高效液相色谱法测定洗发护发产品中18种防腐剂和去屑剂

建立高效液相色谱法(HPLC)同时测定不同基质化妆品中18种防腐剂和去屑剂组分的含量,并对50批市售洗发护发类化妆品进行质量分析。不同基质样品经前处理提取后,采用HPLC法分析,外标法定量。选取C18色谱柱(4.6 mm×250 mm,5μm),甲醇和磷酸二氢钠水溶液(pH调节至3.8)作为流动相,进行梯度洗脱,流速为1.0 mL/min,柱温30℃,选取二极管阵列检测器多波长分析。18种组分在色谱图中分离度良好,峰面积与质量浓度在0.4~600μg/mL范围内呈良好的线性关系(r>0.9983),检出浓度在0.4~10 mg/kg之间。多种组分平均回收率(n=6)为83.1%~110.4%,RSD为0.12%~7.6%,回收率良好;多种组分在24 h内保持稳定,RSD在0.15%~3.8%之间,稳定性良好。50批样品中检出9种成分,吡硫鎓锌、吡罗克酮乙醇胺盐、对氯间甲酚、氯咪巴唑、三氯生、水杨酸的含量分别为2100~6800,39~2900,130~370,24~1600,0.14~0.19,28~1900 mg/kg。苄氯酚、邻氨基苯酚、邻伞花烃-5-醇的含量检出但是含量小于定量限,无法准确定量。该方法经方法学验证,可同时测定化妆品中18种防腐剂和去屑剂组分的含量。

Two-photon live imaging of direct glia-to-neuron conversion in the mouse cortex

Over the past decade,a growing number of studies have reported transcription factor-based in situ reprogramming that can directly conve rt endogenous glial cells into functional neurons as an alternative approach for n euro regeneration in the adult mammalian central ne rvous system.Howeve r,many questions remain regarding how a terminally differentiated glial cell can transform into a delicate neuron that forms part of the intricate brain circuitry.In addition,concerns have recently been raised around the absence of astrocyte-to-neuron conversion in astrocytic lineage-tra cing mice.In this study,we employed repetitive two-photon imaging to continuously capture the in situ astrocyte-to-neuron conversion process following ecto pic expression of the neural transcription factor NeuroD1 in both prolife rating reactive astrocytes and lineage-tra ced astrocytes in the mouse cortex.Time-lapse imaging over several wee ks revealed the ste p-by-step transition from a typical astrocyte with numero us short,tapered branches to a typical neuro n with a few long neurites and dynamic growth cones that actively explored the local environment.In addition,these lineage-converting cells were able to migrate ra dially or to ngentially to relocate to suitable positions.Furthermore,two-photon Ca2+imaging and patch-clamp recordings confirmed that the newly generated neuro ns exhibited synchronous calcium signals,repetitive action potentials,and spontaneous synaptic responses,suggesting that they had made functional synaptic connections within local neural circuits.In conclusion,we directly visualized the step-by-step lineage conversion process from astrocytes to functional neurons in vivo and unambiguously demonstrated that adult mammalian brains are highly plastic with respect to their potential for neuro regeneration and neural circuit reconstruction.

Enhancing Green Ammonia Electrosynthesis Through Tuning Sn Vacancies in Sn‑Based MXene/ MAX Hybrids

Renewable energy driven N_(2) electroreduction with air as nitrogen source holds great promise for realizing scalable green ammonia production.However,relevant out-lab research is still in its infancy.Herein,a novel Sn-based MXene/MAX hybrid with abundant Sn vacancies,Sn@Ti_(2)CTX/Ti_(2)SnC–V,was synthesized by controlled etching Sn@Ti_(2)SnC MAX phase and demonstrated as an efficient electrocatalyst for electrocatalytic N2 reduction.Due to the synergistic effect of MXene/MAX heterostructure,the existence of Sn vacancies and the highly dispersed Sn active sites,the obtained Sn@Ti2CTX/Ti_(2)SnC–V exhibits an optimal NH_(3) yield of 28.4μg h^(−1) mg_(cat)^(−1) with an excellent FE of 15.57% at−0.4 V versus reversible hydrogen electrode in 0.1 M Na_(2)SO_(4),as well as an ultra-long durability.Noticeably,this catalyst represents a satisfactory NH3 yield rate of 10.53μg h^(−1) mg^(−1) in the home-made simulation device,where commercial electrochemical photovoltaic cell was employed as power source,air and ultrapure water as feed stock.The as-proposed strategy represents great potential toward ammonia production in terms of financial cost according to the systematic technical economic analysis.This work is of significance for large-scale green ammonia production.

