Association between vitamin D receptor gene polymorphism and prognosis in patients with end stage renal disease undergoing dialysis

Objective:To investigate the relationship between vitamin D receptor gene polymorphism and prognosis in patients with end stage renal disease(ESRD)undergoing dialysis.Methods:80 patients with ESRD who underwent regular hemodialysis in our hospital were admitted from January 2016 to June 2016,and 80 healthy volunteers from our hospital were collected as control group during the same period.The polymorphisms of rs1544410(BsmI)of vitamin D receptor gene were identified by peripheral blood DNA amplification and specific enzyme digestion,including wild type GG(bb)and mutant GA(Bb)and AA(BB).Then analyze and compare the distribution of BsmI in patients with ESRD and normal volunteers,further analyze the correlation between BsmI locus and clinical characteristics of patients with ESRD,and analyze the relationship between BsmI locus and prognosis of patients with ESRD according to the follow-up results of patients.Results:The incidence of wild type(bb)of vitamin D receptor BsmI locus in patients with ESRD was significantly lower than that in the control group,while the incidence of mutant type(Bb and BB)was higher than that in the control group,with an advantage ratio of 1.378(P=0.004).The allele frequency of BsmI locus showed that the incidence of A-base in patients with ESRD was higher than that in control group,with an advantage ratio of 1.368(P=0.010).Comparing the genotype and clinical characteristics of BsmI locus in patients with ESRD,it was found that there were no differences in age,sex ratio between men and women,BMI,hypertension,diabetes,LDL,HDL,TG,urea nitrogen,creatinine,calcium,phosphorus,albumin and vitamin D levels among different genotypes.One year after treatment,the survival rate of bb group was significantly higher than that of Bb group and BB group(P=0.006).K-M analysis showed that the median survival time of BB group was 20 months,that of BB group was 8 months,and that of BB group was 4 months(P=0.000).Conclusion:There is a high mutation rate of BsmI locus(GA,AA type)in patients with ESRD,that is,the mutation rate of G-base to A is higher,and the survival time of patients with mutation is significantly shortened.

Extreme cold wave in early November 2021 in China and the influences from the meridional pressure gradient over East Asia

In early November 2021,China experienced its second strongest cold wave event during 1981-2021.Although the Siberian high is considered the main factor influencing cold wave events in East Asia,it was not extremely strong from 4 to November 9,2021.The spatial distribution of the correlation coefficients between the sea level pressure and the daily temperature anomalies shows a monopole pattern,with a notable negative centre in the southern part of the Siberian high monitoring domain.However,the correlation between the sea level pressure and temperature drop presents a typical dipole pattern,with a distinct negative centre in the northern monitoring domain and a positive centre in southern East Asia.During the November 2021 super cold wave process,the sea level pressure anomalies display a dipole pattern with a higher centre in the north and a lower centre in the south owing to the northward shift of the Intertropical Convergence Zone.The meridional pressure gradient index clearly reveals the non-negligible effect of subtropical low-pressure on this super cold wave process,indicating its possibly essential supplementary role in enhancing this process.The above findings provide a new understanding of its mechanism and long-range forecasts.