder.

Effect of Cognitive Behavioral Intervention Therapy on Immune Index in Patients with Breast Cancer

Objective: To explore the effect of cognitive behavioral intervention therapy on the cellular immune function of patients undergoing radical mastectomy for the first time, and to provide a scientific basis for improving the treatment of breast cancer patients. Methods: 100 patients with breast cancer who were eligible for admission to the Department of Breast Surgery, Hainan Provincial People’s Hospital from January 2016 to December 2017 were selected as subjects. It is the first time to improve the radical mastectomy. They were randomly divided into control group and intervention group, 50 cases each. The control group used conventional treatment and routine care. On the basis of this, the intervention group conducted cognitive behavioral interventions including cognitive reconstruction and behavioral therapy. The patients were measured for serum IL-2, IL-4, IL-6, IL-8 and TNF-α levels on the second day after admission and three months after discharge. The changes of serum IL-2, IL-4, IL-6, IL-8 and TNF-α levels in the two groups were compared before and after cognitive intervention. Results: The concentrations of IL-2, IL-4, IL-6, IL-8 and TNF-α in the serum of the intervention group and the control group before intervention were compared. The difference was not statistically significant (P > 0.05). After the intervention, the serum levels of IL-2, IL-4 and IL-8 in the intervention group were lower than before the intervention. The concentration of TNF-α was higher than before the intervention. The difference was statistically significant (P Conclusion: Cognitive behavioral intervention therapy can change the levels of IL-2, IL-4, IL-6, IL-8 and TNF-α in serum of breast cancer patients. It has a positive effect on the regulation of immune function in breast cancer patients.

Research on HOXA11-AS in Malignant Tumors

Long-chain non-coding RNA HOXA11 antisense RNA (HOXA11-AS) is a kind of lncRNA discovered in recent years. Long-chain non-coding RNA (LncRNA) is an important regulatory factor of protein-coding genes, especially the disorder of LncRNA in more and more diseases which are found, including cancer. HOXA11-AS was first discovered in mouse embryo cDNA library using probes, and then it was discovered by scholars and played an important role in human cervical cancer, gastric cancer, glioma and other malignant tumor cells. Overexpression of HOXA11-AS has been found to promote cell proliferation, migration and tumor invasion, and has a carcinogenic effect. HOXA11-AS can promote tumor proliferation, metastasis and other malignant biological behaviors by interacting with miRNA and EZH2 protein, and is considered to be carcinogenic lncRNA. The discovery of HOXA11-AS provides new ideas for tumor prevention and treatment.

腹腔镜折叠对接缝合联合宫腔镜憩室开渠法治疗剖宫产瘢痕憩室的疗效

目的探讨腹腔镜折叠对接缝合联合宫腔镜憩室开渠术治疗剖宫产瘢痕憩室(CSD)的疗效。方法选择2018年5月至2022年12月在南京医科大学附属淮安第一医院因CSD接受手术治疗86例患者的临床病例资料为研究对象。根据手术治疗方式不同,将其分为实验组(n=56,接受腹腔镜下折叠对接缝合法联合宫腔镜憩室开渠法者)和对照组(n=30,接受腹腔镜下折叠对接缝合法者)。回顾性分析2组患者一般临床资料、围手术期相关指标、术前及术后6个月经期持续时间,以及治疗总有效率等。本研究所遵循的程序符合南京医科大学附属淮安第一医院医学伦理委员会制定的标准,得到该委员会批准(审批文号:YX-P-2018-012-01),并与患者本人或其家属签署临床研究知情同意书。结果①2组CSD患者年龄与CSD残余肌层处厚度、深度及剖宫产次数、子宫位置构成比等一般临床资料比较,差异均无统计学意义(P>0.05)。②2组患者术中出血量、总住院时间、术后住院时间、术后留置尿管时间和术后排气时间比较,差异均无统计学意义(P>0.05)。③实验组与对照组CSD患者术后平均经期分别为(7.9±3.2)d与(8.4±3.2)d,均明显短于术前的(15.2±5.7)d与(12.6±5.1)d,差异均有统计学意义(t=9.59、4.79,P<0.001)。④实验组患者的治疗总有效率为83.9%(47/56),显著高于对照组的63.3%(19/30),并且差异有统计学意义(χ^(2)=4.64,P=0.031)。结论腹腔镜折叠对接缝合联合宫腔镜憩室开渠法治疗CSD患者具有临床效果确切、可保留子宫完整性、缩短经期的优点,适宜临床推广。

Fe^(3+)-stabilized Ti_(3)C_(2)T_(x) MXene enables ultrastable Li-ion storage at low temperature

It is highly important to develop ultrastable electrode materials for Li-ion batteries(LIBs),especially in the low temperature.Herein,we report Fe^(3+)-stabilized Ti_(3)C_(2)T_(x) MXene(donated as T/F-4:1)as the anode material,which exhibits an ultrastable low-temperature Li-ion storage property(135.2 m A h g^(-1)after300 cycles under the current density of 200 m A g^(-1)at-10℃),compared with the negligible capacity for the pure Ti_(3)C_(2)T_(x) MXene(26 m A h g^(-1)at 200 m A g^(-1)).We characterized as-made T/F samples via the Xray photoelectron spectroscopy(XPS),Fourier transformed infrared(FT-IR)and Raman spectroscopy,and found that the terminated functional groups(-O and-OH)in T/F are Li^(+) storage sites.Fe^(3+)-stabilization makes-O/-OH groups in MXene interlayers become active towards Li^(+),leading to much more active sites and thus an enhanced capacity and well cyclic stability.In contrast,only-O/-OH groups on the top and bottom surfaces of pure Ti_(3)C_(2)T_(x) MXene can be used to adsorb Li^(+),resulting in a low capacity.Transmission electron microscopy(TEM)and XPS data confirm that T/F-4:1 holds the highly stable solid electrolyte interphase(SEI)layer during the cycling at-10℃.Density functional theory(DFT)calculations further uncover that T/F has fast diffusion of Li^(+) and consequent better electrochemical performances than pure Ti_(3)C_(2)T_(x) MXene.It is believed that the new strategy used here will help to fabricate advanced MXene-based electrode materials in the energy storage application.