Background: The aim of the study was to investigate the effects of a long term(1 year) hormone replacement therapy(HRT) on QT interval, QT dispersion(QTd) frequencies of arrhythmia and heart rate variability(HRV) para...Background: The aim of the study was to investigate the effects of a long term(1 year) hormone replacement therapy(HRT) on QT interval, QT dispersion(QTd) frequencies of arrhythmia and heart rate variability(HRV) parameters. Methods: Fortysix healthy postmenopausal women(mean age; 55.34±4.21) as a hormone replacement therapy group and 25 healthy premenopausal women(mean age; 35.36±6.06) as a control group were prospectively enrolled to the study. Hormone replacement therapy group was divided into two groups; estrogen replacement therapy(ERT) group(n=23) and progestin-estrogen replacement therapy(PERT) group(n=23). Standard 12 lead electrocardiograms and 24-h ambulatory Holter recording were obtained to evaluate the effects of one year of ERT and PERT on QT intervals, QTd, frequencies of arrhytmias and HRV parameters. Results: Long term use of ERT increases QT interval, QTd, in the frequencies of arrhytmia and HRV indexes of parasympathetic activity; however, the increase in frequencies of arrhythmia was not statistically significant(p>0.05). Long term use of PERT did not effected QT interval, QTd, frequencies of ventricular arrhythmia and HRV parameters(p >0.05).Frequency of supraventricular tachycardia increased in post-treatment PERT group was compared with pre-treatment PERT group. Conclusion: These findings supported the hypothesis that estrogen may directly modulate ventricular repolarization. But progestin do not effect the ventricular repolarization. However, these findings must be supported with a large-scale study.展开更多
Background Assessment of left ventricular(LV)thrombosis risk after acute myocardial infarction(AMI)is important because of potential embolic sequelae that are reduced by oral anticoagulant agents. The goal of this stu...Background Assessment of left ventricular(LV)thrombosis risk after acute myocardial infarction(AMI)is important because of potential embolic sequelae that are reduced by oral anticoagulant agents. The goal of this study was to investigate whether early assessment of LV systolic and diastolic performance with pulsed wave tissue Doppler ultrasound scanning(PWTD)predicts LV thrombosis after AMI.Methods Two-dimensional and Doppler ultrasound scanning echocardiographic examinations were performed in 92 consecutive patients(age, 58±10 years; 11 women)with first anterior AMI within 24 hours after arrival to the coronary care unit. From the apical 4-chamber view, the mitral annular velocities were recorded at the lateral corner of the mitral annulus with PWTD. The myocardial performance index(MPI), which combines parameters of both systolic and diastolic ventricular function, was calculated from the PWTD recordings. To analyze LV thrombus formation, the 2-dimensional echocardiographic examination was repeated on days 3, 7, 15, and 30. The patients were divided in 2 groups according to LV thrombus formation. Results LV thrombus was found in 32 of 92 patients(35%; group 1)and was not found in 60 patients(65%; group 2). The MPI was significantly higher in group 1 than in group 2(0.73±0.20 vs 0.53±0.14; P <.001). When an MPI >0.6 was used as the cutoff, LV thrombus formation could be predicted with a sensitivity rate of 81%, a specificity rate of 73%, a positive predictive value of 62%, and a negative predictive value of 88%. In multivariate analyses, only MPI and LV wall motion score index were independent predictors of LV thrombus formation(P=.038 and P=.047, respectively). Conclusions The MPI derived with PWTD soon after admission appears to be a useful parameter for assessing the risk of LV thrombosis after AMI. Patientswith an MPI>0.6 after AMI seem to be at a higher risk for thrombus formation.展开更多
文摘Background: The aim of the study was to investigate the effects of a long term(1 year) hormone replacement therapy(HRT) on QT interval, QT dispersion(QTd) frequencies of arrhythmia and heart rate variability(HRV) parameters. Methods: Fortysix healthy postmenopausal women(mean age; 55.34±4.21) as a hormone replacement therapy group and 25 healthy premenopausal women(mean age; 35.36±6.06) as a control group were prospectively enrolled to the study. Hormone replacement therapy group was divided into two groups; estrogen replacement therapy(ERT) group(n=23) and progestin-estrogen replacement therapy(PERT) group(n=23). Standard 12 lead electrocardiograms and 24-h ambulatory Holter recording were obtained to evaluate the effects of one year of ERT and PERT on QT intervals, QTd, frequencies of arrhytmias and HRV parameters. Results: Long term use of ERT increases QT interval, QTd, in the frequencies of arrhytmia and HRV indexes of parasympathetic activity; however, the increase in frequencies of arrhythmia was not statistically significant(p>0.05). Long term use of PERT did not effected QT interval, QTd, frequencies of ventricular arrhythmia and HRV parameters(p >0.05).Frequency of supraventricular tachycardia increased in post-treatment PERT group was compared with pre-treatment PERT group. Conclusion: These findings supported the hypothesis that estrogen may directly modulate ventricular repolarization. But progestin do not effect the ventricular repolarization. However, these findings must be supported with a large-scale study.
文摘Background Assessment of left ventricular(LV)thrombosis risk after acute myocardial infarction(AMI)is important because of potential embolic sequelae that are reduced by oral anticoagulant agents. The goal of this study was to investigate whether early assessment of LV systolic and diastolic performance with pulsed wave tissue Doppler ultrasound scanning(PWTD)predicts LV thrombosis after AMI.Methods Two-dimensional and Doppler ultrasound scanning echocardiographic examinations were performed in 92 consecutive patients(age, 58±10 years; 11 women)with first anterior AMI within 24 hours after arrival to the coronary care unit. From the apical 4-chamber view, the mitral annular velocities were recorded at the lateral corner of the mitral annulus with PWTD. The myocardial performance index(MPI), which combines parameters of both systolic and diastolic ventricular function, was calculated from the PWTD recordings. To analyze LV thrombus formation, the 2-dimensional echocardiographic examination was repeated on days 3, 7, 15, and 30. The patients were divided in 2 groups according to LV thrombus formation. Results LV thrombus was found in 32 of 92 patients(35%; group 1)and was not found in 60 patients(65%; group 2). The MPI was significantly higher in group 1 than in group 2(0.73±0.20 vs 0.53±0.14; P <.001). When an MPI >0.6 was used as the cutoff, LV thrombus formation could be predicted with a sensitivity rate of 81%, a specificity rate of 73%, a positive predictive value of 62%, and a negative predictive value of 88%. In multivariate analyses, only MPI and LV wall motion score index were independent predictors of LV thrombus formation(P=.038 and P=.047, respectively). Conclusions The MPI derived with PWTD soon after admission appears to be a useful parameter for assessing the risk of LV thrombosis after AMI. Patientswith an MPI>0.6 after AMI seem to be at a higher risk for thrombus formation.
