Geometry and formation mechanism of tension gashes and their implication on the hydrocarbon accumulation in the deep-seated strata of sedimentary basin:A case from Shunnan area of Tarim Basin

With the theoretical and technological developments related to cratonic strike-slip faults,the Shuntuoguole Low Uplift in the Tarim Basin has attracted considerable attention recently.Affected by multi-stage tectonic movements,the strike-slip faults have controlled the distribution of hydrocarbon resources owing to the special fault characteristics and fault-related structures.In contrast,the kinematics and formation mechanism of strike-slip faults in buried sedimentary basins are difficult to investigate,limiting the discussion of these faults and hydrocarbon accumulation.In this study,we identified the characteristics of massive sigmoidal tension gashes(STGs)that formed in the Shunnan area of the Tarim Basin.High-resolution three-dimensional seismic data and attribute analyses were used to investigate their geometric and kinematic characteristics.Then,the stress state of each point of the STGs was calculated using seismic curvature attributes.Finally,the formation mechanism of the STGs and their roles in controlling hydrocarbon migration and accumulation were discussed.The results suggest that:(1)the STGs developed in the Shunnan area have a wide distribution,with a tensile fault arranged in an enéchelon pattern,showing an S-shaped bending.These STGs formed in multiple stages,and differential rotation occurred along the direction of strike-slip stress during formation.(2)Near the principal displacement zone of the strike-slip faults,the stress value of the STGs was higher,gradually decreasing at both ends.The shallow layer deformation was greater than the deep layer deformation.(3)STGs are critical for connecting source rocks,migrating oil and gas,sealing horizontally,and developing efficient reservoirs.This study not only provides seismic evidence for the formation and evolution of super large STGs,but also provides certain guidance for oil and gas exploration in this area.

Stability and variability of molecular subtypes:comparative analysis of primary and metastatic triple-negative breast cancer

Objective:Triple-negative breast cancer(TNBC)is a heterogeneous and aggressive cancer.Although our previous study classified primary TNBC into four subtypes,comprehensive longitudinal investigations are lacking.Methods:We assembled a large-scale,real-world cohort comprised of 880 TNBC patients[465 early-stage TNBC(eTNBC)and 415 metastatic TNBC(mTNBC)patients]who were treated at Fudan University Shanghai Cancer Center.The longitudinal dynamics of TNBC subtypes during disease progression were elucidated in this patient cohort.Comprehensive analysis was performed to compare primary and metastatic lesions within specific TNBC subtypes.Results:The recurrence and metastasis rates within 3 years after initial diagnosis in the eTNBC cohort were 10.1%(47/465).The median overall survival(OS)in the mTNBC cohort was 27.2 months[95%confidence interval(CI),24.4–30.2 months],which indicated a poor prognosis.The prognostic significance of the original molecular subtypes in both eTNBC and mTNBC patients was confirmed.Consistent molecular subtypes were maintained in 77.5%of the patients throughout disease progression with the mesenchymal-like(MES)subtype demonstrating a tendency for subtype transition and brain metastasis.Additionally,a precision treatment strategy based on the metastatic MES subtype of target lesions resulted in improved progression-free survival in the FUTURE trial.Conclusions:Our longitudinal study comprehensively revealed the clinical characteristics and survival of patients with the original TNBC subtypes and validated the consistency of most molecular subtypes throughout disease progression.However,we emphasize the major importance of repeat pathologic confirmation of the MES subtype.

