Long noncoding RNAs(lnc RNAs) are RNA molecules comprising more than 200 nucleotides, which are not translated into proteins. Many studies have shown that lnc RNAs are involved in regulating a variety of biological pr...Long noncoding RNAs(lnc RNAs) are RNA molecules comprising more than 200 nucleotides, which are not translated into proteins. Many studies have shown that lnc RNAs are involved in regulating a variety of biological processes, including immune, cancer, stress, development and differentiation at the transcriptional, epigenetic or post-transcriptional levels. Here, we review the role of lnc RNAs in the process of neurodevelopment, neural differentiation, synaptic function, and pathogenesis of Parkinson’s disease(PD). These pathomechanisms include protein misfolding and aggregation, disordered protein degradation, mitochondrial dysfunction, oxidative stress, autophagy, apoptosis, and neuroinflammation. This information will provide the basis of lnc RNA-based disease diagnosis and drug treatment for PD.展开更多
As an antibiotic,sulfadiazine has posed a serious threat to humans and ecosystems due to its chronic toxicity.The advanced oxidation processes (AOPs) via heterogeneous catalytic activation of peroxymonosulfate (PMS) h...As an antibiotic,sulfadiazine has posed a serious threat to humans and ecosystems due to its chronic toxicity.The advanced oxidation processes (AOPs) via heterogeneous catalytic activation of peroxymonosulfate (PMS) have significant potential for the degradation of antibiotics.However,there are multiple restrictions including non-specifically binding to target contaminants,which would deplete oxidation capacity,and lacking energy effectiveness due to inefficient utilization of reactive oxygen species (ROS).To overcome these obstacles,we adopted the“bait-hook&destroy”strategy in this study.Herein,we synthesized a novel micrometer-sized Ni OOH hierarchical spheres assembled from nanosheets,which have relatively large specific surface areas and yield specified cavities to“bait-hook”sulfadiazine and PMS onto the surface cavities.This process was further conductive to effective generation of ROS and subsequently“destruction”of sulfadiazine with elevated mass transformation rate.20.4%of sulfadiazine can adsorb to Ni OOH surface in less than 30 min (0.0051 min^(-1)),and then sulfadiazine was completely degraded in 90min intervals in the Ni OOH/PMS system.The degradation rate constant (k=0.0537 min^(-1)) was about5.3,2.5 and 2.2 times higher than that in Ni_(2)O_(3)/PMS,NiO/PMS and Ni(OH)_(2)/PMS system,respectively.This was ascribed to the synergistic catalytic oxidation and adsorption process occurred on the surface of Ni OOH.Appreciably,there were both non-radicals (^(1)O_(2)) and radicals (O_(2)^(·-)and SO_(4)^(·-)) involved in the Ni OOH/PMS system,and^(1)O_(2)was distinguished as the dominated ROS for degradation of sulfadiazine.This study provides a novel strategy via synergistic adsorption and catalytic oxidation,and indicates that the micrometer-sized Ni OOH hierarchical sphere as heterogeneous catalyst is an attractive candidate for potential application of the SR-AOPs technology in water treatment.展开更多
基金CAMS Innovation Fund for Medical Sciences,Grant/Award Number:2017-I2M-2-005 and 2016-I2M-2-006Beijing Natural Science Foundation,Grant/Award Number:5171001
文摘Long noncoding RNAs(lnc RNAs) are RNA molecules comprising more than 200 nucleotides, which are not translated into proteins. Many studies have shown that lnc RNAs are involved in regulating a variety of biological processes, including immune, cancer, stress, development and differentiation at the transcriptional, epigenetic or post-transcriptional levels. Here, we review the role of lnc RNAs in the process of neurodevelopment, neural differentiation, synaptic function, and pathogenesis of Parkinson’s disease(PD). These pathomechanisms include protein misfolding and aggregation, disordered protein degradation, mitochondrial dysfunction, oxidative stress, autophagy, apoptosis, and neuroinflammation. This information will provide the basis of lnc RNA-based disease diagnosis and drug treatment for PD.
基金funded by the National Key R&D Program of China (No.2018YFC0406503)the National Natural Science Foundation of China (No.52070086)+1 种基金the Natural Science Foundation of Jilin Provincial Science & Technology Department (No.20200403034SF)the Open Project Program of Engineering Research Center of Groundwater Pollution Control and Remediation,Ministry of Education。
文摘As an antibiotic,sulfadiazine has posed a serious threat to humans and ecosystems due to its chronic toxicity.The advanced oxidation processes (AOPs) via heterogeneous catalytic activation of peroxymonosulfate (PMS) have significant potential for the degradation of antibiotics.However,there are multiple restrictions including non-specifically binding to target contaminants,which would deplete oxidation capacity,and lacking energy effectiveness due to inefficient utilization of reactive oxygen species (ROS).To overcome these obstacles,we adopted the“bait-hook&destroy”strategy in this study.Herein,we synthesized a novel micrometer-sized Ni OOH hierarchical spheres assembled from nanosheets,which have relatively large specific surface areas and yield specified cavities to“bait-hook”sulfadiazine and PMS onto the surface cavities.This process was further conductive to effective generation of ROS and subsequently“destruction”of sulfadiazine with elevated mass transformation rate.20.4%of sulfadiazine can adsorb to Ni OOH surface in less than 30 min (0.0051 min^(-1)),and then sulfadiazine was completely degraded in 90min intervals in the Ni OOH/PMS system.The degradation rate constant (k=0.0537 min^(-1)) was about5.3,2.5 and 2.2 times higher than that in Ni_(2)O_(3)/PMS,NiO/PMS and Ni(OH)_(2)/PMS system,respectively.This was ascribed to the synergistic catalytic oxidation and adsorption process occurred on the surface of Ni OOH.Appreciably,there were both non-radicals (^(1)O_(2)) and radicals (O_(2)^(·-)and SO_(4)^(·-)) involved in the Ni OOH/PMS system,and^(1)O_(2)was distinguished as the dominated ROS for degradation of sulfadiazine.This study provides a novel strategy via synergistic adsorption and catalytic oxidation,and indicates that the micrometer-sized Ni OOH hierarchical sphere as heterogeneous catalyst is an attractive candidate for potential application of the SR-AOPs technology in water treatment.
