In this paper, we suggest one compound chaos image encryption method with time- varying multilevel initial parameters. This algorithm combines Subsection-linearity mapping, Chebyshev mapping with Logistic mapping in o...In this paper, we suggest one compound chaos image encryption method with time- varying multilevel initial parameters. This algorithm combines Subsection-linearity mapping, Chebyshev mapping with Logistic mapping in order to disturbing values of each image point and the array of original images based on chaotic second-scrambling way. The chaotic system uses time-varying system clock to change the first chaotic mapping initial parameter, and takes those chaotic sequences which generated by the first chaotic mapping as the initial parameters for the second chaotic mapping, then generate two-dimensional image pixel position scrambling matrix, and uses the same system clock to lock Chebyshev mapping initial parameter, then generate two-dimensional image pixel value transforming matrix. By this way for using the time-varying system clock, The encryption system can randomly changes many initial parameters of chaotic image encryption system to enhance image transmission security, has the capability of “one time one secret”. The simulation results show that this algorithm is simple, safe, easy to achieve with software and has huge secret key space.展开更多
Lithium sulfur(Li-S)batteries are the promising power sources,but their commercialization is significantly impeded by poor energy-storage functions at high sulfur loading.Here we report that such an issue can be effec...Lithium sulfur(Li-S)batteries are the promising power sources,but their commercialization is significantly impeded by poor energy-storage functions at high sulfur loading.Here we report that such an issue can be effectively addressed by using a mussel-inspired binder comprised of chitosan grafted with catecholic moiety for sulfur cathodes.The resulting sulfur cathodes possess a high loading up to 12.2 mg cm-2 but also exhibit one of the best electrochemical properties among their counterparts.The excellent performances are attributed to the strong adhesion of the binder to sulfur particles,conducting agent,current collector,and polysulfide.The versatile adhesion effectively increases the sulfur loading,depresses the shuttle effect,and alleviates mechanical pulverization during cycling processes.The present investigation offers a new insight into high performance sulfur cathodes through a bio-adhesion viewpoint.展开更多
Objective:The ataxia telangiectasia mutated(ATM)gene is a master regulator in cellular DNA damage response.The dysregulation of ATM expression is frequent in breast cancer,and is known to be involved in the carcinogen...Objective:The ataxia telangiectasia mutated(ATM)gene is a master regulator in cellular DNA damage response.The dysregulation of ATM expression is frequent in breast cancer,and is known to be involved in the carcinogenesis and prognosis of cancer.However,the underlying mechanism remains unclear.The bioinformatic analysis predicted a potential antisense transcript ATM-antisense(AS)from the opposite strand of the ATM gene.The purpose of this study was to identify ATM-AS and investigate the possible effect of ATM-AS on the ATM gene regulation.Methods:Single strand-specific RT-PCR was performed to verify the predicted antisense transcript ATM-AS within the ATM gene locus.qRT-PCR and Western blotting were used to detect the expression levels of ATM-AS and ATM in normal and breast cancer cell lines as well as in tissue samples.Luciferase reporter gene assays,biological mass spectrometry,ChIP-qPCR and RIP were used to explore the function of ATM-AS in regulating the ATM expression.Immunofluorescence and host-cell reactivation(HCR)assay were performed to evaluate the biological significance of ATM-AS in ATM-mediated DNA damage repair.Breast cancer tissue samples were used for evaluating the correlation of the ATM-AS level with the ATM expression as well as prognosis of the patients.Results:The ATM-AS significantly upregulated the ATM gene activity by recruiting KAT5 histone acetyltransferase to the gene promoter.The reduced ATM-AS level led to the abnormal downregulation of ATM expression,and impaired the ATM-mediated DNA damage repair in normal breast cells in vitro.The ATM-AS level was positively correlated with the ATM expression in the examined breast cancer tissue samples,and the patient prognosis.Conclusion:The present study demonstrated that ATM-AS,an antisense transcript located within the ATM gene body,is an essential positive regulator of ATM expression,and functions by mediating the binding of KAT5 to the ATM promoter.These findings uncover the novel mechanism underlying the dysregulation of the ATM gene in breast cancer,and enrich our understanding of how an antisense transcript regulates its host gene.展开更多
northeastern China is an important old industrial base in China. Mineral resources are the foundation of industry development. However, because of long-term exploitation of mineral resources in northeastern China, the...northeastern China is an important old industrial base in China. Mineral resources are the foundation of industry development. However, because of long-term exploitation of mineral resources in northeastern China, the mineral resources reserves decrease gradually and some mineral resources are nearly exhausted, which restricts revitalization and sustainable development of the northeast old industrial base. On the basis of the comprehensive analysis of development and utilization status of mineral resources and supply and demand situation of main mineral resources in northeastern China, the authors put forward countermeasures on main mineral resources sustainable supply in northeastern China.展开更多
文摘In this paper, we suggest one compound chaos image encryption method with time- varying multilevel initial parameters. This algorithm combines Subsection-linearity mapping, Chebyshev mapping with Logistic mapping in order to disturbing values of each image point and the array of original images based on chaotic second-scrambling way. The chaotic system uses time-varying system clock to change the first chaotic mapping initial parameter, and takes those chaotic sequences which generated by the first chaotic mapping as the initial parameters for the second chaotic mapping, then generate two-dimensional image pixel position scrambling matrix, and uses the same system clock to lock Chebyshev mapping initial parameter, then generate two-dimensional image pixel value transforming matrix. By this way for using the time-varying system clock, The encryption system can randomly changes many initial parameters of chaotic image encryption system to enhance image transmission security, has the capability of “one time one secret”. The simulation results show that this algorithm is simple, safe, easy to achieve with software and has huge secret key space.
