A Review on Engineering Design for Enhancing Interfacial Contact in Solid-State Lithium–Sulfur Batteries

The utilization of solid-state electrolytes(SSEs)presents a promising solution to the issues of safety concern and shuttle effect in Li–S batteries,which has garnered significant interest recently.However,the high interfacial impedances existing between the SSEs and the electrodes(both lithium anodes and sulfur cathodes)hinder the charge transfer and intensify the uneven deposition of lithium,which ultimately result in insufficient capacity utilization and poor cycling stability.Hence,the reduction of interfacial resistance between SSEs and electrodes is of paramount importance in the pursuit of efficacious solid-state batteries.In this review,we focus on the experimental strategies employed to enhance the interfacial contact between SSEs and electrodes,and summarize recent progresses of their applications in solidstate Li–S batteries.Moreover,the challenges and perspectives of rational interfacial design in practical solid-state Li–S batteries are outlined as well.We expect that this review will provide new insights into the further technique development and practical applications of solid-state lithium batteries.

Therapeutic effect and apoptosis mechanism of lung-tonifying and expectorant decoction on lung cancer rats with Qi deficiency and blood stasis

Objective:To explore the effect and specific mechanism of lung-tonifying and expectorant decoction on lung cancer rats with Qi deficiency and blood stasis,and aim to provide a new idea on treating the disease with traditional Chinese medicine based on syndrome differentiation.Methods:A total of 60 C57BL/6J male rats were included in the study.The model of Qi deficiency and blood stasis was established in 60 rats by using multiple-factor stimulation.About 10 rats were randomly taken to verify whether the model establishment was successful and the rest of 50 rats were divided into 5 groups with 10 rats each:blank control group,cisplatin group,low dose group,medium dose group and high dose group.The blank control group was treated with normal saline,and cisplatin group was treated with cisplatin while the other three groups were treated with lung-tonifying and expectorant decoction at different doses.The volume change in transplanted tumor,tumor inhibition rate,apoptosis rate,and expression of Bc1-2,Bax.cleaved caspase-3 and cleaved caspase-9 in 5 groups were compared.Results:The rapidest growth rate of transplanted tumor volume was observed in blank control group and the slowest in cisplatin group.The growth rate was gradually decreased with the increasing dose of lung-tonifying and expectorant decoction,and the difference in growth of tumor volume among groups was statistically significant(P<0.05).The cisplatin group showed the highest tumor inhibition rate,with dose-dependent increase(P<0.05).The apoptosis rate in low dose group was higher than blank control group but lower than high dose group(P<0.05).The apoptosis rate in medium dose group was significantly higher man blank control group(P).05).The apoptosis rate in high dose group was significantly higher than control group(P<0.05).The positive expression rates of Bel-2 and Bax in all groups showed statistically significant difference(P<0.05),while expression of cleaved caspase-3 and cleaved caspase-9 in 5 groups was significantly different,with dose-dependent increase(P<0.05).Conclusions:The lung-tonifying and expectorant decoction inhibits the proliferation of tumor cells by inducing and activating the cell apoptosis in treatment of lung cancer with Qi deficiency and blood stasis,probably with good clinical therapeutic effect.

基于大样本调研的社区老年教育多元主体行动认可度研究

社区老年教育的运行需要多元主体的介入。通过实证调研,探究不同分类样本群体对社区老年教育的多元主体维度行动指标的认可度。结果发现,在按照性别、年龄、工作时间、工作单位来源分类的样本群体,对社区老年教育的学校层面、社区层面、社会力量层面和老年学习者多元主体的行动有认可度的差异;发现以上多元主体层面行动的认可度之间均有较强的相关性,说明这几个多元主体维度的指标在社区老年教育运行中发挥着重要功能。基于此得出启示,社区老年教育要良好运行,有必要构建政府顶层设计与引导的决策行动、学校资源供给与配置的供给行动、社区人财物资助与提供的支持行动、社会力量投资与参与的服务行动、学习者反馈与合作的反馈行动。

Inverse of Rensch’s Rule of Allometry for Sexual Size Dimorphism in Bufo andrewsi

