By employing the Hirota’s bilinear method and different test functions, the breather solutions of HSI equation with different structures are obtained based on symbolic calculation with perturbation parameters. Some n...By employing the Hirota’s bilinear method and different test functions, the breather solutions of HSI equation with different structures are obtained based on symbolic calculation with perturbation parameters. Some new lump solitons are found in the process of studying the degradation behavior of breather solutions. The interaction between lump solution and soliton solution is constructed in the form of lump solution, and the motion trajectory of lump is obtained. In addition, the theorem of lump solitons and N-solitons superposition is given and proved. The superposition formula of lump is derived from the theorem, and its spatial evolution behavior is given.展开更多
In this paper, the evolutionary behavior of N-solitons for a (2 + 1)-dimensional Konopelchenko-Dubrovsky equations is studied by using the Hirota bilinear method and the long wave limit method. Based on the N-soliton ...In this paper, the evolutionary behavior of N-solitons for a (2 + 1)-dimensional Konopelchenko-Dubrovsky equations is studied by using the Hirota bilinear method and the long wave limit method. Based on the N-soliton solution, we first study the evolution from N-soliton to T-order (T=1,2) breather wave solutions via the paired-complexification of parameters, and then we get the N-order rational solutions, M-order (M=1,2) lump solutions, and the hybrid behavior between a variety of different types of solitons combined with the parameter limit technique and the paired-complexification of parameters. Meanwhile, we also provide a large number of three-dimensional figures in order to better show the degeneration of the N-soliton and the interaction behavior between different N-solitons.展开更多
目的探讨C臂CT引导下经皮三叉神经半月节球囊压迫术治疗三叉神经痛的应用价值。方法回顾性分析采用C臂CT(Xper-CT)引导下经皮三叉神经半月节球襄压迫术治疗三叉神经痛患者40例,所有患者均进行C臂CT程序扫描,并通过X-travision工作站进...目的探讨C臂CT引导下经皮三叉神经半月节球囊压迫术治疗三叉神经痛的应用价值。方法回顾性分析采用C臂CT(Xper-CT)引导下经皮三叉神经半月节球襄压迫术治疗三叉神经痛患者40例,所有患者均进行C臂CT程序扫描,并通过X-travision工作站进行颅骨后处理重建,引导穿刺针进入卵圆孔及球囊到位,确定球囊头端位于Meckel’s腔,充盈球囊。术后记录手术剂量面积乘积(dose area product,DAP)、空气比释动能(cumulative air kerma,CAK)、曝光时间(fluo time,FT),分析辐射剂量。结果40例患者均通过C臂CT后处理重建技术引导卵圆孔穿刺成功(其中小卵圆孔2例);40例患者中通过C臂CT后处理重建技术确定球囊一次性到位并获得满意梨形21例(52%),通过C臂CT后处理重建技术分析后多次调整球囊位置及方向,使球囊头端位于岩骨切迹,并获得满意梨形12例(30%),7例(18%)患者未获得满意梨形。术后40例患者疼痛完全消失17例(42%),疼痛满意缓解21例(53%);疼痛缓解不满意2例(5%);总有效率95%。术后伴面部麻木26例(65%),咀嚼肌无力9例(23%)。40例患者DAP、CAK、FT分别为(79.39±23.15)Gycm^(2)、(245.07±84.04)mGy、(5.20±1.30)min。结论C臂CT引导下经皮三叉神经半月节球囊压迫术直观准确显示穿刺针、卵圆孔、球囊、岩骨脊的三维结构及其相互位置关系,尤其对解剖变异或异常增生的显示更具优势。展开更多
Global prevalence of coronavirus disease 2019(COVID-19)calls for an urgent development of anti-viral regime.Compared with the development of new drugs,drug repurposing can significantly reduce the cost,time,and safety...Global prevalence of coronavirus disease 2019(COVID-19)calls for an urgent development of anti-viral regime.Compared with the development of new drugs,drug repurposing can significantly reduce the cost,time,and safety risks.Given the fact that coronavirus harnesses spike protein to invade host cells through angiotensinconverting enzyme 2(ACE2),hence we see if any previous anti-virtual compounds can block spike-ACE2 interaction and inhibit the virus entry.The results of molecular docking and molecular dynamic simulations revealed that remdesivir exhibits better than expected anti-viral invasion potential against COVID-19 among the three types of compounds including remdesivir,tenofovir and lopinavir.In addition,a positive correlation between the surface area occupied by remdesivir and anti-viral invasion potential was also found.As such,the structure of remdesivir was modified by linking an N-benzyl substituted diamidine derivative to its hydroxyl group through an ester bond.It was found that this compound has a higher anti-viral invasion potential and greater specificity.展开更多
文摘By employing the Hirota’s bilinear method and different test functions, the breather solutions of HSI equation with different structures are obtained based on symbolic calculation with perturbation parameters. Some new lump solitons are found in the process of studying the degradation behavior of breather solutions. The interaction between lump solution and soliton solution is constructed in the form of lump solution, and the motion trajectory of lump is obtained. In addition, the theorem of lump solitons and N-solitons superposition is given and proved. The superposition formula of lump is derived from the theorem, and its spatial evolution behavior is given.
