A healthy psychological state is the premise for children to carry out various activities.Previous surveys have shown that children with special needs are affected by their own obstacles and are more prone to psycholo...A healthy psychological state is the premise for children to carry out various activities.Previous surveys have shown that children with special needs are affected by their own obstacles and are more prone to psychological problems such as sensitivity,low self-esteem,and impulsiveness.Therefore,it is necessary to provide more sys-tematic mental health education support for special children.Mental health education programs are an efficient form of maintaining children’s mental health.However,in thefield of special education,the number of mental health education courses developed according to the physical and mental characteristics and developmental needs of special children is relatively small,and there are many difficulties in the implementation process.Autism dis-order(ASD)is a kind of pervasive developmental dysfunction that is relatively common and representative in clinical practice.In recent years,the number of autistic children has continued to surge,and has gradually expanded from a family problem to a serious social problem.At present,the evaluation of the effect of autism intervention mainly relies on various behavioral scales,which are subjective to a certain extent.At the same time,due to the unclear pathogenesis of autism,the treatment of autism cannot be predicated on the right medicine,and can only be intervened in various ways.The purpose of this paper is to explore the difference between the EEG signals of autistic children and typically developing control(TD)children through the analysis method of EEG signals,and based on the analysis of EEG signals from an objective point of view,to study whether the music therapy method of Chinese Zither playing training can effectively Improving the brain functional status of chil-dren with autism yields positive therapeutic outcomes.The experimental results show that the complexity of brain electrical signals of ASD children is much lower than that of TD children,and there is a significant difference in the brain functional state between the two.The music therapy method based on Chinese zither playing training can improve the brain function of autistic patients,and there is a positive therapeutic effect.And with the exten-sion of the training period,the effect may be more significant.Chinese zither playing training can provide a new direction for the intervention of autism.展开更多
The distribution and source of the solvent-extractable organic and inorganic components in PM2.5 (aerodynamics equivalent diameter below 2.5 microns), and PM10 (aerodynamics equivalent diameter below 10 microns) f...The distribution and source of the solvent-extractable organic and inorganic components in PM2.5 (aerodynamics equivalent diameter below 2.5 microns), and PM10 (aerodynamics equivalent diameter below 10 microns) fractions of airborne particles were studied weekly from September 2006 to August 2007 in Beijing. The extracted organic and inorganic compounds identified in both particle size ranges consisted of n-alkanes, PAHs (polycyclic aromatic hydrocarbons), fatty acids and water soluble ions. The potential emission sources of these organic compounds were reconciled by combining the values of n-alkane carbon preference index (CPI), %waxCn, selected diagnostic ratios of PAHs and principal component analysis in both size ranges. The mean cumulative concentrations of n-alkanes reached 1128.65 ng/m3 in Beijing, 74% of which (i.e., 831.7 ng/m3) was in the PM2.5 fraction, PAHs reached 136.45 ng/m3 (113.44 ng/m3 or 83% in PM2.5), and fatty acids reached 436.99 ng/m3 (324.41 ng/m3 or 74% in PM2.5), which resulted in overall enrichment in the fine particles. The average concentrations of SO42-, NO3-, and NH4+ were 21.3 ± 15.2, 6.1 ±1.8, 12.5 ± 6.1 μg/m3 in PM2.5, and 25.8±15.5, 8.9± 2.6, 16.9±9.5 μg/m3 in PM10, respectively. These three secondary ions primarily existed as ammonium sulfate ((NH4)2SO4), ammonium bisulfate (NH4HSO4) and ammonium nitrate (NH4NO3). The characteristic ratios of PAHs revealed that the primary sources of PAHs were coal combustion, followed by gasoline combustion. The ratios of stearic/palmitic acid indicated the major contribution of vehicle emissions to fatty acids in airborne particles. The major alkane sources were biogenic sources and fossil fuel combustion. The major sources of PAHs were vehicular emission and coal combustion.展开更多
RNA secondary structure has become the most exploitable feature for ab initio detection of non-coding RNA(nc RNA) genes from genome sequences. Previous work has used Minimum Free Energy(MFE) based methods develope...RNA secondary structure has become the most exploitable feature for ab initio detection of non-coding RNA(nc RNA) genes from genome sequences. Previous work has used Minimum Free Energy(MFE) based methods developed to identify nc RNAs by measuring sequence fold stability and certainty. However, these methods yielded variable performances across different nc RNA species. Designing novel reliable structural measures will help to develop effective nc RNA gene finding tools. This paper introduces a new RNA structural measure based on a novel RNA secondary structure ensemble constrained by characteristics of native RNA tertiary structures. The new method makes it possible to achieve a performance leap from the previous structure-based methods. Test results on standard nc RNA datasets(benchmarks) demonstrate that this method can effectively separate most nc RNAs families from genome backgrounds.展开更多
