Clinical Observation on the Treatment of Diabetic Kidney Disease with Damp-heat Stasis Syndrome in Clinical Proteinuria Stage by Kunkui Kidney Preserving Paste

[Objectives]To evaluate the clinical efficacy and safety of Kunkui Kidney Preserving Paste in the treatment of diabetic kidney disease(DKD)patients with damp-heat stasis syndrome in the clinical proteinuria stage.[Methods]Retrospective analysis was made on 30 patients with DKD who were diagnosed with damp-heat stasis syndrome in the clinical proteinuria stage from March 2021 to March 2023 in Jiangsu Province Hospital of Chinese Medicine,and who took Kunkui Kidney Preserving Paste continuously for six months.The urinary albumin/creatinine ratio(UACR),urinary complement C3,and urea nitrogen(BUN)of DKD patients before and after treatment were compared,and estimated glomerular filtration rate(eGFR),blood creatinine(Scr),and cystatin C(CysC)were estimated,and the therapeutic effects on renal function and urinary protein were evaluated.[Results]After treatment,UACR significantly decreased(P<0.01),and urinary complement C3 and Scr decreased(P<0.05),while other indicators showed no significant statistical difference(P>0.05).In terms of evaluating the efficacy of urinary protein therapy,8 cases showed recent relief;8 cases showed significant effect;9 cases were effective,and 5 cases were invalid after treatment,with a total effective rate of 83.33%.In terms of renal function efficacy evaluation,8 cases showed significant effect;4 cases were effective;11 cases were stable,and 7 cases were invalid,with a total effective rate of 76.67%.In the safety evaluation,there were no obvious adverse reactions.[Conclusions]The Kunkui Kidney Preserving Past has significant clinical efficacy and safety in treating DKD patients with damp-heat stasis syndrome in the clinical proteinuria period.It has significant advantages in reducing urinary protein and protecting renal function,which is worthy of clinical promotion.

免疫检查点抑制剂相关神经系统不良反应的临床诊治建议

免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)可引起神经系统的不良反应,发生率在0.1%-12%,80%发生在应用前4个月内。可以引起神经系统各部位的病变,包括无菌性脑膜炎,脑膜脑炎,坏死性脑炎,脑干脑炎,横贯性脊髓炎等中枢神经系统病变,也可引起颅神经周围神经病、多灶性神经根神经病、格林巴利综合征、脊神经根神经病、重症肌无力、肌病等周围神经病变。对于神经系统的这些并发症,均需要症状体征,并结合影像学、脑脊液细胞学、脑电图或肌电图等检查,除外感染或恶性肿瘤后获得诊断。治疗中,在严重病例需停用ICIs,并用大剂量糖皮质激素或丙种球蛋白治疗和对症支持治疗。在出现神经系统不良反应后,严重病例预后较差。

缺铁性贫血致青年缺血性脑卒中1例

贫血是全世界最常见营养缺乏症之一,约95%的患者与缺铁饮食有关,而青年缺铁性贫血患病率约为20%[1]。缺铁性贫血(iron-deficiency anemia,IDA)与多种疾病有关。已有IDA导致小儿脑卒中病例报道[2]。IDA致青年脑卒中病例报道较少,本文对陕西省人民医院收治的IDA致青年缺血性脑卒中1例进行分析,现报道如下。