文摘In this paper, the evolutionary behavior of N-solitons for a (2 + 1)-dimensional Konopelchenko-Dubrovsky equations is studied by using the Hirota bilinear method and the long wave limit method. Based on the N-soliton solution, we first study the evolution from N-soliton to T-order (T=1,2) breather wave solutions via the paired-complexification of parameters, and then we get the N-order rational solutions, M-order (M=1,2) lump solutions, and the hybrid behavior between a variety of different types of solitons combined with the parameter limit technique and the paired-complexification of parameters. Meanwhile, we also provide a large number of three-dimensional figures in order to better show the degeneration of the N-soliton and the interaction behavior between different N-solitons.
文摘目的探讨C臂CT引导下经皮三叉神经半月节球囊压迫术治疗三叉神经痛的应用价值。方法回顾性分析采用C臂CT(Xper-CT)引导下经皮三叉神经半月节球襄压迫术治疗三叉神经痛患者40例,所有患者均进行C臂CT程序扫描,并通过X-travision工作站进行颅骨后处理重建,引导穿刺针进入卵圆孔及球囊到位,确定球囊头端位于Meckel’s腔,充盈球囊。术后记录手术剂量面积乘积(dose area product,DAP)、空气比释动能(cumulative air kerma,CAK)、曝光时间(fluo time,FT),分析辐射剂量。结果40例患者均通过C臂CT后处理重建技术引导卵圆孔穿刺成功(其中小卵圆孔2例);40例患者中通过C臂CT后处理重建技术确定球囊一次性到位并获得满意梨形21例(52%),通过C臂CT后处理重建技术分析后多次调整球囊位置及方向,使球囊头端位于岩骨切迹,并获得满意梨形12例(30%),7例(18%)患者未获得满意梨形。术后40例患者疼痛完全消失17例(42%),疼痛满意缓解21例(53%);疼痛缓解不满意2例(5%);总有效率95%。术后伴面部麻木26例(65%),咀嚼肌无力9例(23%)。40例患者DAP、CAK、FT分别为(79.39±23.15)Gycm^(2)、(245.07±84.04)mGy、(5.20±1.30)min。结论C臂CT引导下经皮三叉神经半月节球囊压迫术直观准确显示穿刺针、卵圆孔、球囊、岩骨脊的三维结构及其相互位置关系,尤其对解剖变异或异常增生的显示更具优势。
文摘Global prevalence of coronavirus disease 2019(COVID-19)calls for an urgent development of anti-viral regime.Compared with the development of new drugs,drug repurposing can significantly reduce the cost,time,and safety risks.Given the fact that coronavirus harnesses spike protein to invade host cells through angiotensinconverting enzyme 2(ACE2),hence we see if any previous anti-virtual compounds can block spike-ACE2 interaction and inhibit the virus entry.The results of molecular docking and molecular dynamic simulations revealed that remdesivir exhibits better than expected anti-viral invasion potential against COVID-19 among the three types of compounds including remdesivir,tenofovir and lopinavir.In addition,a positive correlation between the surface area occupied by remdesivir and anti-viral invasion potential was also found.As such,the structure of remdesivir was modified by linking an N-benzyl substituted diamidine derivative to its hydroxyl group through an ester bond.It was found that this compound has a higher anti-viral invasion potential and greater specificity.