文摘A healthy psychological state is the premise for children to carry out various activities.Previous surveys have shown that children with special needs are affected by their own obstacles and are more prone to psychological problems such as sensitivity,low self-esteem,and impulsiveness.Therefore,it is necessary to provide more sys-tematic mental health education support for special children.Mental health education programs are an efficient form of maintaining children’s mental health.However,in thefield of special education,the number of mental health education courses developed according to the physical and mental characteristics and developmental needs of special children is relatively small,and there are many difficulties in the implementation process.Autism dis-order(ASD)is a kind of pervasive developmental dysfunction that is relatively common and representative in clinical practice.In recent years,the number of autistic children has continued to surge,and has gradually expanded from a family problem to a serious social problem.At present,the evaluation of the effect of autism intervention mainly relies on various behavioral scales,which are subjective to a certain extent.At the same time,due to the unclear pathogenesis of autism,the treatment of autism cannot be predicated on the right medicine,and can only be intervened in various ways.The purpose of this paper is to explore the difference between the EEG signals of autistic children and typically developing control(TD)children through the analysis method of EEG signals,and based on the analysis of EEG signals from an objective point of view,to study whether the music therapy method of Chinese Zither playing training can effectively Improving the brain functional status of chil-dren with autism yields positive therapeutic outcomes.The experimental results show that the complexity of brain electrical signals of ASD children is much lower than that of TD children,and there is a significant difference in the brain functional state between the two.The music therapy method based on Chinese zither playing training can improve the brain function of autistic patients,and there is a positive therapeutic effect.And with the exten-sion of the training period,the effect may be more significant.Chinese zither playing training can provide a new direction for the intervention of autism.
基金supported by the Science and Technology Project of Beijing (No. D09040903670902)the Chinese Academy of Sciences for Key Topics in Innovation Engineering (No. KZCX2-YW-Q02-03)the Basic Research and Development Program (973) of China (No.2007CB407303)
文摘The distribution and source of the solvent-extractable organic and inorganic components in PM2.5 (aerodynamics equivalent diameter below 2.5 microns), and PM10 (aerodynamics equivalent diameter below 10 microns) fractions of airborne particles were studied weekly from September 2006 to August 2007 in Beijing. The extracted organic and inorganic compounds identified in both particle size ranges consisted of n-alkanes, PAHs (polycyclic aromatic hydrocarbons), fatty acids and water soluble ions. The potential emission sources of these organic compounds were reconciled by combining the values of n-alkane carbon preference index (CPI), %waxCn, selected diagnostic ratios of PAHs and principal component analysis in both size ranges. The mean cumulative concentrations of n-alkanes reached 1128.65 ng/m3 in Beijing, 74% of which (i.e., 831.7 ng/m3) was in the PM2.5 fraction, PAHs reached 136.45 ng/m3 (113.44 ng/m3 or 83% in PM2.5), and fatty acids reached 436.99 ng/m3 (324.41 ng/m3 or 74% in PM2.5), which resulted in overall enrichment in the fine particles. The average concentrations of SO42-, NO3-, and NH4+ were 21.3 ± 15.2, 6.1 ±1.8, 12.5 ± 6.1 μg/m3 in PM2.5, and 25.8±15.5, 8.9± 2.6, 16.9±9.5 μg/m3 in PM10, respectively. These three secondary ions primarily existed as ammonium sulfate ((NH4)2SO4), ammonium bisulfate (NH4HSO4) and ammonium nitrate (NH4NO3). The characteristic ratios of PAHs revealed that the primary sources of PAHs were coal combustion, followed by gasoline combustion. The ratios of stearic/palmitic acid indicated the major contribution of vehicle emissions to fatty acids in airborne particles. The major alkane sources were biogenic sources and fossil fuel combustion. The major sources of PAHs were vehicular emission and coal combustion.
基金supported in part by NSF MRI 0821263NIH BISTI R01GM072080-01A1 grant+1 种基金NIH ARRA Administrative Supplement to NIH BISTI R01GM072080-01A1NSF IIS grant of award No 0916250
文摘RNA secondary structure has become the most exploitable feature for ab initio detection of non-coding RNA(nc RNA) genes from genome sequences. Previous work has used Minimum Free Energy(MFE) based methods developed to identify nc RNAs by measuring sequence fold stability and certainty. However, these methods yielded variable performances across different nc RNA species. Designing novel reliable structural measures will help to develop effective nc RNA gene finding tools. This paper introduces a new RNA structural measure based on a novel RNA secondary structure ensemble constrained by characteristics of native RNA tertiary structures. The new method makes it possible to achieve a performance leap from the previous structure-based methods. Test results on standard nc RNA datasets(benchmarks) demonstrate that this method can effectively separate most nc RNAs families from genome backgrounds.