Composition,function,and timing:exploring the early‑life gut microbiota in piglets for probiotic interventions

Background The establishment of a robust gut microbiota in piglets during their early developmental stage holds the potential for long-term advantageous effects.However,the optimal timeframe for introducing probiotics to achieve this outcome remains uncertain.Results In the context of this investigation,we conducted a longitudinal assessment of the fecal microbiota of 63 piglets at three distinct pre-weaning time points.Simultaneously,we gathered vaginal and fecal samples from 23 sows.Employing 16S rRNA gene and metagenomic sequencing methodologies,we conducted a comprehensive analysis of the fluctuation patterns in microbial composition,functional capacity,interaction networks,and colonization resistance within the gut microbiota of piglets.As the piglets progressed in age,discernible modifications in intestinal microbial diversity,composition,and function were observed.A source-tracking analysis unveiled the pivotal role of fecal and vaginal microbiota derived from sows in populating the gut microbiota of neonatal piglets.By D21,the microbial interaction network displayed a more concise and efficient configuration,accompanied by enhanced colonization resistance relative to the other two time points.Moreover,we identified three strains of Ruminococcus sp.at D10 as potential candidates for improving piglets’weight gain during the weaning phase.Conclusions The findings of this study propose that D10 represents the most opportune juncture for the introduction of external probiotic interventions during the early stages of piglet development.This investigation augments our comprehension of the microbiota dynamics in early-life of piglets and offers valuable insights for guiding forthcoming probiotic interventions.

Efficacy of borneol-gypsum in skin regeneration and pain control in toxic epidermal necrolysis:A case report

BACKGROUND Toxic epidermal necrolysis(TEN)is a life-threatening dermatological emergency mainly induced by drug hypersensitivity reactions.Standard management includes discontinuation of culprit drug and application of immunomodulatory therapy.However,mortality remains high due to complications like septic shock and multiorgan failures.Innovative approaches for skin care are crucial.This report introduces borneol-gypsum,a traditional Chinese drug but a novel dressing serving as an adjuvant of TEN therapy,might significantly improve skin conditions and patient outcomes in TEN.CASE SUMMARY A 38-year-old woman diagnosed with eosinophilic granulomatosis with polyangiitis experienced gangrenous complications and motor nerve involvement.After initial treatment of high-dose corticosteroids and cyclophosphamide,symptom of foot drop improved,absolute eosinophil counts decreased,while limb pain sustained.Duloxetine was added to alleviate her symptom.Subsequently,TEN developed.Additional topical application of borneol-gypsum dressing not only protected the skin lesions from infection but also significantly eased localized pain.This approach demonstrated its merit in TEN management by promoting skin healing and potentially reducing infection risks.CONCLUSION Borneol-gypsum dressing is a promising adjuvant that could significantly improve TEN management,skin regeneration,and patient comfort.

Research on Vector Road Data Matching Method Based on Deep Learning

Most of the existing vector data matching methods use traditional feature geometry attribute features to match, however, many of the similarity indicators are not suitable for cross-scale data, resulting in less accuracy in identifying objects. In order to solve this problem effectively, a deep learning model for vector road data matching is proposed based on siamese neural network and VGG16 convolutional neural network, and matching experiments are carried out. Experimental results show that the proposed vector road data matching model can achieve an accuracy of more than 90% under certain data support and threshold conditions.

The latest research progress on minimally invasive treatments for hepatocellular carcinoma