基金supported by the National Natural Science Foundation of China(51473041)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(51521003)+2 种基金China Postdoctoral Science Foundation(no.2017M621262)Fundamental Research Funds for the Central Universities(No.HIT.NSRIF.201831)Postdoctoral Foundation of Hei long Jiang Province(LBH-Z17065)。
文摘Lithium sulfur(Li-S)batteries are the promising power sources,but their commercialization is significantly impeded by poor energy-storage functions at high sulfur loading.Here we report that such an issue can be effectively addressed by using a mussel-inspired binder comprised of chitosan grafted with catecholic moiety for sulfur cathodes.The resulting sulfur cathodes possess a high loading up to 12.2 mg cm-2 but also exhibit one of the best electrochemical properties among their counterparts.The excellent performances are attributed to the strong adhesion of the binder to sulfur particles,conducting agent,current collector,and polysulfide.The versatile adhesion effectively increases the sulfur loading,depresses the shuttle effect,and alleviates mechanical pulverization during cycling processes.The present investigation offers a new insight into high performance sulfur cathodes through a bio-adhesion viewpoint.
基金supported by the National Natural Science Foundation of China(No.81802670 and No.82072580).
文摘Objective:The ataxia telangiectasia mutated(ATM)gene is a master regulator in cellular DNA damage response.The dysregulation of ATM expression is frequent in breast cancer,and is known to be involved in the carcinogenesis and prognosis of cancer.However,the underlying mechanism remains unclear.The bioinformatic analysis predicted a potential antisense transcript ATM-antisense(AS)from the opposite strand of the ATM gene.The purpose of this study was to identify ATM-AS and investigate the possible effect of ATM-AS on the ATM gene regulation.Methods:Single strand-specific RT-PCR was performed to verify the predicted antisense transcript ATM-AS within the ATM gene locus.qRT-PCR and Western blotting were used to detect the expression levels of ATM-AS and ATM in normal and breast cancer cell lines as well as in tissue samples.Luciferase reporter gene assays,biological mass spectrometry,ChIP-qPCR and RIP were used to explore the function of ATM-AS in regulating the ATM expression.Immunofluorescence and host-cell reactivation(HCR)assay were performed to evaluate the biological significance of ATM-AS in ATM-mediated DNA damage repair.Breast cancer tissue samples were used for evaluating the correlation of the ATM-AS level with the ATM expression as well as prognosis of the patients.Results:The ATM-AS significantly upregulated the ATM gene activity by recruiting KAT5 histone acetyltransferase to the gene promoter.The reduced ATM-AS level led to the abnormal downregulation of ATM expression,and impaired the ATM-mediated DNA damage repair in normal breast cells in vitro.The ATM-AS level was positively correlated with the ATM expression in the examined breast cancer tissue samples,and the patient prognosis.Conclusion:The present study demonstrated that ATM-AS,an antisense transcript located within the ATM gene body,is an essential positive regulator of ATM expression,and functions by mediating the binding of KAT5 to the ATM promoter.These findings uncover the novel mechanism underlying the dysregulation of the ATM gene in breast cancer,and enrich our understanding of how an antisense transcript regulates its host gene.
文摘northeastern China is an important old industrial base in China. Mineral resources are the foundation of industry development. However, because of long-term exploitation of mineral resources in northeastern China, the mineral resources reserves decrease gradually and some mineral resources are nearly exhausted, which restricts revitalization and sustainable development of the northeast old industrial base. On the basis of the comprehensive analysis of development and utilization status of mineral resources and supply and demand situation of main mineral resources in northeastern China, the authors put forward countermeasures on main mineral resources sustainable supply in northeastern China.