The Anti-Penetration Performance and Mechanism of Metal Materials:A Review

This article reviews the anti-penetration principles and strengthening mechanisms of metal materials,ranging from macroscopic failure modes to microscopic structural characteristics,and further summarizes the micro-macro correlation in the anti-penetration process.Finally,it outlines the constitutive models and numerical simulation studies utilized in the field of impact and penetration.From the macro perspective,nine frequent penetration failure modes of metal materials are summarized,with a focus on the analysis of the cratering,compression shear,penetration,and plugging stages of the penetration process.The reasons for the formation of adiabatic shear bands(ASBs)in metal materials with different crystal structures are elaborated,and the formation mechanism of the equiaxed grains in the ASB is explored.Both the strength and the toughness of metal materials are related to the materials’crystal structures and microstructures.The toughness is mainly influenced by the deformation mechanism,while the strength is explained by the strengthening mechanism.Therefore,the mechanical properties of metal materials depend on their microstructures,which are subject to the manufacturing process and material composition.Regarding numerical simulation,the advantages and disadvantages of different constitutive models and simulation methods are summarized based on the application characteristics of metal materials in high-speed penetration practice.In summary,this article provides a systematic overview of the macroscopic and microscopic characteristics of metal materials,along with their mechanisms and correlation during the anti-penetration and impact-resistance processes,thereby making an important contribution to the scientific understanding of anti-penetration performance and its optimization in metal materials.

Microscopic growth mechanism and edge states of monolayer 1T'-MoTe_(2)

Transition metal ditellurides(TMTDs)have versatile physical properties,including non-trivial topology,Weyl semimetal states and unique spin texture.Controlled growth of high-quality and large-scale monolayer TMTDs with preferred crystal phases is crucial for their applications.Here,we demonstrate the epitaxial growth of 1T'-MoTe_(2) on Au(111)and graphitized silicon carbide(Gr/SiC)by molecular beam epitaxy(MBE).We investigate the morphology of the grown1T'-MoTe_(2) at the atomic level by scanning tunnelling microscopy(STM)and reveal the corresponding microscopic growth mechanism.It is found that the unique ordered Te structures preferentially deposited on Au(111)regulate the growth of monolayer single crystal 1T'-MoTe_(2),while the Mo clusters were preferentially deposited on the Gr/SiC substrate,which impedes the ordered growth of monolayer MoTe_(2).We confirm that the size of single crystal 1T'-MoTe_(2) grown on Au(111)is nearly two orders of magnitude larger than that on Gr/SiC.By scanning tunnelling spectroscopy(STS),we observe that the STS spectrum of the monolayer 1T'-MoTe_(2) nano-island at the edge is different from that at the interior,which exhibits enhanced conductivity.

Fracturing timing of Jurassic reservoirs in the Dibei-Tuziluoke gas field,Kuqa foreland basin:Evidence from petrography,fluid inclusions,and clumped isotopes

Determining the timing of fracturing is crucial for understanding reservoir evolution and hydrocarbon accumulation in foreland basins.Using fracturing data from cores,borehole images,and outcrops,combined with the clumped isotope(D47)and fluid inclusion analyses of carbonate minerals filled in pores and fractures,this study ascertained the fracturing timing of the Jurassic reservoirs in the Dibei-Tuziluoke Gas Field,Kuqa Foreland Basin.Data from outcrops and borehole images show two dominant fracture sets in the study area:W-E and NE-SW striking fractures.Some W-E striking fractures are carbonate-filled,while NE-SW striking fractures lack mineral fillings.Bitumen veins,not easy to be identified in borehole images,are prevalent in cores.The petrographic analysis reveals that these bitumen veins formed before the calcite cementation in pores and display high viscosity and low maturity.Homogenization temperatures(T_(h))from primary fluid inclusion assemblages in two representative calcite vein samples were notably lower than T_(△47) values from corresponding samples.This suggests the △_(47) signature underwent alteration due to partial reordering during burial.Thus,△_(47)-derived temperatures(apparent temperatures)may not faithfully represent the mineral precipitation temperatures.When plotting these apparent temperatures vs.the burial history,only the possible latest ages of fracturing emerged.These ages were further refined by considering petroleum charging,tectonic evolution,and stress orientation.Bitumen-filled fractures likely resulted from the Late Cretaceous uplift,marking the migration of low-maturity hydrocarbons in the study area.Carbonate-filled E-W striking fractures emerged during the late Miocene(~13-6.5 Ma)alongside fold development.NE-striking fractures that crosscut W-E ones possibly formed recently due to stress reorientation.

