Pim-3 is a member of the provirus integration site for Moloney murine leukemia virus(Pim)family proteins that exhibit serine/threonine kinase activity.Similar to the other Pim kinases(Pim-1 and Pim-2),Pim-3 is involve...Pim-3 is a member of the provirus integration site for Moloney murine leukemia virus(Pim)family proteins that exhibit serine/threonine kinase activity.Similar to the other Pim kinases(Pim-1 and Pim-2),Pim-3 is involved in many cellular processes,including cell proliferation,survival,and protein synthesis.Although Pim-3is expressed in normal vital organs,it is overexpressed particularly in tumor tissues of endoderm-derived organs,including the liver,pancreas,and colon.Silencing of Pim-3 expression can retard in vitro cell proliferation of hepatocellular,pancreatic,and colon carcinoma cell lines by promoting cell apoptosis.Pim-3 lacks the regulatory domains similarly as Pim-1 and Pim-2 lack,and therefore,Pim-3 can exhibit its kinase activity once it is expressed.Pim-3 expression is regulated at transcriptional and post-transcriptional levels by transcription factors(e.g.,Ets-1)and post-translational modifiers(e.g.,translationally-controlled tumor protein),respectively.Pim-3 could promote growth and angiogenesis of human pancreatic cancer cells in vivo in an orthotopic nude mouse model.Furthermore,a Pim-3 kinase inhibitor inhibited cell proliferation when human pancreatic cancer cells were injected into nude mice,without inducing any major adverse effects.Thus,Pim-3 kinase may serve as a novel molecular target for developing targeting drugs against pancreatic and other types of cancer.展开更多
We demonstrated an Fe:ZnSe laser pumped by a 2.93-μm Cr, Er:YAG laser at liquid nitrogen and room temperature in single-shot free-running operation for the first time. The xenon flash lamp pumped Cr, Er:YAG laser had...We demonstrated an Fe:ZnSe laser pumped by a 2.93-μm Cr, Er:YAG laser at liquid nitrogen and room temperature in single-shot free-running operation for the first time. The xenon flash lamp pumped Cr, Er:YAG laser had a maximum single pulse energy of 1.414 J, and the threshold and slope efficiency were 141.70 J and 0.70% which were respectively reduced by 29.3% and increased by 52.2% compared with the Er:YAG laser. At liquid nitrogen temperature of 77 K, the maximum single pulse energy of the Fe:ZnSe laser was 197.6 m J, corresponding to a slope efficiency of 13.4%. The central wavelength and full width at half maximum(FWHM) linewidth were 4037.4 nm and 122.0 nm, respectively. At room temperature, the laser generated a maximum single pulse energy of 3.5 mJ at the central wavelength of 4509.6 nm with an FWHM linewidth of 171.5 nm.展开更多
We demonstrate a Fe:ZnSe laser gain-switched by a 2.9 m ZnGeP2 optical parametric oscillator under pulse repetition frequency of 1 kHz at liquid nitrogen temperature of 77 K. The maximum output power is 63 m W with pu...We demonstrate a Fe:ZnSe laser gain-switched by a 2.9 m ZnGeP2 optical parametric oscillator under pulse repetition frequency of 1 kHz at liquid nitrogen temperature of 77 K. The maximum output power is 63 m W with pulse duration of 34.4 ns. The wavelength covers 3686.6–4088.6 nm and centers at 3897.7 nm. The output power decreases with increasing the temperature of the crystal in 77–222 K.展开更多
We demonstrate a gain-switched Fe:ZnSe laser pumped by a 2958 nm pulsed Ho,Pr:LLF laser. The maximum single pulse energy is 16.4uJ with a minimum pulse duration of 13.9 ns at the pulse repetition frequency of1 Hz when...We demonstrate a gain-switched Fe:ZnSe laser pumped by a 2958 nm pulsed Ho,Pr:LLF laser. The maximum single pulse energy is 16.4uJ with a minimum pulse duration of 13.9 ns at the pulse repetition frequency of1 Hz when the Fe:ZnSe crystal is cooled to 77 K by liquid nitrogen, corresponding to a slope efficiency of 22.9%.The central wavelength and FWHM linewidth are 3957.4 nm and 23.2 nm, respectively. The output energy monotonically decreases as the crystal temperature increases in the range 77–293 K.展开更多
