The subthalamic nucleus(STN)is considered the best target for deep brain stimulation treatments of Parkinson’s disease(PD).It is difficult to localize the STN due to its small size and deep location.Multichannel micr...The subthalamic nucleus(STN)is considered the best target for deep brain stimulation treatments of Parkinson’s disease(PD).It is difficult to localize the STN due to its small size and deep location.Multichannel microelectrode arrays(MEAs)can rapidly and precisely locate the STN,which is important for precise stimulation.In this paper,16-channel MEAs modified with multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(MWCNT/PEDOT:PSS)nanocomposites were designed and fabricated,and the accurate and rapid identification of the STN in PD rats was performed using detection sites distributed at different brain depths.These results showed that nuclei in 6-hydroxydopamine hydrobromide(6-OHDA)-lesioned brains discharged more intensely than those in unlesioned brains.In addition,the MEA simultaneously acquired neural signals from both the STN and the upper or lower boundary nuclei of the STN.Moreover,higher values of spike firing rate,spike amplitude,local field potential(LFP)power,and beta oscillations were detected in the STN of the 6-OHDA-lesioned brain,and may therefore be biomarkers of STN localization.Compared with the STNs of unlesioned brains,the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta band of 6-OHDA-lesioned brains.This may be a cause of sleep and motor disorders associated with PD.Overall,this work describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei.展开更多
We examine the profile of second harmonic generation(SHG)for GaAs/GaAlAs spherical quantum dots(QDs)of Woods-Saxon(WS)plus attractive inversely quadratic(AIQ)potential under the joint influence of additional factors(p...We examine the profile of second harmonic generation(SHG)for GaAs/GaAlAs spherical quantum dots(QDs)of Woods-Saxon(WS)plus attractive inversely quadratic(AIQ)potential under the joint influence of additional factors(pressure and temperature)and structural parameters(strengths and radius).The energies and wave functions in GaAs/GaAlAs spherical QDs under WS-AIQ limiting potential are calculated using the parametric Nikiforov-Uvarov(NU)method.Depending on the calculated energies and corresponding wave functions,the SHG coefficient is examined by the iterative procedure in the density matrix method for this system.Finally,the calculated results display that a strong SHG coefficient response,and red shift or blue shift energy can be acquired by adjusting parameters.展开更多
基金funded by the National Natural Science Foundation of China(Nos.L2224042,T2293731,62121003,61960206012,61973292,62171434,61975206,and 61971400)the Frontier Interdisciplinary Project of the Chinese Academy of Sciences(No.XK2022XXC003)+2 种基金the National Key Research and Development Program of China(Nos.2022YFC2402501 and 2022YFB3205602)the Major Program of Scientific and Technical Innovation 2030(No.2021ZD02016030)the Scientific Instrument Developing Project of he Chinese Academy of Sciences(No.GJJSTD20210004).The authors thank Yilin Song for her advice on grammar revisions and polishing.
文摘The subthalamic nucleus(STN)is considered the best target for deep brain stimulation treatments of Parkinson’s disease(PD).It is difficult to localize the STN due to its small size and deep location.Multichannel microelectrode arrays(MEAs)can rapidly and precisely locate the STN,which is important for precise stimulation.In this paper,16-channel MEAs modified with multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(MWCNT/PEDOT:PSS)nanocomposites were designed and fabricated,and the accurate and rapid identification of the STN in PD rats was performed using detection sites distributed at different brain depths.These results showed that nuclei in 6-hydroxydopamine hydrobromide(6-OHDA)-lesioned brains discharged more intensely than those in unlesioned brains.In addition,the MEA simultaneously acquired neural signals from both the STN and the upper or lower boundary nuclei of the STN.Moreover,higher values of spike firing rate,spike amplitude,local field potential(LFP)power,and beta oscillations were detected in the STN of the 6-OHDA-lesioned brain,and may therefore be biomarkers of STN localization.Compared with the STNs of unlesioned brains,the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta band of 6-OHDA-lesioned brains.This may be a cause of sleep and motor disorders associated with PD.Overall,this work describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei.
基金the National Natural Science Foundation of China(Grant Nos.51702003,61775087,11674312,52174161 and 12174161)the Provincial Foundation for Excellent Top Talents of Colleges and Universities of Anhui Province of China(Grant No.gxgwfx2019016)+1 种基金the Anhui Provincial Natural Science Foundation,China(Grant Nos.1808085ME130 and 1508085QF140)University Outstanding Young Talents Support Program Fund(Grant No.gxyqZ D2018039)。
文摘We examine the profile of second harmonic generation(SHG)for GaAs/GaAlAs spherical quantum dots(QDs)of Woods-Saxon(WS)plus attractive inversely quadratic(AIQ)potential under the joint influence of additional factors(pressure and temperature)and structural parameters(strengths and radius).The energies and wave functions in GaAs/GaAlAs spherical QDs under WS-AIQ limiting potential are calculated using the parametric Nikiforov-Uvarov(NU)method.Depending on the calculated energies and corresponding wave functions,the SHG coefficient is examined by the iterative procedure in the density matrix method for this system.Finally,the calculated results display that a strong SHG coefficient response,and red shift or blue shift energy can be acquired by adjusting parameters.