Research status and hotspots of tight junctions and colorectal cancer:A bibliometric and visualization analysis

BACKGROUND Colorectal cancer(CRC)is the third most common cancer worldwide and the second leading cause of cancer-related death.Over the past two decades,numerous researchers have provided important evidence regarding the role of tight junction(TJ)proteins in the occurrence and progression of CRC.The causal relationship between the presence of specific TJ proteins and the development of CRC has also been confirmed.Despite the large number of publications in this field,a bibliometric study to review the current state of research and highlight the research trends and hotspots in this field has not yet been performed.AIM To analyze research on TJs and CRC,summarize the field’s history and current status,and predict future research directions.METHODS We searched the Science Citation Index Expanded database for all literature on CRC and TJs from 2001-2023.We used bibliometrics to analyze the data of these papers,such as the authors,countries,institutions,and references.Co-authorship,co-citation,and co-occurrence analyses were the main methods of analysis.CiteSpace and VOSviewer were used to visualize the results.RESULTS A total of 205 studies were ultimately identified.The number of publications on this topic has steadily increased since 2007.China and the United States have made the largest contributions to this field.Anticancer Research was the most prolific journal,publishing 8 articles,while the journal Oncogene had the highest average citation rate(68.33).Professor Dhawan P was the most prolific and cited author in this field.Co-occurrence analysis of keywords revealed that“tight junction protein expression”,“colorectal cancer”,“intestinal microbiota”,and“inflammatory bowel disease”had the highest frequency of occurrence,revealing the research hotspots and trends in this field.CONCLUSION This bibliometric analysis evaluated the scope and trends of TJ proteins in CRC,providing valuable research perspectives and future directions for studying the connection between the two.It is recommended to focus on emerging research hotspots,such as the correlations among intestinal microbiota,inflammatory bowel disease,TJ protein expression,and CRC.

DADOS:A Cloud-based Data-driven Design Optimization System

This paper presents a cloud-based data-driven design optimization system,named DADOS,to help engineers and researchers improve a design or product easily and efficiently.DADOS has nearly 30 key algorithms,including the design of experiments,surrogate models,model validation and selection,prediction,optimization,and sensitivity analysis.Moreover,it also includes an exclusive ensemble surrogate modeling technique,the extended hybrid adaptive function,which can make use of the advantages of each surrogate and eliminate the effort of selecting the appropriate individual surrogate.To improve ease of use,DADOS provides a user-friendly graphical user interface and employed flow-based programming so that users can conduct design optimization just by dragging,dropping,and connecting algorithm blocks into a workflow instead of writing massive code.In addition,DADOS allows users to visualize the results to gain more insights into the design problems,allows multi-person collaborating on a project at the same time,and supports multi-disciplinary optimization.This paper also details the architecture and the user interface of DADOS.Two examples were employed to demonstrate how to use DADOS to conduct data-driven design optimization.Since DADOS is a cloud-based system,anyone can access DADOS at www.dados.com.cn using their web browser without the need for installation or powerful hardware.

基于改进YOLOv5的小目标烟雾检测算法

为解决火灾中的小目标烟雾检测精度不高的问题,提出一种基于改进YOLOv5的小目标烟雾检测算法。首先,将特征融合注意力(FFA)模块引入至主干网络中,使模型专注于小目标烟雾特征信息的提取;其次,通过采用多尺度金字塔解耦头(MPDH)模块替换卷积层模块,以改进YOLOv5算法中预测头层的检测部分,用于提升小目标烟雾的定位精度;最后,在专有数据集上进行试验验证与分析。结果表明:基于改进的YOLOv5小目标烟雾检测算法在目标检测精度上达到85.4%,在准确率、召回率方面,相较于原始算法分别提高了3.2%、6.3%。

Assessment of the Mechanical Properties of Carbon-Fiber Heating Cables in Snow and Ice Melting Applications

