In recent years,reactive species-based cancer therapies have attracted tremendous attention due to their simplicity,controllability,and effectiveness.Herein,we overviewed the state-of-art advance for photo-controlled ...In recent years,reactive species-based cancer therapies have attracted tremendous attention due to their simplicity,controllability,and effectiveness.Herein,we overviewed the state-of-art advance for photo-controlled generation of highly reactive radical species with nanomaterials for cancer therapy.First,we summarized the most widely explored reactive species,such as singlet oxygen,superoxide radical anion(O2●-),nitric oxide(●NO),carbon monoxide,alkyl radicals,and their corresponding secondary reactive species generated by interaction with other biological molecules.Then,we discussed the generating mechanisms of these highly reactive species stimulated by light irradiation,followed by their anticancer effect,and the synergetic principles with other therapeutic modalities.This review might unveil the advantages of reactive species-based therapeutic methodology and encourage the pre-clinical exploration of reactive species-mediated cancer treatments.展开更多
基金This work was financially supported by the National Natural Science Foundation of China(31900990 and 51873228)the International Cooperation Project of Science and Technology Commission of Shanghai Municipality(20430711800)the Scientific Research Foundation of Nantong University(135420623085).
文摘In recent years,reactive species-based cancer therapies have attracted tremendous attention due to their simplicity,controllability,and effectiveness.Herein,we overviewed the state-of-art advance for photo-controlled generation of highly reactive radical species with nanomaterials for cancer therapy.First,we summarized the most widely explored reactive species,such as singlet oxygen,superoxide radical anion(O2●-),nitric oxide(●NO),carbon monoxide,alkyl radicals,and their corresponding secondary reactive species generated by interaction with other biological molecules.Then,we discussed the generating mechanisms of these highly reactive species stimulated by light irradiation,followed by their anticancer effect,and the synergetic principles with other therapeutic modalities.This review might unveil the advantages of reactive species-based therapeutic methodology and encourage the pre-clinical exploration of reactive species-mediated cancer treatments.
