期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
果蝇限制端粒转座子的分子机制
1
作者 王承贤 容益康 崔敏 《遗传》 CAS CSCD 北大核心 2023年第3期221-228,共8页
端粒是保护线性染色体末端的核酸-蛋白复合物。与常见的真核生物短重复序列组成的端粒不同,黑腹果蝇(Drosophila melanogaster)端粒DNA由反转座子组成,其转座行为被果蝇宿主严格限制在端粒,既实现延长端粒的功能,也减少转座子跳跃对基... 端粒是保护线性染色体末端的核酸-蛋白复合物。与常见的真核生物短重复序列组成的端粒不同,黑腹果蝇(Drosophila melanogaster)端粒DNA由反转座子组成,其转座行为被果蝇宿主严格限制在端粒,既实现延长端粒的功能,也减少转座子跳跃对基因组的损伤。但果蝇宿主是如何完成如此精确调控的机制尚不明确。目前已知的全基因组范围抑制转座子表达包括H3K9me3参与的异染色质形成途径和piRNA路径,而近期研究发现果蝇端粒保护蛋白参与端粒反转座子的特异调控。本文主要综述了端粒保护蛋白在调控端粒转座子中的具体功能。对果蝇端粒转座子调控的研究有利于更好地理解宿主与转座子协同进化的分子机制。 展开更多
关键词 端粒保护蛋白 反转座子 转座子转录调控 PIRNA 端粒酶
下载PDF
Genome Editing:From Drosophila to Non-Model Insects and Beyond 被引量:1
2
作者 Yueping Huang Zhiping Liu yikang s.rong 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2016年第5期263-272,共10页
Insect is the largest group of animals on land.Many insect species inflict economical and health losses to humans.Yet many more benefit us by helping to maintain balances in our ecosystem.The benefits that insects off... Insect is the largest group of animals on land.Many insect species inflict economical and health losses to humans.Yet many more benefit us by helping to maintain balances in our ecosystem.The benefits that insects offer remain largely untapped,justifying our continuing efforts to develop tools to better understand their biology and to better manage their activities.Here we focus on reviewing the progresses made in the development of genome engineering tools for model insects.Instead of detailed descriptions of the molecular mechanisms underlying each technical advance,we focus our discussion on the logistics for implementing similar tools in non-model insects.Since none of the tools were developed specific for insects,similar approaches can be applied to other non-model organisms. 展开更多
关键词 Insect transgenesis Drosophila Black soldier fly Gene targeting Site-specific recombination Piggybac transposon
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部