The use of carbon-fiber heating cables(CFHC)to achieve effective melting of snow and ice deposited on roads is a method used worldwide.In this study,tensile and compressive tests have been conducted to analyze the mechan-ical properties of the CFHC and assess whether the maximum tensile and compressive strengths can meet the pavement design specifications.In order to study the aging produced by multiple cycles of heating and cooling,in particular,the CFHC was repeatedly heated in a cold chamber with an ambient temperature ranging between-20℃ and+40℃.Moreover,to evaluate how the strength of the pavement is affected by its presence,the CFHC was embedded at different depths and concrete blocks with different curing ages were subjected to relevant com-pression and splitting tensile tests.Numerical simulations based on the ANSYS software have also been performed and compared with the outcomes of the static loading tests.The results show that the CFHC embedded in the concrete does not affect the compressive splitting tensile strengths of the pavement.Overall,the CFHC meets the conditions required for continued use in road ice melting applications.

化学实验室安全教育虚拟仿真实验教学设计与探索

高校化学实验室事故种类繁多,已引起了社会的广泛关注,对学生的安全教育刻不容缓。利用三维可视化、网络通信、多媒体、人机交互等技术,构建了化学实验室安全教育虚拟仿真教学系统。该系统把化学实验室(无机化学实验室、有机化学实验室、分析化学实验室、物理化学实验室)涉及到的“典型事故案例”“隐患排查”“事故急救与逃生”等内容制作成可交互的虚拟仿真实验,为学生提供了高度仿真的虚拟实验环境,使学生“身临其境”学习如何解决火灾、药品灼伤、气瓶泄漏、触电等安全事故。这种虚实结合的教学方式,增强了学生的学习兴趣,避免了演练实操的不安全和高成本问题,提高了学生的安全技能和解决问题的能力,达到了安全教育的目的,推进了三全育人的教育方针。

透皮给药实心微针阵列的紫外压印工艺方法

文中提出了一种紫外压印技术成型透皮给药实心微针的工艺方法,以C-coating光刻胶作为微针成型的原材料,采用微机电技术加工的聚二甲基硅氧烷(PDMS)微针模具,探究了紫外压印实验中影响微针成型质量的工艺条件。实验结果表明,利用C-coating光刻胶抽真空12 min以上,紫外曝光170~200 s时,制备的紫外压印微针的高度能达到230μm。通过纳米压痕力学测试和猪皮离体皮肤穿刺实验,证明这种紫外压印微针的针尖在承受50 mN的力时没有发生断裂破坏现象,并且能够顺利刺入猪皮达到良好的透皮给药效果,为紫外压印技术成型透皮给药微针提供了一定的技术参考。

γ干扰素释放试验联合IL-6检测对活动性肺结核的诊断价值

目的探讨γ-干扰素释放试验(IGRA)联合白细胞介素-6(IL-6)检测对活动性肺结核的诊断价值。方法选取2018年6月-2019年6月同济大学附属上海市肺科医院收治的700例结核病患者作为研究对象,其中包含活动性肺结核患者587例(A组)和非活动性肺结核患者113例(B组),另取同期该院体检的100例健康人群作为对照组。比较3组IGRA阳性率及血清IL-6水平。采用ROC曲线评价IGRA、IL-6对活动性肺结核的诊断效能。结果3组血清IL-6水平及IGRA阳性率比较,差异有统计学意义(P<0.05),A组高于B组及对照组(P<0.05),且B组高于对照组(P<0.05)。通过ROC曲线分析,IGRA诊断活动性肺结核的敏感性、特异性分别为80.92%(95%CI:77.74,158.66)和70.80%(95%CI:62.41,133.21)。IL-6≥20.24 ng/L时,其敏感性、特异性分别为74.79%(95%CI:71.27,146.06)和83.19%(95%CI:76.29,159.48);两者联合诊断的敏感性、特异性分别为84.33%(95%CI:81.39,165.71)和85.84%(95%CI:79.41,165.25)。结论IGRA、IL-6对活动性肺结核具有较高的诊断价值,且两者联合的敏感性、特异性更高,可用于临床中活动性肺结核的辅助诊断。

