A series of novel dinucleosides linked by s-triazine were synthesized via the nucleophilic substitution reaction of amino nucleoside and cyanuric chloride in THF/H20. The biological activities of these novel dinucleos...A series of novel dinucleosides linked by s-triazine were synthesized via the nucleophilic substitution reaction of amino nucleoside and cyanuric chloride in THF/H20. The biological activities of these novel dinucleoside analogs against HIV-RT, HeLa and A-549 cell lines in vitro were evaluated.展开更多
基金Projected supported by the National Basic Research 973 Pre-research Program of China （No. 2010CB534913）, the National Natural Science Foundations of China （NSFC） （Nos. 20672027 and 20972039）, the Natural Science Foundations of Hebei Province （No. B2008000588） and the program of Science and Technology （S ＆ T） of Hebei Province （No. 09276418D-13）.
文摘A series of novel dinucleosides linked by s-triazine were synthesized via the nucleophilic substitution reaction of amino nucleoside and cyanuric chloride in THF/H20. The biological activities of these novel dinucleoside analogs against HIV-RT, HeLa and A-549 cell lines in vitro were evaluated.
