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不同年龄段Ⅱ期和Ⅲ期结肠癌患者术后辅助治疗及预后分析
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作者 周启阳 张乐杨 +4 位作者 周雨迪 杨刚 叶一如 欧阳一鸣 周晓俊 《中华普通外科杂志》 CSCD 北大核心 2022年第12期890-895,共6页
目的比较不同年龄段Ⅱ期和Ⅲ期结肠癌患者术后辅助治疗情况及预后。方法回顾性分析2013年1月至2017年12月期间于苏州大学附属第一医院行结肠癌根治术770例患者的临床资料。根据发病年龄分为3组:青年组(18~49岁)112例,中年组(50~64岁)351... 目的比较不同年龄段Ⅱ期和Ⅲ期结肠癌患者术后辅助治疗情况及预后。方法回顾性分析2013年1月至2017年12月期间于苏州大学附属第一医院行结肠癌根治术770例患者的临床资料。根据发病年龄分为3组:青年组(18~49岁)112例,中年组(50~64岁)351例,老年组(65~75岁)307例。结果青年组患者表现为更少的合并症,并且相对于中老年组患者发生癌结节、脉管癌栓及神经侵犯的概率更低(12.5%比15.4%比14.3%;7.1%比9.4%比8.5%;2.7%比8.8%比5.5%),但病理类型为印戒细胞癌和黏液腺癌的概率更高(5.4%比1.4%比1.6%;14.3%比11.4%比13.4%),Ⅲ期结肠癌患者的占比更大(49.1%比45.0%比47.2%),更愿意接受术后化疗(83.9%比81.8%比60.3%)。在Ⅱ期和Ⅲ期结肠癌患者中,青年组和中年组患者接受术后全身化疗的可能性是老年组患者的3~4倍[OR=4.153(95%CI:1.964~8.785)、2.906(95%CI:1.845~4.579)、3.120(95%CI:1.310~7.429),3.588(95%CI:1.964~6.556)]。在接受化疗的患者中,青年组和中年组比老年组也更有可能接受多药方案[OR=2.050(95%CI:0.937~4.488)、2.750(95%CI:1.536~4.923)]。在仅接受手术治疗的患者中,不同年龄组患者生存率差异无统计学意义,但在接受手术联合辅助化疗的Ⅲ期患者中,青年组和中年组患者比老年组患者有更长的生存期[HR=0.284(95%CI:0.127~0.632)、0.521(95%CI:0.333~0.816)]。结论在Ⅱ期和Ⅲ期结肠癌患者中,青中年患者术后更倾向于接受辅助化疗,并使用更激进的化疗方案治疗。Ⅱ期青中年结肠癌患者存在过度使用化疗的状况,但是并未使其获得相匹配的生存获益。 展开更多
关键词 结肠肿瘤 辅助治疗 预后
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Biomass-derived nitrogen self-doped porous activation carbon as an effective bifunctional electrocatalysts 被引量:2
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作者 Yuanqing Sun yiming ouyang +6 位作者 Jiaqing Luo Huihui Cao Xiang Li Jingwen Ma Jian Liu Yuanhao Wang Lin Lu 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第1期92-98,共7页
The strategy of adopting cheap precursors or abundant resources,which can be obtained directly from nature,is a simple and excellent method of introducing accessible research into environmentally friendly development.... The strategy of adopting cheap precursors or abundant resources,which can be obtained directly from nature,is a simple and excellent method of introducing accessible research into environmentally friendly development.Moreover,this is also an urgent requirement for the sustainable development of green technology.Herein,we introduce a simplistic and expandable method to prepare metal-free biomassderived nitrogen self-doped porous activation carbon(N-PAC) with large specific surface area(S_(BET)=1300.58 m^(2)/g).Moreover,the manufactural electrocatalysts exhibit prominent oxygen reduction reaction(ORR) performance in all PH values.As compared with the commercial Pt/C catalyst,the N-PAC/800 with a positive onset potential at 10 mA/cm^(2)(0.93 V),half-wave potential(0.87 V),and limiting current(6.34 mA/cm^(2)) bring to light excellent catalytic stability,selectivity,and much-enhanced methanol tolerance.Furthermore,the prepared electrocatalysts possess considerable hydrogen evolution reaction(HER) performance with a less onset potential of 0.218 V(acidic medium) and0.271 V(alkaline medium) respectively,which can show similar catalytic activity across the whole pH range.Such bifunctional electrocatalyst,with excellent electrocatalytic properties,resource-rich,low cost,and environmental-friendly,hold a promising application in energy conversion and reserve. 展开更多
关键词 Biomass-derived High specific surface area Bifunctional electrocatalysts METAL-FREE Nitrogen-doped carbon
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Anti-Interference Low-Power Double-Edge Triggered Flip-Flop Based on C-Elements
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作者 Zhengfeng Huang Xiao Yang +4 位作者 Tai Song Haochen Qi yiming ouyang Tianming Ni Qi Xu 《Tsinghua Science and Technology》 SCIE EI CAS CSCD 2022年第1期1-12,共12页