利用短周期P波确定小震震源参数的新方法

提出了一种通过短周期(0.5～2Hz)P波反演来确定小震震源机制和地震矩的新方法,其中用已知震源机制的4级地震来校正没有给定模型的速度结构的影响。校正基于震群波形的分析,其结果显示震群中不同大小的地震事件,例如4级和2级,在短周期频带上显示出相似的信号,表明了传播过程的稳定。由于4级和2级地震事件的拐角频率都高于2Hz,因此可以认为是点源,并且没有给定模型的结构对短周期P波的影响可以由已知震源机制的4级地震推导出。同样,已经很好确定了参数的2级小震也能够为在更高频率,例如2～8Hz上研究更小的地震事件提供校正。尤其是我们发现,未给定模型的结构对短周期P波的影响主要是数据和一维合成之间的振幅的差异。我们定义"振幅放大因子"(AAF)为数据和一维合成之间的振幅比,不同的震群事件得到的AAF基本一致,有很好的稳定性且与震源机制无关,因此,它的简单函数为研究小震提供了有用的校正。我们用校正过的数据和短周期P波的合成来确定震源机制,并且采用网格搜索的方法来使拟合的误差最小化。确认检验显示了在重现可靠结果中AAF因子校正的重要性和有用性。我们以2003年的大贝尔震群为例对这一方法进行了说明。但该方法对南加州其他震源区的应用结果也同样很好,因为我们已经说明10km×10km的震源区AAF因子的稳定性和与震源机制的无关性。根据定义,AAF因子包含台站场地效应、路经效应和地壳散射效应。尽管想要分离出这些效应已经证明是很困难的,但AAF的稳定性和与震源机制无关性说明它们主要受接收台站附近场地结构的影响。另外,不同地区不同地震事件的垂向分量和径向分量AAF的比值看起来一致,说明这些AAF(v)/AAF(r)比值可能是场地条件的简单函数。本文得到了92个大贝尔地震序列ML2.0级以上地震的震源机制和地震矩。这些震源平面解包含了大量精细的断层结构情况,但仍与地震活动图案吻合得很好。最后我们提出符合3个震级档(2.0<ML<5.5)所有数据点的log(M0)与ML之间的线性关系为:log(M0)=1.12ML+17.29。

Highly selective synthesis for 4,4′-bisphenol F from phenol and formaldehyde catalyzed with [C_4mim][HSO_4] ionic liquid

The effects of N-methylimidazole cation [Cnmim] with different alkyl chain lengths, the types of cations and anions of ionic liquids and the reaction parameters on the catalytic activity and the selectivity for 4,4′-bisphenol F were investigated. The hydrogen bonding between the hydroxyl of phenol and the C2-position hydrogen of imidazole moiety in hydrophilic imidazole-based ionic liquid has important influence on the selectivity for 4,4′-bisphenol F, and under the conditions of the molar ratio of phenol/[C4mim][HSO4] 1:1, reaction temperature65 °C and the theoretical molar ratio of phenol/formaldehyde 2:1, the selectivity for 4,4′-bisphenol F reached69.1%. Compared with the high phenol/formaldehyde ratio reported in literatures, the low molar ratio of phenol/formaldehyde and the low reaction temperature can greatly reduce energy consumption, and has important significance for industrial application.

A trigonometric series expansion method for the Orr-Sommerfeld equation

A trigonometric series expansion method and two similar modified methods for the Orr-Sommerfeld equation are presented. These methods use the trigonometric series expansion with an auxiliary function added to the highest order derivative of the unknown function and generate the lower order derivatives through successive integra- tions. The proposed methods are easy to implement because of the simplicity of the chosen basis functions. By solving the plane Poiseuille flow (PPF), plane Couette flow (PCF), and Blasius boundary layer flow with several homogeneous boundary conditions, it is shown that these methods yield results with the same accuracy as that given by the conventional Chebyshev collocation method but with better robustness, and that ob- tained by the finite difference method but with fewer modal number.

知识员工激励因素实证研究

依据文献综述和基本假设,构建知识员工激励因素研究模型。以辽沈地区知识型企业的知识员工为研究对象,通过实证研究得出知识员工激励因素与知识员工被激励程度成显著正相关的结论,同时发现知识员工的性别、年龄、学历、工作年限、年薪水平和工作性质对于各项激励因素的感受程度存在显著性影响。

Feasibility of Transabdominal Real-time CDFI and HDFI Techniques for Fetal Pulmonary Vein Display in the First Trimester