双馈电源接入对变压器差动保护的影响机理分析

变压器是电网的重要组成部分,其正常运行对电网安全运行极为重要。然而双馈风电机组异于传统同步发电机的故障电流特性,将可能影响变压器差动保护性能。首先,考虑双馈风电感应机组低电压穿越运行的影响,分析了双馈风电感应机组的短路电流特征。其次,分析双馈风电感应机组接入对变压器差动保护的影响。最后,通过仿真案例对研究结论的正确性进行了验证。为双馈感应发电机组接入后的电网继电保护配置提供参考。

术前弥散张量成像重建联合术中面听神经电生理监测对听神经瘤术后面神经保护作用的研究

目的探究术前弥散张量成像(DTI)重建联合术中面听神经电生理监测对听神经瘤术后面神经的保护作用。方法收集2016年7月—2021年10月南京医科大学附属苏州医院收治的82例听神经瘤患者的病历资料进行回顾性分析,根据治疗方案将其分为对照组和研究组,每组41例。对照组术前采用磁共振成像(MRI)平扫及增强扫描;研究组在对照组基础上联合DTI面神经重建。比较两组患者肿瘤和面神经空间位置、面神经走行判定准确率、手术时间、术中出血量及手术切除情况,记录两组患者术后并发症发生情况。术后3个月随访,比较两组患者的面神经功能及患侧术后听力水平。结果两组患者肿瘤和面神经空间位置比较,差异无统计学意义(P>0.05)。两组患者术前面神经走行判定准确率比较,差异有统计学意义(P<0.05),研究组高于对照组。两组患者术中出血量、手术时间比较,差异有统计学意义(P<0.05),研究组出血量少于对照组,手术时间短于对照组,两组患者手术切除情况比较,差异无统计学意义(P>0.05)。术前两组患者面神经功能等级比较,差异无统计学意义(P>0.05),术后研究组面神经功能优于对照组(P<0.05)。两组患者术前和术后听力水平比较,差异无统计学意义(P>0.05)。两组患者术后并发症发生率比较,差异无统计学意义(P<0.05)。结论术前DTI重建联合术中面听神经电生理监测应用于听神经瘤切除术,有助于提高术前对面神经定位的精准度,减少术中出血量,缩短手术时间,降低面神经功能损伤风险。

visual bone marrow mesenchymal stem cell transplantation in the repair of spinal cord injury

An important factor in improving functional recovery from spinal cord injury using stem cells is maximizing the number of transplanted cells at the lesion site. Here, we established a contusion model of spinal cord injury by dropping a weight onto the spinal cord at T7_8. Superparamagnet- ic iron oxide-labeled bone marrow mesenchymal stem cells were transplanted into the injured spinal cord via the subarachnoid space. An outer magnetic field was used to successfully guide the labeled cells to the lesion site. Prussian blue staining showed that more bone marrow mesen- chymal stem cells reached the lesion site in these rats than in those without magnetic guidance or snperparamagnetic iron oxide labeling, and immunofluorescence revealed a greater number of complete axons at the lesion site. Moreover, the Basso, Beattie and Bresnahan （BBB） locomotor rating scale scores were the highest in rats with superparamagnetic labeling and magnetic guid- ance. Our data confirm that superparamagnetic iron oxide nanoparticles effectively label bone marrow mesenchymal stem cells and impart sufficient magnetism to respond to the external magnetic field guides. More importantly, superparamagnetic iron oxide-labeled bone marrow mesenchymal stem cells can be dynamically and non-invasively tracked in vivo using magnetic resonance imaging. Superparamagnetic iron oxide labeling of bone marrow mesenchymal stem cells coupled with magnetic guidance offers a promising avenue for the clinical treatment of spinal cord injury.