Background:Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer-related death worldwide.Due to the high prevalence of hepatitis B virus(HBV)infection in China,the incidence of HCC in China is high,and liver cirrhosis caused by chronic hepatitis also brings great challenges to treatment.This paper reviewed the latest research progress on minimally invasive treatments for HCC,including percutaneous thermal ablation and new nonthermal ablation techniques,and introduced the principles,advantages,and clinical applications of various therapeutic methods in detail.Data sources:The data of treatments for HCC were systematically collected from the Pub Med,Science Direct,American Chemical Society and Web of Science databases published in English,using“minimally invasive”and“hepatocellular carcinoma”or“liver cancer”as the keywords.Results:Percutaneous thermal ablation is still a first-line strategy for the minimally invasive treatment of HCC.The effect of microwave ablation(MWA)on downgrading treatment before liver transplantation is better than that of radiofrequency ablation(RFA),while RFA is more widely used in the clinical practice.High-intensity focused ultrasound(HIFU)is mainly used for the palliative treatment of advanced liver cancer.Electrochemotherapy(ECT)delivers chemotherapeutic drugs to the target cells while reducing the blood supply around HCC.Irreversible electroporation(IRE)uses a microsecond-pulsed electric field that induces apoptosis and necrosis and triggers a systemic immune response.The nanosecond pulsed electric field(ns PEF)has achieved a good response in the ablation of mice with HCC,but it has not been reported in China for the treatment of human HCC.Conclusions:A variety of minimally invasive treatments provide a sufficient survival advantage for HCC patients.Nonthermal ablation will lead to a new wave with its unique advantage of antitumor recurrence and metastasis.

Improving the accuracy of genomic prediction for meat quality traits using whole genome sequence data in pigs

Background Pork quality can directly affect customer purchase tendency and meat quality traits have become valu-able in modern pork production.However,genetic improvement has been slow due to high phenotyping costs.In this study,whole genome sequence(WGS)data was used to evaluate the prediction accuracy of genomic best linear unbiased prediction(GBLUP)for meat quality in large-scale crossbred commercial pigs.Results We produced WGS data(18,695,907 SNPs and 2,106,902 INDELs exceed quality control)from 1,469 sequenced Duroc×(Landrace×Yorkshire)pigs and developed a reference panel for meat quality including meat color score,marbling score,L*(lightness),a*(redness),and b*(yellowness)of genomic prediction.The prediction accuracy was defined as the Pearson correlation coefficient between adjusted phenotypes and genomic estimated breeding values in the validation population.Using different marker density panels derived from WGS data,accuracy differed substantially among meat quality traits,varied from 0.08 to 0.47.Results showed that MultiBLUP outperform GBLUP and yielded accuracy increases ranging from 17.39%to 75%.We optimized the marker density and found medium-and high-density marker panels are beneficial for the estimation of heritability for meat quality.Moreover,we conducted genotype imputation from 50K chip to WGS level in the same population and found average concord-ance rate to exceed 95%and r^(2)=0.81.Conclusions Overall,estimation of heritability for meat quality traits can benefit from the use of WGS data.This study showed the superiority of using WGS data to genetically improve pork quality in genomic prediction.

小胶质细胞及星形胶质细胞在阿尔茨海默病发生发展中的作用

阿尔茨海默病(AD)是以记忆障碍和认知能力下降为特征的一种进行性神经变性疾病,最终影响言语、行为、视觉空间定位和运动系统。Aβ沉积到一定剂量将启动一些机制引起病理改变,导致记忆力下降。在众多机制中炎症反应起着重要作用。近年来的研究发现,小胶质细胞和星形胶质细胞的活化可以促进神经炎症反应,造成神经元损伤。本文从小胶质细胞及星形胶质细胞方面对AD的作用影响及中药调控神经炎症治疗AD进行系统性的整理和归纳,为AD的治疗及进一步的研究提供一定的理论参考依据。

Replacement of leisure-time sedentary behavior with various physical activities and the risk of dementia incidence and mortality:A prospective cohort study