BACKGROUND Diphallia is a highly uncommon congenital urogenital abnormality and a few connected reports have been published.However,no case of intraabdominal heterotopic diphallus has been documented to date.In the pr...BACKGROUND Diphallia is a highly uncommon congenital urogenital abnormality and a few connected reports have been published.However,no case of intraabdominal heterotopic diphallus has been documented to date.In the present study,we present a rare case of intraperitoneal ectopic bipenis.CASE SUMMARY A 49-year-old man was hospitalized with the chief complaint of hydronephrosis of both kidneys,which was discovered three days earlier through regular physical examination performed using urological ultrasound without significant lumbar or abdominal pain or bladder irritation.Physical examination showed normal external penile development,bilateral testes located on the left side of the scrotum,and a fused epididymis.Urological plain and enhanced computed tomography suggested bilateral hydronephrosis,bilateral ureters opened to the left side of the bladder wall;an intrapelvic soft tissue shadow on the left side of the bladder was considered a germline malformation called bipenis(hidden penis in the abdominal cavity).Based on the urological plain and enhanced computed tomography results,a 49-year-old man was diagnosed with bipenis(one hidden in the abdominal cavity).Ectopic penile compression produced bilateral ureteral dilatation and hydronephrosis.The ectopic penis was amputated and partially removed during surgery,and bilateral ureteral replantation was successfully performed.At a 2-mo follow-up,the patient was very satisfied with the operation,there was no significant hydronephrosis in both kidneys,and urination and erectile function were normal.CONCLUSION To our knowledge,this is the first report of diphallia with an intraperitoneal ectopic penis.Computed tomography or magnetic resonance imaging can be used to assess the associated internal anomalies before surgery.Postoperative pathological findings are the gold standard for the diagnosis.展开更多
In this paper,we propose a modified proximal gradient method for solving a class of nonsmooth convex optimization problems,which arise in many contemporary statistical and signal processing applications.The proposed m...In this paper,we propose a modified proximal gradient method for solving a class of nonsmooth convex optimization problems,which arise in many contemporary statistical and signal processing applications.The proposed method adopts a new scheme to construct the descent direction based on the proximal gradient method.It is proven that the modified proximal gradient method is Q-linearly convergent without the assumption of the strong convexity of the objective function.Some numerical experiments have been conducted to evaluate the proposed method eventually.展开更多
基金Supported by the National Science Foundation of China(in part),No.30973476 and No.812727
文摘Pim-3 is a member of the provirus integration site for Moloney murine leukemia virus(Pim)family proteins that exhibit serine/threonine kinase activity.Similar to the other Pim kinases(Pim-1 and Pim-2),Pim-3 is involved in many cellular processes,including cell proliferation,survival,and protein synthesis.Although Pim-3is expressed in normal vital organs,it is overexpressed particularly in tumor tissues of endoderm-derived organs,including the liver,pancreas,and colon.Silencing of Pim-3 expression can retard in vitro cell proliferation of hepatocellular,pancreatic,and colon carcinoma cell lines by promoting cell apoptosis.Pim-3 lacks the regulatory domains similarly as Pim-1 and Pim-2 lack,and therefore,Pim-3 can exhibit its kinase activity once it is expressed.Pim-3 expression is regulated at transcriptional and post-transcriptional levels by transcription factors(e.g.,Ets-1)and post-translational modifiers(e.g.,translationally-controlled tumor protein),respectively.Pim-3 could promote growth and angiogenesis of human pancreatic cancer cells in vivo in an orthotopic nude mouse model.Furthermore,a Pim-3 kinase inhibitor inhibited cell proliferation when human pancreatic cancer cells were injected into nude mice,without inducing any major adverse effects.Thus,Pim-3 kinase may serve as a novel molecular target for developing targeting drugs against pancreatic and other types of cancer.