Modifed Multifdelity Surrogate Model Based on Radial Basis Function with Adaptive Scale Factor

Multifdelity surrogates(MFSs)replace computationally intensive models by synergistically combining information from diferent fdelity data with a signifcant improvement in modeling efciency.In this paper,a modifed MFS(MMFS)model based on a radial basis function(RBF)is proposed,in which two fdelities of information can be analyzed by adaptively obtaining the scale factor.In the MMFS,an RBF was employed to establish the low-fdelity model.The correlation matrix of the high-fdelity samples and corresponding low-fdelity responses were integrated into an expansion matrix to determine the scaling function parameters.The shape parameters of the basis function were optimized by minimizing the leave-one-out cross-validation error of the high-fdelity sample points.The performance of the MMFS was compared with those of other MFS models(MFS-RBF and cooperative RBF)and single-fdelity RBF using four benchmark test functions,by which the impacts of diferent high-fdelity sample sizes on the prediction accuracy were also analyzed.The sensitivity of the MMFS model to the randomness of the design of experiments(DoE)was investigated by repeating sampling plans with 20 diferent DoEs.Stress analysis of the steel plate is presented to highlight the prediction ability of the proposed MMFS model.This research proposes a new multifdelity modeling method that can fully use two fdelity sample sets,rapidly calculate model parameters,and exhibit good prediction accuracy and robustness.

Distributed hydrological models for addressing effects of spatial variability of roughness on overland flow

In this study, we investigated the origin of the overland flow roughness problem and divided the current overland flow roughness research into three types, as follows: the first type of research takes into account the effects of roughness on the volume and velocity of surface runoff, flood peaks, and the scouring capability of flows, but has not addressed the spatial variability of roughness in detail; the second type of research considers that surface roughness varies spatially with different land usage types, land-cover conditions, and different tillage forms, but lacks a quantitative study of the spatial variability; and the third type of research simply deals with the spatial variability of roughness in each grid cell or land type. We present three shortcomings of the current overland flow roughness research, including(1) the neglect of roughness in distributed hydrological models when simulating the overland flow direction and distribution,(2) the lack of consideration of spatial variability of roughness in hydrological models, and(3) the failure to distinguish the roughness formulas in different overland flow regimes. To solve these problems,distributed hydrological model research should focus on four aspects in regard to overland flow: velocity field observations, flow regime mechanisms, a basic roughness theory, and scale problems.

SMILE手术中角膜切削厚度精确性的研究

目的:评估不同程度近视患者SMILE术前预估角膜切削厚度与术后实际角膜切削厚度的差异,探究SMILE术中角膜基质切削厚度的精确性。方法:前瞻性研究。收集2017-01/2019-08在我院行SMILE手术的近视患者143例234眼,根据术前等效球镜度分为低(-0.50^-3.00D,78眼)、中(>-3.00^-6.00D,78眼)、高(>-6.00D,78眼)度近视组,观察三组患者手术前后视力和等效球镜度,并分别于术前和术后1mo采用Pentacam眼前节综合分析系统测量中央角膜厚度,比较术前预估角膜切削厚度与术后1mo实际切削厚度的差异,探讨SMILE术中不同屈光状态角膜基质切削厚度的精确性。结果:术后1mo,所有患眼裸眼视力均达0.8以上,98.3%患眼裸眼视力达1.0以上。所有患者术后1mo角膜平均实际切削厚度低于平均预估切削厚度(84.92±23.15μm vs 100.07±26.83μm,P<0.01),平均切削差异值为15.15±10.34μm。低、中、高度近视组患者角膜实际切削厚度均低于各组预估角膜切削厚度(P<0.01),切削差异值分别为8.81±7.78、15.59±9.27、21.05±10.03μm。术前,本研究纳入患者平均等效球镜度为-4.85±2.15D,术前等效球镜度与切削差异值之间具有直线回归关系(Y=-2.2495X+3.9287,R^2=0.1589),等效球镜度数越大,切削差异值越大(t=-6.620,P<0.001)。结论:SMILE手术的角膜基质实际切削厚度低于预估切削厚度,且近视度数越高,切削差异越大,但术后屈光矫正效果理想,术中角膜切削厚度的差异并不影响屈光矫正手术的精确性。

