We report on a chalcogenide glass fiber doped with Pr^(3+) that can be used for commercialized 1.5-μm and 2-μm laser excitations by emitting broadband 3 μm–5.5 μm fluorescence, which is extruded into a preform an...We report on a chalcogenide glass fiber doped with Pr^(3+) that can be used for commercialized 1.5-μm and 2-μm laser excitations by emitting broadband 3 μm–5.5 μm fluorescence, which is extruded into a preform and then drawn into a step-index fiber. The spectroscopic properties of the fiber and glass are reported, and the mid-infrared fiber lasers are also numerically investigated. Cascade lasing is employed to increase the inversion population of the upper laser level. The particle swarm approach is applied to optimize the fiber laser parameters. The output power can reach 1.28 W at 4.89-μm wavelength, with a pump power of 5 W, excitation wavelength at 2.04 μm, Pr^(3+) ion concentration at 4.22 × 10^(25) ions/m^3,fiber length at 0.94 m, and fiber background loss at 3 dB/m.展开更多
The self-assembled nanomaterials based on peptides,which have not only good biocompatibility and low toxicity but also high stability and performance,are increasingly becoming an important way for cancer treatment.In ...The self-assembled nanomaterials based on peptides,which have not only good biocompatibility and low toxicity but also high stability and performance,are increasingly becoming an important way for cancer treatment.In this review,we highlight the progress of in vivo self-assembled polymer-peptide conjugates(PPCs)and their application,showing the recent advances in the development of“in vivo self-assembly”strategy for cancer treatment.Given the diverse microenvironments of tumor cells,different responsive assembly strategies(enzyme,pH,redox,temperature,etc.)have been developed to precisely control the assembly at different biological levels,realizing enhanced drug delivery and improved anticancer efficacy.展开更多
基金Project supported by the Young Scientists Fund of the National Natural Science Foundation of China(Grant No.61605095)the Natural Science Foundation of Zhejiang Province,China(Grant No.LY19F050004)+2 种基金the Natural Science Foundation of Ningbo City(Grant No.2015A610038)the Open Fund of the Guangdong Engineering Technology Research and Development Center of Special Optical Fiber Materials and Devices(South China University of Technology)(Grant No.2016-4)the K C Wong Magna Fund at Ningbo University
文摘We report on a chalcogenide glass fiber doped with Pr^(3+) that can be used for commercialized 1.5-μm and 2-μm laser excitations by emitting broadband 3 μm–5.5 μm fluorescence, which is extruded into a preform and then drawn into a step-index fiber. The spectroscopic properties of the fiber and glass are reported, and the mid-infrared fiber lasers are also numerically investigated. Cascade lasing is employed to increase the inversion population of the upper laser level. The particle swarm approach is applied to optimize the fiber laser parameters. The output power can reach 1.28 W at 4.89-μm wavelength, with a pump power of 5 W, excitation wavelength at 2.04 μm, Pr^(3+) ion concentration at 4.22 × 10^(25) ions/m^3,fiber length at 0.94 m, and fiber background loss at 3 dB/m.
基金supported by the National Key R&D Program of China(2021YFB3801002)the National Natural Science Foundation of China(31870998,51725302 and 11621505)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB36000000)the Beijing Nova Program of Science and Technology(Z191100001119091 and Z211100002121148).
文摘The self-assembled nanomaterials based on peptides,which have not only good biocompatibility and low toxicity but also high stability and performance,are increasingly becoming an important way for cancer treatment.In this review,we highlight the progress of in vivo self-assembled polymer-peptide conjugates(PPCs)and their application,showing the recent advances in the development of“in vivo self-assembly”strategy for cancer treatment.Given the diverse microenvironments of tumor cells,different responsive assembly strategies(enzyme,pH,redox,temperature,etc.)have been developed to precisely control the assembly at different biological levels,realizing enhanced drug delivery and improved anticancer efficacy.