Background:Whether or not there is targeted pharmacotherapy for dementia,an active and healthy lifestyle that includes physical activity(PA)may be a better option than medication for preventing dementia.We examined the association between leisure-time sedentary behavior(SB)and the risk of dementia incidence and mortality.We further quantified the effect on dementia risk of replacing sedentary time with an equal amount of time spent on different physical activities.Methods:In the UK Biobank,484,169 participants(mean age=56.5 years;45.2%men)free of dementia were followed from baseline(2006-2010)through July 30,2021.A standard questionnaire measured individual leisure-time SB(watching TV,computer use,and driving)and PA(walking for pleasure,light and heavy do-it-yourself activity,strenuous sports,and other exercise)frequency and duration in the 4 weeks prior to evaluation.Apolipoprotein E(APOE)genotype data were available for a subset of 397,519(82.1%)individuals.A Cox proportional hazard model and an isotemporal substitution model were used in this study.Results:During a median 12.4 years of follow-up,6904 all-cause dementia cases and 2115 deaths from dementia were recorded.In comparison to participants with leisure-time SB<5 h/day,the hazard ratio((HR),95%confidence interval(95%CI))of dementia incidence was 1.07(1.02-1.13)for 5-8 h/day and 1.25(1.13-1.38)for>8 h/day,and the HR of dementia mortality was 1.35(1.12-1.61)for>8 h/day.A 1 standard deviation increment of sedentary time(2.33 h/day)was strongly associated with a higher incidence of dementia and mortality(HR=1.06,95%CI:1.03-1.08 and HR=1.07,95%CI:1.03-1.12,respectively).The association between sedentary time and the risk of developing dementia was more profound in subjects<60 years than in those>60 years(HR=1.26,95%CI:1.00-1.58 vs.HR=1.21,95%CI:1.08-1.35 in>8 h/day,p for interaction=0.013).Replacing 30 min/day of leisure sedentary time with an equal time spent in total PA was associated with a6%decreased risk and 9%decreased mortality from dementia,with exercise(e.g.,swimming,cycling,aerobics,bowling)showing the strongest benefit(HR=0.82,95%CI:0.78-0.86 and HR=0.79,95%CI:0.72-0.86).Compared with APOEε4 noncarriers,APOEε4 carriers are more likely to see a decrease in Alzheimer’s disease incidence and mortality when PA is substituted for SB.Conclusion:Leisure-time SB was positively associated with the risk of dementia incidence and mortality.Replacing sedentary time with equal time spent doing PA may be associated with a significant reduction in dementia incidence and mortality risk.

Correlations between trace elements in pyrite and gold mineralization of gold deposits on the North China platform

By studying both the microscopic physical and chemical typomorphic characteristics of typical mineral pyrite samples associated with representative gold deposits on the north-central margin of the North China Platform,this paper seeks to identify macroscopic metallogenic mechanisms of gold deposits and to reveal the formation mechanism of lattice gold in pyrite.Typomorphic characteristics of pyrite reveal that pyrite grain size has a negative correlation with gold content.Cubic pyrite,as the dominant crystal form,contains more gold than pentagonal dodecahedral pyrite.Both pyrite crystal forms and chemical compositions indicate that the replacement style of gold deposit formed in a low saturability,low sulfur fugacity,and at temperatures either much higher or much lower than its best forming temperature;comparatively,that of the quartz vein style of gold deposit occurred under conditions with the best temperature,rich in sulfur,and with high sulfur fugacity.The Au/Ag ratios of the pyrites show that both the replacement and quartz vein styles of deposits are mesothermal and hypothermal,while the Co/Ni ratios of the pyrites indicate that the quartz vein style is of magmatic-hydrothermal origin.The X-ray diffraction intensity of pyrite rich in gold is lower than that of pyrite poor in gold at the quartz vein style.In general,with an increase in gold content in pyrite,the total sum intensityΣI decreases.The pyroelectricity coefficient has a negative correlation trend with the values of(Co+Ni+Se+Te)-As and(Co+Ni+Se+Te)/As.The pyrite pyroelectricity of the replacement style is N-type,indicating that it formed under low sulfur fugacity,while that of the quartz vein style is a mixture of P-N types,indicating that it formed under high sulfur fugacity.On the pyroelectricity-temperature diagram,pyrite of the replacement style is mainly distributed between 200 and 270°C,while that of the quartz vein style varies between 90–118 and274–386°C,demonstrating a multistage forming process.In contrast to previous researchers'conclusions,the authors confirm the existence of lattice gold in pyrites through the use of an electron paramagnetic resonance(EPR)test.Au in the form of Au~+,entering pyrite as an isomorph and producing electron–hole centers,makes the centers produce spin resonance absorption and results in EPR absorption peak II.The intensity of auriferous pyrite absorption peak II has certain direct positive correlations with pyrite gold content.The#I and#III absorption peaks of pyrites possibly result from the existence of Ni^(2+)and/or Cu^(2+).γ1,γ2,andγ3 are the strongest and most typical absorption peaks of the infrared spectra of the pyrites.Generally,with the increase in gold content in the pyrite samples,γ1,γ2,andγ3 tend to shift to higher wavenumbers,and the gold content in the pyrite samples has a positive correlation with their relative absorbance.

Novel concepts of mechanical technology for gas recovery from marine hydrate reservoir

According to the characteristics of marine natural gas hydrate,China has proposed the solid-state fluidization exploitation technology or natural gas hydrate,with subsea exploitation being key to the commercial recovery of gas.In this paper,two new integrated tools are proposed for breaking and collecting natural gas hydrate,and their working principles and steps are illustrated.Finite element analysis,three-dimensional modeling,and simulations were conducted for both exploitation tools to verify their technological feasibility.The results show that the two exploitation tools can effectively improve the efficiency of hydrate exploitation and ensure the stability of the hydrate reservoir.This provides a reference for further research on the solid-state fluidization exploitation technology of marine gas hydrates.

