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绵羊FecB突变对BMPR1B活性及BMP/SMAD通路的影响研究进展 被引量:3
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作者 龚一鸣 王翔宇 +4 位作者 贺小云 刘玉芳 余平 储明星 狄冉 《遗传》 CAS CSCD 北大核心 2023年第4期295-305,共11页
BMPR1B是绵羊中被鉴定的第一个多羔主效基因,但该基因中FecB突变增加绵羊排卵数的分子机制尚未解析。近年来发现BMPR1B活性受小分子抑制蛋白FKBP1A调控,该蛋白充当了BMPR1B及BMP/SMAD通路活性控制开关的关键作用且FecB突变恰好位于FKBP1... BMPR1B是绵羊中被鉴定的第一个多羔主效基因,但该基因中FecB突变增加绵羊排卵数的分子机制尚未解析。近年来发现BMPR1B活性受小分子抑制蛋白FKBP1A调控,该蛋白充当了BMPR1B及BMP/SMAD通路活性控制开关的关键作用且FecB突变恰好位于FKBP1A与BMPR1B结合位点附近。本文首先总结了BMPR1B和FKBP1A的蛋白结构,阐明二者空间结合区域及FecB突变的位置,进而预测了FecB突变与二者结合强弱的关系,最终提出了FecB突变通过影响BMPR1B与FKBP1A结合强度改变BMP/SMAD通路活性的科学假设,为后续探明FecB突变影响绵羊排卵数的分子机制提供了新思路。 展开更多
关键词 绵羊 FecB突变 BMPR1B FKBP1A BMP/SMAD通路
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Composition and Construction of High-and Low-Energy Ooid Shoals and Their Relationships with Environmental Changes: A Case Study from the Cambrian Zhangxia Formation in the Ordos Basin, North China
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作者 Zhen Wang yiming gong 《Journal of Earth Science》 SCIE CAS CSCD 2023年第1期156-172,共17页
On the basis of systematic study of sedimentary facies, microfacies and geochemistry of measured strata sections and wells, the ooid shoals of the Cambrian Miaolingian Zhangxia Formation in the southern Ordos Basin ar... On the basis of systematic study of sedimentary facies, microfacies and geochemistry of measured strata sections and wells, the ooid shoals of the Cambrian Miaolingian Zhangxia Formation in the southern Ordos Basin are composed of both high-and low-energy ooid shoals. The characteristics of the high-energy shoals are sparry cementation, with moderate to well sorting, large grain size, high ooid content and low micrite, weak micritization, and well-preserved internal textures of the ooids. Macroscopically, the high-energy ooid shoals display a thick-bedded aggradational stacking pattern in upward coarsening and thickening sequences. The low-energy ooid shoals are mainly made up of micritic cementation, with moderate to poor sorting, relatively small grain size, lower ooid content and higher micrite, strong micritization, and poorly-preserved internal textures of the ooids. Macroscopically, the low-energy ooid shoals show a thin-bedded, interbedded stacking pattern in upward fining and thinning sequences. The sedimentological evidence and carbon isotope data show that the differences of internal fabric and sedimentary evolution of both high-and low-energy ooid shoals are closely related to the sea-level change. 展开更多
关键词 CAMBRIAN sedimentary model North China ooid shoals Ordos Basin Zhangxia Formation
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Abnormal changes of dynamic derivatives at low reduced frequencies 被引量:2
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作者 Weiwei ZHANG yiming gong Yilang LIU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2018年第7期1428-1436,共9页
A number of studies have found that abnormal changes of dynamic derivatives occurred at very low reduced frequencies, but its inducement mechanism is not very clear. This paper has researched the abnormal changes and ... A number of studies have found that abnormal changes of dynamic derivatives occurred at very low reduced frequencies, but its inducement mechanism is not very clear. This paper has researched the abnormal changes and analyzed the influence on some parameters by solving the unsteady flow around forced oscillation airfoils based on Navier-Stokes equations. Results indicate that when the reduced frequency approaches to zero, the dynamic derivatives obtained by the numerical method will diverge. We have also proven it in theory that this phenomenon is not physical but completely caused by numerical singularity. Furthermore, the abnormal phenomenon can be effectively mitigated by using the time spectral method to solve the aerodynamic forces and the integral method to obtain the dynamic derivatives. When the reduced frequency is in the range of 0.001–0.01, the dynamic derivative maintains nearly unchanged for the whole speed region. This study can provide a reference for the reasonable choice of the reduced frequency in calculations and experiments of dynamic derivatives. 展开更多
关键词 Dynamic derivatives Numerical diverge Reduced frequency Time spectral method Unsteady flow
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