基金Project supported by the National Natural Science Foundation of China(Grant No.61405047)
文摘We demonstrated an Fe:ZnSe laser pumped by a 2.93-μm Cr, Er:YAG laser at liquid nitrogen and room temperature in single-shot free-running operation for the first time. The xenon flash lamp pumped Cr, Er:YAG laser had a maximum single pulse energy of 1.414 J, and the threshold and slope efficiency were 141.70 J and 0.70% which were respectively reduced by 29.3% and increased by 52.2% compared with the Er:YAG laser. At liquid nitrogen temperature of 77 K, the maximum single pulse energy of the Fe:ZnSe laser was 197.6 m J, corresponding to a slope efficiency of 13.4%. The central wavelength and full width at half maximum(FWHM) linewidth were 4037.4 nm and 122.0 nm, respectively. At room temperature, the laser generated a maximum single pulse energy of 3.5 mJ at the central wavelength of 4509.6 nm with an FWHM linewidth of 171.5 nm.
基金Supported by the National Natural Science Foundation of China under Grant No 51572053the Science Fund for Outstanding Youths of Heilongjiang Province under Grant No JQ201310
文摘We demonstrate a Fe:ZnSe laser gain-switched by a 2.9 m ZnGeP2 optical parametric oscillator under pulse repetition frequency of 1 kHz at liquid nitrogen temperature of 77 K. The maximum output power is 63 m W with pulse duration of 34.4 ns. The wavelength covers 3686.6–4088.6 nm and centers at 3897.7 nm. The output power decreases with increasing the temperature of the crystal in 77–222 K.
基金the National Natural Science Foundation of China under Grant No 61405047
文摘We demonstrate a gain-switched Fe:ZnSe laser pumped by a 2958 nm pulsed Ho,Pr:LLF laser. The maximum single pulse energy is 16.4uJ with a minimum pulse duration of 13.9 ns at the pulse repetition frequency of1 Hz when the Fe:ZnSe crystal is cooled to 77 K by liquid nitrogen, corresponding to a slope efficiency of 22.9%.The central wavelength and FWHM linewidth are 3957.4 nm and 23.2 nm, respectively. The output energy monotonically decreases as the crystal temperature increases in the range 77–293 K.
文摘BACKGROUND Diphallia is a highly uncommon congenital urogenital abnormality and a few connected reports have been published.However,no case of intraabdominal heterotopic diphallus has been documented to date.In the present study,we present a rare case of intraperitoneal ectopic bipenis.CASE SUMMARY A 49-year-old man was hospitalized with the chief complaint of hydronephrosis of both kidneys,which was discovered three days earlier through regular physical examination performed using urological ultrasound without significant lumbar or abdominal pain or bladder irritation.Physical examination showed normal external penile development,bilateral testes located on the left side of the scrotum,and a fused epididymis.Urological plain and enhanced computed tomography suggested bilateral hydronephrosis,bilateral ureters opened to the left side of the bladder wall;an intrapelvic soft tissue shadow on the left side of the bladder was considered a germline malformation called bipenis(hidden penis in the abdominal cavity).Based on the urological plain and enhanced computed tomography results,a 49-year-old man was diagnosed with bipenis(one hidden in the abdominal cavity).Ectopic penile compression produced bilateral ureteral dilatation and hydronephrosis.The ectopic penis was amputated and partially removed during surgery,and bilateral ureteral replantation was successfully performed.At a 2-mo follow-up,the patient was very satisfied with the operation,there was no significant hydronephrosis in both kidneys,and urination and erectile function were normal.CONCLUSION To our knowledge,this is the first report of diphallia with an intraperitoneal ectopic penis.Computed tomography or magnetic resonance imaging can be used to assess the associated internal anomalies before surgery.Postoperative pathological findings are the gold standard for the diagnosis.
基金the National Natural Science Foundation of China(No.61179033).
文摘In this paper,we propose a modified proximal gradient method for solving a class of nonsmooth convex optimization problems,which arise in many contemporary statistical and signal processing applications.The proposed method adopts a new scheme to construct the descent direction based on the proximal gradient method.It is proven that the modified proximal gradient method is Q-linearly convergent without the assumption of the strong convexity of the objective function.Some numerical experiments have been conducted to evaluate the proposed method eventually.
