Development of Ecological Fishery in Poyang Lake Area

Through in-depth analysis on history and current situations of fishery development in Poyang Lake area,this paper presents location,resource and environment advantages in development of ecological fishery.According to orientation of leading functions,Poyang Lake can be divided into breeding development,capture operation,enhancement protection and ecological rehabilitation functional zones.In accordance with industrial foundation and ecological advantages of cities and counties in Poyang Lake,it determines the reasonable distribution of 8 leading industries:river crabs,shrimps(Procambarus clarkia),eels,Pengze crucian carp,Siniperca chuatsi,Channa argus,Ietalurus Punetaus,and pearl.On the basis of systematically summing up exploration experience,it comes up with the development path"ecology oriented fishery and industrialization oriented ecological fishery"for ecological fishery in Poyang Lake area.It proposes a series of key technological measures,including reducing fertilizer and drugs,increasing output and benefits,low consumption and emission,high quality and safety,and standardization,to realize a benign cycle of"cost saving,benefit increasing,quality improving and low carbon"and the multi-win objective of coordination between ecology,economy and society.

Anthrax lethal toxin and tumor necrosis factor-a synergize on intestinal epithelia to induce mouse death

Bacillus anthracis lethal toxin(LT)is a determinant of lethal anthrax.Its function in myeloid cells is required for bacterial dissemination,and LT itself can directly trigger dysfunction of the cardiovascular system.The interplay between LT and the host responses is important in the pathogenesis,but our knowledge on this interplay remains limited.Tumor necrosis factor-a(TNF-a)is a pleiotropic pro-inflammatory cytokine induced by bacterial infections.Since LT accumulates and cytokines,predominantly TNF,amass during B.anthracis infection,co-treatment of TNF+LT in mice was used to mimic in vivo conditions for LT to function in inflamed hosts.Bone marrow transplantation and genetically engineered mice showed unexpectedly that the death of intestinal epithelial cells(IECs)rather than that of hematopoietic cells led to LT+TNF-induced lethality.Inhibition of p38a mitogen-activated protein kinase(MAPK)signaling by LT in IECs promoted TNF-induced apoptosis and necroptosis of IECs,leading to intestinal damage and mouse death.Consistently,p38a inhibition by LT enhanced TNF-mediated cell death in human colon epithelial HT-29 cells.As intestinal damage is one of the leading causes of lethality in anthrax patients,the IEC damage caused by LT+TNF would most likely be a mechanism underneath this clinical manifestation and could be a target for interventions.