When the input signal has been interfered and glitches occur,the power consumption of Double-Edge Triggered Flip-Flops(DETFFs)will significantly increase.To effectively reduce the power consumption,this paper presents... When the input signal has been interfered and glitches occur,the power consumption of Double-Edge Triggered Flip-Flops(DETFFs)will significantly increase.To effectively reduce the power consumption,this paper presents an anti-interference low-power DETFF based on C-elements.The improved C-element is used in this DETFF,which effectively blocks the glitches in the input signal,prevents redundant transitions inside the DETFF,and reduces the charge and discharge frequencies of the transistor.The C-element has also added pull-up and pull-down paths,reducing its latency.Compared with other existing DETFFs,the DETFF proposed in this paper only flips once on the clock edge,which greatly reduces the redundant transitions caused by glitches and effectively reduces power consumption.This paper uses HSPICE to simulate the proposed DETFF and other 10 DETFFs.The findings show that compared with the other 10 types of DETFFs,the proposed DETFF has achieved large performance indexes in the total power consumption,total power consumption with glitches,delays,and power delay product.A detailed analysis of variance indicates that the proposed DETFF features less sensitivity to process,voltage,temperature,and Negative Bias Temperature Instability(NBTI)-induced aging variations. 展开更多
关键词 Double-Edge Triggered Flip-Flop(DETFF) glitch LOW-POWER C-element
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Fault-Tolerant Design for Data Efficient Retransmission in WiNoC
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作者 yiming ouyang Qi Wang +2 位作者 Zhe Li Huaguo Liang Jianhua Li 《Tsinghua Science and Technology》 SCIE EI CAS CSCD 2021年第1期85-94,共10页
There is a sharp decline in the network performance when the wireless link fails as a data path in the Wireless Network-on-Chip(WiNoC).To counteract this problem,we propose a fault-tolerance mechanism for the efficien... There is a sharp decline in the network performance when the wireless link fails as a data path in the Wireless Network-on-Chip(WiNoC).To counteract this problem,we propose a fault-tolerance mechanism for the efficient retransmission of data in the WiNoC.When an error is detected in the data transmission process,this mechanism works to feed back the fault information to the source node in real time via fault signal lines.In the source node,the highest transmission priority is assigned to the backup retransmitted data,and the corresponding direct link is positioned to enable the data packet for its efficient retransmission to the destination node,thereby ensuring efficiency in fault tolerance.Additionally,we have improved the receiving port of the wireless router,added the corresponding redundant buffers and mux,and dynamically selected the retransmitted non-faulty data packets to be written to the local router in order to avoid the disorderly retransmission of the data packets.The evaluation results of this paper demonstrate that compared with the methods which are under different fault conditions,this fault-tolerant method drastically improves the data throughput rate,reduces the delay,effectively guarantees the reliability of the network,and improves the system performance. 展开更多
关键词 wireless network-on-chip RETRANSMISSION FAULT-TOLERANT RELIABILITY
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