Nonlinear semi-analytical modeling of liquid sloshing in rectangular container with horizontal baffles

A nonlinear semi-analytical scheme is proposed for investigating the finiteamplitude nonlinear sloshing in a horizontally baffled rectangular liquid container under the seismic excitation.The sub-domain method is developed to analytically derive the modal behaviors of the baffled linear sloshing.The viscosity dissipation effects from the interior liquid and boundary layers are considered.With the introduction of the generalized time-dependent coordinates,the surface wave elevation and velocity potential are represented by a series of linear modal eigenfunctions.The infinite-dimensional modal system of the nonlinear sloshing is formulated based on the Bateman-Luke variational principle,which is further reduced to the finite-dimensional modal system by using the NarimanovMoiseev asymptotic ordering.The base force and overturning moment induced by the nonlinear sloshing are derived as the functions of the generalized time-dependent coordinates.The present results match well with the available analytical,numerical,and experimental results.The paper examines the surface wave elevation,base force,and overturning moment versus the baffle parameters and excitation amplitude in detail.

Effect of polytetrafluoroethylene hollow fiber microstructure on formaldehyde carbonylation performance in membrane contactor

Membrane contactor is regarded as a promising method for reaction and process intensification. The feasibility of formaldehyde carbonylation to synthesize glycolic acid using polytetrafluoroethylene(PTFE)membrane contactor has been proved in our previous study. In this paper, the effect of membrane microstructure on process performance was further investigated. Three porous PTFE hollow fibers with different pore sizes and one polydimethylsiloxane(PDMS)/PTFE composite membrane with dense layer were fabricated for comparison. The physical and chemical properties of four membranes, including chemical composition, morphology, contact angle, liquid entry pressure, thermodynamic analysis and gas permeability, were systemically characterized. Experiments of formaldehyde carbonylation under different reaction conditions were conducted. The results indicated that the yield of glycolic acid increased with decreasing pore size for porous membranes, which was due to the improvement of wetting behavior. The dense layer of PDMS in composite hollow fiber could effectively prevent the solvent from entering membrane pores, thus the membrane exhibited the best performance. At reaction temperature of 120℃ and operation pressure of 3.0 MPa, the yield of glycolic acid was always higher than 90% as the mass ratio of trioxane and phosphotungstic acid increased from 0.2:1 to 0.8:1. The highest turnover frequency was up to 26.37 mol·g^(-1)·h^(-1). This study provided a reference for the understanding and optimization of membrane contactors for the synthesis of glycolic acid using solvent with low surface tension.

Turing pattern selection for a plant-wrack model with cross-diffusion

We investigate the Turing instability and pattern formation mechanism of a plant-wrack model with both self-diffusion and cross-diffusion terms.We first study the effect of self-diffusion on the stability of equilibrium.We then derive the conditions for the occurrence of the Turing patterns induced by cross-diffusion based on self-diffusion stability.Next,we analyze the pattern selection by using the amplitude equation and obtain the exact parameter ranges of different types of patterns,including stripe patterns,hexagonal patterns and mixed states.Finally,numerical simulations confirm the theoretical results.

绿色广告对消费者购买节能产品意图的影响机制研究——基于SOR模型

能源消耗导致能源危机和环境问题,节能消费对减少能耗具有重要意义。本文基于刺激-有机体-反应(SOR)框架,引入感知价值和积极情绪,构建了一个绿色广告影响消费者节能消费的模型。同时,基于一致性理论,探讨了自我形象一致性的影响。采用问卷调查法,对413名被调查者进行调查。结果显示,绿色广告接受度对感知价值、积极情绪及购买意愿有正向影响,绿色广告接受度与感知价值也受到自我形象一致性的正向调节,但绿色广告接受度与积极情绪的关系不受自我形象一致性的调节。在此基础上,讨论了本研究的应用价值及进一步研究展望。

Detection of the anthropogenic signal and urbanization effects in extreme temperature changes in eastern China

