A multivariable regression analysis of the in-situ stress field, which considers the non-linear deformation behavior of faults in practical projects, is presented based on a newly developed three-dimensional displacem...A multivariable regression analysis of the in-situ stress field, which considers the non-linear deformation behavior of faults in practical projects, is presented based on a newly developed three-dimensional displacement discontinuity method （DDM） program. The Bar- ton-Bandis model and the Kulhaway model are adopted as the normal and the tangential deformation model of faults, respectively, where the Mohr-Coulomb failure criterion is satisfied. In practical projects, the values of the mechanical parameters of rock and faults are restricted in a bounded range for in-situ test, and the optimal mechanical parameters are obtained from this range by a loop. Comparing with the traditional finite element method （FEM）, the DDM regression results are more accurate.展开更多
Tumor antigens can be divided into tumor-associated antigens and tumor-specific antigens according to their specificity. Tumorassociated antigens are not unique to tumor cells, and can also be synthesized in small amo...Tumor antigens can be divided into tumor-associated antigens and tumor-specific antigens according to their specificity. Tumorassociated antigens are not unique to tumor cells, and can also be synthesized in small amounts by normal cells. Tumor-specific antigens, also called neoantigens, are formed by peptides that are entirely absent from the normal human genome [1]. Neoantigens are展开更多
基金financially supported by the Western Transport Technical Project of the Ministry of Transport, China (No. 2009318000046)
文摘A multivariable regression analysis of the in-situ stress field, which considers the non-linear deformation behavior of faults in practical projects, is presented based on a newly developed three-dimensional displacement discontinuity method （DDM） program. The Bar- ton-Bandis model and the Kulhaway model are adopted as the normal and the tangential deformation model of faults, respectively, where the Mohr-Coulomb failure criterion is satisfied. In practical projects, the values of the mechanical parameters of rock and faults are restricted in a bounded range for in-situ test, and the optimal mechanical parameters are obtained from this range by a loop. Comparing with the traditional finite element method （FEM）, the DDM regression results are more accurate.
基金supported by a grant from the Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine(CAMS-2017-I2M-4-002)
文摘Tumor antigens can be divided into tumor-associated antigens and tumor-specific antigens according to their specificity. Tumorassociated antigens are not unique to tumor cells, and can also be synthesized in small amounts by normal cells. Tumor-specific antigens, also called neoantigens, are formed by peptides that are entirely absent from the normal human genome [1]. Neoantigens are