Difference in body size between males and females(sexual size dimorphism:SSD)and its variation are a common phenomenon in animal kingdom.Rensch’s rule predicts that the degree of SSD variation increases with the enlarged mean body size when males are larger than females and decreases when females are larger than males.Here,whether the patterns of variations in SSD in the Andrew’s toad(Bufo andrewsi)follow Rensch’s rule was tested using unpublished data from 14 populations and published data from 17 populations.Results show the reduced major axis regression of log10(male size)on log10(female size)across all populations displayed a significant hyperallometric relationship,which was consistent with inverse Rensch’s rule(the degree of SSD increased with enlarged mean body size).SSD could also be explained by sexual age difference(SAD)due to a positive SSD–SAD relationship among all populations.The findings suggest that the occurrence of inverse Rensch’s rule in B.andrewsi is likely to be a result of fecundity selection on increased reproductive investments in larger females.

Abnormal characteristics and effectiveness evaluation of the micro-seismic signal before the Debao MS4.8 earthquake

The Debao MS4.8 earthquake occurred in western Guangxi on August 5,2021,near where the Jingxi MS5.2 earthquake occurred in 2019.To study the increasing seismicity in western Guangxi,it is necessary to determine whether there was an anomaly related to the earthquake source near the Pingxiang gravity station,which is located approximately 100 km from the epicenter of the Debao MS4.8 earthquake.In this study,the R-value scoring method was used to analyze the anomaly and evaluate the prediction efficiency of the double frequency(DF)micro-seismic signal vertical displacement(referred to as vertical displacement,VD)and the absolute value of monthly extreme rate(referred to as the monthly rate).Results show that earthquakes larger than MS4.0 in the 350 km range from the Pingxiang station tend to coincide with yearly typhoons,and the VD of micro-seismic signals correspondingly changes from low to high.The Debao MS4.8 earthquake occurred during a gradual VD increase from 0.05×10^(-6)to 0.10×10^(-6)m.When discussing the relationships among R,the rate threshold,and the effective duration of prediction,the rate threshold of the micro-seismic signal converges from 0.00039×10^(-6)to 0.00031×10^(-6)m/month,the effective duration of prediction is approximately 6-10 months,and R also converges from 0.29 to 0.31.By comparing the results of three gPhone gravity stations in Guangxi,we found that the increase of short-term VD before the Debao earthquake was related to the enhancement of the DF micro-seismic signal excited by the typhoon.When the typhoon track was perpendicular to the coastline of China,the possibility of an earthquake occurring was increased.This study provides evidence and reference for the future occurrence period of earthquakes above MS4.0 in western Guangxi.

First acceptance testing of multiple A10 absolute gravimeters in China and analysis of the comparison results

Three A10 absolute gravimeters(AGs) were first acquired in China by the Hubei Earthquake Agency under the Belt and Road Seismic Monitoring Network Project. Although AG measuring and testing technique is not new, the purchase and simultaneous testing of 3 A10 absolute gravimeters is unprecedented in China. This study conducted the first acceptance testing of the AGs at 3 locations(the Jiufengshan Gravity Observation Station, the Global Navigation Satellite System Observation Station in Wuhan, and the Jiugongshan Observation Station in Xianning). The results were compared using a method based on expert validation, and the acceptance testing scheme was formulated by referring to the Technical Regulations for Tectonic Environment Monitoring Networks in China and Specifications for Gravimetry Control. Based on the repeatability, precision, and consistency of the measured g values, the results from each instrument were evaluated using the air pressure precision test. Comparing the instrument reference values, the final test results can identify the indicator parameters for 3 A10 AGs, the effects of the surrounding environment, and the related parameters on measurement precision. The precision of A10-059, A10-058, and A10-057 exceeded 0.78 μGal, 0.79 μGal, and 0.42 μGal, respectively.This testing scheme can be used as a reference for conducting acceptance testing of AGs in the future and obtaining absolute gravimetric measurements.