Objective This study aimed to assess the feasibility and usefulness of transabdominal color Doppler flow imaging(CDFI)technology and the high-definition flow imaging(HDFI)technique in detecting fetal pulmonary veins(PVs)in the first trimester(11–13^(+6)weeks).Methods From December 2018 to October 2019,328 pregnant women with 328 normal singleton fetuses(crown-rump length:45–84 mm)who had undergone CDFI and HDFI scans for fetal heart and vessel examination were enrolled in this study.The cases were divided into three groups according to the gestational age:group A,11^(+0)−11^(+6)weeks;group B,12^(+0)−12^(+6)weeks;and group C,13^(+0)−13^(+6)weeks.Baseline sonograms and CDFI and HDFI images were analyzed by two senior radiologists independently and blindly.The abilities of CDFI and HDFI to display PVs were compared.Results Successful PV display rates via CDFI and HDFI were 2.3%and 68.2%(P<0.01),22.4%and 82.4%(P<0.01),41.5%and 91.2%(P<0.01)for group A,group B,and group C,respectively.The total successful display rates for the two methods were 28.9%(CDFI)and 84.8%(HDFI)(P<0.01).Conclusions The HDFI technique is more valuable than CDFI for detecting PVs in early pregnancy(11–13^(+6)weeks).HDFI can detect at least one PV in all cases and may be used to detect pulmonary venous anomalies early.

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and MAXI.This outburst can be classified roughly into four different states.Type-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this work.Meanwhile,we study various physical quantities related to QPO frequency.The QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain it.The relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

Intermarriage between amorphous and polycrystalline materials in perovskite solar cells:positive or not?

In recent few years,the research field of perovskite solar cells(PSCs)has witnessed an unprecedentedly rapid advancement in terms of skyrocketed power conversion efficiencies(PCEs)owing to the appealing optoelectronic properties of magic metal halide perovskite(MHP)materials,such as high absorption coefficient.

Anomalous tqγCouplings and Radiative B Meson Decays

Motivated by the recent ATLAS results in terms of the branching ratios B r(t→qγ),we consider the effects of the anomalous t qγcouplings on the radiative B meson decays¯B→X Dγand B→Vγwith V being light vector mesonsρ,ω,ϕand K∗.Comparing with the corresponding experimental measured data,we obtain the constraints on anomalous t qγcouplings.

The Preparation and Properties of Starch Based Shape Memory Hydrogel

In this work,the–catechol and–thiol modified starch was prepared by the esterification and amino condensation reaction,then a fully starch based hydrogel was prepared via the thiol-catechol Michael addition reaction.The starch hydrogel gained shape memory behaviors by coordinate with Fe^(3+)ions at alkaline condition.1H-NMR had been used to character the structure of the starch derivatives and its character peaks.The hydrogel’s modulus had also been measured before and after coordinating with Fe^(3+)ions in linear area and the result showed that both the hydrogel’s storage modulus and loss modulus kept constant in linear area from 0.1 rad/s to 100 rad/s,which demonstrated a good network was formed inside the hydrogel.Furthermore,the shape memory behaviors had been tested by changing the pH value in solution.The result showed that the hydrogel can keep its temporary shape in high pH condition and recover to its original state after the shaped hydrogel immersed into acidic solution.This hydrogel might have great application prospects in the field of biomedical and engineering.

Donald V.Helmberger,the master mentor:Testimonials from former international students

Don trained many Ph.D.students over the〜5 decades of his career,at least 45 were advised or co-advised according to a Caltech account.A large number were international students including a high percentage of Chinese students.The contributors to this article graduated over a time span of 26 years,and we are now distributed in 6 countries across 14 time zones,yet we represent only a small fraction of his former students and postdocs.

