Telomerase is a special reverse transcriptase,which adds telomeric DNA repeats to the ends of chromosome to offset loss.A vast majority of cancer cells have been shown that their telomerase was up-regulated and sustai...Telomerase is a special reverse transcriptase,which adds telomeric DNA repeats to the ends of chromosome to offset loss.A vast majority of cancer cells have been shown that their telomerase was up-regulated and sustain proliferation and growth.Hepatocellular carcinoma(HCC)is one of the most commonly occurring cancers worldwide.It is also one of the leading causes of cancer death,and is connected with abnormal telomerase function.However,reports about the telomerase mutations and HCC are still insufficient.In this review,the structure and mechanism of action of telomerase,inherited disorders caused by its mutations,hepatocarcinoma,and drug development targeting telomerase are reviewed.However,further investigations are needed to elucidate human telomerase RNA gene regulation for initiation and progression of the liver cancer.展开更多
文摘Telomerase is a special reverse transcriptase,which adds telomeric DNA repeats to the ends of chromosome to offset loss.A vast majority of cancer cells have been shown that their telomerase was up-regulated and sustain proliferation and growth.Hepatocellular carcinoma(HCC)is one of the most commonly occurring cancers worldwide.It is also one of the leading causes of cancer death,and is connected with abnormal telomerase function.However,reports about the telomerase mutations and HCC are still insufficient.In this review,the structure and mechanism of action of telomerase,inherited disorders caused by its mutations,hepatocarcinoma,and drug development targeting telomerase are reviewed.However,further investigations are needed to elucidate human telomerase RNA gene regulation for initiation and progression of the liver cancer.