Evidence for Expensive Tissue Hypothesis in the Asian Common Toad(Duttaphrynus melanostictus)

Dear Editor,Phenotypic plasticity of an organism by modifying morphological and physiological traits responding to diverse environments is widely recognized across animal taxa(Muñoz-Muñoz et al.,2021;Donihue et al.,2021;Giacomini et al.,2022;Zamora-Camacho et al.,2022;Jiang et al.,2022;Chen et al.,2023).The brain,as a critical phenotypic trait,displays a significant variation in size among different species(Striedter,2006).

Multiplex network infomax:Multiplex network embedding via information fusion

For networking of big data applications,an essential issue is how to represent networks in vector space for further mining and analysis tasks,e.g.,node classification,clustering,link prediction,and visualization.Most existing studies on this subject mainly concentrate on monoplex networks considering a single type of relation among nodes.However,numerous real-world networks are naturally composed of multiple layers with different relation types;such a network is called a multiplex network.The majority of existing multiplex network embedding methods either overlook node attributes,resort to node labels for training,or underutilize underlying information shared across multiple layers.In this paper,we propose Multiplex Network Infomax(MNI),an unsupervised embedding framework to represent information of multiple layers into a unified embedding space.To be more specific,we aim to maximize the mutual information between the unified embedding and node embeddings of each layer.On the basis of this framework,we present an unsupervised network embedding method for attributed multiplex networks.Experimental results show that our method achieves competitive performance on not only node-related tasks,such as node classification,clustering,and similarity search,but also a typical edge-related task,i.e.,link prediction,at times even outperforming relevant supervised methods,despite that MNI is fully unsupervised.

Research and Practice on the Multi-dimensional Course Goal Achievement Evaluation of Software Engineering

According to the standards of engineering education accreditation,the achievement paths and evaluation criteria of course goals are presented,aimed at the objectives of software engineering courses and the characteristics of hybrid teaching in Kunming University of Science and Technology.Then a multi-dimensional evaluation system for course goal achievement of software engineering is proposed.The practice’s results show that the multi-dimensional course goal achievement evaluation is helpful to the continuous improvement of course teaching,which can effectively support the evaluation of graduation outcomes.

The genomic clock:exploring the relationship between telomere length and mental disorders

In the realm of neurology and cellular aging,a compelling nexus is being drawn between mental disorders and the intricate clockwork of our genetic machinery,specifically telomere length(TL)[1-3].This bond hints at an unexpected interplay between mental health and aging,promising insights that could reshape our understanding of both arenas.

戈壁光伏电站气象要素特征

在能源发展低碳化的背景下,光伏产业发展迅速。西北戈壁是我国建设光伏电站的主要区域,为了更好地理解戈壁光伏电站对局地气候和环境的影响,本文利用2019年12月、2020年4月、7月和10月新疆五家渠戈壁光伏电站与参考站点的观测资料,对比分析了光伏电站与参考站点的气象要素特征及差异。结果表明:光伏电站与参考站气温表现出明显的昼夜差异和季节差异,夜间各个季节光伏电站2 m高度气温都低于参考点,随着高度增加,夜间冷却效应减弱。白天春、夏、秋季光伏电站内2 m高度气温高于参考站点,而冬季低于参考站点。随高度增加,光伏电站在春、夏季白天的升温效应减弱,秋、冬季升温效应增强;由于光伏面板比土壤比热容低,白天光伏面板温度高于参考站地表温度,温差随太阳辐射增强而增大;由于光伏阵列对风的阻挡作用,光伏电站内相比参考站风向单一、风速更低。随着高度增加,光伏阵列对风场的影响减小。

Electrochemical performance of a nickel-rich LiNi0.6Co0.2Mn0.2O2 cathode material for lithium-ion batteries under different cut-off voltages