Polyfluorene-Polytriarylamine Block Copolymer as an Additive for Electroluminescent Devices Based on Polymer Blends

Electroluminescent characteristics were investigated for the blue emitting devices fabricated with the blend systems consisting of hole transporting polytriarylamine (PTAA), electron transporting polyfluorene (PF), and a block copolymer with both segments (PF-b-PTAA) as an active layer in order to elucidate the relationship between the chemical nature and morphology of the active layer, and EL performance. The addition of PF-b-PTAA to PF homopolymer afforded the hole injecting and/or electron blocking ability to increase the efficiency. The addition to PF/PTAA blend keeping the chemical composition constant also improved the performance by controlling the morphology and/or the domain size in phase-separated films.

Development and validation of an immunogenic cell death-related prognostic model, and landscape of the tumor immune microenvironment in glioblastoma

The important role of immunogenic cell death(ICD)in many tumors is increasingly being discovered.However,its mechanisms and potential as a biomarker and therapeutic target in glioblastoma(GBM)have not been well studied.We obtained GBM samples from the Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)databases,as well as the immunotherapy cohort from the IMvigor210 study.We used unsupervised clustering to obtain two ICDrelated clusters,corresponding to the ICD-low and ICD-high subtypes respectively,and the tumor immune microenvironment and prognosis of the two subtypes were significantly different.

Promoting Bone Mesenchymal Stem Cells and Inhibiting Bacterial Adhesion of Acid-Etched Nanostructured Titanium by Ultraviolet Functionalization

Titanium(Ti) and its alloys are used extensively in orthopedic implants because of their excellent biocompatibility,mechanical properties and corrosion resistance. However,titanium-based implant materials face many severe complications,such as implant loosening due to poor osseointegration and bacterial infections,which may lead to implant failure. Hence,preparing a biomaterial surface,which enhances the interactions with host cells and inhibits bacterial adhesion,may be an optimal strategy to reduce the incidence of implant failure. This study aims to improve osseointegration and confer antibacterial properties on Ti through a combination of two surface modifications including nanostructuring generated by acid etching and ultraviolet(UV) light treatment.Our results showed that without UV treatment,the acid etching treatment of Ti surface was effective at both improving the adhesion of bone mesenchymal stem cells(BMSCs) and increasing bacterial adhesion. A further UV treatment of the acid-etched surface however,not only significantly improved the cell adhesion but also inhibited bacterial adhesion. The acid-etched nanostructured titanium with UV treatment also showed a significant enhancement on cell proliferation,alkaline phosphatase(ALP) activity and mineralization. These results suggest that such nanostructured materials with UV treatment can be expected to have a good potential in orthopedic applications.

酸性土壤下缓解大豆铝胁迫的研究进展

大豆是我国重要的油料作物,具有独特的营养成分,在我国各地区被广泛种植.铝毒是植物在酸性土壤环境中的重要胁迫因子,影响植物生长发育,具体表现为阻碍营养物质交换、引起细胞DNA损伤等.近年来,随着工业发展,我国土壤酸性不断增强,植物受铝胁迫影响日益加剧,大豆作为铝毒敏感作物,其生长、产量乃至品质受到极大的限制.因此,揭示铝离子对大豆生长发育的影响及大豆对铝胁迫的防御机制,对了解大豆耐铝性和治理大豆铝毒害具有重要意义.本文基于铝毒对大豆作用及大豆对铝胁迫的抗性机制两方面进行探究,综合分析酸性土壤下大豆根际的环境变化,列举缓解铝毒害的主要措施,并提出需要从分子生物学角度更进一步深入构建铝胁迫分子调控机制,为推进大豆耐铝性研究而努力,以期为该领域更深入的探索提供参考.

