A convenient synthetic route was developed for the synthesis of the novel glycolipids: 1, 2-di-O-acyl-3-O-(2-acylamide-2-deoxy-a-D-glucopyranosyl)-sn-glycerols. 10 new compounds of glycolipids with different acyl grou...A convenient synthetic route was developed for the synthesis of the novel glycolipids: 1, 2-di-O-acyl-3-O-(2-acylamide-2-deoxy-a-D-glucopyranosyl)-sn-glycerols. 10 new compounds of glycolipids with different acyl groups were obtained.展开更多
The Ugi four-component reaction (U-4CR) was utilized to prepare divalent and trivalent cluster mannosides. Thus, two target compounds 6 and 8 were obtained efficiently using carboxymethyl 2, 3, 4, 6-tetra-O-acetyl--D-...The Ugi four-component reaction (U-4CR) was utilized to prepare divalent and trivalent cluster mannosides. Thus, two target compounds 6 and 8 were obtained efficiently using carboxymethyl 2, 3, 4, 6-tetra-O-acetyl--D-mannopyranoside 4 as acid component, and 1, 6-hexanediamine or tris(2-aminoethyl)amine as the multivalent scaffolds.展开更多
The synthesis and biological evaluation of two series of salicylanilide derivatives on the EGFR and ErbB-2 tyrosine kinases inhibitory activities were conducted.Of the tested compounds those having an additional aryl ...The synthesis and biological evaluation of two series of salicylanilide derivatives on the EGFR and ErbB-2 tyrosine kinases inhibitory activities were conducted.Of the tested compounds those having an additional aryl group substituted on the anilino ring were active on the EGFR tyrosine kinase inhibition（7a-c and 13a,13c,13d,13f）.The inhibitory activities were all in the low micromolar or submicromolar range.In addition,compound 13a was found to have dual inhibitory activities both on EGFR and ErbB-2 tyrosine kinases（1.654±1.280 and 7.134±1.265μmol/L）.展开更多
Integrated urban water management （IUWM） is a useful tool that can be used to alleviate water resource shortages in developing regions like Macao, where 98% of the raw water comes from China's Mainland. In Macao...Integrated urban water management （IUWM） is a useful tool that can be used to alleviate water resource shortages in developing regions like Macao, where 98% of the raw water comes from China's Mainland. In Macao, scarce water resources deteriorate rapidly in emergency situations, such as accidental chemical spills upstream of the supply reservoir or salty tides. During these times, only the water from the two freshwater reservoirs in Macao can be used. In this study, we developed urban water management optimization models that integrated the raw water supply from the two reservoirs with various proposed governmental policies （wastewater reuse, rainwater collection, and water saving）. We then determined how various water resource strategies would influence the urban water supply in Macao in emergency situations. Our results showed that, without imported raw water, the water supply from only the two Macao reservoirs would last for 7.95 days. However, when all the government policies were included in the model, the supply could be extended to 13.79 days. Out of the three non-conventional water resources, wastewater reuse is the most beneficial for increasing the Macao water supply, and rainwater collection also has great potential.展开更多
文摘A convenient synthetic route was developed for the synthesis of the novel glycolipids: 1, 2-di-O-acyl-3-O-(2-acylamide-2-deoxy-a-D-glucopyranosyl)-sn-glycerols. 10 new compounds of glycolipids with different acyl groups were obtained.
文摘The Ugi four-component reaction (U-4CR) was utilized to prepare divalent and trivalent cluster mannosides. Thus, two target compounds 6 and 8 were obtained efficiently using carboxymethyl 2, 3, 4, 6-tetra-O-acetyl--D-mannopyranoside 4 as acid component, and 1, 6-hexanediamine or tris(2-aminoethyl)amine as the multivalent scaffolds.
基金supported by the Research Fund for the Doctoral Program of Higher Education of China(No 20100071120051)the Fundamental Research Funds for the Central Universities(No10FX061)
文摘The synthesis and biological evaluation of two series of salicylanilide derivatives on the EGFR and ErbB-2 tyrosine kinases inhibitory activities were conducted.Of the tested compounds those having an additional aryl group substituted on the anilino ring were active on the EGFR tyrosine kinase inhibition（7a-c and 13a,13c,13d,13f）.The inhibitory activities were all in the low micromolar or submicromolar range.In addition,compound 13a was found to have dual inhibitory activities both on EGFR and ErbB-2 tyrosine kinases（1.654±1.280 and 7.134±1.265μmol/L）.
基金supported by the Fundo para lo Desenvolvimento das Ciências e da Tecnologia (FDCT), under Grant No. FDCT/069/2014/A2the Research Committee of the University of Macao, under Grant No MYRG072(Y1-L2)-FST13-LIC
文摘Integrated urban water management （IUWM） is a useful tool that can be used to alleviate water resource shortages in developing regions like Macao, where 98% of the raw water comes from China's Mainland. In Macao, scarce water resources deteriorate rapidly in emergency situations, such as accidental chemical spills upstream of the supply reservoir or salty tides. During these times, only the water from the two freshwater reservoirs in Macao can be used. In this study, we developed urban water management optimization models that integrated the raw water supply from the two reservoirs with various proposed governmental policies （wastewater reuse, rainwater collection, and water saving）. We then determined how various water resource strategies would influence the urban water supply in Macao in emergency situations. Our results showed that, without imported raw water, the water supply from only the two Macao reservoirs would last for 7.95 days. However, when all the government policies were included in the model, the supply could be extended to 13.79 days. Out of the three non-conventional water resources, wastewater reuse is the most beneficial for increasing the Macao water supply, and rainwater collection also has great potential.