A spherical-like Ni_(0.6)Co_(0.2)Mn_(0.2)(OH)_2 precursor was tuned homogeneously to synthesize LiNi_(0.6)Co_(0.2)Mn_(0.2)O_2 as a cathode material for lithium-ion batteries.The effects of calcination temperature on the crystal structure,morphology,and the electrochemical performance of the as-prepared LiNi_(0.6)Co_(0.2)Mn_(0.2)O_2 were investigated in detail.The as-prepared material was characterized by X-ray diffraction,scanning electron microscopy,laser particle size analysis,charge–discharge tests,and cyclic voltammetry measurements.The results show that the spherical-like LiNi_(0.6)Co_(0.2)Mn_(0.2)O_2 material obtained by calcination at 900°C displayed the most significant layered structure among samples calcined at various temperatures,with a particle size of approximately 10 μm.It delivered an initial discharge capacity of 189.2 m Ah×g^(-1) at 0.2C with a capacity retention of 94.0% after 100 cycles between 2.7 and 4.3 V.The as-prepared cathode material also exhibited good rate performance,with a discharge capacity of 119.6 m Ah×g^(-1) at 5C.Furthermore,within the cut-off voltage ranges from 2.7 to 4.3,4.4,and 4.5 V,the initial discharge capacities of the calcined samples were 170.7,180.9,and 192.8 m Ah×g^(-1),respectively,at a rate of 1C.The corresponding retentions were 86.8%,80.3%,and 74.4% after 200 cycles,respectively.

The prognostic value of serum C-reactive protein-bound serum amyloid A in early-stage lung cancer

Background:Elevated levels of serum C-reactive protein(CRP) have been reported to have prognostic significance in lung cancer patients.This study aimed to further identify CRP-bound components as prognostic markers for lung cancer and validate their prognostic value.Methods:CRP-bound components obtained from the serum samples from lung cancer patients or healthy controls were analyzed by differential proteomics analysis.CRP-bound serum amyloid A(CRP-SAA) was evaluated by coimmunoprecipitation(IP).Serum samples from two independent cohorts with lung cancer(retrospective cohort,242patients;prospective cohort,222 patients) and healthy controls(159 subjects) were used to evaluate the prognostic value of CRP-SAA by enzyme-linked immunosorbent assay.Results:CRP-SAA was identified specifically in serum samples from lung cancer patients by proteomic analysis.CRP binding to SAA was confirmed by co-IP in serum samples from lung cancer patients and cell culture media.The level of CRP-SAA was significantly higher in patients than in healthy controls(0.37 ± 0.58 vs.0.03 ± 0.04,P < 0.001).Elevated CRP-SAA levels were significantly associated with severe clinical features of lung cancer.The elevation of CRPSAA was associated with lower survival rates for both the retrospective(hazard ration[HR]= 2.181,95%confidence interval[CI]= 1.641-2.897,P < 0.001) and the prospective cohorts(HR = 2.744,95%CI = 1.810-4.161,P < 0.001).Multivariate Cox analysis showed that CRP-SAA was an independent prognostic marker for lung cancer.Remarkably,in stages l-ll patients,only CRP-SAA,not total SAA or CRP,showed significant association with overall survival in two cohorts.Moreover,univariate and multivariate Cox analyses also showed that only CRP-SAA could be used as an independent prognostic marker for early-stage lung cancer patients.Conclusion:CRP-SAA could be a better prognostic marker for lung cancer than total SAA or CRP,especially in earlystage patients.

Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions

BACKGROUND Study shows that signal transducer and activator of transcription 3(STAT3) can increase the Warburg effect by stimulating hexokinase 2 in breast cancer and upregulate lactate dehydrogenase A and pyruvate dehydrogenase kinase 1 in myeloma. STAT3 and pyruvate kinase M2(PKM2) can also be activated and enhance the Warburg effect in hepatocellular carcinoma. Precancerous lesions are critical to human and rodent hepatocarcinogenesis. However, the underlying molecular mechanism for the development of liver precancerous lesions remains unknown. We hypothesized that STAT3 promotes the Warburg effect possibly by upregulating p-PKM2 in liver precancerous lesions in rats.AIM To investigate the mechanism of the Warburg effect in liver precancerous lesions in rats.METHODS A model of liver precancerous lesions was established by a modified Solt-Farber method. The liver pathological changes were observed by HE staining and immunohistochemistry. The transformation of WB-F344 cells induced with Nmethyl-N'-nitro-N-nitrosoguanidine and hydrogen peroxide was evaluated by the soft agar assay and aneuploidy. The levels of glucose and lactate in the tissue and culture medium were detected with a spectrophotometer. The protein levels of glutathione S-transferase-π, proliferating cell nuclear antigen(PCNA), STAT3,and PKM2 were examined by Western blot and immunofluorescence.RESULTS We found that the Warburg effect was increased in liver precancerous lesions in rats. PKM2 and p-STAT3 were upregulated in activated oval cells in liverprecancerous lesions in rats. The Warburg effect, p-PKM2, and p-STAT3 expression were also increased in transformed WB-F344 cells. STAT3 activation promoted the clonal formation rate, aneuploidy, alpha-fetoprotein expression,PCNA expression, G1/S phase transition, the Warburg effect, PKM2 phosphorylation, and nuclear translocation in transformed WB-F344 cells.Moreover, the Warburg effect was inhibited by stattic, a specific inhibitor of STAT3, and further reduced in transformed WB-F344 cells after the intervention for PKM2.CONCLUSION The Warburg effect is initiated in liver precancerous lesions in rats. STAT3 activation promotes the Warburg effect by enhancing the phosphorylation of PKM2 in transformed WB-F344 cells.

Ischemic preconditioning protects against ischemic brain injury

In this study, we hypothesized that an increase in integrin α_vβ_3 and its co-activator vascular endothelial growth factor play important neuroprotective roles in ischemic injury. We performed ischemic preconditioning with bilateral common carotid artery occlusion for 5 minutes in C57BL/6J mice. This was followed by ischemic injury with bilateral common carotid artery occlusion for 30 minutes. The time interval between ischemic preconditioning and lethal ischemia was 48 hours. Histopathological analysis showed that ischemic preconditioning substantially diminished damage to neurons in the hippocampus 7 days after ischemia. Evans Blue dye assay showed that ischemic preconditioning reduced damage to the blood-brain barrier 24 hours after ischemia. This demonstrates the neuroprotective effect of ischemic preconditioning. Western blot assay revealed a significant reduction in protein levels of integrin α_vβ_3, vascular endothelial growth factor and its receptor in mice given ischemic preconditioning compared with mice not given ischemic preconditioning 24 hours after ischemia. These findings suggest that the neuroprotective effect of ischemic preconditioning is associated with lower integrin α_vβ_3 and vascular endothelial growth factor levels in the brain following ischemia.

Rational Design of MOF-Based Materials for Next-Generation Rechargeable Batteries

Metal–organic framework(MOF)-based materials with high porosity,tunable compositions,diverse structures,and versatile functionalities provide great scope for next-generation rechargeable battery applications.Herein,this review summarizes recent advances in pristine MOFs,MOF composites,MOF derivatives,and MOF composite derivatives for high-performance sodium-ion batteries,potassiumion batteries,Zn-ion batteries,lithium–sulfur batteries,lithium–oxygen batteries,and Zn–air batteries in which the unique roles of MOFs as electrodes,separators,and even electrolyte are highlighted.Furthermore,through the discussion of MOFbased materials in each battery system,the key principles for controllable synthesis of diverse MOF-based materials and electrochemical performance improvement mechanisms are discussed in detail.Finally,the major challenges and perspectives of MOFs are also proposed for next-generation battery applications.

Clonal variations in nutritional components of Pinus koreansis seeds collected from seed orchards in Northeastern China

From four Korean pine(Pinus koraiensis)orchards, 60 clones were selected and analyzed for the fatty acid and amino acid components of the seeds to reveal the variations and correlations of the seed characteristics among the clonal source orchards and clones. The nutritional components of the seeds of the P. koraiensis trees exhibited rich genetic variation; the variation coefficient of the fatty acids was 2.24–66.83 %, while the variation coefficient of the amino acids was 14.70–38.88 %. Relatively high genetic-improvement potential exists for the nutritional components of the seeds. The phenotypic differentiation of the fatty acid and amino acid components reveals that variation within the population(85.18 %) was the primary source for the variation of the fatty acid components; variation among the orchards(63.08 %) was the primary source of the variation of the amino acid components. Data drawn from various clonal source orchards all showed that the seed characteristics were highly controlled by heritability(h2[ 80 %), and the seed characteristics of the P. koraiensis trees exhibited a similar genetic gain trend. The principal components were analyzed to obtain the comprehensive principal component value for each clonal seed orchard. Twelve clones were selected based on a clonal selection rate of 20 %. Correlation and multiple stepwise-regression analyses were conducted, considering different location conditions, to reveal the stable correlations between the seed characteristics to facilitate improvements of the seed yield of P.koraiensis trees and the clonal selection. Species of real characteristics in P. koraiensis were controlled by higher heritability. Genetic gain was obtained by selecting of superior clones.