作为中国经济最发达的地区,中国东部受到城市热岛效应和温室气体排放等人类活动的明显影响.本文利用最新的观测和全球气候模式资料,对极端温度强度,频率和持续时间等16个极端温度指数进行了检测归因分析,研究了人为强迫和城市化效应对中国东部极端温度变化的影响.结果表明,近年来极端温度持续增暖,极端暖事件增加,极端冷事件减少.新一代全球气候模式能够合理地反映这些变暖特征,但是部分模式可能高估或低估了观测到的变化.基于最优指纹方法的双信号检测表明,人为信号和城市化效应只能在暖夜和冷夜两个频率指标上同时被检测并分离,其变化约三分之二可归因于人类活动,剩余的三分之一可归因于城市化效应.而在极端温度其他指数的变化中,只有人类活动的影响能够被检测到.

Selection of specific nanobodies against peanut allergen through unbiased immunization strategy and the developed immuno-assay

Peanut allergy is considered to be a major health issue with global effects.To date,no effective curative approach has been applied for the therapy of the anaphylaxis resulting from the peanut allergens.The accurate and effective detection methods for the surveillance of allergens in food are still the primary strategies to avoid allergic diseases.In this study,nanobodies(Nbs)derived from the Heavy-Chain only Antibodies(HCAbs)were selected against the general peanut protein extract through the unbiased strategy to facilitate the development of the sandwich ELISA for the detection and surveillance of peanut allergen contamination.The target antigen of the selected Nb was identified as peanut allergen Ara h 3,and a cross-reaction was observed with the member of Gly 1 from the Ara h 3 family.The applicability of the self-paired Nb P43 on the establishment of the immuno-assay was verified.A sandwich ELISA against peanut allergen was developed,which reached a linear range of 0.2-10.6μg/mL,and a limit of detection of 53.13 ng/mL.

A Trusted Multi-Task Distribution Mechanism for Internet of Vehicles Based on Smart Contract

In this paper,a trusted multi-task distribution mechanism for Internet of Vehicles based on smart contract is proposed to improve the security and efficiency for the task distribution in Internet of Vehicles.Firstly,a three-tier trusted multi-task distribution framework is presented based on smart contract.The smart contract will be triggered by the task request.As the important part of the smart contract,the task distribution algorithm is stored on the blockchain and run automatically.In the process of the task distribution,the cost of the task distribution and the system stability play a critical role.Therefore,the task distribution problem is formulated to minimize the cost of the task distribution whilst maintaining the stability of the system based on Lyapunov theorem.Unfortunately,this problem is a mixed integer nonlinear programming problem with NP-hard characteristics.To tackle this,the optimization problem is decomposed into two sub problems of computing resource allocation and task distribution decision,and an effective task distribution algorithm is proposed.Simulation results show that the proposed algorithm can effectively improves system performance.

Effect of Dandelion(Taraxacum mongolicum Hand.-Mazz.)Intercropping with Different Plant Spacing on Blight and Growth of Pepper(Capsicum annuum L.)

Intercropping of crops that can secrete bacteriostatic active substances can not only inhibit the occurrence of disease but also have an important effect on plant growth.However,the effects of dandelion intercropping on pepper blight control and pepper growth remain unclear.In this study,the control effect of dandelion on pepper blight was studied by inoculating the pepper leaves with Phytophthora infestans,and it also discusses the correlation of the occurrence of pepper epidemic disease with the pepper canopy environment,soil environment,pepper photo-synthesis,and yield index.The results showed that best plant distance for dandelion intercropping was 20 cm(P20),and the control effect reached 43.31%.As compared to the CK,SOD enzyme,POD enzyme,and PAL enzyme were significantly up-regulated during the growth of pepper;chlorophyll content in pepper leaves was significantly increased;photosynthetic characteristics were significantly increased;stem diameter and yield of crop pepper were effectively improved;and the quality of the pepper product was better,but intercropping dandelion resulted in a significant decrease of nutrients in the soil environment of pepper,so a reasonable intercropping distance was needed.The correlation analysis shows that the incidence of pepper blight(A)was significantly positively correlated with soil temperature(Q),intercellular carbon dioxide(L),and canopy air temperature(O).The incidence of capsicum blight(A)was significantly negatively correlated with chlorophyll content(F),net photo-synthetic rate(K),stomatal conductance(M),ww rate(N),soil sucrase activity(W),vitamin C(AB),and leaf PAL enzyme(J).Finally,it was deduced that intercropping dandelion could effectively control the occurrence of pepper blight while also demonstrating a complex interaction with the pepper growing environment.