Autophagy is a process of lysosome degradation,which plays an important role in maintaining cell homeostasis and organ integrity through the degradation of misfolded proteins,removal of damaged organelles and excess l...Autophagy is a process of lysosome degradation,which plays an important role in maintaining cell homeostasis and organ integrity through the degradation of misfolded proteins,removal of damaged organelles and excess lipids,which is one of the research hotspots in recent years.Liver disease often develops into chronic disease with high mortality,which seriously affects the life safety and quality of life of patients.Studies have shown that autophagy participates in the processes of cellular immunity and oxidative stress,plays an important role in a variety of liver diseases,has the characteristics of two-way regulation,and moderate autophagy has a protective effect.Excessive or dysfunctional autophagy can promote cell death and lead to the occurrence and development of the disease.at present,regulating autophagy is considered as a potential treatment.Based on chronic viral hepatitis,liver fibrosis,non-alcoholic fatty liver disease,acute liver failure and primary liver cancer,this paper reviews the functional characteristics and regulatory mechanism of autophagy in liver diseases.to explore new therapeutic targets for liver diseases,in order to provide new ideas and basis for clinical diagnosis and treatment.展开更多
Hepatocytes can divide rapidly and proliferate in the absence of inflammation and fibroplasia in the damaged or partial hepatectomy(PHx)of the liver,which is essential for the recovery of related patients.Recent studi...Hepatocytes can divide rapidly and proliferate in the absence of inflammation and fibroplasia in the damaged or partial hepatectomy(PHx)of the liver,which is essential for the recovery of related patients.Recent studies have found that bile acids(BA)play an important role in the process of liver regeneration.In the early stages of PHx,bile acid overload occurs,and liver injury is aggravated by loading.Later bile acids can induce protective and proliferative responses in the liver and promote liver regeneration.In this paper,we summarize the negative effects after bile acid overload and its positive role as a signaling molecule involved in related signaling pathways on liver regeneration,including protection of the liver and promotion of liver regeneration,and its double-edswordged"in Liver regeneration.This provides a theoretical basis for subsequent in-depth study of the mechanism and benefit avoidance in clinical treatment.展开更多
基金General Program of National Natural Science Foundation of China(No.81774236)National Natural Science Foundation of China(No.81960841)+1 种基金Guangxi Science and Technology Planning Project(No.GuikeAD17129001)Project supported by Guangxi Natural Science Foundation(No.2018GXNSFAA281096)。
文摘Autophagy is a process of lysosome degradation,which plays an important role in maintaining cell homeostasis and organ integrity through the degradation of misfolded proteins,removal of damaged organelles and excess lipids,which is one of the research hotspots in recent years.Liver disease often develops into chronic disease with high mortality,which seriously affects the life safety and quality of life of patients.Studies have shown that autophagy participates in the processes of cellular immunity and oxidative stress,plays an important role in a variety of liver diseases,has the characteristics of two-way regulation,and moderate autophagy has a protective effect.Excessive or dysfunctional autophagy can promote cell death and lead to the occurrence and development of the disease.at present,regulating autophagy is considered as a potential treatment.Based on chronic viral hepatitis,liver fibrosis,non-alcoholic fatty liver disease,acute liver failure and primary liver cancer,this paper reviews the functional characteristics and regulatory mechanism of autophagy in liver diseases.to explore new therapeutic targets for liver diseases,in order to provide new ideas and basis for clinical diagnosis and treatment.
基金General Program of National Natural Science Foundation of China(No.81774236,81960841)。
文摘Hepatocytes can divide rapidly and proliferate in the absence of inflammation and fibroplasia in the damaged or partial hepatectomy(PHx)of the liver,which is essential for the recovery of related patients.Recent studies have found that bile acids(BA)play an important role in the process of liver regeneration.In the early stages of PHx,bile acid overload occurs,and liver injury is aggravated by loading.Later bile acids can induce protective and proliferative responses in the liver and promote liver regeneration.In this paper,we summarize the negative effects after bile acid overload and its positive role as a signaling molecule involved in related signaling pathways on liver regeneration,including protection of the liver and promotion of liver regeneration,and its double-edswordged"in Liver regeneration.This provides a theoretical basis for subsequent in-depth study of the mechanism and benefit avoidance in clinical treatment.