Modeling of co- and post-seismic surface deformation and gravity changes of M W 6.9 Yushu, Qinghai,earthquake

Based on the elastic dislocation theory, multilayered crustal model, and rupture model obtained by seismic waveform inversion, we calculated the coand post-seismic surface deformation and gravity changes caused by the Yushu M W 6.9 earthquake occurred on April 14, 2010. The observed GPS velocity field and gravity field in Yushu areas are disturbed by the coand post-seismic effects induced by Yushu earthquake, thus the theoretical coand post-seismic deformation and gravity changes will provide important modification for the background tectonic movement of Yushu and surrounding regions. The time relaxation results show that the influences of Yushu earthquake on Yushu and surrounding areas will last as long as 30 to 50 years. The maximum horizontal displacement, vertical uplift and settlement are about 1.96, 0.27 and 0.16 m, respectively, the maximal positive and negative value of gravity changes are 8.892×10-7 m·s-2 and -4.861×10-7 m·s-2 , respectively. Significant spatial variations can be found on the coand post-seismic effects: The co-seismic effect mainly concentrates in the region near the rupture fault, while viscoelastic relaxation mostly acts on the far field. Therefore, when using the geodetic data to research tectonic motion, we should not only consider the effect of co-seismic caused by earthquake, but also pay attention to the effect of viscoelastic relaxation.

Catalytic effect of Ni@rGO on the hydrogen storage properties of MgH2

Uniform-uispersed Ni nanoparticics(NPs)anchored on reduced graphene oxide(Ni@rGO)catalyzed MgH2(MH-Ni@rGO)has been fabricated by mechanical milling.The effects of milling time and Ni loading amount on the hydrogen storage properties of MgH2 have been investigated.The initial hydrogen desorption temperature of MgH2 catalyzed by 10 wt.%Ni4@rGO6 for milling 5 h is significantly decreased from 251℃ to 190℃.The composite can absorb 5.0 wt.%hydrogen in 20 min at 100℃,while it can desorb 6.1 wt.%within 15 min at 300℃.Through the investigation of the phase transformation and dehydrogenation kinetics during hydrogen ab/desorption cycles,we found that the in-situ formed Mg2Ni/Mg2NiH4 exhibited better catalytic effect than Ni.When Ni loading amount is 45 wt.%,the rGO in Ni@rGO catalysts can prevent the reaction of Ni and Mg due to the strong interaction between rGO and Ni NPs.

基础设施PPP项目治理:契约治理、关系治理和正式制度环境

交易过程中出现的机会主义行为等问题会导致项目损失,因此需要对基础设施PPP项目进行治理来提高绩效。论文构建了契约治理、关系治理和正式制度环境对基础设施PPP项目治理绩效影响的理论框架,并通过结构方程模型分析其作用机理。实证分析结果表明:契约治理、关系治理和正式制度环境对基础设施PPP项目治理绩效均具有正向影响作用,其中契约治理的作用最为重要。契约治理与关系治理在正式制度环境对项目治理绩效的影响关系中起中介作用。良好的正式制度环境能够显著强化契约治理和关系治理的作用,间接提升项目治理绩效。此外,关系治理在契约治理对项目治理绩效的影响关系中起中介作用。契约治理能够显著增强关系治理,进而对项目治理绩效产生间接作用。论文丰富了基础设施PPP项目治理的研究,并在正式制度环境及契约治理—关系治理二者之间的关系等方面提供了实证依据,为基础设施PPP项目治理提供了更明确的解释逻辑。