Lactobacillus levels and prognosis of patients with acute myocardial infarction

OBJECTIVE To explore the relationship between Lactobacillus and prognosis of acute myocardial infarction(AMI)patients treated by percutaneous coronary intervention(PCI)and its correlation with clinical parameters.METHODS Consecutive patients with AMI in the coronary care unit of Tianjin Chest Hospital in China who received emergency PCI between July 2017 and December 2018 were enrolled.Subjects’fecal 16 S r DNA gene sequencing data were analyzed and subjects were categorized into low,medium and high level groups according to stool Lactobacillus measurements.The primary endpoints were major adverse cardiac events.Cox regression analysis was used to analyze the relationship between Lactobacillus and prognosis.Spearman correlation analysis and trend tests were used to assess the relationship between Lactobacillus and the clinical indicators.RESULTS The data of 254 patients were included in the analysis.Mean age was 65.90±11.56 years,and 152 patients(59.84%)were male.Follow-up time was 652(548.25-753.00)days.Multivariate Cox regression analysis showed a significantly lower risk of major adverse cardiac events in patients with Lactobacillus>7.1 copies/g[adjusted hazard ratio(HR)=0.216,95%CI:0.094-0.493,P<0.001]compared to patients with Lactobacillus≤3.6 copies/g.Statistically significant differences were shown in ST-segment elevation myocardial infarction(STEMI)(HR=0.217,95%CI:0.085-0.551,P=0.001).Lactobacillus was a protective factor for male smokers aged over 60 years whose brain natriuretic peptide was over 1,000 pg/m L.Spearman correlation analysis showed that Lactobacillus correlated negatively with white blood cells,neutrophils,high-sensitivity C-reactive protein,Troponin T,creatine kinase,creatine kinase-MB and brain natriuretic peptide(downward trend),and correlated positively with left ventricular ejection fraction(upward trend).CONCLUSIONS This study is the first to reveal the correlation between Lactobacillus and inflammation and myocardial damage after STEMI.STEMI patients,especially male smokers aged over 60 years with severe impairment of cardiac function,have better outcomes with high levels of Lactobacillus,suggesting new therapeutic strategies for improving the prognosis and quality of life of AMI patients.

Incidence of pocket hematoma after electrophysiological device placement：dual antiplatelet therapy versus low-molecular-weight heparin regimen

Background Given the increasing number of patients who require dual antiplatelet （DAP） therapy and electrophysiological device （EPD） placement, perioperative antiplatelet management is a current challenge. In this study, we investigated the incidence of pocket hema-toma formation after EPD placement in patients undergoing DAP therapy or an alternative low-molecular-weight heparin （LMWH） regimen. Methods This clinical observational study was performed from July 2010 to July 2012. In total, 171 patients were enrolled in the analysis after meeting the inclusion criteria. These patients were divided into two groups： 86 patients were treated with DAP therapy at the time of device implantation, and the DAP therapy was discontinued for 5 to 7 days and replaced with enoxaparin before device implantation in the other 85 patients. Adenosine phosphate （ADP）-mediated platelet aggregation and arachidonic acid-induced platelet aggregation were tested preoperatively. We compared the incidence of pocket hematoma between the two groups and the association of pocket hematoma develop-ment with ADP-mediated platelet aggregation and arachidonic acid-induced platelet aggregation.Results The incidence of pocket hema-toma in the patients who continued DAP was lower than that in the patients who replaced the dual antiplatelet regimen with LMWH （3.49%vs. 16.47%, respectively;X2 = 6.66,P 〈 0.01）. Among the patients who continued DAP therapies, the rate of ADP-mediated platelet aggre-gation inhibition in patients with pocket hematomas was higher than that in patients without pocket hematomas. None of the patients under-going DAP or enoxaparin therapy developed pocket infection, thromboembolic events, or other serious complications. Multiple logistic re-gression analysis revealed that LMWH therapy was an independent risk factor for the development of pocket hematoma （RR = 0.054, 95%CI = 0.012-0.251）. Furthermore, patients undergoing LMWH therapy were 5.1-fold more likely to develop pocket hematomas than were DAP-treated individuals.Conclusion Continuance of DAP therapy does not increase the risk of pocket hematoma formation after EPD placement.