B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis

Hyperhomocysteinemia(HHcy)is a risk factor for chronic kidney diseases(CKDs)that affects about 85%CKD patients.HHcy stimulates B cells to secrete pathological antibodies,although it is unknown whether this pathway mediates kidney injury.In HHcytreated 2-kidney,1-clip(2K1C)hypertensive murine model,HHcy-activated B cells secreted anti-beta 2 glycoprotein I(β2GPI)antibodies that deposited in glomerular endothelial cells(GECs),exacerbating glomerulosclerosis and reducing renal function.Mechanistically,HHcy 2K1C mice increased phosphatidylethanolamine(PE)(18:0/20:4,18:0/22:6,16:0/20:4)in kidney tissue,as determined by lipidomics.GECs oxidative lipidomics validated the increase of oxidized phospholipids upon Hcy-activated B cells culture medium(Hcy-B CM)treatment,including PE(18:0/20:4+3[O],PE(18:0a/22:4+1[O],PE(18:0/22:4+2[O]and PE(18:0/22:4+3[O]).PE synthases ethanolamine kinase 2(etnk2)and ethanolamine-phosphate cytidylyltransferase 2(pcyt2)were increased in the kidney GECs of HHcy 2K1C mice and facilitated polyunsaturated PE synthesis to act as lipid peroxidation substrates.In HHcy 2K1C mice and Hcy-B CM-treated GECs,the oxidative environment induced by iron accumulation and the insufficient clearance of lipid peroxides caused by transferrin receptor(TFR)elevation and down-regulation of SLC7A11/glutathione peroxidase 4(GPX4)contributed to GECs ferroptosis of the kidneys.In vivo,pharmacological depletion of B cells or inhibition of ferroptosis mitigated the HHcy-aggravated hypertensive renal injury.Consequently,our findings uncovered a novel mechanism by which B cell-derived pathogenic anti-β2GPI IgG generated by HHcy exacerbated hypertensive kidney damage by inducing GECs ferroptosis.Targeting B cells or ferroptosis may be viable therapeutic strategies for ameliorating lipid peroxidative renal injury in HHcy patients with hypertensive nephropathy.

靶向钝化与界面载流子动力学优化以提高无空穴传输层的窄带隙钙钛矿太阳电池的效率和稳定性

窄带隙锡-铅混合钙钛矿太阳电池(PSCs)的效率有望接近Shockley-Queisser极限,然而,易氧化的亚锡离子Sn^(2+)以及载流子传输层/钙钛矿未优化的界面接触会导致严重的界面电荷复合和器件性能下降,这在很大程度上阻碍了锡-铅混合钙钛矿太阳电池的实际应用,本文通过在钙钛矿中掺入少量有机膦酸咔唑分子,成功地制备了无空穴传输层锡-铅混合钙钛矿太阳电池.相对于Pb^(2+),有机磷酸咔唑分子在晶界处和晶体表面与Sn^(2+)离子有更强的化学配位作用,从而有效抑制Sn^(2+)的氧化,钝化缺陷并抑制非辐射复合。在移除空穴传输层的情况下,此类有机膦酸咔唑分子靶向修饰作用可有效增强内建电场(~100mV),优化透明导电基底与钙钛矿层的能级排列,从而加速光生电荷分离,促进界面空穴抽取和传输.最终,无空穴传输层的锡-铅混合钙钛矿太阳电池获得最高20.21%的光电转换效率,开路电压高达0.87V,同时实现了超过2400小时的长期稳定性。

Synergistic effects of multiple rotors and hydrogen-bond interactions lead to sensitive near-infrared viscosity probes for live-cell microscopy

Changes in cellular viscosity are associated with various physiological processes and pathological conditions.To study these cellular processes and functions,highly sensitive fluorescent probes that detect subtle changes in viscosity are urgently needed but remain lacking.In this study,we present a series of viscosity-responsive near-infrared(NIR)fluorescent probes based on styrene-coated boron dipyrromethene(BODIPY).The probe modified with dimethylaminostyrene and piperazine at the two terminals of the BODIPY scaffold showed extremely high viscosity sensitivity values(x,around 1.54),with excellent performance for detecting viscosity below 20 c P.This outstanding property is attributed to the synergistic effects of multiple rotatable bonds and hydrogen-bond interactions.Additionally,this probe has been successfully deployed to monitor viscosity changes in various cellular compartments(i.e.,cytoplasm)and processes(such as during autophagy).This work provides a rational molecular design strategy to construct fluorescent probes with high viscosity sensitivity for exploring cell functions.