Bone defects caused by trauma, infection or bone tumor resection, are highly prevalent. A small number(5%–10%) of these injuries fail to heal due to non-union and require surgical intervention. Currently, the princip...Bone defects caused by trauma, infection or bone tumor resection, are highly prevalent. A small number(5%–10%) of these injuries fail to heal due to non-union and require surgical intervention. Currently, the principal treatment options for these defects are autografts, allografts, xenografts or synthetic grafts. The main problems associated with these therapies include pain,infection and donor site morbidity. Bone tissue engineering is a diverse field that focuses on the regeneration of bone by combining cells, scaffolds, growth factors and dynamic forces. There have been many recent studies utilizing biomineralized polymer matrix composites which mimic the natural structure of bone. The principal focus of this review is on recent advances in the synthesis of various types of biomineralized polymer matrix composite. Examples of the biomineralization of naturallyderived and synthetic polymers widely used for bone engineering are also summarized.展开更多
Cation-πinteraction is considered one of the strongest noncovalent interactions in aqueous solutions,which endows natural biomolecules(e.g.,proteins)with robust wet adhesion and cohesion in humid/underwater environme...Cation-πinteraction is considered one of the strongest noncovalent interactions in aqueous solutions,which endows natural biomolecules(e.g.,proteins)with robust wet adhesion and cohesion in humid/underwater environments.However,it remains a challenge to construct synthetic functional materials(e.g.,self-healing hydrogels)by adopting the cation-πinteractions rationally.Herein,we present a facile and novel strategy to fabricate injectable self-healing synthetic hydrogel from self-assembly of a thermoresponsive ABA triblock copolymer via cation-πinteractions.展开更多
基金supported by the National Key Research and Development Program of China (2017YFC1103500, 2017YFC1103502)the National Natural Science Foundation of China (31525009)+2 种基金Sichuan Innovative Research Team Program for Young Scientists (2016TD0004)Distinguished Young Scholars of Sichuan University (2011SCU04B18)Sichuan Science and Technology Project (2017GZ0429)
文摘Bone defects caused by trauma, infection or bone tumor resection, are highly prevalent. A small number(5%–10%) of these injuries fail to heal due to non-union and require surgical intervention. Currently, the principal treatment options for these defects are autografts, allografts, xenografts or synthetic grafts. The main problems associated with these therapies include pain,infection and donor site morbidity. Bone tissue engineering is a diverse field that focuses on the regeneration of bone by combining cells, scaffolds, growth factors and dynamic forces. There have been many recent studies utilizing biomineralized polymer matrix composites which mimic the natural structure of bone. The principal focus of this review is on recent advances in the synthesis of various types of biomineralized polymer matrix composite. Examples of the biomineralization of naturallyderived and synthetic polymers widely used for bone engineering are also summarized.
基金supports of the National Natural Science Foundation of China(no.21876119)Special Engineering Team of Sichuan University(no.2020SCUNG122)+1 种基金and Chengdu Science and Technology Program(no.2019-GH02-00029-HZ)H.Z.acknowledges the financial support from the Natural Sciences and Engineering Research Council of Canada(NSERC),Canada Foundation Innovation(CFI),and the Canada Research Chairs Program.
文摘Cation-πinteraction is considered one of the strongest noncovalent interactions in aqueous solutions,which endows natural biomolecules(e.g.,proteins)with robust wet adhesion and cohesion in humid/underwater environments.However,it remains a challenge to construct synthetic functional materials(e.g.,self-healing hydrogels)by adopting the cation-πinteractions rationally.Herein,we present a facile and novel strategy to fabricate injectable self-healing synthetic hydrogel from self-assembly of a thermoresponsive ABA triblock copolymer via cation-πinteractions.
